The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development
Open accessAbstract
The mammary gland consists of cells with gene expression patterns reflecting their cellular origins, function, and spatiotemporal context. However, knowledge of developmental kinetics and mechanisms of lineage specification is lacking. We address this significant knowledge gap by generating a single-cell transcriptome atlas encompassing embryonic, postnatal, and adult mouse mammary development. From these data, we map the chronology of transcriptionally and epigenetically distinct cell states and distinguish fetal mammary stem cells (fMaSCs) from their precursors and progeny. fMaSCs show balanced co-expression of factors associated with discrete adult lineages and a metabolic gene signature that subsides during maturation but reemerges in some human breast cancers and metastases. These data provide a useful resource for illuminating mammary cell heterogeneity, the kinetics of differentiation, and developmental correlates of tumorigenesis.
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Cites
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
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Comprehensive molecular portraits of human breast tumours
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Generation of a functional mammary gland from a single stem cell
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Distinct stem cells contribute to mammary gland development and maintenance
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From single-cell to cell-pool transcriptomes: Stochasticity in gene expression and RNA splicing
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Cited by
Ireland, A. S., Micinski, A. M., Kastner, D. W., Guo, B., Wait, S. J., Spainhower, K. B., Conley, C. C., Chen, O. S., Guthrie, M. R., Soltero, D., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.05.001 · Cited by 508
Self-citationStem Cells and the Differentiation Hierarchy in Mammary Gland Development
Fu, N. Y., Nolan, E., Lindeman, G. J., & Visvader, J. E. (2020) · Physiological Reviews · doi:10.1152/physrev.00040.2018 · Cited by 267
Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing
Li, C. M.-C., Shapiro, H., Tsiobikas, C., Selfors, L. M., Chen, H., Rosenbluth, J., Moore, K., Gupta, K. P., Gray, G. K., Oren, Y., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108566 · Cited by 184
Cancer Stem Cells and Epithelial-to-Mesenchymal Transition in Cancer Metastasis
Celià-Terrassa, T., & Jolly, M. K. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036905 · Cited by 163
Metadata
- Authors
- Giraddi, R. R., Chung, C.-Y., Heinz, R. E., Balcioglu, O., Novotny, M., Trejo, C. L., Dravis, C., Hagos, B. M., Mehrabad, E. M., Rodewald, L. W., Hwang, J. Y., Fan, C., Lasken, R., Varley, K. E., Perou, C. M., Wahl, G. M., & Spike, B. T.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 24
- Issue
- 6
- Pages
- 1653-1666.e7
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2887779955
- Cited by
- 164
- References
- 12
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- gold
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