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Cited by 149Functional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsNeural dynamics and brain function

Three distinct sets of connector hubs integrate human brain function

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Gordon, Evan M., Lynch, Charles J., Gratton, Caterina, Laumann, Timothy O., Gilmore, Adrian W., Greene, Deanna J., Ortega, Mario, Nguyen, Annie L. +4 more·2018·Cell Reports
DOI 10.1016/j.celrep.2018.07.050PMC PMC6886580
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Abstract

Control over behavior is enabled by the brain's control networks, which interact with lower-level sensory motor and default networks to regulate their functions. Such interactions are facilitated by specialized "connector hub" regions that interconnect discrete networks. Previous work has treated hubs as a single category of brain regions, although their unitary nature is dubious when examined in individual brains. Here we investigated the nature of hubs by using fMRI to characterize individual-specific hub regions in two independent datasets. We identified three separable sets of connector hubs that integrate information between specific brain networks. These three hub categories occupy different positions within the brain's network structure; they affect networks differently when artificially lesioned, and they are differentially engaged during cognitive and motor task performance. This work suggests a model of brain organization in which different connector hubs integrate control functions and enable top-down control of separate processing streams.

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  • These convergence zones may serve as connector hubs that integrate information across DMN subnetworks.

    “These convergence zones may serve as connector hubs 84,115 that integrate information across DMN subnetworks, thereby facilitating flexible and adaptive integration of self-referential, social, episodic memory, language, and semantic memory processes described in this review.”

    From 20 years of the default mode network: A review and synthesis. (2023) · cites this paper as [84]

    The Results section (‘Connector Hubs Cluster into Three Discrete Categories’; page unavailable) identifies control-default connector hubs with strong connectivity to the DMN, FPN, and CAN. The Discussion (‘Different Hub Categories Integrate Different Aspects of Human Brain Function’; page unavailable) proposes that these hubs integrate information between control and processing systems, specifically linking the DMN and FPN. It does not establish that the cited hubs are the convergence zones in question or that they integrate information across DMN subnetworks. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Gordon, E. M., Lynch, C. J., Gratton, C., Laumann, T. O., Gilmore, A. W., Greene, D. J., Ortega, M., Nguyen, A. L., Schlaggar, B. L., Petersen, S. E., Dosenbach, N. U. F., & Nelson, S. M.
Affiliations
  • Baylor University (US)
  • Georgetown University (US)
  • Washington University in St. Louis (US)
  • National Institutes of Health (US)
Corresponding author
Gordon, Evan M.
ORCID
Venue
Cell Reports
Publisher
Elsevier BV
Published
2018-08
Volume
24
Issue
7
Pages
1687-1695.e4
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2018.07.050
PMC
PMC6886580
OpenAlex
W2885824833
Cited by
149
References
9
Citations by year
2026: 12 · 2025: 14 · 2024: 19 · 2023: 19 · 2022: 20 · 2021: 18 · 2020: 34 · 2019: 9 · 2018: 3
FWCI
9.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Reports (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Hope Center for Neurological Disorders
  • McDonnell Center for Systems Neuroscience
  • American Psychological Association
  • Child Neurology Foundation
  • James S. McDonnell Foundation
  • Jacobs Foundation
  • National Institutes of Health (MH104592, TR000448, NS088590)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
connector hubs, brain network integration, control network, default mode network, sensorimotor network, top-down control, cognitive task performance, motor task performance, brain organization
MeSH terms
Adult, Brain, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways, Connectome, Datasets as Topic

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