Serine and one-carbon metabolism in cancer

5-Fluorouracil: mechanisms of action and clinical strategies

Longley, D. B., Harkin, D. P., & Johnston, P. G. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1074 · Cited by 5,332 · see citing works

The future of immune checkpoint therapy

Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878 · see citing works

Modulation of oxidative stress as an anticancer strategy

Gorrini, C., Harris, I. S., & Mak, T. W. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4002 · Cited by 3,579 · see citing works

Reactive oxygen species in cancer

Liou, G., & Störz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,394 · see citing works

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,177 · see citing works

Physiological Roles of Mitochondrial Reactive Oxygen Species

Sena, L. A., & Chandel, N. S. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.025 · Cited by 2,632 · see citing works

From Krebs to clinic: glutamine metabolism to cancer therapy

Altman, B. J., Stine, Z. E., & Dang, C. V. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.71 · Cited by 2,119 · see citing works

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

Serine, glycine and one-carbon units: cancer metabolism in full circle

Locasale, J. W. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3557 · Cited by 1,669 · see citing works

AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

Hardie, D. G. (2011) · Genes & Development · doi:10.1101/gad.17420111 · Cited by 1,638 · see citing works

The return of metabolism: biochemistry and physiology of the pentose phosphate pathway

Stincone, A., Prigione, A., Cramer, T., Wamelink, M. M. C., Campbell, K., Cheung, E., Olin‐Sandoval, V., Grüning, N., Krüger, A., Tauqeer Alam, M., et al. (2015) · Biological Reviews · doi:10.1111/brv.12140 · Cited by 1,576 · see citing works

Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

Jain, M., Nilsson, R., Sharma, S., Madhusudhan, N., Kitami, T., Souza, A. L., Kafri, R., Kirschner, M. W., Clish, C. B., & Mootha, V. K. (2012) · Science · doi:10.1126/science.1218595 · Cited by 1,403 · see citing works

Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming

Mitsuishi, Y., Taguchi, K., Kawatani, Y., Shibata, T., Nukiwa, T., Aburatani, H., Yamamoto, M., & Motohashi, H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.05.016 · Cited by 1,395 · see citing works

Oxidative stress inhibits distant metastasis by human melanoma cells

Piskounova, E., Agathocleous, M., Murphy, M. M., Hu, Z., Huddlestun, S. E., Zhao, Z., Leitch, A. M., Johnson, T. M., DeBerardinis, R. J., & Morrison, S. J. (2015) · Nature · doi:10.1038/nature15726 · Cited by 1,269 · see citing works

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Anastasiou, D., Poulogiannis, G., Asara, J. M., Boxer, M. B., Jiang, J., Shen, M., Bellinger, G., Sasaki, A. T., Locasale, J. W., Auld, D. S., et al. (2011) · Science · doi:10.1126/science.1211485 · Cited by 1,196 · see citing works

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

Locasale, J. W., Grassian, A. R., Melman, T., Lyssiotis, C. A., Mattaini, K. R., Bass, A. J., Heffron, G., Metallo, C. M., Muranen, T., Sharfi, H., et al. (2011) · Nature Genetics · doi:10.1038/ng.890 · Cited by 1,120 · see citing works

Glutathione dysregulation and the etiology and progression of human diseases

Ballatori, N., Krance, S. M., Notenboom, S., Shi, S., Tieu, K., & Hammond, C. L. (2009) · Biological Chemistry · doi:10.1515/bc.2009.033 · Cited by 1,118 · see citing works

Quantitative flux analysis reveals folate-dependent NADPH production

Fan, J., Ye, J., Kamphorst, J. J., Shlomi, T., Thompson, C. B., & Rabinowitz, J. D. (2014) · Nature · doi:10.1038/nature13236 · Cited by 1,114 · see citing works

P53 in survival, death and metabolic health: a lifeguard with a licence to kill.

Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080 · see citing works

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

Maddocks, O. D. K., Berkers, C. R., Mason, S. M., Zheng, L., Blyth, K., Gottlieb, E., & Vousden, K. H. (2013) · Nature · doi:10.1038/nature11743 · Cited by 1,007 · see citing works

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795 · see citing works

NRF2 regulates serine biosynthesis in non–small cell lung cancer

DeNicola, G. M., Chen, P.-H., Mullarky, E., Sudderth, J., Hu, Z., Wu, D., Tang, H., Xie, Y., Asara, J. M., Huffman, K. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3421 · Cited by 747 · see citing works

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

Mentch, S. J., Mehrmohamadi, M., Huang, L., Liu, X., Gupta, D., Mattocks, D. A. L., Padilla, P. G., Ables, G. P., Bamman, M. M., Thalacker‐Mercer, A. E., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.024 · Cited by 706 · see citing works

Compartmentalization of Mammalian Folate-Mediated One-Carbon Metabolism

Tibbetts, A. S., & Appling, D. R. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104810 · Cited by 692 · see citing works

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661 · see citing works

Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis

Zhang, W. C., Shyh-Chang, N., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B. S., Sun, L. L., Tai, B. C., Nga, M. E., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.050 · Cited by 660 · see citing works

Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer

Nilsson, R., Jain, M., Madhusudhan, N., Sheppard, N. G., Strittmatter, L., Kampf, C., Huang, J., Asplund, A., & Mootha, V. K. (2014) · Nature Communications · doi:10.1038/ncomms4128 · Cited by 607 · see citing works

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Jiang, L., Shestov, A. A., Swain, P., Yang, C., Parker, S. J., Wang, Q. A., Terada, L. S., Adams, N. D., McCabe, M. T., Pietrak, B., et al. (2016) · Nature · doi:10.1038/nature17393 · Cited by 582 · see citing works

Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells

Labuschagne, C. F., van den Broek, N. J. F., Mackay, G. M., Vousden, K. H., & Maddocks, O. D. K. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.04.045 · Cited by 576 · see citing works

A Mitochondrial Switch Promotes Tumor Metastasis

Porporato, P. E., Payen, V. L., Pérez‐Escuredo, J., Saedeleer, C. J. D., Danhier, P., Copetti, T., Dhup, S., Tardy, M., Vazeille, T., Bouzin, C., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.043 · Cited by 571 · see citing works

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.05.008 · Cited by 562 · see citing works

p73: Friend or foe in tumorigenesis

Melino, G., Laurenzi, V. D., & Vousden, K. H. (2002) · Nature reviews. Cancer · doi:10.1038/nrc861 · Cited by 554 · see citing works

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Pacold, M. E., Brimacombe, K. R., Chan, S. H., Rohde, J. M., Lewis, C. A., Swier, L. J. Y. M., Possemato, R., Chen, W. W., Sullivan, L. B., Fiske, B. P., et al. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2070 · Cited by 553 · see citing works

The role of peroxisome proliferator-activated receptors in carcinogenesis and chemoprevention

Peters, J. M., Shah, Y. M., & Gonzalez, F. J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3214 · Cited by 494 · see citing works

KDM4/JMJD2 Histone Demethylases: Epigenetic Regulators in Cancer Cells

Berry, W. L., & Janknecht, R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4300 · Cited by 453 · see citing works

Serine Catabolism Regulates Mitochondrial Redox Control during Hypoxia

Ye, J., Fan, J., Venneti, S., Wan, Y.-W., Pawel, B. R., Zhang, J., Finley, L. W. S., Lu, C., Lindsten, T., Cross, J. R., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0250 · Cited by 452 · see citing works

Serine Metabolism Supports the Methionine Cycle and DNA/RNA Methylation through De Novo ATP Synthesis in Cancer Cells

Maddocks, O. D. K., Labuschagne, C. F., Adams, P. D., & Vousden, K. H. (2016) · Molecular Cell · doi:10.1016/j.molcel.2015.12.014 · Cited by 440 · see citing works

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Bao, X. R., Ong, S., Goldberger, O., Peng, J., Sharma, R., Thompson, D. A., Vafai, S. B., Cox, A. G., Marutani, E., Ichinose, F., et al. (2016) · eLife · doi:10.7554/elife.10575 · Cited by 439 · see citing works

Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

Gonen, N., & Assaraf, Y. G. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.07.002 · Cited by 435 · see citing works

Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth

Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.09.020 · Cited by 434 · see citing works

S‐Adenosyl‐Methionine‐Dependent Methyltransferases: Highly Versatile Enzymes in Biocatalysis, Biosynthesis and Other Biotechnological Applications

Struck, A., Thompson, M. L., Wong, L. S., & Micklefield, J. (2012) · ChemBioChem · doi:10.1002/cbic.201200556 · Cited by 428 · see citing works

Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway

Ducker, G. S., Chen, L., Morscher, R. J., Ghergurovich, J. M., Esposito, M., Teng, X., Kang, Y., & Rabinowitz, J. D. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.016 · Cited by 419 · see citing works

Metabolic control of epigenetics in cancer

Kinnaird, A. S., Zhao, S., Wellen, K. E., & Michelakis, E. D. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.82 · Cited by 419 · see citing works

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation

Ye, J., Mancuso, A., Tong, X., Ward, P. S., Fan, J., Rabinowitz, J. D., & Thompson, C. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1204176109 · Cited by 410 · see citing works

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature · doi:10.1038/nature14363 · Cited by 368 · see citing works

Beneficial role of Nrf2 in regulating NADPH generation and consumption

Wu, K. C., Cui, J. Y., & Klaassen, C. D. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr183 · Cited by 368 · see citing works

Emerging concepts of T cell metabolism as a target of immunotherapy

Chang, C., & Pearce, E. L. (2016) · Nature Immunology · doi:10.1038/ni.3415 · Cited by 337 · see citing works

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers

Mullarky, E., Lucki, N. C., Beheshti Zavareh, R., Anglin, J. L., Gomes, A. P., Nicolay, B. N., Wong, J. C. Y., Christen, S., Takahashi, H., Singh, P. K., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521548113 · Cited by 333 · see citing works

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions

Sun, L., Song, L., Wan, Q., Wu, G., Li, X., Wang, Y., Wang, J., Liu, Z., Zhong, X., He, X., et al. (2015) · Cell Research · doi:10.1038/cr.2015.33 · Cited by 311 · see citing works

Resurgence of Serine: An Often Neglected but Indispensable Amino Acid

Kalhan, S. C., & Hanson, R. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.357194 · Cited by 306 · see citing works

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

Valencia, T., Kim, J. Y., Abu-Baker, S., Moscat-Pardos, J., Ahn, C. S., Reina-Campos, M., Duran, A., Castilla, E. A., Metallo, C. M., Diaz-Meco, M. T., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.004 · Cited by 304 · see citing works

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism

Nikkanen, J., Forsström, S., Euro, L., Paetau, I., Kohnz, R. A., Wang, L., Chilov, D., Viinamäki, J., Roivainen, A., Marjamäki, P., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.01.019 · Cited by 285 · see citing works

THE METHYL FOLATE TRAP A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid-induced exacerbation of subacute combined degeneration in pernicious anaemia

SCOTT, J. (1981) · The Lancet · doi:10.1016/s0140-6736(81)90650-4 · Cited by 269 · see citing works

Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis

Pollari, S., Käkönen, S.-M., Edgren, H., Wolf, M., Kohonen, P., Sara, H., Guise, T., Nees, M., & Kallioniemi, O. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-0848-5 · Cited by 269 · see citing works

Enzymes of serine metabolism in normal, developing and neoplastic rat tissues

Snell, K. (1984) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(84)90021-9 · Cited by 267 · see citing works

Cytoplasmic Serine Hydroxymethyltransferase Mediates Competition between Folate-dependent Deoxyribonucleotide andS-Adenosylmethionine Biosyntheses

Herbig, K., Chiang, E. I., Lee, L.-R., Hills, J., Shane, B., & Stover, P. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205000200 · Cited by 264 · see citing works

Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells

Tedeschi, P. M., Markert, E. K., Gounder, M. K., Lin, H., Dvorzhinski, D., Dolfi, S. C., Chan, L. L.-Y., Qiu, J., DiPaola, R. S., Hirshfield, K. M., et al. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.393 · Cited by 261 · see citing works

N EW P ERSPECTIVES ON F OLATE C ATABOLISM

Suh, J. R., Herbig, A. K., & Stover, P. J. (2001) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.21.1.255 · Cited by 261 · see citing works

The methotrexate story: A paradigm for development of cancer chemotherapeutic agents

Huennekens, F. M. (1994) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(94)90025-6 · Cited by 251 · see citing works

The Histone H3 Methyltransferase G9A Epigenetically Activates the Serine-Glycine Synthesis Pathway to Sustain Cancer Cell Survival and Proliferation

Ding, J., Li, T., Wang, X., Zhao, E., Choi, J.-H., Yang, L., Zha, Y., Dong, Z., Huang, S., Asara, J. M., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.11.004 · Cited by 244 · see citing works

Spatial colocalization and functional link of purinosomes with mitochondria

French, J. B., Jones, S. A., Deng, H., Pedley, A. M., Kim, D., Chan, C. Y., Hu, H., Pugh, R. J., Zhao, H., Zhang, Y., et al. (2016) · Science · doi:10.1126/science.aac6054 · Cited by 241 · see citing works

Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges

Phillips, M. M., Sheaff, M. T., & Szlosarek, P. W. (2013) · Cancer Research and Treatment · doi:10.4143/crt.2013.45.4.251 · Cited by 229 · see citing works

Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

Grüning, N., Rinnerthaler, M., Bluemlein, K., Mülleder, M., Wamelink, M. M. C., Lehrach, H., Jakobs, C., Breitenbach, M., & Ralser, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.017 · Cited by 215 · see citing works

Betaine–Homocysteine Methyltransferase Expression in Porcine and Human Tissues and Chromosomal Localization of the Human Gene

Sunden, S. L. F., Renduchintala, M. S., Park, E. I., et al. (1997) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0246 · Cited by 205 · see citing works

Control of Nutrient Stress-Induced Metabolic Reprogramming by PKCζ in Tumorigenesis

Ma, L., Tao, Y., Durán, Á., Lladó, V., Galvez, A. S., Barger, J. F., Castilla, E. A., Chen, J., Yajima, T., Porollo, A., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.028 · Cited by 204 · see citing works

Pharmacogenomic and metabolic biomarkers in the folate pathway and their association with methotrexate effects during dosage escalation in rheumatoid arthritis

Dervieux, T., Greenstein, N. S., & Kremer, J. M. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22129 · Cited by 201 · see citing works

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d -2-Hydroxyglutarate

Fan, J., Teng, X., Liu, L., Mattaini, K. R., Looper, R., Heiden, M. G. V., & Rabinowitz, J. D. (2014) · ACS Chemical Biology · doi:10.1021/cb500683c · Cited by 201 · see citing works

Small molecule activation of PKM2 in cancer cells induces serine auxotrophy

Kung, C., Hixon, J., Choe, S., Marks, K., Gross, S., Murphy, E., DeLaBarre, B., Cianchetta, G., Sethumadhavan, S., Wang, X., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.021 · Cited by 192 · see citing works

Mutations in MTFMT Underlie a Human Disorder of Formylation Causing Impaired Mitochondrial Translation

Tucker, E. J., Hershman, S. G., Köhrer, C., Belcher-Timme, C. A., Patel, J., Goldberger, O., Christodoulou, J., Silberstein, J. M., McKenzie, M., Ryan, M. T., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.07.010 · Cited by 176 · see citing works

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

Subramani, R., Gonzalez, E., Arumugam, A., Nandy, S., Gonzalez, V., Medel, J., Camacho, F. A., Ortega, A. P., Bonkoungou, S., Narayan, M., et al. (2016) · Scientific Reports · doi:10.1038/srep19819 · Cited by 172 · see citing works

Comparative Oncogenomics Identifies PSMB4 and SHMT2 as Potential Cancer Driver Genes

Lee, G. Y., Haverty, P. M., Li, L., Kljavin, N. M., Bourgon, R., Lee, J., Stern, H. M., Modrusan, Z. D., Seshagiri, S., Zhang, Z., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2683 · Cited by 162 · see citing works

KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism

Zhao, E., Ding, J., Xia, Y., Liu, M., Ye, B., Choi, J.-H., Yan, C., Dong, Z., Huang, S., Zha, Y., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.053 · Cited by 162 · see citing works

Targeted disruption of the mouse 3-phosphoglycerate dehydrogenase gene causes severe neurodevelopmental defects and results in embryonic lethality

Yoshida, K., Furuya, S., Osuka, S., Mitoma, J., Shinoda, Y., Watanabe, M., Azuma, N., Tanaka, H., Hashikawa, T., Itohara, S., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300507200 · Cited by 161 · see citing works

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

Mehrmohamadi, M., Liu, X., Shestov, A. A., & Locasale, J. W. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.026 · Cited by 157 · see citing works

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

Ou, Y., Wang, S.-J., Jiang, L., Zheng, B., & Gu, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616359 · Cited by 154 · see citing works

Tracer-derived total and folate-dependent homocysteine remethylation and synthesis rates in humans indicate that serine is the main one-carbon donor

Davis, S. R., Stacpoole, P. W., Williamson, J., Kick, L. S., Quinlivan, E. P., Coats, B. S., Shane, B., Bailey, L. B., & Gregory, J. F. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00351.2003 · Cited by 149 · see citing works

Protein and RNA Synthesis in the Skeletal Muscle of Hereditary Dystrophic Mouse

Hayashi, Y., Suzuki, H., & Totsuka, T. (1975) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a130780 · Cited by 148 · see citing works

Cytoplasmic Serine Hydroxymethyltransferase Regulates the Metabolic Partitioning of Methylenetetrahydrofolate but Is Not Essential in Mice

MacFarlane, A. J., Liu, X., Perry, C. A., Flodby, P., Allen, R. H., Stabler, S. P., & Stover, P. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802671200 · Cited by 148 · see citing works

PHGDH amplification and altered glucose metabolism in human melanoma

Mullarky, E., Mattaini, K. R., Heiden, M. G. V., Cantley, L. C., & Locasale, J. W. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00919.x · Cited by 147 · see citing works

Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53

Riscal, R., Schrepfer, E., Arena, G., Cissé, M. Y., Bellvert, F., Heuillet, M., Rambow, F., Bonneil, É., Sabourdy, F., Vincent, C., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.033 · Cited by 139 · see citing works

Serine deprivation enhances antineoplastic activity of biguanides

Gravel, S.-P., Hulea, L., Toban, N., Birman, E., Blouin, M.-J., Zakikhani, M., Zhao, Y., Topisirovic, I., St-Pierre, J., & Pollak, M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-2643-t · Cited by 138 · see citing works

Enzymic imbalance in serine metabolism in human colon carcinoma and rat sarcoma

Snell, K., Natsumeda, Y., Eble, J., Glover, J., & Weber, G. (1988) · British Journal of Cancer · doi:10.1038/bjc.1988.15 · Cited by 133 · see citing works

Malic enzyme tracers reveal hypoxia-induced switch in adipocyte NADPH pathway usage

Liu, L., Shah, S., Fan, J., Park, J. O., Wellen, K. E., & Rabinowitz, J. D. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2047 · Cited by 128 · see citing works

Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

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p73 regulates serine biosynthesis in cancer

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