Evaluation of DNA from the Papanicolaou test to detect ovarian and endometrial cancers.
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Mutant DNA from ovarian and endometrial tumors can be detected in Pap smear specimens through massively parallel sequencing.
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- Authors
- Kinde, I., Bettegowda, C., Wang, Y., Wu, J., Agrawal, N., Shih, I.-M., Kurman, R., Dao, F., Levine, D. A., Giuntoli, R., Roden, R., Eshleman, J. R., Carvalho, J. P., Marie, S. K. N., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., & Diaz, L. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Johns Hopkins University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Universidade de São Paulo (BR)
- Corresponding author
- Kinde, Isaac
- Bettegowda, Chetan
- Wang, Yuxuan
- Vogelstein, Bert
- Diaz, Luis A.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2013-01-09
- Volume
- 5
- Issue
- 167
- Pages
- 167ra4-167ra4
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3757513
- OpenAlex
- W2160541773
- Cited by
- 327
- References
- 52
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 10 · 2023: 21 · 2022: 20 · 2021: 24 · 2020: 22 · 2019: 36 · 2018: 23 · 2017: 31 · 2016: 19 · 2015: 37 · 2014: 23 · 2013: 25
- FWCI
- 12.20
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (n01cn43309-10-0-1)
- National Cancer Institute (N01 CN043309, R01CA129825, CA43460, N01 CN43309, R37CA043460, CA129825, P50CA062924, CA062924, P50CA098252)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- endometrial cancer, ovarian cancer, tumor DNA detection, somatic mutations, liquid biopsy, gynecologic cancer screening, early cancer detection, exome sequencing, next-generation sequencing
- MeSH terms
- DNA, Neoplasm, Female, Humans, Mutation, Ovarian Neoplasms, Vaginal Smears, Endometrial Neoplasms, Papanicolaou Test
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