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Cholesterol determines the cytosolic entry and seeded aggregation of tau
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In an in vitro model of tau entry into neurons, depletion of cholesterol from the plasma membrane or addition of 24(S)-HC promoted tau entry into the cytosol whereas 25-HC reduced it.
“A recent study using an in vitro model of tau entry into neurons showed that depletion of cholesterol from the plasma membrane or addition of 24(S)-HC promoted tau entry into the cytosol whereas 25-HC reduced it (Tuck et al., 2022).”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Tuck et al., 2022
25-HC has a protective role in blocking tau entry into neurons in vitro.
“A protective role for 25-HC in blocking tau entry into neurons has been reported in a recent in vitro study (Tuck et al., 2022).”
From Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy (2024) · cites this paper as Tuck et al., 2022
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PICALM and Alzheimer’s Disease: An Update and Perspectives
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Metadata
- Authors
- Tuck, B. J., Miller, L. V. C., Katsinelos, T., Smith, A. E., Wilson, E. L., Keeling, S., Cheng, S., Vaysburd, M. J., Knox, C., Tredgett, L., Metzakopian, E., James, L. C., & McEwan, W. A.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 39
- Issue
- 5
- Pages
- 110776
- ISSN
- 2211-1247
- PMC
- PMC9108550
- Cited by
- 57
- References
- 21
- Language
- en
- Licence
- Funders
- Horizon 2020 Framework Programme
- Alzheimer’s Research UK
- European Federation of Pharmaceutical Industries and Associations
- Gates Cambridge Trust
- Medical Research Council
- Staatssekretariat für Bildung, Forschung und Innovation (17.00038)
- Royal Society (206248/Z/17/Z)
- Innovative Medicines Initiative (116060)
- Wellcome Trust
- UK Dementia Research Institute
- European Commission
- Alzheimer's Society
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