AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training
Open accessAbstract
Two intermingled hypothalamic neuron populations specified by expression of agouti-related peptide (AGRP) or pro-opiomelanocortin (POMC) positively and negatively influence feeding behavior, respectively, possibly by reciprocally regulating downstream melanocortin receptors. However, the sufficiency of these neurons to control behavior and the relationship of their activity to the magnitude and dynamics of feeding are unknown. To measure this, we used channelrhodopsin-2 for cell type-specific photostimulation. Activation of only 800 AGRP neurons in mice evoked voracious feeding within minutes. The behavioral response increased with photoexcitable neuron number, photostimulation frequency and stimulus duration. Conversely, POMC neuron stimulation reduced food intake and body weight, which required melanocortin receptor signaling. However, AGRP neuron-mediated feeding was not dependent on suppressing this melanocortin pathway, indicating that AGRP neurons directly engage feeding circuits. Furthermore, feeding was evoked selectively over drinking without training or prior photostimulus exposure, which suggests that AGRP neurons serve a dedicated role coordinating this complex behavior.
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Optogenetic and chemogenetic activation of AgRP neurons can evoke feeding in fed mice and promote motivationally, food-seeking behavior.
“Optogenetic and chemogenetic activation of AgRP neurons can evoke feeding in fed mice and promote motivationally, food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [26]
AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding and food-seeking behavior.
“A number of studies have shown that AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding [28] and food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [26]
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- Authors
- Aponte, Y., Atasoy, D., & Sternson, S. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Sternson, Scott M
- Venue
- Nature Neuroscience
- Published
- 2011-01-05
- Volume
- 14
- Issue
- 3
- Pages
- 351-355
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3049940
- OpenAlex
- W2139359479
- Cited by
- 1,157
- References
- 38
- Citations by year
- 2026: 40 · 2025: 91 · 2024: 82 · 2023: 79 · 2022: 79 · 2021: 94 · 2020: 78 · 2019: 74 · 2018: 90 · 2017: 93 · 2016: 88 · 2015: 82 · 2014: 59 · 2013: 55 · 2012: 45
- FWCI
- 27.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- AgRP neurons, feeding behavior, hypothalamus, proopiomelanocortin neurons, melanocortin receptors, optogenetic stimulation, channelrhodopsin-2, dietary intake, body weight, anorexigenic neurons
- MeSH terms
- Channelrhodopsins, Animals, Behavior, Animal, Conditioning, Classical, Eating, Feeding Behavior, Hypothalamus, Neurons, Photic Stimulation, Pro-Opiomelanocortin, Recombinant Fusion Proteins, Mice, Melanocortins, Agouti-Related Protein
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