Cancer-associated mutations in endometriosis without cancer
Open accessAbstract
BACKGROUND: Endometriosis, defined as the presence of ectopic endometrial stroma and epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain and infertility. Endometriotic lesions are considered to be benign inflammatory lesions but have cancerlike features such as local invasion and resistance to apoptosis. METHODS: We analyzed deeply infiltrating endometriotic lesions from 27 patients by means of exomewide sequencing (24 patients) or cancer-driver targeted sequencing (3 patients). Mutations were validated with the use of digital genomic methods in microdissected epithelium and stroma. Epithelial and stromal components of lesions from an additional 12 patients were analyzed by means of a droplet digital polymerase-chain-reaction (PCR) assay for recurrent activating KRAS mutations. RESULTS: Exome sequencing revealed somatic mutations in 19 of 24 patients (79%). Five patients harbored known cancer driver mutations in ARID1A, PIK3CA, KRAS, or PPP2R1A, which were validated by Safe-Sequencing System or immunohistochemical analysis. The likelihood of driver genes being affected at this rate in the absence of selection was estimated at P=0.001 (binomial test). Targeted sequencing and a droplet digital PCR assay identified KRAS mutations in 2 of 3 patients and 3 of 12 patients, respectively, with mutations in the epithelium but not the stroma. One patient harbored two different KRAS mutations, c.35G→T and c.35G→C, and another carried identical KRAS c.35G→A mutations in three distinct lesions. CONCLUSIONS: We found that lesions in deep infiltrating endometriosis, which are associated with virtually no risk of malignant transformation, harbor somatic cancer driver mutations. Ten of 39 deep infiltrating lesions (26%) carried driver mutations; all the tested somatic mutations appeared to be confined to the epithelial compartment of endometriotic lesions.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
While nucleotide variants or mutations were noted sporadically in the epithelial component of ovarian endometriomas or deep-infiltrating endometriosis, stromal cells consistently lack any somatic mutations.
“While nucleotide variants or mutations were noted sporadically in the epithelial component of ovarian endometriomas or deep-infiltrating endometriosis, stromal cells consistently lack any somatic mutations (Anglesio et al., 2017).”
From Endometriosis and nuclear receptors (2019) · cites this paper as Anglesio et al., 2017
The Results report somatic mutations in epithelial cells but not stroma in the compartments tested, and the Conclusions say that all tested somatic mutations appeared confined to epithelium. The claim overstates this as a finding that stromal cells consistently lack any somatic mutations; the paper does not establish that for every stromal cell or lesion. It also reports earlier ovarian-endometriosis mutation findings without establishing the same epithelial–stromal comparison for ovarian endometriomas. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMolecular biology techniques using next-generation sequencing have provided clues to the origin of endometriosis and pathogenesis that cannot be elucidated by epidemiological investigations alone.
“Recently, molecular biology techniques using a next‐generation sequencing have also provided clues to the origin of endometriosis and pathogenesis that cannot be elucidated by epidemiological investigations alone.”
From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [104]
Mutations in cancer-associated genes such as PIK3CA, KRAS, and ARID1A have been identified in extraovarian endometriosis.
“Cancer genomic mutations have also been reported for extraovarian endometriosis in recent years, and mutations in cancer-associated genes, such as PIK3CA, KRAS, and ARID1A, have been identified [106].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [106]
Cancer genomic mutations have been reported for extraovarian endometriosis.
“Cancer genomic mutations have also been reported for extraovarian endometriosis in recent years, and mutations in cancer-associated genes, such as PIK3CA, KRAS, and ARID1A, have been identified [106].”
From Malignancies Associated with Extraovarian Endometriosis: A Literature Review (2021) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Stratton, M. R., Campbell, P. J., & Futreal, P. A. (2009) · Nature · doi:10.1038/nature07943 · Cited by 3,458 · see citing works
Sampson, J. A. (1927) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(15)30003-x · Cited by 2,334 · see citing works
COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
Forbes, S. A., Bindal, N., Bamford, S., Cole, C., Kok, C. Y., Beare, D., Jia, M., Shepherd, R., Leung, K., Menzies, A., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq929 · Cited by 2,278 · see citing works
Giudice, L. C. (2010) · New England Journal of Medicine · doi:10.1056/nejmcp1000274 · Cited by 1,924 · see citing works
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works
High burden and pervasive positive selection of somatic mutations in normal human skin
Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770 · see citing works
<i>ARID1A</i> Mutations in Endometriosis-Associated Ovarian Carcinomas
Wiegand, K. C., Shah, S. P., Al-Agha, O. M., Zhao, Y., Tse, K., Zeng, T., Senz, J., McConechy, M. K., Anglesio, M. S., Kalloger, S. E., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1008433 · Cited by 1,712 · see citing works
Self-citationDetection and quantification of rare mutations with massively parallel sequencing
Kinde, I., Wu, J., Papadopoulos, N., Kinzler, K. W., & Vogelstein, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105422108 · Cited by 1,205 · see citing works
Self-citationSimoens, S., Dunselman, G., Dirksen, C., Hummelshoj, L., Bokor, A., Brandes, I., Brodszky, V., Canis, M., Colombo, G. L., DeLeire, T., et al. (2012) · Human Reproduction · doi:10.1093/humrep/des073 · Cited by 1,070 · see citing works
(1927) · PubMed Central · Cited by 1,008 · see citing works
The Dualistic Model of Ovarian Carcinogenesis
Kurman, R. J., & Shih, I. (2016) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.11.011 · Cited by 933 · see citing works
Self-citationMosaic Copy Number Variation in Human Neurons
McConnell, M. J., Lindberg, M. R., Brennand, K. J., Piper, J. C., Voet, T., Cowing-Zitron, C., Shumilina, S., Lasken, R. S., Vermeesch, J. R., Hall, I. M., et al. (2013) · Science · doi:10.1126/science.1243472 · Cited by 551 · see citing works
Vercellini, P., Fedele, L., Aimi, G., Pietropaolo, G., Consonni, D., & Crosignani, P. G. (2007) · Human Reproduction · doi:10.1093/humrep/del339 · Cited by 547 · see citing works
De Graaff, A. A., D'Hooghe, T. M., Dunselman, G. A. J., Dirksen, C. D., Hummelshoj, L., WERF EndoCost Consortium, Simoens, S., Bokor, A., Brandes, I., Brodszky, V., et al. (2013) · Human Reproduction · doi:10.1093/humrep/det284 · Cited by 473 · see citing works
Sato, N., Tsunoda, H., Nishida, M., Morishita, Y., Takimoto, Y., Kubo, T., & Noguchi, M. (2000) · PubMed · Cited by 451 · see citing works
Endometriosis: Diagnosis and Management
Leyland, N., Casper, R., Laberge, P., Singh, S. S., Allen, L., Arendas, K., Leyland, N., Allaire, C., Awadalla, A., Best, C., et al. (2010) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34589-3 · Cited by 427 · see citing works
Self-citation<i>Stem Cells and the Pathogenesis of Endometriosis</i>
Sasson, I. E., & Taylor, H. S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1434.014 · Cited by 371 · see citing works
Masuda, H., Matsuzaki, Y., Hiratsu, E., Ono, M., Nagashima, T., Kajitani, T., Arase, T., Oda, H., Uchida, H., Asada, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010387 · Cited by 303 · see citing works
Economic burden of endometriosis
Gao, X., Outley, J., Botteman, M., Spalding, J., Simon, J. A., & Pashos, C. L. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.06.015 · Cited by 289 · see citing works
Mutation and Loss of Expression of ARID1A in Uterine Low-grade Endometrioid Carcinoma
Guan, B., Mao, T., Panuganti, P. K., Kuhn, E., Kurman, R. J., Maeda, D., Chen, E., Jeng, Y., Wang, T., & Shih, I. (2011) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318212782a · Cited by 287 · see citing works
Self-citationYamamoto, S., Tsuda, H., Takano, M., Tamai, S., & Matsubara, O. (2011) · Modern Pathology · doi:10.1038/modpathol.2011.189 · Cited by 259 · see citing works
Whole-exome Sequencing analyses of Inflammatory Bowel Disease-associated Colorectal Cancers
Robles, A., Traverso, G., Zhang, M., Roberts, N. J., Khan, M. A., Joseph, C. G., Lauwers, G., Selaru, F., Popoli, M., Pittman, M., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2015.12.036 · Cited by 252 · see citing works
Self-citationJubanyik, K. J., & Comite, F. (1997) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/s0889-8545(05)70311-9 · Cited by 237 · see citing works
Rahmioglu, N., Fassbender, A., Vitonis, A. F., Tworoger, S. S., Hummelshoj, L., D'Hooghe, T. M., Adamson, G. D., Giudice, L. C., Becker, C. M., Zondervan, K. T., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1208 · Cited by 227 · see citing works
Self-citationSynchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality
Anglesio, M. S., Wang, Y. K., Maassen, M., Horlings, H. M., Bashashati, A., Senz, J., Mackenzie, R., Grewal, D. S., Li-Chang, H. H., Karnezis, A. N., et al. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv428 · Cited by 227 · see citing works
Self-citationPathogenetic Mechanisms of Deep Infiltrating Endometriosis
Tosti, C., Pinzauti, S., Santulli, P., Chapron, C., & Petraglia, F. (2015) · Reproductive Sciences · doi:10.1177/1933719115592713 · Cited by 222 · see citing works
Stem cells in endometrium and their role in the pathogenesis of endometriosis
Figueira, P. G. M., Abrão, M. S., Krikun, G., & Taylor, H. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05969.x · Cited by 188 · see citing works
Multifocal endometriotic lesions associated with cancer are clonal and carry a high mutation burden
Anglesio, M. S., Bashashati, A., Wang, Y. K., Senz, J., Ha, G., Yang, W., Aniba, R., Prentice, L., Farahani, H., Chang, H. L., et al. (2015) · The Journal of Pathology · doi:10.1002/path.4516 · Cited by 178 · see citing works
Self-citationReconstruction of endometrium from human endometrial side population cell lines
Cervelló, I., Mas, A., Gil-Sanchis, C., Peris, L., Faus, A., Saunders, P. T. K., Critchley, H. O. D., & Simón, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021221 · Cited by 178 · see citing works
Endometriosis and Ovarian Cancer
Wei, J., William, J., & Bulun, S. E. (2011) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e31821f4b85 · Cited by 174 · see citing works
Ayhan, A., Mao, T., Seckin, T. A., Wu, C., Guan, B., Ogawa, H., Futagami, M., Mizukami, H., Yokoyama, Y., Kurman, R. J., et al. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e31826b5dcc · Cited by 166 · see citing works
Self-citationFassbender, A., Rahmioglu, N., Vitonis, A. F., Viganò, P., Giudice, L. C., D’Hooghe, T. M., Hummelshoj, L., Adamson, G. D., Becker, C. M., Missmer, S. A., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1209 · Cited by 162 · see citing works
Self-citationEndometriosis in an Adolescent Population: The Emory Experience
Reese, K. A., Reddy, S., & Rock, J. A. (1996) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/s1083-3188(96)70021-9 · Cited by 160 · see citing works
Krimmel‐Morrison, J. D., Schmitt, M. W., Harrell, M. I., Agnew, K. J., Kennedy, S. R., Emond, M. J., Loeb, L. A., Swisher, E. M., & Risques, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601311113 · Cited by 155 · see citing works
The Conundrum of Genetic “Drivers” in Benign Conditions
Kato, S., Lippman, S. M., Flaherty, K. T., & Kurzrock, R. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw036 · Cited by 147 · see citing works
Subtype‐specific mutation of PPP2R1A in endometrial and ovarian carcinomas
McConechy, M. K., Anglesio, M. S., Kalloger, S. E., Yang, W., Senz, J., Chow, C., Heravi‐Moussavi, A., Morin, G. B., Mes‐Masson, A., Chenevix‐Trench, G., et al. (2011) · The Journal of Pathology · doi:10.1002/path.2848 · Cited by 131 · see citing works
Self-citationTreatment of pain associated with deep endometriosis: alternatives and evidence
Ferrero, S., Alessandri, F., Racca, A., & Maggiore, U. L. R. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.08.031 · Cited by 124 · see citing works
Mao, T., Ardighieri, L., Ayhan, A., Kuo, K., Wu, C., Wang, T., & Shih, I. (2013) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3182889dc3 · Cited by 110 · see citing works
Self-citationWu, R., Ayhan, A., Maeda, D., Kim, K.-R., Clarke, B. A., Shaw, P. H., Chui, M. H., Rosen, B. P., Shih, I., & Wang, T. (2013) · The Journal of Pathology · doi:10.1002/path.4315 · Cited by 102 · see citing works
Self-citationWhat is the societal burden of endometriosis-associated symptoms? A prospective Belgian study
Klein, S., D’Hooghe, T. M., Meuleman, C., Dirksen, C. D., Dunselman, G. A. J., & Simoens, S. (2013) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2013.09.020 · Cited by 100 · see citing works
Molecular Genetic Defects in Endometriosis
Thomas, E. J., & Campbell, I. (2000) · Gynecologic and Obstetric Investigation · doi:10.1159/000052878 · Cited by 97 · see citing works
Ferguson, B., Bennington, J. L., & Haber, S. (1969) · PubMed · Cited by 96 · see citing works
Samartzis, E. P., Samartzis, N., Noske, A., Fedier, A., Caduff, R. F., Dedes, K. J., Fink, D. A., & Imesch, P. (2012) · Modern Pathology · doi:10.1038/modpathol.2011.217 · Cited by 89 · see citing works
Identifying the Biological Basis of GWAS Hits for Endometriosis1
Fung, J. N., Rogers, P. A. W., & Montgomery, G. W. (2015) · Biology of Reproduction · doi:10.1095/biolreprod.114.126458 · Cited by 69 · see citing works
Cheng, C., Licence, D. R., Cook, E., Luo, F., Arends, M. J., Smith, S. K., Print, C. G., & Jones, D. S. (2011) · The Journal of Pathology · doi:10.1002/path.2852 · Cited by 63 · see citing works
Chene, G., Ouellet, V., Rahimi, K., Barrès, V., Provencher, D. M., & Mes‐Masson, A. (2015) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2015.02.021 · Cited by 60 · see citing works
Aberrant portions of the müllerian duct found in an ovary
Russell, W. (1979) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(79)90890-1 · Cited by 60 · see citing works
Donnez, J., Squifflet, J. P., Pirard, C., Jadoul, P., Wyns, C., & Smets, M. (2002) · Gynecologic and Obstetric Investigation · doi:10.1159/000066288 · Cited by 51 · see citing works
Oncogenic events associated with endometrial and ovarian cancers are rare in endometriosis
Vestergaard, A. L., Thorup, K., Knudsen, U. B., Munk, T., Rosbach, H. K., Poulsen, J. B., Guldberg, P., & Martensen, P. M. (2011) · Molecular Human Reproduction · doi:10.1093/molehr/gar049 · Cited by 39 · see citing works
Borrelli, G. M., Abrão, M. S., TAUBE, E. T., Darb‐Esfahani, S., Köhler, C., Chiàntera, V., & Mechsner, S. (2016) · Molecular Human Reproduction · doi:10.1093/molehr/gaw009 · Cited by 38 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zondervan, K. T., Becker, C. M., & Missmer, S. A. (2020) · New England Journal of Medicine · doi:10.1056/nejmra1810764 · Cited by 2,249 · see citing works
Endometriosis is a chronic systemic disease: Clinical challenges and novel innovations
Taylor, H. S., Kotlyar, A. M., & Flores, V. A. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00389-5 · Cited by 1,425 · see citing works
Zondervan, K. T., Becker, C. M., Koga, K., Missmer, S. A., Taylor, R. N., & Viganò, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0008-5 · Cited by 1,257 · see citing works
Somatic mutant clones colonize the human esophagus with age
Martincorena, I., Fowler, J. C., Wabik, A., Lawson, A. R. J., Abascal, F., Hall, M. W. J., Cagan, A., Murai, K., Mahbubani, K., Stratton, M. R., et al. (2018) · Science · doi:10.1126/science.aau3879 · Cited by 1,113 · see citing works
Endometriosis: Etiology, pathobiology, and therapeutic prospects
Saunders, P. T. K., & Horne, A. W. (2021) · Cell · doi:10.1016/j.cell.2021.04.041 · Cited by 1,022 · see citing works
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019) · Endocrine Reviews · doi:10.1210/er.2018-00242 · Cited by 844 · see citing works
Clinical Management of Endometriosis
Falcone, T., & Flyckt, R. L. (2018) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000002469 · Cited by 582 · see citing works
The emerging role of cell-free DNA as a molecular marker for cancer management
Bronkhorst, A. J., Ungerer, V., & Holdenrieder, S. (2019) · Biomolecular Detection and Quantification · doi:10.1016/j.bdq.2019.100087 · Cited by 566 · see citing works
The endometrial immune environment of women with endometriosis
Vallvé-Juanico, J., Houshdaran, S., & Giudice, L. C. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz018 · Cited by 527 · see citing works
Boretto, M., Maenhoudt, N., Luo, X., Hennes, A., Boeckx, B., Bui, B. N., Heremans, R., Perneel, L., Kobayashi, H., Zundert, I. V., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0360-z · Cited by 507 · see citing works
The mutational landscape of normal human endometrial epithelium
Moore, L., Leongamornlert, D., Coorens, T. H. H., Sanders, M. A., Ellis, P., Dentro, S. C., Dawson, K. J., Butler, T., Rahbari, R., Mitchell, T. J., et al. (2020) · Nature · doi:10.1038/s41586-020-2214-z · Cited by 499 · see citing works
Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain
Nikolaev, S. I., Vetiska, S., Bonilla, X., Boudreau, É., Jauhiainen, S., Jahromi, B. R., Khyzha, N., DiStefano, P. V., Suutarinen, S., Kiehl, T., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1709449 · Cited by 481 · see citing works
The Origin and Pathogenesis of Endometriosis
Wang, Y., Nicholes, K., & Shih, I. (2019) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032654 · Cited by 466 · see citing works
Self-citationMenstruation: science and society
Critchley, H., Babayev, E., Bulun, S. E., Clark, S., Garcia-Grau, I., Gregersen, P. K., Kilcoyne, A., Kim, J.-Y. J., Lavender, M. D., Marsh, E. E., et al. (2020) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.06.004 · Cited by 484 · see citing works
Pathogenesis of endometriosis: The genetic/epigenetic theory
Koninckx, P. R., Ussia, A., Adamyan, L., Wattiez, A., Gomel, V., & Martin, D. C. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.10.013 · Cited by 427 · see citing works
Targeting epigenetic modifications in cancer therapy: erasing the roadmap to cancer
Mohammad, H. P., Barbash, O., & Creasy, C. L. (2019) · Nature Medicine · doi:10.1038/s41591-019-0376-8 · Cited by 418 · see citing works
Suda, K., Nakaoka, H., Yoshihara, K., Ishiguro, T., Tamura, R., Mori, Y., Yamawaki, K., Adachi, S., Takahashi, T., Kase, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.037 · Cited by 414 · see citing works
Clinical actionability of molecular targets in endometrial cancer
Urick, M. E., & Bell, D. W. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0177-x · Cited by 405 · see citing works
The Main Theories on the Pathogenesis of Endometriosis
Lamceva, J., Uljanovs, R., & Strumfa, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054254 · Cited by 324 · see citing works
Endometriosis and cancer: a systematic review and meta-analysis
Kvaskoff, M., Mahamat-Saleh, Y., Farland, L. V., Shigesi, N., Terry, K. L., Harris, H. R., Roman, H., Becker, C. M., As-Sanie, S., Zondervan, K. T., et al. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmaa045 · Cited by 303 · see citing works
Ata, B., Yıldız, Ş., Türkgeldi, E., Pérez‐Brocal, V., Dinleyici, E. Ç., Moyá, A., & Urman, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-39700-6 · Cited by 294 · see citing works
Wang, Y., Li, L., Douville, C. B., Cohen, J. D., Yen, T., Kinde, I., Sundfelt, K., Kjær, S. K., Hruban, R. H., Shih, I., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap8793 · Cited by 245 · see citing works
Self-citationEndometriosis and nuclear receptors
Yilmaz, B. D., & Bulun, S. E. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz005 · Cited by 243 · see citing works
Endometriosis and adenomyosis: shared pathophysiology
Bulun, S. E., Yildiz, S., Adli, M., Chakravarti, D., Parker, J. B., Milad, M., Yang, L., Chaudhari, A., Tsai, S., Wei, J. J., et al. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.03.006 · Cited by 216 · see citing works
Aging and the rise of somatic cancer-associated mutations in normal tissues
Risques, R. A., & Kennedy, S. R. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007108 · Cited by 212 · see citing works
The coming decade in precision oncology: six riddles
Wahida, A., Buschhorn, L., Fröhling, S., Jost, P. J., Schneeweiß, A., Lichter, P., & Kurzrock, R. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00529-3 · Cited by 214 · see citing works
Adenomyosis pathogenesis: insights from next-generation sequencing
Bulun, S. E., Yıldız, Ş., Adli, M., & Wei, J. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab017 · Cited by 211 · see citing works
Single-cell transcriptomic analysis of endometriosis
Fonseca, M. A., Haro, M., Wright, K. N., Lin, X., Abbasi, F., Sun, J. K., Hernández, L., Orr, N. L., Hong, J., Choi-Kuaea, Y., et al. (2023) · Nature Genetics · doi:10.1038/s41588-022-01254-1 · Cited by 203 · see citing works
Self-citationTesta, U., Petrucci, E., Pasquini, L., Castelli, G., & Pelosi, E. (2018) · Medicines · doi:10.3390/medicines5010016 · Cited by 189 · see citing works
Lin, Y.-H., Chen, Y.-H., Chang, H.-Y., Au, H., Tzeng, C., & Huang, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082385 · Cited by 187 · see citing works
Progesterone Actions and Resistance in Gynecological Disorders
MacLean, J. A., & Hayashi, K. (2022) · Cells · doi:10.3390/cells11040647 · Cited by 196 · see citing works
The potential of liquid biopsies for the early detection of cancer
Heitzer, E., Perakis, S. O., Geigl, J. B., & Speicher, M. R. (2017) · npj Precision Oncology · doi:10.1038/s41698-017-0039-5 · Cited by 166 · see citing works
Somatic Mutations in “Benign” Disease
Mustjoki, S. M., & Young, N. S. (2021) · New England Journal of Medicine · doi:10.1056/nejmra2101920 · Cited by 160 · see citing works
Molecular mechanisms of the preventable causes of cancer in the United StatesPreprint
Golemis, E. A., Scheet, P. A., Beck, T. N., Scolnick, E. M., Hunter, D. J., Hawk, E. T., & Hopkins, N. H. (2018) · Genes & Development · doi:10.1101/gad.314849.118 · Cited by 156 · see citing works
Cell competition: the winners and losers of fitness selection
Bowling, S., Lawlor, K., & Rodríguez, T. A. (2019) · Development · doi:10.1242/dev.167486 · Cited by 149 · see citing works
Genomics to immunotherapy of ovarian clear cell carcinoma: Unique opportunities for management
Oda, K., Hamanishi, J., Matsuo, K., & Hasegawa, K. (2018) · Gynecologic Oncology · doi:10.1016/j.ygyno.2018.09.001 · Cited by 143 · see citing works
Oncogenic mutations in histologically normal endometrium: the new normal?
Lac, V., Nazeran, T. M., Tessier‐Cloutier, B., Aguirre-Hernández, R., Albert, A., Lum, A. M., Khattra, J. S., Praetorius, T., Mason, M., Chiu, D. S., et al. (2019) · The Journal of Pathology · doi:10.1002/path.5314 · Cited by 139 · see citing works
Self-citationUterine adenomyosis is an oligoclonal disorder associated with KRAS mutations
Inoue, S., Hirota, Y., Ueno, T., Fukui, Y., Yoshida, E., Hayashi, T., Kojima, S., Takeyama, R., Hashimoto, T., Kiyono, T., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13708-y · Cited by 139 · see citing works
Endometriosis-associated ovarian neoplasia
Matías‐Guiu, X., & Stewart, C. J. R. (2017) · Pathology · doi:10.1016/j.pathol.2017.10.006 · Cited by 131 · see citing works
Hyaluronan, Cancer-Associated Fibroblasts and the Tumor Microenvironment in Malignant Progression
McCarthy, J. B., El‐Ashry, D., & Turley, E. A. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00048 · Cited by 128 · see citing works
Wilson, M. R., Reske, J. J., Holladay, J., Moldovan, G. E., Rhodes, M., Koeman, J. M., Adams, M., Johnson, B. K., Su, R., Joshi, N., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11403-6 · Cited by 128 · see citing works
The Evolution of Ovarian Carcinoma Subclassification
Köbel, M., & Kang, E. Y. (2022) · Cancers · doi:10.3390/cancers14020416 · Cited by 128 · see citing works
Murakami, R., Matsumura, N., Brown, J. B., Higasa, K., Tsutsumi, T., Kamada, M., Abou-Taleb, H., Hosoe, Y., Kitamura, S., Yamaguchi, K. D., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.06.012 · Cited by 127 · see citing works
Epigenetic Dysregulation in Endometriosis: Implications for Pathophysiology and Therapeutics
Marquardt, R. M., Tran, D. N., Lessey, B. A., Rahman, M. S., & Jeong, J. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad020 · Cited by 130 · see citing works
Endometriosis and risk of ovarian cancer: what do we know?
Králíčková, M., Laganà, A. S., Ghezzi, F., & Větvička, V. (2019) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-019-05358-8 · Cited by 122 · see citing works
Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives
Terzić, M., Aimagambetova, G. N., Kunz, J., Bapayeva, G., Aitbayeva, B., Terzic, S., & Laganà, A. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179274 · Cited by 111 · see citing works
Extra-pelvic endometriosis: a review.
Hirata, T., Koga, K., & Osuga, Y. (2020) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12340 · Cited by 107 · see citing works
Dawson, A., Llauradó Fernandez, M., Anglesio, M., Yong, P. J., & Carey, M. S. (2018) · ecancermedicalscience · doi:10.3332/ecancer.2018.803 · Cited by 106 · see citing works
Self-citationEpithelial Mutations in Endometriosis: Link to Ovarian Cancer
Bulun, S. E., Wan, Y., & Matei, D. E. (2019) · Endocrinology · doi:10.1210/en.2018-00794 · Cited by 103 · see citing works
Duska, L., & Kohn, E. C. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx445 · Cited by 101 · see citing works
Salk, J. J., Loubet-Senear, K. J., Maritschnegg, E., Valentine, C. C., Williams, L. N., Higgins, J. E., Horvat, R., Vanderstichele, A., Nachmanson, D., Baker, K. T., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.109 · Cited by 98 · see citing works
Iatrogenic endometriosis harbors somatic cancer-driver mutations
Lac, V, Verhoef, L., Aguirre-Hernandez, R., Nazeran, T. M., Tessier-Cloutier, B., Praetorius, T., Orr, N. L., Noga, H., Lum, A., Khattra, J., et al. (2019) · Human Reproduction · doi:10.1093/humrep/dey332 · Cited by 99 · see citing works
Self-citationCancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology
Guo, S.-W. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmz047 · Cited by 96 · see citing works
Cochrane, D. R., Tessier‐Cloutier, B., Lawrence, K. M., Nazeran, T. M., Karnezis, A. N., Salamanca, C. M., Cheng, A. S., McAlpine, J. N., Hoang, L. N., Gilks, C. B., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4934 · Cited by 94 · see citing works
Self-citationIs it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?
Guo, S., & Groothuis, P. G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy020 · Cited by 93 · see citing works
Clonality in context: hematopoietic clones in their marrow environment
Cooper, J. N., & Young, N. S. (2017) · Blood · doi:10.1182/blood-2017-07-794362 · Cited by 96 · see citing works
Giudice, L. C., Oskotsky, T., Falako, S., Opoku‐Anane, J., & Sirota, M. (2023) · The FASEB Journal · doi:10.1096/fj.202300907 · Cited by 105 · see citing works
Khalaj, K., Miller, J. E., Lingegowda, H., Fazleabas, A. T., Young, S. L., Lessey, B. A., Koti, M., & Tayade, C. (2019) · JCI Insight · doi:10.1172/jci.insight.128846 · Cited by 93 · see citing works
Bolívar, A. M., Luthra, R., Mehrotra, M., Chen, W., Barkoh, B. A., Hu, P. C., Zhang, W., & Broaddus, R. R. (2018) · Modern Pathology · doi:10.1038/s41379-018-0158-8 · Cited by 92 · see citing works
Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
Zhou, W., Liu, H., Yuan, Z., Zundell, J. A., Towers, M., Lin, J., Lombardi, S., Nie, H., Murphy, B., Yang, T., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.03.002 · Cited by 94 · see citing works
Hypoxia: The force of endometriosis
Wu, M., Hsiao, K., & Tsai, S. (2019) · Journal of Obstetrics and Gynaecology Research · doi:10.1111/jog.13900 · Cited by 88 · see citing works
Endometriosis-associated Ovarian Cancers
Anglesio, M. S., & Yong, P. J. (2017) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000320 · Cited by 86 · see citing works
Self-citationSamartzis, E. P., Labidi‐Galy, S. I., Moschetta, M., Uccello, M., Kalaitzopoulos, D. R., Fidalgo, J. A. P., & Boussios, S. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-3022a · Cited by 82 · see citing works
Pathology and Pathogenesis of Adenomyosis
Antero, M. F., Ayhan, A., Segars, J. H., & Shih, I. (2020) · Seminars in Reproductive Medicine · doi:10.1055/s-0040-1718922 · Cited by 85 · see citing works
Self-citationEndometriosis: A Comprehensive Review
Arafah, M., Rashid, S., & Akhtar, M. (2020) · Advances in Anatomic Pathology · doi:10.1097/pap.0000000000000288 · Cited by 82 · see citing works
Endometriosis-Associated Ovarian Cancer: The Origin and Targeted Therapy
Murakami, K., Kotani, Y., Nakai, H., & Matsumura, N. (2020) · Cancers · doi:10.3390/cancers12061676 · Cited by 80 · see citing works
Informing women with endometriosis about ovarian cancer risk
Kvaskoff, M., Horne, A. W., & Missmer, S. A. (2017) · The Lancet · doi:10.1016/s0140-6736(17)33049-0 · Cited by 80 · see citing works
Vercellini, P., Viganò, P., Buggio, L., Makieva, S., Scarfone, G., Cribiù, F. M., Parazzini, F., & Somigliana, E. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.017 · Cited by 80 · see citing works
The duality of human oncoproteins: drivers of cancer and congenital disorders
Castel, P., Rauen, K. A., & McCormick, F. P. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-0256-z · Cited by 77 · see citing works
Cracking the enigma of adenomyosis: an update on its pathogenesis and pathophysiology
Guo, S. (2022) · Reproduction · doi:10.1530/rep-22-0224 · Cited by 79 · see citing works
Pathogenesis of Endometriosis and Endometriosis-Associated Cancers
Adilbayeva, A., & Kunz, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147624 · Cited by 88 · see citing works
Independent development of endometrial epithelium and stroma within the same endometriosis
Noë, M., Ayhan, A., Wang, T., & Shih, I. (2018) · The Journal of Pathology · doi:10.1002/path.5082 · Cited by 77 · see citing works
Self-citationSWI/SNF Complex Mutations in Gynecologic Cancers: Molecular Mechanisms and Models
Wang, Y., Hoang, L. N., Ji, J. X. Y., & Huntsman, D. D. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012917 · Cited by 76 · see citing works
Self-citationA Lifelong Impact on Endometriosis: Pathophysiology and Pharmacological Treatment
Chen, L.-H., Lo, W.-C., Huang, H.-Y., & Wu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087503 · Cited by 85 · see citing works
New Perspectives on the Importance of Cell-Free DNA Biology
Bronkhorst, A. J., Ungerer, V., Oberhofer, A., Gabriel, S., Polatoglou, E., Randeu, H., Uhlig, C., Pfister, H., Mayer, Z., & Holdenrieder, S. (2022) · Diagnostics · doi:10.3390/diagnostics12092147 · Cited by 77 · see citing works
Khalique, S., Naidoo, K., Attygalle, A. D., Kriplani, D., Daley, F. M., Lowe, A., Campbell, J., Jones, T., Hubank, M. J. F., Fenwick, K., et al. (2018) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.103 · Cited by 74 · see citing works
Epithelial defense against cancer (EDAC)
Tanimura, N., & Fujita, Y. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.05.011 · Cited by 73 · see citing works
Wise Management of Ovarian Cancer: On the Cutting Edge
Boussios, S., Mikropoulos, C., Samartzis, E. P., Karihtala, P., Moschetta, M., Sheriff, M., Karathanasi, A., Sadauskaite, A., Rassy, E., & Pavlidis, N. A. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10020041 · Cited by 73 · see citing works
Kennedy, S. A., Jarboui, M. A., Srihari, S., Raso, C., Bryan, K. R., Dernayka, L., Charitou, T., Llinares, M. B., Herrera-Montávez, C., Krstić, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-14224-9 · Cited by 71 · see citing works
Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility
Khan, K. N., Fujishita, A., & Mori, T. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11144057 · Cited by 74 · see citing works
New concepts on the etiology of endometriosis
Cousins, F. L., McKinnon, B. D., Mortlock, S., Fitzgerald, H. C., Zhang, C., Montgomery, G. W., & Gargett, C. E. (2023) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.15549 · Cited by 82 · see citing works
Activating mutations in the MAP‐kinase pathway define non‐ossifying fibroma of bone
Baumhoer, D., Kovac, M. B., Sperveslage, J., Ameline, B., Strobl, A., Krause, A., Trautmann, M., Wardelmann, E., Nathrath, M., Höller, S., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5216 · Cited by 69 · see citing works
Yong, P. J. (2017) · Sexual Medicine Reviews · doi:10.1016/j.sxmr.2017.06.005 · Cited by 68 · see citing works
Self-citationNormal Somatic Mutations in Cancer Transformation
Wijewardhane, N., Dreßler, L., & Ciccarelli, F. D. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.11.002 · Cited by 68 · see citing works
Towards systematic nomenclature for cell-free DNA
Bronkhorst, A. J., Ungerer, V., Diehl, F., Anker, P., Dor, Y., Fleischhacker, M., Gahan, P. B., Hui, L., Holdenrieder, S., & Thierry, A. R. (2020) · Human Genetics · doi:10.1007/s00439-020-02227-2 · Cited by 68 · see citing works
Priemer, D. S., Vortmeyer, A. O., Zhang, S., Chang, H. Y., Curless, K. L., & Liang Cheng, C. (2019) · Human Pathology · doi:10.1016/j.humpath.2019.04.004 · Cited by 67 · see citing works
Organoid technology in female reproductive biomedicine
Khoei, H. H., Esfandiari, F., Hajari, M. A., Ghorbaninejad, Z., Piryaei, A., & Baharvand, H. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00621-z · Cited by 66 · see citing works
Esfandiari, F., Favaedi, R., Khoei, H. H., Chitsazian, F., Yari, S., Piryaei, A., Ghafari, F., Baharvand, H., & Shahhoseini, M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.08.1398 · Cited by 67 · see citing works
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary
Fadare, O., & Parkash, V. (2019) · Surgical pathology clinics · doi:10.1016/j.path.2019.01.009 · Cited by 65 · see citing works
Liew, P., Huang, R., Wu, T.-I., Liao, C.-C., Chen, C.-W., Su, P., Wang, H.-C., Weng, Y., & Lai, H. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0765-3 · Cited by 66 · see citing works
ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
Wilson, M. R., Reske, J. J., Holladay, J., Neupane, S., Ngo, J., Cuthrell, N., Wegener, M., Rhodes, M., Adams, M., Sheridan, R. T. C., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108366 · Cited by 62 · see citing works
Self-citationUpdates of Pathogenesis, Diagnostic and Therapeutic Perspectives for Ovarian Clear Cell Carcinoma
Zhu, C., Xu, Z., Zhang, T., Qian, L., Xiao, W., Wei, H., Jin, T., & Zhou, Y. Y. (2021) · Journal of Cancer · doi:10.7150/jca.53395 · Cited by 65 · see citing works
Sasaki, M., & Ogiwara, H. (2020) · Cancer Science · doi:10.1111/cas.14311 · Cited by 61 · see citing works
Marchetti, F., Cardoso, R., Chen, C. L., Douglas, G. R., Elloway, J. M., Escobar, P. A., Harper, T. A., Heflich, R. H., Kidd, D., Lynch, A. M., et al. (2023) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2023.108466 · Cited by 65 · see citing works
Machine Learning Classifiers for Endometriosis Using Transcriptomics and Methylomics Data
Akter, S., Xu, D. H., Nagel, S. C., Bromfield, J. J., Pelch, K. E., Wilshire, G., & Joshi, T. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00766 · Cited by 64 · see citing works
Endometriosis-Associated Ovarian Carcinomas: How PI3K/AKT/mTOR Pathway Affects Their Pathogenesis
Driva, T. S., Schatz, C., & Haybaeck, J. (2023) · Biomolecules · doi:10.3390/biom13081253 · Cited by 67 · see citing works
The Clinical Management of Clonal Hematopoiesis
Bolton, K. L., Zehir, A., Ptashkin, R. N., Patel, M. A., Gupta, D., Sidlow, R., Papaemmanuil, E., Berger, M. F., & Levine, R. L. (2020) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2019.11.006 · Cited by 60 · see citing works
Casey, L., & Singh, N. (2019) · Histopathology · doi:10.1111/his.13985 · Cited by 60 · see citing works
Tissue specific regulation of transcription in endometrium and association with disease
Mortlock, S., Kendarsari, R. I., Fung, J. N., Gibson, G. C., Yang, F. Y., Restuadi, R., Girling, J. E., Holdsworth‐Carson, S. J., Teh, W. T., Lukowski, S. W., et al. (2019) · Human Reproduction · doi:10.1093/humrep/dez279 · Cited by 60 · see citing works
Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis
Guo, S. (2018) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12221 · Cited by 58 · see citing works
- Authors
- Anglesio, M. S., Papadopoulos, N., Ayhan, A., Nazeran, T. M., Noë, M., Horlings, H. M., Lum, A., Jones, S., Senz, J., Seckin, T., Ho, J., Wu, R.-C., Lac, V., Ogawa, H., Tessier-Cloutier, B., Alhassan, R., Wang, A., Wang, Y., Cohen, J. D., Wong, F., Hasanovic, A., Orr, N., Zhang, M., Popoli, M., McMahon, W., Wood, L. D., Mattox, A., Allaire, C., Segars, J., Williams, C., Tomasetti, C., Boyd, N., Kinzler, K. W., Gilks, C. B., Diaz, L., Wang, T.-L., Vogelstein, B., Yong, P. J., Huntsman, D. G., & Shih, I.-M.
- Affiliations
- University of British Columbia (CA)
- Hiroshima University (JP)
- BC Cancer Agency (CA)
- Howard Hughes Medical Institute (US)
- ORCID
- Anglesio, Michael S.
- Papadopoulos, Nickolas
- Ayhan, Ayse
- Noë, Michaël
- Horlings, Hugo M.
- Lum, Amy
- Jones, Siân
- Senz, Janine
- Seckin, Tamer
- Wu, Ren-Chin
- Lac, Vivian
- Ogawa, Hiroshi
- Wang, Yuxuan
- Cohen, Joshua D.
- Orr, Natasha
- Zhang, Ming
- Popoli, Maria
- Wood, Laura D.
- Mattox, Austin
- Allaire, Catherine
- Segars, James
- Tomasetti, Cristian
- Boyd, Niki
- Kinzler, Kenneth W.
- Gilks, C. Blake
- Diaz, Luis
- Wang, Tian-Li
- Vogelstein, Bert
- Yong, Paul J.
- Shih, Ie-Ming
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2017-05-11
- Volume
- 376
- Issue
- 19
- Pages
- 1835-1848
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC5555376
- OpenAlex
- W2612851374
- Cited by
- 628
- References
- 50
- Citations by year
- 2026: 57 · 2025: 62 · 2024: 51 · 2023: 75 · 2022: 72 · 2021: 75 · 2020: 80 · 2019: 68 · 2018: 69 · 2017: 19
- FWCI
- 74.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA215483, U01CA200469, R01CA057345, T32CA009243, P50CA062924, R37CA057345, P30CA006973)
- National Institute of General Medical Sciences (T32GM007309, T32GM007184)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- endometriosis, deep infiltrating endometriosis, somatic mutations, cancer driver mutations, KRAS mutation, ARID1A, PIK3CA, PPP2R1A, malignant transformation risk, droplet digital PCR
- MeSH terms
- Adult, Cell Transformation, Neoplastic, DNA Mutational Analysis, DNA-Binding Proteins, Endometriosis, Endometrium, Female, Humans, Middle Aged, Mutation, Nuclear Proteins, Transcription Factors, Polymerase Chain Reaction, Proto-Oncogene Proteins p21(ras), Phosphatidylinositol 3-Kinases, Protein Phosphatase 2, Class I Phosphatidylinositol 3-Kinases, Exome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
