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Cholesterol determines the cytosolic entry and seeded aggregation of tau

Tuck, Benjamin J., Miller, Lauren V.C., Katsinelos, Taxiarchis, Smith, Annabel E., Wilson, Emma L., Keeling, Sophie, Cheng, Shi, Vaysburd, Marina J., Knox, Claire, Tredgett, Lucy, Metzakopian, Emmanouil, James, Leo C., McEwan, William A.·2022·Cell Reports

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  1. Ait-Bouziad, 2017, Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes, Nat. Commun., 8, 1678, 10.1038/s41467-017-01575-4 · DOI
  2. Allen, 2002, Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein, J. Neurosci., 22, 9340, 10.1523/JNEUROSCI.22-21-09340.2002 · DOI
  3. Arenas, 2017, Intracellular cholesterol trafficking and impact in neurodegeneration, Front. Mol. Neurosci., 10, 10.3389/fnmol.2017.00382 · DOI
  4. Beaudoin, 2012, Culturing pyramidal neurons from the early postnatal mouse hippocampus and cortex, Nat. Protoc., 7, 1741, 10.1038/nprot.2012.099 · DOI
  5. Biswas, 2019, Cholesterol depletion by MβCD enhances cell membrane tension and its variations-reducing integrity, Biophys. J., 116, 1456, 10.1016/j.bpj.2019.03.016 · DOI
  6. Björkhem, 2018, 24S-Hydroxycholesterol correlates with tau and is increased in cerebrospinal fluid in Parkinson’s disease and corticobasal syndrome, Front. Neurol., 9, 756, 10.3389/fneur.2018.00756 · DOI
  7. Calafate, 2015, Synaptic contacts enhance cell-to-cell tau pathology propagation, Cell Rep., 11, 1176, 10.1016/j.celrep.2015.04.043 · DOI
  8. Calafate, 2016, Loss of Bin1 promotes the propagation of tau pathology, Cell Rep., 17, 931, 10.1016/j.celrep.2016.09.063 · DOI · Paper page
  9. Cheng, 2018, Therapeutic efficacy of regulable GDNF expression for Huntington’s and Parkinson’s disease by a high-induction, background-free “GeneSwitch” vector, Exp. Neurol., 309, 79, 10.1016/j.expneurol.2018.07.017 · DOI
  10. Clavaguera, 2013, Brain homogenates from human tauopathies induce tau inclusions in mouse brain, Proc. Natl. Acad. Sci. U S A, 110, 9535, 10.1073/pnas.1301175110 · DOI
  11. Croft, 2019, Organotypic brain slice cultures to model neurodegenerative proteinopathies, Mol. Neurodegener., 14, 45, 10.1186/s13024-019-0346-0 · DOI
  12. Dai, 2021, Cholesterol metabolism in neurodegenerative diseases: molecular mechanisms and therapeutic targets, Mol. Neurobiol., 58, 2183, 10.1007/s12035-020-02232-6 · DOI
  13. De La-Rocque, 2021, Knockin’ on heaven’s door: molecular mechanisms of neuronal tau uptake, J. Neurochem., 156, 563, 10.1111/jnc.15144 · DOI
  14. Dopico, 2007, A glance at the structural and functional diversity of membrane lipids, Methods Mol. Biol., 400, 1, 10.1007/978-1-59745-519-0_1 · DOI
  15. Egawa, 2016, Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function, J. Physiol., 594, 4565, 10.1113/JP270590 · DOI
  16. Evans, 2018, Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways, Cell Rep., 22, 3612, 10.1016/j.celrep.2018.03.021 · DOI
  17. Evans, 2020, Whole genome CRISPR screens identify LRRK2-regulated endocytosis as a major mechanism for extracellular tau uptake by human neurons, bioRxiv
  18. Falcon, 2018, Galectin-8-mediated selective autophagy protects against seeded tau aggregation, J. Biol. Chem., 293, 2438, 10.1074/jbc.M117.809293 · DOI
  19. Flavin, 2017, Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins, Acta Neuropathol., 134, 629, 10.1007/s00401-017-1722-x · DOI
  20. Garver, 2002, Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae, J. Lipid Res., 43, 579, 10.1016/S0022-2275(20)31487-5 · DOI
  21. Goedert, 1992, Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms, Neuron, 8, 159, 10.1016/0896-6273(92)90117-V · DOI
  22. Goedert, 2017, Propagation of tau aggregates and neurodegeneration, Annu. Rev. Neurosci., 40, 189, 10.1146/annurev-neuro-072116-031153 · DOI · Paper page
  23. Gomes, 2018, Effect of 25-hydroxycholesterol in viral membrane fusion: insights on HIV inhibition, Biochim. Biophys. Acta Biomembr., 1860, 1171, 10.1016/j.bbamem.2018.02.001 · DOI · Paper page
  24. Grabrucker, 2009, Synaptogenesis of hippocampal neurons in primary cell culture, Cell Tissue Res., 338, 333, 10.1007/s00441-009-0881-z · DOI
  25. Grinstein, 1989, Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation, Biochim. Biophys. Acta, 988, 73, 10.1016/0304-4157(89)90004-X · DOI
  26. Guillén-Samander, 2021, VPS13D bridges the ER to mitochondria and peroxisomes via Miro, J. Cell Biol., 220, e202010004, 10.1083/jcb.202010004 · DOI
  27. Iba, 2013, Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer’s-like tauopathy, J. Neurosci., 33, 1024, 10.1523/JNEUROSCI.2642-12.2013 · DOI · Paper page
  28. Ilangumaran, 1998, Effects of cholesterol depletion by cyclodextrin on the sphingolipid microdomains of the plasma membrane, Biochem. J., 335, 433, 10.1042/bj3350433 · DOI
  29. Katsinelos, 2018, Unconventional secretion mediates the trans-cellular spreading of tau, Cell Rep., 23, 2039, 10.1016/j.celrep.2018.04.056 · DOI
  30. Kolay, 2022, Dual fates of exogenous tau seeds: lysosomal clearance vs. cytoplasmic amplification, bioRxiv
  31. Lambert, 2009, Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease, Nat. Genet., 41, 1094, 10.1038/ng.439 · DOI · Paper page
  32. Liu, 2012, Trans-synaptic spread of tau pathology in vivo, PLoS One, 7, e31302, 10.1371/journal.pone.0031302 · DOI
  33. Liu, 2013, Apolipoprotein E and Alzheimer disease: risk, mechanisms, and therapy, Nat. Rev. Neurol., 9, 106, 10.1038/nrneurol.2012.263 · DOI · Paper page
  34. Liu, 2018, 25-Hydroxycholesterol activates the expression of cholesterol 25-hydroxylase in an LXR-dependent mechanism, J. Lipid Res., 59, 439, 10.1194/jlr.M080440 · DOI
  35. Love, 1995, Neurofibrillary tangles in Niemann-Pick disease type C, Brain, 118, 119, 10.1093/brain/118.1.119 · DOI
  36. Martín-Segura, 2019, Age-associated cholesterol reduction triggers brain insulin resistance by facilitating ligand-independent receptor activation and pathway desensitization, Aging Cell, 18, e12932, 10.1111/acel.12932 · DOI
  37. Mayor, 2014, Clathrin-independent pathways of endocytosis, Cold Spring Harb. Perspect. Biol., 6, a016758, 10.1101/cshperspect.a016758 · DOI · Paper page
  38. McEwan, 2017, Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation, Proc. Natl. Acad. Sci. U S A, 114, 574, 10.1073/pnas.1607215114 · DOI · Paper page
  39. Millard, 2000, Niemann-pick type C1 (NPC1) overexpression alters cellular cholesterol homeostasis, J. Biol. Chem., 275, 38445, 10.1074/jbc.M003180200 · DOI
  40. Miller, 2021, Tau assemblies do not behave like independently acting prion-like particles in mouse neural tissue, Acta Neuropathol. Commun., 9, 41, 10.1186/s40478-021-01141-6 · DOI
  41. Mirbaha, 2015, Tau trimers are the minimal propagation unit spontaneously internalized to seed intracellular aggregation, J. Biol. Chem., 290, 14893, 10.1074/jbc.M115.652693 · DOI · Paper page
  42. Mudher, 2017, What is the evidence that tau pathology spreads through prion-like propagation?, Acta Neuropathol. Commun., 5, 99, 10.1186/s40478-017-0488-7 · DOI · Paper page
  43. Notkola, 1998, Serum Total Cholesterol, Apolipoprotein E {FC12}e4 Allele, and Alzheimer’s Disease, Neuroepidemiology, 17, 14, 10.1159/000026149 · DOI
  44. Palomer, 2016, Aging triggers a repressive chromatin state at bdnf promoters in hippocampal neurons, Cell Rep., 16, 2889, 10.1016/j.celrep.2016.08.028 · DOI
  45. Papassotiropoulos, 2002, 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia, J. Psychiatr. Res., 36, 27, 10.1016/S0022-3956(01)00050-4 · DOI
  46. Park, 2003, Identification of 58 novel mutations in Niemann-Pick disease type C: correlation with biochemical phenotype and importance of PTC1-like domains in NPC1, Hum. Mutat., 22, 313, 10.1002/humu.10255 · DOI
  47. Pawlowski, 2017, Inducible and deterministic forward programming of human pluripotent stem cells into neurons, skeletal myocytes, and oligodendrocytes, Stem Cell Rep., 8, 803, 10.1016/j.stemcr.2017.02.016 · DOI
  48. Polanco, 2021, Exosomal and vesicle-free tau seeds - propagation and convergence in endolysosomal permeabilization, FEBS J.
  49. William Rebeck, 1993, Apolipoprotein E in sporadic Alzheimer’s disease: allelic variation and receptor interactions, Neuron, 11, 575, 10.1016/0896-6273(93)90070-8 · DOI · Paper page
  50. Sanders, 2014, Distinct tau prion strains propagate in cells and mice and define different tauopathies, Neuron, 82, 1271, 10.1016/j.neuron.2014.04.047 · DOI · Paper page
  51. Schindelin, 2012, Fiji: an open-source platform for biological-image analysis, Nat. Methods, 9, 676, 10.1038/nmeth.2019 · DOI · Paper page
  52. Shi, 2019, Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model, J. Exp. Med., 216, 2546, 10.1084/jem.20190980 · DOI · Paper page
  53. Shrivastava, 2019, Clustering of Tau fibrils impairs the synaptic composition of α3-Na+/K+-ATPase and AMPA receptors, EMBO J., 38, e99871, 10.15252/embj.201899871 · DOI
  54. Soares, 2021, PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding, J. Biol. Chem., 296, 100636, 10.1016/j.jbc.2021.100636 · DOI
  55. Suzuki, 2010, REAP: a two minute cell fractionation method, BMC Res. Notes, 3, 294, 10.1186/1756-0500-3-294 · DOI
  56. Therriault, 2020, Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β, JAMA Neurol., 77, 470, 10.1001/jamaneurol.2019.4421 · DOI · Paper page
  57. Vagnozzi, 2019, VPS35 regulates tau phosphorylation and neuropathology in tauopathy, Mol. Psychiatry, 26, 6992, 10.1038/s41380-019-0453-x · DOI · Paper page
  58. Valenza, 2006, Cholesterol dysfunction in neurodegenerative diseases: is Huntington’s disease in the list?, Prog. Neurobiol., 80, 165, 10.1016/j.pneurobio.2006.09.005 · DOI
  59. Vanier, 1996, Genetic heterogeneity in Niemann-Pick C disease: a study using somatic cell hybridization and linkage analysis, Am. J. Hum. Genet., 58, 118
  60. Verstraelen, 2018, Image-based profiling of synaptic connectivity in primary neuronal cell culture, Front. Neurosci., 12, 10.3389/fnins.2018.00389 · DOI
  61. Vilariño-Güell, 2011, VPS35 mutations in Parkinson disease, Am. J. Hum. Genet., 89, 162, 10.1016/j.ajhg.2011.06.001 · DOI · Paper page
  62. von Delwig, 2006, Inhibition of macropinocytosis blocks antigen presentation of type II collagen in vitro and in vivo in HLA-DR1 transgenic mice, Arthritis Res. Ther., 8, R93, 10.1186/ar1964 · DOI
  63. Wang, 2021, An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D-TSG101 interactions, Nat. Commun., 12, 1252, 10.1038/s41467-021-21525-5 · DOI
  64. Wegmann, 2016, Formation, release, and internalization of stable tau oligomers in cells, J. Neurochem., 139, 1163, 10.1111/jnc.13866 · DOI
  65. Woerman, 2016, Tau prions from Alzheimer’s disease and chronic traumatic encephalopathy patients propagate in cultured cells, Proc. Natl. Acad. Sci. U S A, 113, E8187, 10.1073/pnas.1616344113 · DOI
  66. Wu, 2013, Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons, J. Biol. Chem., 288, 1856, 10.1074/jbc.M112.394528 · DOI · Paper page
  67. Wu, 2016, Neuronal activity enhances tau propagation and tau pathology in vivo, Nat. Neurosci., 19, 1085, 10.1038/nn.4328 · DOI · Paper page
  68. Yoshimori, 1991, Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells, J. Biol. Chem., 266, 17707, 10.1016/S0021-9258(19)47429-2 · DOI
  69. Yu, 2005, Neurodegeneration in heterozygous niemann-pick type C1 (NPC1) mouse, J. Biol. Chem., 280, 27296, 10.1074/jbc.M503922200 · DOI
  70. Zang, 2020, Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion, Proc. Natl. Acad. Sci. U S A, 117, 32105, 10.1073/pnas.2012197117 · DOI · Paper page
  71. Zhang, 2019, Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases, eLife, 8, e43584, 10.7554/eLife.43584 · DOI

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Metadata

Authors
Tuck, B. J., Miller, L. V. C., Katsinelos, T., Smith, A. E., Wilson, E. L., Keeling, S., Cheng, S., Vaysburd, M. J., Knox, C., Tredgett, L., Metzakopian, E., James, L. C., & McEwan, W. A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2022-05
Volume
39
Issue
5
Pages
110776
ISSN
2211-1247
Cited by
57
References
21
Language
en
Funders
  • Horizon 2020 Framework Programme
  • Alzheimer’s Research UK
  • European Federation of Pharmaceutical Industries and Associations
  • Gates Cambridge Trust
  • Medical Research Council
  • Staatssekretariat für Bildung, Forschung und Innovation (17.00038)
  • Royal Society (206248/Z/17/Z)
  • Innovative Medicines Initiative (116060)
  • Wellcome Trust
  • UK Dementia Research Institute
  • European Commission
  • Alzheimer's Society

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