Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
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Increasing evidence supports that cellular dysregulations in the degradative routes contribute to the initiation and progression of neurodegenerative diseases, including Alzheimer's disease. Autophagy and endolysosomal homeostasis need to be maintained throughout life as they are major cellular mechanisms involved in both the production of toxic amyloid peptides and the clearance of misfolded or aggregated proteins. As such, alterations in endolysosomal and autophagic flux, as a measure of degradation activity in these routes or compartments, may directly impact as well on disease-related mechanisms such as amyloid-β clearance through the blood-brain-barrier and the interneuronal spreading of amyloid-β and/or Tau seeds, affecting synaptic function, plasticity and metabolism. The emerging of several genetic risk factors for late-onset Alzheimer's disease that are functionally related to endocytic transport regulation, including cholesterol metabolism and clearance, supports the notion that in particular the autophagy/lysosomal flux might become more vulnerable during ageing thereby contributing to disease onset. In this review we discuss our current knowledge of the risk genes APOE4, BIN1, CD2AP, PICALM, PLD3 and TREM2 and their impact on endolysosomal (dys)regulations in the light of late-onset Alzheimer's disease pathology.
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Multiple genetic risk alleles associated with AD are thought to be active in the endosome/lysosome pathway.
“multiple genetic risk alleles associated with AD are thought to be active in this pathway [34].”
From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [34]
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- Authors
- Van Acker, Z. P., Bretou, M., & Annaert, W.
- Affiliations
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Corresponding author
- Annaert, Wim
- Venue
- Molecular Neurodegeneration
- Published
- 2019-06-03
- Volume
- 14
- Issue
- 1
- Pages
- 20-20
- ISSN
- 1750-1326 (ISSN-L)
- PMC
- PMC6547588
- OpenAlex
- W2948656839
- Cited by
- 222
- References
- 171
- Citations by year
- 2026: 10 · 2025: 31 · 2024: 53 · 2023: 26 · 2022: 26 · 2021: 40 · 2020: 31 · 2019: 5
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Neurodegeneration (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Lirias (KU Leuven) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Onderzoeksraad, KU Leuven (C16/15/073)
- FWO (S006617N, G078117N, G05601N)
- Hercules (AKUL/11/30, AKUL/13/39)
- SAO (2917/033, S#20180020)
- Alzheimer Association (AARF-18-564825)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- late-onset Alzheimer's disease, endolysosomal dysfunction, autophagy, autophagic flux, lysosomal homeostasis, genetic risk factors, APOE ε4, BIN1, CD2AP, PICALM, PLD3, TREM2, amyloid-beta clearance, blood-brain barrier, cholesterol metabolism, endocytic transport, aging, neurodegeneration
- MeSH terms
- Alzheimer Disease, Animals, Autophagy, Humans, Lysosomes, Membrane Glycoproteins, Risk Factors, Amyloid beta-Protein Precursor
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