Regulatory mechanisms of one-carbon metabolism enzymes
Open accessAbstract
One-carbon metabolism is a central metabolic pathway critical for the biosynthesis of several amino acids, methyl group donors, and nucleotides. The pathway mostly relies on the transfer of a carbon unit from the amino acid serine, through the cofactor folate (in its several forms), and to the ultimate carbon acceptors that include nucleotides and methyl groups used for methylation of proteins, RNA, and DNA. Nucleotides are required for DNA replication, DNA repair, gene expression, and protein translation, through ribosomal RNA. Therefore, the one-carbon metabolism pathway is essential for cell growth and function in all cells, but is specifically important for rapidly proliferating cells. The regulation of one-carbon metabolism is a critical aspect of the normal and pathological function of the pathway, such as in cancer, where hijacking these regulatory mechanisms feeds an increased need for nucleotides. One-carbon metabolism is regulated at several levels: via gene expression, posttranslational modification, subcellular compartmentalization, allosteric inhibition, and feedback regulation. In this review, we aim to inform the readers of relevant one-carbon metabolism regulation mechanisms and to bring forward the need to further study this aspect of one-carbon metabolism. The review aims to integrate two major aspects of cancer metabolism-signaling downstream of nutrient sensing and one-carbon metabolism, because while each of these is critical for the proliferation of cancerous cells, their integration is critical for comprehensive understating of cellular metabolism in transformed cells and can lead to clinically relevant insights.
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Increasing the intensity of anabolism requires the coordinated up-regulation of a number of biosynthetic processes, for which glycolysis and one-carbon metabolism are crucial sources of structural units.
“Increasing the intensity of anabolism requires the coordinated up-regulation of a number of biosynthetic processes, for which glycolysis and one-carbon metabolism are crucial sources of structural units [37,45,46].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [37]
Glycolysis supplies one-carbon metabolism through serine biosynthesis from 3-phosphoglycerate.
“Glycolysis supplies one-carbon metabolism through serine biosynthesis from 3-phosphoglycerate [37,49].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [37]
c-Myc is the master regulator of the metabolic network, affecting different metabolic processes and transactivating almost all genes that code for enzymes of glycolysis and one-carbon metabolism.
“c-Myc is known as the master regulator of the metabolic network, affecting different metabolic processes and transactivating almost all genes that code for enzymes of glycolysis and one-carbon metabolism [35,36,37].”
From 20-Hydroxyecdysone Boosts Energy Production and Biosynthetic Processes in Non-Transformed Mouse Cells (2024) · cites this paper as [37]
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Sorted by citations
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- Authors
- Petrova, B., Maynard, A. G., Wang, P., & Kanarek, N.
- Affiliations
- Boston Children's Hospital (US)
- Broad Institute (US)
- Corresponding author
- Kanarek, Naama
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2023-12
- Volume
- 299
- Issue
- 12
- Pages
- 105457
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC10758965
- OpenAlex
- W4388536689
- Cited by
- 103
- References
- 217
- Citations by year
- 2026: 50 · 2025: 31 · 2024: 21 · 2023: 1
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Gabrielle's Angel Foundation for Cancer Research (125)
- NIAID (U19 AI118608-05S3)
- Harvard Stem Cell Institute (DP-0193-21)
- National Institutes of Health
- Croucher Foundation
- Charles H Hood Foundation
- Starr Foundation
- Richard and Susan Smith Family Foundation
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- one-carbon metabolism, folic acid, serine, nucleotide synthesis, methylation, enzyme regulation, post-translational modification, subcellular compartmentalization, allosteric inhibition, feedback regulation, gene expression regulation, cancer metabolism, nutrient sensing, cell proliferation
- MeSH terms
- Amino Acids, Carbon, Enzyme Activation, Enzymes, Folic Acid, Humans, Methylation, Neoplasms, Nucleotides, Serine, Cell Proliferation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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