An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior

Identification of a cold receptor reveals a general role for TRP channels in thermosensation

McKemy, D. D., Neuhausser, W., & Julius, D. J. (2002) · Nature · doi:10.1038/nature719 · Cited by 2,716 · see citing works

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46229 · Cited by 1,578 · see citing works

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

Aponte, Y., Atasoy, D., & Sternson, S. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2739 · Cited by 1,157 · see citing works

Regulation of Body Temperature by the Nervous System

Tan, C. L., & Knight, Z. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.022 · Cited by 798 · see citing works

Neurons for hunger and thirst transmit a negative-valence teaching signal

Betley, J. N., Xu, S., Cao, Z. F. H., Gong, R., Magnus, C. J., Yu, Y., & Sternson, S. M. (2015) · Nature · doi:10.1038/nature14416 · Cited by 704 · see citing works

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

Chen, Y., Lin, Y.-C., Kuo, T.-W., & Knight, Z. A. (2015) · Cell · doi:10.1016/j.cell.2015.01.033 · Cited by 660 · see citing works

Toward a Wiring Diagram Understanding of Appetite Control

Andermann, M. L., & Lowell, B. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.014 · Cited by 606 · see citing works

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

Krashes, M. J., Shah, B. P., Madara, J. C., Olson, D. P., Strochlic, D. E., Garfield, A. S., Vong, L., Pei, H., Watabe-Uchida, M., Uchida, N., et al. (2014) · Nature · doi:10.1038/nature12956 · Cited by 603 · see citing works

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

Betley, J. N., Cao, Z. F. H., Ritola, K., & Sternson, S. M. (2013) · Cell · doi:10.1016/j.cell.2013.11.002 · Cited by 591 · see citing works

Central Mechanisms for Thermoregulation

Morrison, S. F., & Nakamura, K. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114546 · Cited by 577 · see citing works

Thirst-associated preoptic neurons encode an aversive motivational drive.

Allen, W. E., DeNardo, L. A., Chen, M. Z., Liu, C. D., Loh, K. M., Fenno, L. E., Ramakrishnan, C., Deisseroth, K., & Luo, L. (2017) · Science · doi:10.1126/science.aan6747 · Cited by 390 · see citing works

Three Pillars for the Neural Control of Appetite

Sternson, S. M., & Eiselt, A.-K. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-104948 · Cited by 336 · see citing works

The dorsomedial hypothalamus: a new player in thermoregulation

DiMicco, J. A., & Zaretsky, D. V. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00498.2006 · Cited by 300 · see citing works

Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons

Wang, D., He, X., Zhao, Z., Feng, Q., Lin, R., Sun, Y., Ding, T., Xu, F., Luo, M., & Zhan, C. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00040 · Cited by 298 · see citing works

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife · doi:10.7554/elife.07122 · Cited by 290 · see citing works

Hunger neurons drive feeding through a sustained, positive reinforcement signal.

Chen, Y., Lin, Y.-C., Zimmerman, C. A., Essner, R. A., & Knight, Z. A. (2016) · eLife · doi:10.7554/elife.18640 · Cited by 196 · see citing works

Influence of Local Temperature Changes in the Preoptic Area and Rostral Hypothalamus on the Regulation of Food and Water Intake

Andersson, B., & Larsson, B. (1961) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1961.tb02203.x · Cited by 183 · see citing works

Central nervous system circuits that control body temperature

Madden, C. J., & Morrison, S. F. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.11.027 · Cited by 171 · see citing works

Estrogen-sensitive medial preoptic area neurons coordinate torpor in mice

Zhang, Z., Reis, F. M., He, Y., Park, J. W., DiVittorio, J. R., Sivakumar, N., van Veen, J. E., Maesta‐Pereira, S., Shum, M., Nichols, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20050-1 · Cited by 138 · see citing works

Preoptic mechanism for cold‐defensive responses to skin cooling

Nakamura, K., & Morrison, S. F. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.152686 · Cited by 133 · see citing works

Functional architecture of behavioural thermoregulation

Flouris, A. D. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1602-8 · Cited by 131 · see citing works

Effects of heating and cooling of the spinal cord on preoptic unit activity

Guieu, J. D., & Hardy, J. D. (1970) · Journal of Applied Physiology · doi:10.1152/jappl.1970.29.5.675 · Cited by 90 · see citing works

Food intake and temperature regulation in rats with rostral hypothalamic lesions

HAMILTON, C. L., & Brobeck, J. R. (1964) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1964.207.2.291 · Cited by 64 · see citing works

Agouti-Related Protein Neuron Circuits That Regulate Appetite

Sternson, S. M., & Atasoy, D. (2014) · Neuroendocrinology · doi:10.1159/000369072 · Cited by 60 · see citing works

Cold-induced hyperphagia requires AgRP neuron activation in mice

Deem, J. D., Faber, C. L., Pedersen, C. E., Phan, B. A., Larsen, S. A., Ogimoto, K., Nelson, J. T., Damian, V. M., Tran, M. A., Palmiter, R. D., et al. (2020) · eLife · doi:10.7554/elife.58764 · Cited by 57 · see citing works

The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections

Tao, C., Zhang, G., Huang, J., Li, Z., Tao, H. W., & Zhang, L. I. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01397-2 · Cited by 60 · see citing works

Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

Sun, J., Yuan, Y., Wu, X., Liu, A., Wang, J., Yang, S., Liu, B., Kong, Y., Wang, L., Zhang, K., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.08.010 · Cited by 53 · see citing works

Sensory input, sex and function shape hypothalamic cell type development

Kaplan, H. S., Logeman, B. L., Zhang, K., Yawitz, T. A., Santiago, C., Sohail, N., Talay, M., Seo, C., Naumenko, S., Sui, S. J. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08603-0 · Cited by 53 · see citing works

Cold-sensitive ventromedial hypothalamic neurons control homeostatic thermogenesis and social interaction-associated hyperthermia

Feng, C., Wang, Y., Zha, X., Cao, H., Huang, S., Cao, D., Zhang, K., Xie, T., Xu, X., Liang, Z., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.05.002 · Cited by 45 · see citing works

Early adversity promotes binge-like eating habits by remodeling a leptin-responsive lateral hypothalamus–brainstem pathway

Shin, S., You, I., Jeong, M., Bae, Y., Wang, X., Cawley, M. L., Han, A., & Lim, B. K. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01208-0 · Cited by 40 · see citing works

A temperature-regulated circuit for feeding behavior

Qian, S., Yan, S., Pang, R., Zhang, J., Liu, K., Shi, Z., Wang, Z., Chen, P., Zhang, Y., Luo, T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31917-w · Cited by 34 · see citing works

Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem

Chen, J. W., Cai, M., & Zhan, C. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01335-7 · Cited by 34 · see citing works

Xiphoid nucleus of the midline thalamus controls cold-induced food seeking

Lal, N. K., Le, P., Aggarwal, S., Zhang, A., Wang, K., Qi, T., Pang, Z., Yang, D., Nudell, V., Yeo, G. W.-M., et al. (2023) · Nature · doi:10.1038/s41586-023-06430-9 · Cited by 30 · see citing works

Dopamine systems and biological rhythms: Let’s get a move on

Tang, Q., Assali, D. R., Güler, A. D., & Steele, A. D. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.957193 · Cited by 25 · see citing works

Role of TRPM8 in cold avoidance behaviors and brain activation during innocuous and nocuous cold stimuli

Kasuga, R., Shiraki, C., Horikawa, R., YOSHIMURA, R., Kurganov, E., & Miyata, S. (2022) · Physiology & Behavior · doi:10.1016/j.physbeh.2022.113729 · Cited by 21 · see citing works

Social defeat drives hyperexcitation of the piriform cortex to induce learning and memory impairment but not mood-related disorders in mice

Wang, H., Li, F., Zheng, X., Meng, L., Chen, M., Hui, Y., Li, Y., Xie, K., Zhang, J., & Guo, G. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02151-1 · Cited by 21 · see citing works

Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency

Gui, Y., Dahir, N. S., Wu, Y., Downing, G., Sweeney, P. R., & Cone, R. D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113188 · Cited by 18 · see citing works

Bidirectional regulation of levodopa-induced dyskinesia by a specific neural ensemble in globus pallidus external segment

Shen, C., Shen, B., Liu, D., Han, L., Zou, K., Gan, L., Ren, J., Wu, B., Tang, Y., Zhao, J., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101566 · Cited by 14 · see citing works

A neural circuit for sex-dependent conditioned pain hypersensitivity in mice

Zhang, M., Ni, Z., Ma, J., Liu, A., Liu, Y., Lou, Q., Dong, W., Zhang, Z., Li, J., & Cao, P. (2025) · Nature Communications · doi:10.1038/s41467-025-58851-x · Cited by 10 · see citing works

Hypothalamic AgRP neurons regulate the hyperphagia of lactation

Catalbas, K., Pattnaik, T., Congdon, S., Nelson, C., Villano, L., & Sweeney, P. R. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101975 · Cited by 8 · see citing works

The Hypothalamic Medial Preoptic Area–Paraventricular Nucleus Circuit Modulates Depressive-Like Behaviors in a Mouse Model of Postpartum Depression

Fu, P., Liu, C.-P., Liu, C.-Y., Zhang, Y.-C.-F., Xu, J.-P., Mao, R.-T., Ding, X., Li, F., Zhang, Y.-L., Yang, H., et al. (2025) · Research · doi:10.34133/research.0701 · Cited by 7 · see citing works

Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus

Wang, T., Han, S., Wang, Y., Li, Y., Li, Y., Xing, Z., Zhang, S., Xia, Y., Zhu, F., Chen, Z., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.021 · Cited by 8 · see citing works

High-fat diet feeding disrupts the coupling of thermoregulation to energy homeostasis

Deem, J. D., Tingley, D., Watts, C. A., Ogimoto, K., Bryan, C. L., Phan, B. A., Damian, V. M., Bruchas, M. R., Scarlett, J. M., Schwartz, M. W., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101835 · Cited by 7 · see citing works

Parabrachial nucleus neuron circuits that control feeding behavior and energy balance

Zhao, Z., Chen, Y., Xuan, Y., Zhou, G., & Qiu, W. (2023) · Obesity Medicine · doi:10.1016/j.obmed.2023.100509 · Cited by 7 · see citing works

Influence of water-based exercise on energy intake, appetite, and appetite-related hormones in adults: A systematic review and meta-analysis

Grigg, M. J., Thake, C. D., Allgrove, J. E., King, J. A., Thackray, A. E., Stensel, D. J., Owen, A., & Broom, D. R. (2023) · Appetite · doi:10.1016/j.appet.2022.106375 · Cited by 6 · see citing works

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Luo, P., Tong, K., Gan, Y., Tang, M., Niu, Y., Liu, K., Ni, S., Wu, S., Jiang, X., Jiang, H., et al. (2025) · Advanced Science · doi:10.1002/advs.202502421 · Cited by 5 · see citing works

Cortical regulation of collective social dynamics during environmental challenge

Raam, T., Li, Q., Gu, L., Elagio, G., Lim, K. Y., Taimish, J. Y., Zhang, X., Sandoval, N. P., Correa, S. M., & Hong, W. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02224-0 · Cited by 5 · see citing works

Brain-wide input-output analysis of tuberal nucleus somatostatin neurons reveals hierarchical circuits for orchestrating feeding behavior

Senol, E., Wang, M., Xin, Y., Jiao, Z., Mohammad, H., Yeo, X. Y., Si, T., Young, D. M., Huang, H., Wang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60585-9 · Cited by 4 · see citing works

Lateral Habenula Neurons Signal Cold Aversion and Participate in Cold Aversion

Liu, R., Xiang, H., Liu, C., Jiang, Q., Liang, Y., Wang, G., Wang, L., Sun, Y., & Yang, G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-04076-7 · Cited by 4 · see citing works

Effects of cold-water immersion on energy expenditure, ad-libitum energy intake and appetite in healthy adults

Grigg, M. J., Thake, C. D., Allgrove, J. E., & Broom, D. R. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.114914 · Cited by 3 · see citing works

Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus

Fu, Y. (2025) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes25059 · Cited by 3 · see citing works

An obligatory role for AgRP neurons in maintaining body temperature during time-restricted feeding

Su, C., Cai, J., Xu, Y., Arenkiel, B. R., & Tong, Q. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156595 · Cited by 2 · see citing works

Preoptic Neural Circuitry for Dramatic and Gentle Thermoregulation

Pang, R., Yu, H., Wang, J., Shi, Z., Wen, H., Wu, G., Zhang, X., Zhang, Y., Wei, Q., Li, B., et al. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01434-z · Cited by 2 · see citing works

Xiphoid nucleus of the midline thalamus controls cold-induced food seekingPreprint

Lal, N. K., Le, P., Aggarwal, S., Zhang, A., Wang, K., Qi, T., Pang, Z., Yang, D., Nudell, V., Yeo, G. W.-M., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.16.533067 · Cited by 2 · see citing works

Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic mannerPreprint

Luo, P., Yang, X., Xu, Q., How, L. L., Irizarry, V. C. T., CARRILLO-SÁENZ, L., Munoz, M. D., Dong, W., Ibrahimi, L., Schaul, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.25.661575 · Cited by 2 · see citing works

Computer vision analysis of mother-infant interaction identified efficient pup retrieval in V1b receptor knockout mice

Sajjaviriya, C., Fujianti, Azuma, M., Tsuchiya, H., & Koshimizu, T. (2024) · Peptides · doi:10.1016/j.peptides.2024.171226 · Cited by 1 · see citing works

GLP-2 attenuates antipsychotics’ adverse metabolic effects

Pereira, S., & Hahn, M. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01248-3 · Cited by 1 · see citing works

Mechanistic Networks and Precision Intervention Strategies for Feed Intake Control in Sows: Bridging Reproductive Potential, Physiological Homeostasis and Swine Industry Production

Chai, H., Zhao, D., Yu, X., Shaoshuai, Z., Ji, F., Peng, W., Song, J., Diao, X., & Wu, H. (2026) · Agriculture · doi:10.3390/agriculture16141508 · Cited by 1 · see citing works

Parabrachial neurons orchestrate cold-induced homeostatic responses

Jung, S., Kondaurova, A., Lee, M., Kwon, J. J., Shin, H., & Kim, S. (2026) · Nature Metabolism · doi:10.1038/s42255-026-01565-1 · Cited by 1 · see citing works

Temporal regulation of AgRP neurons mediates context-induced feedingPreprint

Reed, F. M., Dempsey, H., Clarke, R., Reichenbach, A., Méquinion, M., Stark, R., Rawlinson, S., Foldi, C. J., Lockie, S. H., & Andrews, Z. B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.30.526347

Involvement of the AVP/OT System and Lateral Septum in the Modulation of Anxiety/Depression Caused by 14-Week and 20-Week Social Isolation

Liu, J., Zhang, W., Bai, Y., Fu, R., Lin, M., Li, J., Nie, L., Dang, X., Wang, Q., Zhu, Y., et al. (2025) · Neuroendocrinology · doi:10.1159/000544839

Identification of a neural basis for energy expenditure in the arcuate hypothalamusPreprint

Wang, T., Han, S., Wang, Y., Li, Y., Zhang, S., Zhu, F., Chen, Z., Xing, Z., Li, Y. Z., Wang, J., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.11.642601

Neural Circuit Remodeling Underlying Enhanced Feeding During Pregnancy in MicePreprint

Inada, K., Tasaka, G., Hagihara, M., Kobayashi, K., Yukinaga, H., & Miyamichi, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.07.669199

Thermal challenge and food intake: Mutual regulatory mechanisms

Alpár, A. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00170

The Hypothalamic–Pituitary–Adrenal Axis Orchestrates Energy Homeostasis during Cold ExposurePreprint

Perez, M. L., Gao, X., Heimerl, L., Wang, Y., Schnabl, K., Firzlaff, U., Luksch, H., Klingenspor, M., Uhlenhaut, N. H., Wang, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.18.677113

Recent progress in understanding hypothalamic regulation of energy homeostasis

ZHANG, Z., Yu, Z. E. N. G., Cui, Z., & TieMin, L. I. U. (2026) · Scientia Sinica Vitae · doi:10.1360/ssv-2025-0283

Molecular and functional heterogeneity of hypothalamic preoptic neurons

Carta, I., Arora, T., Bambah-Mukku, D., & Autry, A. E. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106891

Central circuits in control of energy expenditure: connecting energy and temperature homeostasis

Kinney, C., Kaiser, L., Morrison, C. D., Hr, B., & Münzberg, H. (2026) · Journal of Comparative Physiology B · doi:10.1007/s00360-026-01688-7

A hypothalamic neuronal population coordinates metabolic adaptations to cold

Liu, H., Liu, Q., Bean, J. C., Wang, F., Jian, J., Li, Y., Conde, K., Wang, M., Deng, Y., Yang, Y., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.08.024

Cold-induced hyperphagia requires AgRP neuron activation in mice

Deem, J. D., Faber, C. L., Pedersen, C. E., Phan, B. A., Larsen, S. A., Ogimoto, K., Nelson, J. T., Damian, V. M., Tran, M. A., Palmiter, R. D., et al. (2020) · eLife · doi:10.7554/elife.58764 · Cited by 57 · see citing works

209-OR: Evidence that Agrp Neuron Activation Drives Cold-Induced Hyperphagia

Deem, J. D., Faber, C. L., Pedersen, C. E., Phan, B. A., Ogimoto, K., LARSEN, S. A., Tran, M. A., Damian, V. M., Kaiyala, K. J., Scarlett, J. M., et al. (2020) · Diabetes · doi:10.2337/db20-209-or

98-OR: Cold-Induced Hyperphagia Requires AgRP Neuron Activation

Deem, J. D., Ogimoto, K., Nelson, J. T., Phan, B. A., VELASCO, K. R., Damian, V. M., Schwartz, M. W., & Morton, G. J. (2019) · Diabetes · doi:10.2337/db19-98-or

157-OR: High-Fat–Diet Feeding Disrupts Thermal Responsiveness of AgRP Neurons

Deem, J. D., DOAN, T. P., PHAN, B. A. N., Ogimoto, K., HU, S. J. W., WU, B., Schwartz, M. W., & Morton, G. J. (2022) · Diabetes · doi:10.2337/db22-157-or

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

Mandelblat-Cerf, Y., Ramesh, R. N., Burgess, C. R., Patella, P., Yang, Z., Lowell, B. B., & Andermann, M. L. (2015) · eLife · doi:10.7554/elife.07122 · Cited by 290 · see citing works