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Ultra-Sensitive TP53 Sequencing for Cancer Detection Reveals Progressive Clonal Selection in Normal Tissue over a Century of Human Lifespan
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“Deep sequencing of normal tissues has shown that expansion of clones bearing acquired mutations in well-established cancer drivers is pervasive with age8–15.”
From Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy (2025) · cites this paper as [9]
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Cited by
Cancer as a disease of old age: changing mutational and microenvironmental landscapes
Laconi, E., Marongiu, F., & DeGregori, J. (2020) · British Journal of Cancer · doi:10.1038/s41416-019-0721-1 · Cited by 348
Macroscopic somatic clonal expansion in morphologically normal human urothelium
Li, R., Du, Y., Chen, Z., Xu, D., Lin, T., Jin, S., Wang, G., Liu, Z., Lu, M., Chen, X., et al. (2020) · Science · doi:10.1126/science.aba7300 · Cited by 206
Germline genetic variation impacts clonal hematopoiesis landscape and progression to malignancy
Liu, J., Tran, D., Xue, L., Wiley, B. J., Vlasschaert, C., Watson, C. J., MacGregor, H. A. J., Zong, X., Chan, I. C. C., Das, I., et al. (2025) · Nature Genetics · doi:10.1038/s41588-025-02250-x · Cited by 33
Metadata
- Authors
- Salk, J. J., Loubet-Senear, K., Maritschnegg, E., Valentine, C. C., Williams, L. N., Higgins, J. E., Horvat, R., Vanderstichele, A., Nachmanson, D., Baker, K. T., Emond, M. J., Loter, E., Tretiakova, M., Soussi, T., Loeb, L. A., Zeillinger, R., Speiser, P., & Risques, R. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 28
- Issue
- 1
- Pages
- 132-144.e3
- ISSN
- 2211-1247
- PMC
- PMC6639023
- Cited by
- 95
- References
- 12
- Language
- en
- Licence
- Funders
- National Institutes of Health (R01CA181308)
- Mary Kay Foundation (045-15, 174261, 567612, CA077852, CA193649, R44CA221426, T32CA009515)
- Small Business Innovation Research
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