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Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny
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“In addition to these well‐described waves, there are other HSC‐like progenitors generated (presumably) in the embryo proper starting at E9.0. 45 , 46”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [46]
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Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135 · cited 2×
“Similar to other innate immune lineages, such as macrophages and mast cells (Gentek et al., 2018; Hoeffel et al., 2015), in the adult, LTi cells are replaced by cells from definitive HSCs.”
BackgroundSpecification of tissue-resident macrophages during organogenesis
Mass, E., Ballesteros, I., Farlik, M., Halbritter, F., Günther, P., Crozet, L., Jacome-Galarza, C. E., Händler, K., Klughammer, J., Kobayashi, Y., et al. (2016) · Science · doi:10.1126/science.aaf4238 · Cited by 891
Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity
van de Pavert, S. A., Ferreira, M., Domingues, R. G., Ribeiro, H., Molenaar, R., Moreira-Santos, L., Almeida, F. F., Ibiza, S., Barbosa, I., Goverse, G., et al. (2014) · Nature · doi:10.1038/nature13158 · Cited by 374
Complementarity and redundancy of IL-22-producing innate lymphoid cells
Rankin, L. C., Girard-Madoux, M. J. H., Seillet, C., Mielke, L. A., Kerdiles, Y., Fenis, A., Wieduwild, E., Putoczki, T., Mondot, S., Lantz, O., et al. (2016) · Nature Immunology · doi:10.1038/ni.3332 · Cited by 249
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Research works printed but not linked: 40
- Baron, 2018, Single-cell transcriptomics reveal the dynamic of haematopoietic stem cell production in the aorta, Nat. Commun., 9, 2517, 10.1038/s41467-018-04893-3 · DOI
- Boisset, 2010, In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium, Nature, 464, 116, 10.1038/nature08764 · DOI · Paper page
- Chea, 2016, Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling, Cell Rep., 14, 1500, 10.1016/j.celrep.2016.01.015 · DOI
- Drayton, 2006, Lymphoid organ development: from ontogeny to neogenesis, Nat. Immunol., 7, 344, 10.1038/ni1330 · DOI
- Gao, 2018, The hematopoietic stem cell niche: from embryo to adult, Development, 145, dev139691, 10.1242/dev.139691 · DOI · Paper page
- Gentek, 2018, Hemogenic Endothelial Fate Mapping Reveals Dual Developmental Origin of Mast Cells, Immunity, 48, 1160, 10.1016/j.immuni.2018.04.025 · DOI · Paper page
- Hepworth, 2013, Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria, Nature, 498, 113, 10.1038/nature12240 · DOI
- Ishizuka, 2016, The Innate Lymphoid Cell Precursor, Annu. Rev. Immunol., 34, 299, 10.1146/annurev-immunol-041015-055549 · DOI
- Ishizuka, 2016, Single-cell analysis defines the divergence between the innate lymphoid cell lineage and lymphoid tissue-inducer cell lineage, Nat. Immunol., 17, 269, 10.1038/ni.3344 · DOI
- Koga, 2018, Peripheral PDGFRα+gp38+ mesenchymal cells support the differentiation of fetal liver-derived ILC2, J. Exp. Med., 215, 1609, 10.1084/jem.20172310 · DOI
- La Manno, 2018, RNA velocity of single cells, Nature, 560, 494, 10.1038/s41586-018-0414-6 · DOI · Paper page
- Lancrin, 2009, The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage, Nature, 457, 892, 10.1038/nature07679 · DOI
- Mackley, 2015, CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes, Nat. Commun., 6, 5862, 10.1038/ncomms6862 · DOI
- Madisen, 2010, A robust and high-throughput Cre reporting and characterization system for the whole mouse brain, Nat. Neurosci., 13, 133, 10.1038/nn.2467 · DOI · Paper page
- McGrath, 1999, Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4, Dev. Biol., 213, 442, 10.1006/dbio.1999.9405 · DOI
- McGrath, 2015, Early hematopoiesis and macrophage development, Semin. Immunol., 27, 379, 10.1016/j.smim.2016.03.013 · DOI
- McGrath, 2015, Distinct Sources of Hematopoietic Progenitors Emerge before HSCs and Provide Functional Blood Cells in the Mammalian Embryo, Cell Rep., 11, 1892, 10.1016/j.celrep.2015.05.036 · DOI · Paper page
- Park, 2018, Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential, Cell Rep., 23, 2467, 10.1016/j.celrep.2018.04.092 · DOI
- Rennert, 1998, Lymph node genesis is induced by signaling through the lymphotoxin beta receptor, Immunity, 9, 71, 10.1016/S1074-7613(00)80589-0 · DOI
- Sawa, 2010, Lineage relationship analysis of RORgammat+ innate lymphoid cells, Science, 330, 665, 10.1126/science.1194597 · DOI
- Scandella, 2008, Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone, Nat. Immunol., 9, 667, 10.1038/ni.1605 · DOI
- Schneider, 2019, Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming, Immunity, 50, 1425, 10.1016/j.immuni.2019.04.019 · DOI
- Seillet, 2016, Deciphering the Innate Lymphoid Cell Transcriptional Program, Cell Rep., 17, 436, 10.1016/j.celrep.2016.09.025 · DOI
- Shigeta, 2019, Endocardially Derived Macrophages Are Essential for Valvular Remodeling Article Endocardially Derived Macrophages Are Essential for Valvular Remodeling, Dev. Cell, 48, 617, 10.1016/j.devcel.2019.01.021 · DOI
- Sörensen, 2009, DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries, Blood, 113, 5680, 10.1182/blood-2008-08-174508 · DOI
- Sparwasser, 2004, General method for the modification of different BAC types and the rapid generation of BAC transgenic mice, Genesis, 38, 39, 10.1002/gene.10249 · DOI
- van de Pavert, 2010, New insights into the development of lymphoid tissues, Nat. Rev. Immunol., 10, 664, 10.1038/nri2832 · DOI
- van de Pavert, 2016, Differentiation and function of group 3 innate lymphoid cells, from embryo to adult, Int. Immunol., 28, 35, 10.1093/intimm/dxv052 · DOI
- van de Pavert, 2009, Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation, Nat. Immunol., 10, 1193, 10.1038/ni.1789 · DOI
- Veiga-Fernandes, 2007, Tyrosine kinase receptor RET is a key regulator of Peyer’s patch organogenesis, Nature, 446, 547, 10.1038/nature05597 · DOI
- Vivier, 2018, Innate Lymphoid Cells: 10 Years On, Cell, 174, 1054, 10.1016/j.cell.2018.07.017 · DOI
- Vondenhoff, 2009, LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen, J. Immunol., 182, 5439, 10.4049/jimmunol.0801165 · DOI
- Walker, 2019, Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow, Immunity, 51, 104, 10.1016/j.immuni.2019.05.002 · DOI
- Werner, 2020, Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke, Nat. Neurosci., 23, 351, 10.1038/s41593-020-0585-y · DOI · Paper page
- Xu, 2019, An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials, Immunity, 50, 1054, 10.1016/j.immuni.2019.02.022 · DOI
- Yoder, 2014, Inducing definitive hematopoiesis in a dish, Nat. Biotechnol., 32, 539, 10.1038/nbt.2929 · DOI
- Yokomizo, 2011, Three-dimensional imaging of whole midgestation murine embryos shows an intravascular localization for all hematopoietic clusters, Blood, 117, 6132, 10.1182/blood-2011-02-334037 · DOI
- Yzaguirre, 2016, Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic sites, Dev. Dyn., 245, 1011, 10.1002/dvdy.24430 · DOI
- Zovein, 2008, Fate tracing reveals the endothelial origin of hematopoietic stem cells, Cell Stem Cell, 3, 625, 10.1016/j.stem.2008.09.018 · DOI · Paper page
- Zovein, 2010, Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters, Blood, 116, 3435, 10.1182/blood-2010-04-279497 · DOI
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Mast cell ontogeny: From fetal development to life‐long health and disease
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Metadata
- Authors
- Simic, M., Manosalva, I., Spinelli, L., Gentek, R., Shayan, R. R., Siret, C., Girard-Madoux, M., Wang, S., de Fabritus, L., Verschoor, J., Kerdiles, Y. M., Bajenoff, M., Stumm, R., Golub, R., & van de Pavert, S. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 32
- Issue
- 6
- Pages
- 108004
- ISSN
- 2211-1247
- Cited by
- 63
- References
- 4
- Language
- en
- Licence
- Funders
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
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