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Cited by 247Hematopoietic Stem Cell TransplantationMesenchymal stem cell researchDevelopmental Biology and Gene Regulation

The hematopoietic stem cell niche: from embryo to adult

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Gao, Xin, Xu, Chunliang, Asada, Noboru, Frenette, Paul S.·2018·Development
DOI 10.1242/dev.139691PMC PMC5825844
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Abstract

Hematopoietic stem cells (HSCs) develop in discrete anatomical niches, migrating during embryogenesis from the aorta-gonad-mesonephros (AGM) region to the fetal liver, and finally to the bone marrow, where most HSCs reside throughout adult life. These niches provide supportive microenvironments that specify, expand and maintain HSCs. Understanding the constituents and molecular regulation of HSC niches is of considerable importance as it could shed new light on the mechanistic principles of HSC emergence and maintenance, and provide novel strategies for regenerative medicine. However, controversy exists concerning the cellular complexity of the bone marrow niche, and our understanding of the different HSC niches during development remains limited. In this Review, we summarize and discuss what is known about the heterogeneity of the HSC niches at distinct stages of their ontogeny, from the embryo to the adult bone marrow, drawing predominantly on data from mouse studies.

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  • During human development, skin is derived from the surface ectoderm, while blood vessels and immune cells are both derived from the mesoderm.

    “During human development, skin is derived from the surface ectoderm, while blood vessels and the immune cells are both derived from the mesoderm.[ 51 , 60 , 61 ]”

    From Coordinated Development of Immune Cell Populations in Vascularized Skin Organoids from Human Induced Pluripotent Stem Cells (2025) · cites this paper as [60]

    The Introduction states that the hematopoietic system is of mesodermal origin and describes the mouse embryonic region containing the dorsal aorta as mesoderm-derived. It does not address skin’s origin from surface ectoderm, and its vessel-development example is in mice rather than humans. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Gao, X., Xu, C., Asada, N., & Frenette, P. S.
Affiliations
Albert Einstein College of Medicine (US)
ORCID
Venue
Development
Publisher
The Company of Biologists
Published
2018-01-15
Volume
145
Issue
2
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.139691
PMC
PMC5825844
OpenAlex
W2785053083
Cited by
247
References
9
Citations by year
2026: 19 · 2025: 23 · 2024: 38 · 2023: 21 · 2022: 29 · 2021: 35 · 2020: 31 · 2019: 26 · 2018: 24 · 2017: 1
FWCI
4.77
Type
journal article
Language
en
Open access
Licence
www.biologists.com/user-licence-1-1 (vor, 181 d)
Locations
  • Development (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • National Institutes of Health (DK056638, HL069438)
  • Leukemia and Lymphoma Society (LLS-TRP 6475-15)
  • New York State Department of Health (NYSTEM IIRP C029570, C029154)
Topics
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
hematopoietic stem cells, stem cell niche, aorta-gonad-mesonephros, fetal liver, bone marrow microenvironment, HSC maintenance, HSC migration, embryonic development, regenerative medicine
MeSH terms
Aging, Animals, Aorta, Female, Gonads, Hematopoietic Stem Cells, Hematopoietic System, Humans, Male, Mesonephros, Placenta, Pregnancy, Sympathetic Nervous System, Stromal Cells, Cell Lineage, Hematologic Neoplasms, Mice, Stem Cell Niche

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