Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases
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Summary: Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and Smith-Lemli Opitz syndrome (SLOS). However, the molecular mechanisms underlying the correlation between altered cholesterol metabolism and the neurological deficits are, for the most part, not clear. NPC disease and SLOS are caused by mutations in genes involved in the biosynthesis or intracellular trafficking of cholesterol, respectively. However, the types of neurological impairments, and the areas of the brain that are most affected, differ between these diseases. Some, but not all, studies indicate that high levels of plasma cholesterol correlate with increased risk of developing AD. Moreover, inheritance of the E4 isoform of apolipoprotein E (APOE), a cholesterol-carrying protein, markedly increases the risk of developing AD. Whether or not treatment of AD with statins is beneficial remains controversial, and any benefit of statin treatment might be due to anti-inflammatory properties of the drug. Cholesterol balance is also altered in HD and PD, although no causal link between dysregulated cholesterol homeostasis and neurodegeneration has been established. Some important considerations for treatment of neurodegenerative diseases are the impermeability of the blood-brain barrier to many therapeutic agents and difficulties in reversing brain damage that has already occurred. This article focuses on how cholesterol balance in the brain is altered in several neurodegenerative diseases, and discusses some commonalities and differences among the diseases.
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Astrocytes supply cholesterol to neurons through transport of apolipoprotein E (APOE) particles.
“Additionally, astrocytes supply cholesterol to neurons through the transport of apolipoprotein E (APOE) particles (Vance, 2012).”
From Sterol dysregulation in Smith–Lemli–Opitz syndrome causes astrocyte immune reactivity through microglia crosstalk (2022) · cites this paper as Vance, 2012
Astrocytes supplement neuronal cholesterol through lipoprotein transfer.
“since astrocytes supplement neuronal cholesterol through lipoprotein transfer45,46.”
From A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome (2013) · cites this paper as [46]
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2 retracted
Prasanthi, J. R. P., Feist, G., Thomasson, S., Thompson, A. J., Schommer, E., & Ghribi, O. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05736.x · Cited by 88 · see citing works
RetractedMarwarha, G., Rhen, T., Schommer, T., & Ghribi, O. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07497.x · Cited by 82 · see citing works
RetractedCorder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works
A Receptor-Mediated Pathway for Cholesterol Homeostasis
Brown, M. S., & Goldstein, J. L. (1986) · Science · doi:10.1126/science.3513311 · Cited by 5,703 · see citing works
Alzheimer's Disease Is a Synaptic Failure
Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420 · see citing works
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
Corder, E. H., Saunders, A. M., Risch, N. J., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Rimmler, J. B., Locke, P. A., Conneally, P. M., Schmader, K. E., et al. (1994) · Nature Genetics · doi:10.1038/ng0694-180 · Cited by 1,920 · see citing works
Statins and the risk of dementia
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works
Wolozin, B. L. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,401 · see citing works
Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360 · see citing works
Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance
Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · cited 12× · see citing works
“Importantly, inheritance of the APOE4 allele is the strongest known genetic risk factor for the development of late-onset AD (Corder et al., 1993).”
BackgroundInfluentialApolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons
Simons, M., Keller, P., Strooper, B. D., Beyreuther, K. T., Dotti, C. G., & Simons, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6460 · Cited by 1,167 · see citing works
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts
Ehehalt, R., Keller, P., Haass, C., Thiele, C., & Simons, K. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207113 · Cited by 1,107 · see citing works
Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works
Differential loss of striatal projection neurons in Huntington disease.
Reiner, A. J., Albin, R. L., Anderson, K. D., D’Amato, C. J., Penney, J. B., & Young, A. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.15.5733 · Cited by 999 · see citing works
Cholesterol metabolism in the brain
Dietschy, J. M., & Turley, S. D. (2001) · Current Opinion in Lipidology · doi:10.1097/00041433-200104000-00003 · Cited by 906 · see citing works
Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804 · see citing works
Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro
Nathan, B. P., Bellosta, S., Sanan, D. A., Weisgraber, K. H., Mahley, R. W., & Pitas, R. E. (1994) · Science · doi:10.1126/science.8171342 · Cited by 795 · see citing works
A newly recognized syndromeof multiple congenital anomalies
Smith, D. W., Lemli, L., & Opitz, J. M. (1964) · The Journal of Pediatrics · doi:10.1016/s0022-3476(64)80264-x · Cited by 650 · see citing works
Vanier, M., & Millat, G. (2003) · Clinical Genetics · doi:10.1034/j.1399-0004.2003.00147.x · Cited by 578 · see citing works
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works
Expression of apolipoprotein E during nerve degeneration and regeneration.
Ignatius, M. J., Gebicke‐Haerter, P. J., Skene, J. H. P., Schilling, J., Weisgraber, K. H., Mahley, R. W., & Shooter, E. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.4.1125 · Cited by 568 · see citing works
Radhakrishnan, A., Goldstein, J. L., McDonald, J. G., & Brown, M. S. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.008 · Cited by 561 · see citing works
Sparks, D. L., Scheff, S. W., Hunsaker, J. C., Liu, H., Landers, T. M., & Gross, D. R. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1044 · Cited by 559 · see citing works
Clearing the brain's amyloid cobwebs
Selkoe, D. J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00475-5 · Cited by 541 · see citing works
Boyles, J. K., Zoellner, C. D., Anderson, L. J., Kosik, L. M., Pitas, R. E., Weisgraber, K. H., Hui, D. Y., Mahley, R. W., Gebicke‐Haerter, P. J., & Ignatius, M. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113943 · Cited by 533 · see citing works
Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T., & Holtzman, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407963200 · Cited by 474 · see citing works
Malformation syndromes caused by disorders of cholesterol synthesis
Porter, F. D., & Herman, G. E. (2011) · Journal of Lipid Research · doi:10.1194/jlr.r009548 · Cited by 473 · see citing works
The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol
Barrett, P. J., Song, Y., Horn, W. D. V., Hustedt, E. J., Schafer, J. M., Hadziselimovic, A., Beel, A. J., & Sanders, C. R. (2012) · Science · doi:10.1126/science.1219988 · Cited by 472 · see citing works
Cholesterol Modulates α-Secretase Cleavage of Amyloid Precursor Protein
Bodovitz, S., & Klein, W. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4436 · Cited by 447 · see citing works
Wild-Type Huntingtin Protects from Apoptosis Upstream of Caspase-3
Rigamonti, D., Bauer, J. H., De‐Fraja, C., Conti, L., Sipione, S., Sciorati, C., Clementi, E., Hackam, A. S., Hayden, M. R., Li, Y., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-10-03705.2000 · Cited by 406 · see citing works
Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404 · see citing works
Neurodegeneration in the Central Nervous System of apoE-Deficient Mice
Masliah, E., Mallory, M. E., Ge, N., Alford, M. F., Veinbergs, I., & Roses, A. D. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1088 · Cited by 402 · see citing works
Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain
Hirsch-Reinshagen, V., Zhou, S., Burgess, B. L., Bernier, L., McIsaac, S. A., Chan, J. Y., Tansley, G. H., Cohn, J. S., Hayden, M. R., & Wellington, C. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407962200 · Cited by 385 · see citing works
Liu, B., Turley, S. D., Burns, D. K., Miller, A. M., Repa, J. J., & Dietschy, J. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810895106 · Cited by 376 · see citing works
Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Kim, J., Li, A., Knoten, A., Jain, S., Hirsch-Reinshagen, V., Wellington, C. L., Bales, K. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33622 · Cited by 370 · cited 1× · see citing works
“Consistent with these findings, overexpression of ABCA1 in AD mice reduced amyloid deposition (Wahrle et al., 2008).”
ResultBlood—Brain Barrier Permeability Precedes Senile Plaque Formation in an Alzheimer Disease Model
UJIIE, M., DICKSTEIN, D. L., CARLOW, D. A., & JEFFERIES, W. A. (2003) · Microcirculation · doi:10.1038/sj.mn.7800212 · Cited by 351 · see citing works
Bosco, D. A., Fowler, D. M., Zhang, Q., Nieva, J. J., Powers, E. T., Wentworth, P., Lerner, R. A., & Kelly, J. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio782 · Cited by 349 · see citing works
A randomized, double-blind, placebo-controlled trial of simvastatin to treat Alzheimer disease
Sano, M., Bell, K. L., Galasko, D., Galvin, J. E., Thomas, R. G., van Dyck, C. H., & Aisen, P. S. S. (2011) · Neurology · doi:10.1212/wnl.0b013e318228bf11 · Cited by 336 · see citing works
Deletion of Abca1 Increases Aβ Deposition in the PDAPP Transgenic Mouse Model of Alzheimer Disease
Wahrle, S. E., Jiang, H., Parsadanian, M., Hartman, R. E., Bales, K. R., Paul, S. M., & Holtzman, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508780200 · Cited by 325 · see citing works
Cholesterol 24-Hydroxylase: an enzyme of cholesterol turnover in the brain
Russell, D. W., Halford, R. W., Ramirez, D. M. O., Shah, R., & Kotti, T. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.78.072407.103859 · Cited by 317 · see citing works
Liscum, L., Ruggiero, R. M., & Faust, J. R. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.5.1625 · Cited by 307 · see citing works
Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats
Nieweg, K., Schaller, H., & Pfrieger, F. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05917.x · Cited by 307 · see citing works
Dysfunction of the Cholesterol Biosynthetic Pathway in Huntington's Disease
Valenza, M., Rigamonti, D., Goffredo, D., Zuccato, C., Fenu, S., Jamot, L., Strand, A., Tarditi, A., Woodman, B., Racchi, M., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3355-05.2005 · Cited by 298 · see citing works
Kim, J., Castellano, J. M., Jiang, H., Basak, J. M., Parsadanian, M., Pham, V., Mason, S. M., Paul, S. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.11.013 · Cited by 274 · cited 2× · see citing works
“, 1997) – have been linked to an increased incidence of AD (Elder et al., 2007; Fryer et al., 2005; Kim et al., 2009).”
BackgroundHuman<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works
Jiang, X., Sidhu, R., Porter, F. D., Yanjanin, N. M., Speak, A. O., Vruchte, D. T., Platt, F. M., Fujiwara, H., Scherrer, D. E., Zhang, J., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.d015735 · Cited by 270 · see citing works
Rosenbaum, A. I., Zhang, G., Warren, J. D., & Maxfield, F. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914309107 · Cited by 267 · see citing works
Michikawa, M., Fan, Q., Isobe, I., & Yanagisawa, K. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741008.x · Cited by 244 · see citing works
Hirsch-Reinshagen, V., Maia, L. F., Burgess, B. L., Blain, J.-F., Naus, K. E., McIsaac, S. A., Parkinson, P. F., Chan, J. Y., Tansley, G. H., Hayden, M. R., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508781200 · Cited by 233 · see citing works
Herz, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00234-3 · Cited by 233 · see citing works
Patterned Purkinje cell degeneration in mouse models of Niemann‐Pick type C disease
Sarna, J. R., Larouche, M., Marzban, H., Sillitoe, R. V., Rancourt, D. E., & Hawkes, R. B. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10522 · Cited by 223 · see citing works
Cholesterol Level and Statin Use in Alzheimer Disease
Shepardson, N. E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.203 · Cited by 221 · see citing works
Vaughan, C. J., & Gotto, A. M. (2004) · Circulation · doi:10.1161/01.cir.0000139312.10076.ba · Cited by 218 · see citing works
Wang, M. L., Motamed, M., Infante, R. E., Abi-Mosleh, L., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.016 · Cited by 214 · see citing works
Oxysterols as biomarkers in neurodegenerative diseases
Leoni, V., & Caccia, C. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.04.002 · Cited by 212 · see citing works
Role of Lipoproteins in the Delivery of Lipids to Axons during Axonal Regeneration
de Chaves, E. I. P., Rusiñol, A. E., Vance, D. E., Campenot, R. B., & Vance, J. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30766 · Cited by 209 · see citing works
Self-citationBryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913828107 · Cited by 209 · see citing works
Total cholesterol and the risk of Parkinson disease
Hu, G., Antikaínen, R., Jousilahti, P., Kivipelto, M., & Tuomilehto, J. (2008) · Neurology · doi:10.1212/01.wnl.0000312511.62699.a8 · Cited by 205 · see citing works
Serum Cholesterol Levels and the Risk of Parkinson's Disease
de Lau, L. M. L., Koudstaal, P. J., Albert Hofman, D., & Breteler, M. M. B. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj283 · Cited by 205 · see citing works
Hudry, E., Dam, D. V., Kulik, W., Deyn, P. P. D., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougneres, P. F., Aubourg, P. R., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.175 · Cited by 196 · see citing works
Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures
Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313828200 · Cited by 191 · see citing works
Self-citationLower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease
Huang, X., Chen, H., Miller, W. C., Mailman, R. B., Woodard, J. L., Chen, P., Xiang, D., Murrow, R. W., Wang, Y., & Poole, C. (2006) · Movement Disorders · doi:10.1002/mds.21290 · Cited by 189 · see citing works
Cholesterol Level and Statin Use in Alzheimer Disease
Shepardson, N. E. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.242 · Cited by 181 · see citing works
Lee, C. Y. D., Tse, W., Smith, J. D., & Landreth, G. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.295451 · Cited by 178 · see citing works
Formation and function of apolipoprotein E-containing lipoproteins in the nervous system
Vance, J. E., & Hayashi, H. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.007 · Cited by 178 · see citing works
Self-citationOntogenesis and regulation of cholesterol metabolism in the central nervous system of the mouse
Quan, G., Xie, C., Dietschy, J. M., & Turley, S. D. (2003) · Developmental Brain Research · doi:10.1016/j.devbrainres.2003.09.015 · Cited by 177 · see citing works
Baudry, M., Yao, Y., Simmons, D. A., Liu, J., & Bi, X. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00345-5 · Cited by 174 · see citing works
Burns, M. P., Gaynor, K., Olm, V., Mercken, M. H., LaFrancois, J. J., Wang, L., Mathews, P. M., Noble, W. J., Matsuoka, Y., & Duff, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05645.2003 · Cited by 172 · see citing works
Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5471-06.2007 · Cited by 170 · see citing works
Self-citationBien-Ly, N., Gillespie, A. K., Walker, D., Yoon, S. Y., & Huang, Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0033-12.2012 · Cited by 170 · see citing works
Statins reduce neuronal α‐synuclein aggregation in in vitro models of Parkinson’s disease
Bar‐On, P., Crews, L. A., Koob, A. O., Mizuno, H., Adame, A., Spencer, B. J., & Masliah, E. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05254.x · Cited by 166 · see citing works
Valenza, M., Leoni, V., Karasinska, J. M., Petricca, L., Fan, J., Carroll, J., Pouladi, M. A., Fossale, E., Nguyen, H. P., Riess, O., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0917-10.2010 · Cited by 166 · see citing works
Functions of lipoprotein receptors in neurons
Beffert, U., Stolt-Bergner, P. C., & Herz, J. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300017-jlr200 · Cited by 156 · see citing works
Oxysterols and Alzheimer's disease
Björkhem, I., Heverin, M., Leoni, V., Meaney, S., & Diczfalusy, U. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00684.x · Cited by 154 · see citing works
Cholesterol metabolism in Huntington disease
Karasinska, J. M., & Hayden, M. R. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.132 · Cited by 154 · see citing works
Aqul, A. A., Liu, B., Ramírez, C. M., Pieper, A. A., Estill, S. J., Burns, D. K., Liu, B., Repa, J. J., Turley, S. D., & Dietschy, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1317-11.2011 · Cited by 152 · see citing works
Karten, B., Vance, D. E., Campenot, R. B., & Vance, J. E. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01220.x · Cited by 149 · see citing works
Self-citationPlasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging
Gupta, V. B., Laws, S. M., Villemagne, V. L., Ames, D., Bush, A. I., Ellis, K. A., Lui, J. K., Masters, C., Rowe, C. C., Szoeke, C., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e318211c352 · Cited by 149 · see citing works
The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain
Fantini, J., Carlus, D., & Yahi, N. (2011) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2011.06.017 · Cited by 147 · see citing works
Severe learning deficits in apolipoprotein E-knockout mice in a water maze task
Oitzl, M. S., Mulder, M. T., Lucassen, P. J., Havekes, L. M., Grootendorst, J., & de Kloet, E. R. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01448-5 · Cited by 142 · see citing works
Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502143200 · Cited by 139 · see citing works
Crews, L. A., Mizuno, H., Desplats, P., Rockenstein, E. M., Adame, A., Patrick, C., Winner, B., Winkler, J., & Masliah, E. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0066-08.2008 · Cited by 131 · see citing works
Fassbender, K. C., Stroick, M., Bertsch, T., Ragoschke, A., Kuehl, S., Walter, S., Walter, J., Brechtel-Curth, K., Muehlhauser, F., von Bergmann, K., et al. (2002) · Neurology · doi:10.1212/wnl.59.8.1257 · Cited by 119 · see citing works
Fagan, A. M., Murphy, B. A., Patel, S. N., Kilbridge, J. F., Mobley, W. C., Bu, G., & Holtzman, D. M. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6818 · Cited by 116 · see citing works
Cholesterol modification of proteins
Mann, R. K. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00148-7 · Cited by 113 · see citing works
Trafficking of Cholesterol from Cell Bodies to Distal Axons in Niemann Pick C1-deficient Neurons
Karten, B., Vance, D. E., Campenot, R. B., & Vance, J. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205406200 · Cited by 106 · see citing works
Self-citationMolecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
Maity, T. K., Fuse, N., & Beachy, P. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507848102 · Cited by 106 · see citing works
Uptake of lipoproteins for axonal growth of sympathetic neurons
Posse de Chaves, E. I., Vance, D. E., Campenot, R. B., Kiss, R. S., & Vance, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.26.19883 · Cited by 105 · see citing works
Self-citationAnatomically Defined Neuron-Based Rescue of Neurodegenerative Niemann–Pick Type C Disorder
Lopez, M. E., Klein, A. D., Dimbil, U. J., & Scott, M. P. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5981-10.2011 · Cited by 104 · see citing works
Shafaati, M., Marutle, A., Pettersson, H. I., Lövgren‐Sandblom, A., Olin, M., Pikuleva, I. A., Winblad, B. G., Nordberg, A. K., & Björkhem, I. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014548 · Cited by 102 · see citing works
Peake, K., & Vance, J. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.326405 · Cited by 96 · see citing works
Self-citationProspects of Statins in Parkinson Disease
Roy, A., & Pahan, K. (2011) · The Neuroscientist · doi:10.1177/1073858410385006 · Cited by 96 · see citing works
Björkhem, I., & Hansson, M. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.140 · Cited by 92 · see citing works
Cholesterol storage and tau pathology in Niemann–Pick type C disease in the brain
Distl, R., Treiber-Held, S., Albert, F., Meske, V., HARZER, K., & Ohm, T. G. (2003) · The Journal of Pathology · doi:10.1002/path.1320 · Cited by 91 · see citing works
β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis
Tan, J., & Evin, G. M. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07623.x · Cited by 87 · see citing works
Nerve Regeneration Occurs in the Absence of Apolipoprotein E in Mice
Popko, B., Goodrum, J. F., Bouldin, T. W., Zhang, S. H., & Maeda, N. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03268.x · Cited by 80 · see citing works
Umeda, T., Tomiyama, T., Kitajima, E., Idomoto, T., Nomura, S., Lambert, M. P., Klein, W. L., & Mori, H. (2012) · Life Sciences · doi:10.1016/j.lfs.2011.12.022 · Cited by 78 · see citing works
The role of APP proteolytic processing in lipid metabolism
Grimm, M. O. W., Rothhaar, T. L., & Hartmann, T. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2975-6 · Cited by 68 · see citing works
Schoor, J. V. (2008) · Pharmacy management · Cited by 65 · see citing works
Yu, T., Shakkottai, V. G., Chung, C., & Lieberman, A. P. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr372 · Cited by 65 · see citing works
Leoni, V., Solomon, A., & Kivipelto, M. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381021 · Cited by 65 · see citing works
Hirsch-Reinshagen, V., & Wellington, C. L. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32813aeabf · Cited by 61 · see citing works
Mailman, T. M., Hariharan, M., & Karten, B. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07474.x · Cited by 58 · see citing works
Hayashi, H., Campenot, R. B., Vance, D. E., & Vance, J. E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.039560 · Cited by 58 · see citing works
Self-citationThe Niemann-Pick C1 protein in recycling endosomes of presynaptic nerve terminals
Karten, B., Campenot, R. B., Vance, D. E., & Vance, J. E. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500482-jlr200 · Cited by 53 · see citing works
Self-citationBjörnsson, Ó. G., Sparks, J. D., Sparks, C. E., & Gibbons, G. F. (1994) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1994.tb00979.x · Cited by 45 · see citing works
Generation and function of astroglial lipoproteins from Niemann–Pick type C1-deficient mice
Karten, B., Hayashi, H., Francis, G. A., Campenot, R. B., Vance, D. E., & Vance, J. E. (2005) · Biochemical Journal · doi:10.1042/bj20041694 · Cited by 43 · see citing works
Self-citationAltered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice
Veinbergs, I., Jung, M. W., Young, S. J., Uden, E. V., Groves, P. M., & Masliah, E. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00399-1 · Cited by 42 · see citing works
Cholesterol precursors and facial clefting
Porter, F. D. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29872 · Cited by 37 · see citing works
Xue, Y., Lee, S., & Ha, Y. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1103407108 · Cited by 36 · see citing works
Hawes, C. M., Wiemer, H., Krueger, S., & Karten, B. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06768.x · Cited by 33 · see citing works
Transfer of Cholesterol by the NPC Team
Vance, J. E. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.07.004 · Cited by 27 · see citing works
Self-citationElder, G. A., Cho, J. Y., English, D. F., Franciosi, S., Schmeidler, J., Sosa, M. A. G., Gasperi, R. D., Fisher, E. A., Mathews, P. M., Haroutunian, V., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04614.x · Cited by 26 · see citing works
Niemann-Pick Type C1 deficiency in microglia does not cause neuron death in vitro
Peake, K., Campenot, R. B., Vance, D. E., & Vance, J. E. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.003 · Cited by 24 · see citing works
Self-citationSimvastatin and Other HMG-CoA Reductase Inhibitors on Brain Cholesterol Levels in Alzheimers Disease
Longenberger, J., & Shah, Z. A. (2011) · Current Alzheimer Research · doi:10.2174/156720511795745393 · Cited by 21 · see citing works
Lipoprotein receptors: beacons to neurons?
Herz, J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01768-9 · Cited by 20 · see citing works
Björkhem, I., Lövgren‐Sandblom, A., Piehl, F., Khademi, M., Pettersson, H. I., Leoni, V., Olsson, T. P., & Diczfalusy, U. (2010) · Journal of Lipid Research · doi:10.1194/jlr.d011072 · Cited by 20 · see citing works
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Brain lipidomics: From functional landscape to clinical significance
Yoon, J. H., Seo, Y., Jo, Y. S., Lee, S., Cho, E., Cazenave-Gassiot, A., Shin, Y.-S., Moon, M. H., An, H. J., Wenk, M. R., et al. (2022) · Science Advances · doi:10.1126/sciadv.adc9317 · Cited by 324 · see citing works
Cholesterol in brain disease: Sometimes determinant and frequently implicated
Martín, M. G., Pfrieger, F., & Dotti, C. G. (2014) · The EMBO Reports · doi:10.15252/embr.201439225 · Cited by 304 · see citing works
Oxysterols in the pathogenesis of major chronic diseases
Poli, G., Biasi, F., & Leonarduzzi, G. (2013) · Redox Biology · doi:10.1016/j.redox.2012.12.001 · Cited by 304 · see citing works
NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress
Höglinger, D., Burgoyne, T., Sánchez-Heras, E., Hartwig, P., Colaço, A., Newton, J. C., Futter, C. E., Spiegel, S., Platt, F. M., & Eden, E. R. (2019) · Nature Communications · doi:10.1038/s41467-019-12152-2 · Cited by 280 · see citing works
Habchi, J., Chia, S., Galvagnion, C., Michaels, T. C. T., Bellaiche, M. M. J., Ruggeri, F. S., Sanguanini, M., Idini, I., Kumita, J. R., Sparr, E., et al. (2018) · Nature Chemistry · doi:10.1038/s41557-018-0031-x · Cited by 245 · see citing works
Complex lipid trafficking in Niemann‐Pick disease type C
Vanier, M. T. (2014) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-014-9794-4 · Cited by 241 · see citing works
A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome
Buchovecky, C. M., Turley, S. D., Brown, H. M., Kyle, S. M., McDonald, J. G., Liu, B., Pieper, A. A., Huang, W., Katz, D. M., Russell, D. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2714 · Cited by 234 · see citing works
Heart disease as a risk factor for dementia
Hakim, A., Ng, & Turek (2013) · Clinical Epidemiology · doi:10.2147/clep.s30621 · Cited by 229 · see citing works
Djelti, F., Braudeau, J., Hudry, E., Dhenain, M., Varin, J., Bièche, I., Marquer, C., Chali, F., Ayciriex, S., Auzeil, N., et al. (2015) · Brain · doi:10.1093/brain/awv166 · Cited by 223 · see citing works
Kim, D.-G., Krenz, A., Toussaint, L. E., Maurer, K. J., Robinson, S.-A., Yan, A., Torres, L., & Bynoe, M. S. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0467-5 · Cited by 330 · see citing works
Petrov, A. M., Kasimov, M. R., & Zefirov, A. L. (2016) · Acta Naturae · doi:10.32607/20758251-2016-8-1-58-73 · Cited by 194 · see citing works
Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets
Dai, L., Zou, L. B., Meng, L., Qiang, G., Yan, M., & Zhang, Z. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02232-6 · Cited by 195 · see citing works
Pathogenesis of SCA3 and implications for other polyglutamine diseases
McLoughlin, H. S., Moore, L. R., & Paulson, H. L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104635 · Cited by 185 · see citing works
Mitochondrial cholesterol: Metabolism and impact on redox biology and disease
Goicoechea, L., de la Rosa, L. C., Torres, S., García‐Ruiz, C., & Fernández-Checa, J. C. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102643 · Cited by 183 · see citing works
ApoE Lipidation as a therapeutic target in Alzheimer’s disease
Lanfranco, M. F., Ng, C. A., & Rebeck, G. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176336 · Cited by 189 · see citing works
Trapecar, M., Wogram, E., Svoboda, D., Communal, C., Omer, A., Lungjangwa, T., Sphabmixay, P., Velazquez, J., Schneider, K., Wright, C. W., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd1707 · Cited by 176 · see citing works
Yeganeh, B., Wiecheć, E., Ande, S. R., Sharma, P. K., Moghadam, A. R., Post, M., Freed, D. H., Hashemi, M. M., Shojaei, S., Zeki, A. A., et al. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.02.007 · Cited by 172 · see citing works
Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis
Bandrés‐Ciga, S., Noyce, A. J., Hemani, G., Nicolas, A., Calvo, A., Mora, G., Tienari, P., Stone, D. J., Nalls, M. A., Singleton, A., et al. (2019) · Annals of Neurology · doi:10.1002/ana.25431 · Cited by 162 · see citing works
Fatty Acid Signaling Mechanisms in Neural Cells: Fatty Acid Receptors
Falomir‐Lockhart, L. J., Cavazzutti, G. F., Giménez, E., & Toscani, A. M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00162 · Cited by 162 · see citing works
Intracellular Cholesterol Trafficking and Impact in Neurodegeneration
Arenas, F., García‐Ruiz, C., & Fernández-Checa, J. C. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00382 · Cited by 161 · see citing works
Endogenous Allosteric Modulators of G Protein–Coupled Receptors
van der Westhuizen, E. T., Valant, C., Sexton, P. M., & Christopoulos, A. (2015) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.221606 · Cited by 144 · see citing works
Insulin action in the brain regulates both central and peripheral functions
Agrawal, R., Reno, C. M., Sharma, S., CHRISTENSEN, C. G., Huang, Y., & Fisher, S. J. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00642.2020 · Cited by 143 · see citing works
GM1 Ganglioside: Past Studies and Future Potential
Aureli, M., Mauri, L., Ciampa, M. G., Prinetti, A., Toffano, G., Secchieri, C., & Sonnino, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9136-z · Cited by 140 · see citing works
Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology
Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.011 · Cited by 137 · see citing works
Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease.
Popp, J., Meichsner, S., Kölsch, H., Lewczuk, P., Maier, W., Kornhuber, J., Jessen, F., & Lütjohann, D. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.12.007 · Cited by 129 · see citing works
D’Erchia, A. M., Gallo, A., Manzari, C., Raho, S., Horner, D. S., Chiara, M., Valletti, A., Aiello, I., Mastropasqua, F., Ciaccia, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-10488-7 · Cited by 129 · see citing works
Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration
Jha, S. K., Jha, N. K., Kumar, D., Ambasta, R. K., & Kumar, P. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.015 · Cited by 122 · see citing works
Statins and the Brain: More than Lipid Lowering Agents?
Fracassi, A., Marangoni, M., Rosso, P., Pallottini, V., Fioramonti, M., Siteni, S., & Segatto, M. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170703101816 · Cited by 116 · see citing works
Rassart, É., Desmarais, F., Najyb, O., Bergeron, K., & Mounier, C. (2020) · Gene · doi:10.1016/j.gene.2020.144874 · Cited by 113 · see citing works
Molino, Y., David, M., Varini, K., Jabès, F., Gaudin, N., Fortoul, A., Bakloul, K., Masse, M., Bernard, A., Drobecq, L., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201600827r · Cited by 112 · see citing works
Mast, N., Saadane, A., Valencia‐Olvera, A. C., Constans, J., Maxfield, E., Arakawa, H., Li, Y., Landreth, G. E., & Pikuleva, I. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.06.026 · Cited by 108 · see citing works
Jeong, W., Lee, H. G., Cho, S., & Seo, J. (2019) · PubMed Central · doi:10.14348/molcells.2019.0200 · Cited by 104 · see citing works
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Ríos, J. A., Cisternas, P., Arrese, M. A., Salesa Barja, Y., & Inestrosa, N. C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.07.004 · Cited by 104 · see citing works
Lee, S.-I., Jeong, W., Lim, H., Cho, S., Lee, H., Jang, Y., Cho, J., Bae, S., Lin, Y.-T., Tsai, L.-H., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.07.017 · Cited by 105 · see citing works
Cholesterol and metal ions in Alzheimer's disease
Lee, H. J., Korshavn, K. J., Kochi, A., Derrick, J. S., & Lim, M. H. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00005f · Cited by 97 · see citing works
Lipids in regulating oligodendrocyte structure and function
Montani, L. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.07.016 · Cited by 94 · see citing works
Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues
Gliozzi, M., Musolino, V., Bosco, F., Scicchitano, M., Scarano, F., Nucera, S., Zito, M. C., Ruga, S., Carresi, C., Macrì, R., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105215 · Cited by 92 · see citing works
Ren, L., Zheng, Y., Wu, L., Gu, Y., He, Y., Jiang, B., Zhang, J., Zhang, L., & Li, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-21983-w · Cited by 90 · see citing works
Jeremic, D., Sanchez-Rodriguez, I., Jimenez-Diaz, L., & Navarro-Lopez, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107808 · Cited by 89 · see citing works
Jacquet, A. D. R., Tancredi, J. L., Lemire, A. L., DeSantis, M. C., Li, W., & O’Shea, E. K. (2021) · eLife · doi:10.7554/elife.73062 · Cited by 89 · see citing works
Lipoproteins in the Central Nervous System: From Biology to Pathobiology
Raulin, A.-C., Martens, Y. A., & Bu, G. (2022) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104801 · Cited by 89 · see citing works
Yang, S.-H., Li, W., Sumien, N., Forster, M. J., Simpkins, J. W., & Liu, R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.005 · Cited by 86 · see citing works
Lipid Rafts in Neurodegeneration and Neuroprotection
Sonnino, S., Aureli, M., Grassi, S., Mauri, L., Prioni, S., & Prinetti, A. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8614-4 · Cited by 85 · see citing works
Nóbrega, C., Mendonça, L. S., Marcelo, A., Lamazière, A., Tomé, S. O., Després, G., Matos, C. A., Mechmet, F., Langui, D., den Dunnen, W. F. A., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02019-7 · Cited by 83 · see citing works
Cholesterol imbalance and neurotransmission defects in neurodegeneration
Shin, K. C., Moussa, H. Y. A., & Park, Y. (2024) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01273-4 · Cited by 81 · see citing works
Cui, M., Xiao, Z., Sun, B., Wang, Y., Zheng, M., Ye, L., & Zhang, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.02.068 · Cited by 78 · see citing works
A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization
Hofmann, K., Thiele, C., Schött, H.-F., Gaebler, A., Schoene, M., Kiver, Y., Friedrichs, S., Litjohann, D., & Kuerschner, L. (2013) · Journal of Lipid Research · doi:10.1194/jlr.d044727 · Cited by 77 · see citing works
The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration
Saravi, S. S. S., Saravi, S. S. S., Arefidoust, A., & Dehpour, A. R. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-017-0021-5 · Cited by 75 · see citing works
Statins—From Fungi to Pharmacy
Sadowska, A. J., Osiński, P., Roztocka, A., Kaczmarz-Chojnacka, K., Zapora, E., Sawicka, D., & Car, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010466 · Cited by 77 · see citing works
Brain Region Mapping Using Global Metabolomics
Ivanišević, J., Epstein, A. A., Kurczy, M. E., Benton, P., Uritboonthai, W., Fox, H. S., Boska, M. D., Gendelman, H. E., & Siuzdak, G. E. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.016 · Cited by 74 · see citing works
Więckowska‐Gacek, A., Mietelska‐Porowska, A., Chutorański, D., Wydrych, M., Długosz, J., & Wojda, U. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.654509 · Cited by 69 · see citing works
Gangliosides in Membrane Organization
Sonnino, S., Chiricozzi, E., Grassi, S., Mauri, L., Prioni, S., & Prinetti, A. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.12.007 · Cited by 68 · see citing works
Martins, I. J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226190 · Cited by 67 · see citing works
microRNAs in Neurodegeneration: Current Findings and Potential Impacts
Sharma, S., & Lu, H. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000420 · Cited by 66 · see citing works
Elcombe, E. L., Lagopoulos, J., Duffy, S. L., Lewis, S. J. G., Norrie, L. M., Hickie, I. B., & Naismith, S. L. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142016 · Cited by 65 · see citing works
Effects of oxysterols on the blood–brain barrier: Implications for Alzheimer’s disease
Gosselet, F., Saint‐Pol, J., & Fénart, L. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.059 · Cited by 61 · see citing works
Cholesterol – A putative endogenous contributor towards Parkinson's disease
Paul, R. K., Choudhury, A., & Borah, A. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.025 · Cited by 61 · see citing works
Tuccori, M., Montagnani, S., Mantarro, S., Capogrosso-Sansone, A., Ruggiero, E., Saporiti, A., Antonioli, L., Fornai, M., & Blandizzi, C. (2014) · CNS Drugs · doi:10.1007/s40263-013-0135-1 · Cited by 58 · see citing works
Petrov, A. M., Kasimov, M. R., & Zefirov, A. L. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-1-26-37 · Cited by 56 · see citing works
Hammond, N., Munkacsi, A. B., & Sturley, S. L. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2019.04.002 · Cited by 57 · see citing works
Bai, X., Mai, M., Yao, K., Zhang, M., Huang, Y. M., Zhang, W., Guo, X., Xu, Y., Zhang, Y., Qurban, A., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01338-3 · Cited by 56 · see citing works
Ng, F., Sengupta, S., Huang, Y., Yu, A. M., You, S., Roberts, M. A., Iyer, L. K., Yang, Y., & Jackson, F. R. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00146 · Cited by 56 · see citing works
Cholesterol determines the cytosolic entry and seeded aggregation of tau
Tuck, B. J., Miller, L. V. C., Katsinelos, T., Smith, A. E., Wilson, E. L., Keeling, S., Cheng, S., Vaysburd, M. J., Knox, C., Tredgett, L., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110776 · Cited by 56 · see citing works
Myelin Pathology in Alzheimer's Disease: Potential Therapeutic Opportunities
Huang, Z., Jordan, J. D., & Zhang, Q. (2023) · Aging and Disease · doi:10.14336/ad.2023.0628 · Cited by 54 · see citing works
Astrocytes and endoplasmic reticulum stress: A bridge between obesity and neurodegenerative diseases
Martín-Jiménez, C., García-Vega, Á. S., Cabezas, R., Aliev, G., Echeverrı́a, V., González, J., & Barreto, G. E. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.001 · Cited by 55 · see citing works
Structural insights into GIRK2 channel modulation by cholesterol and PIP2
Mathiharan, Y. K., Glaaser, I. W., Zhao, Y., Robertson, M. J., Skiniotis, G., & Slesinger, P. A. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109619 · Cited by 52 · see citing works
Role of Trisomy 21 Mosaicism in Sporadic and Familial Alzheimer's Disease
Potter, H., Granic, A., & Caneus, J. (2015) · Current Alzheimer Research · doi:10.2174/156720501301151207100616 · Cited by 53 · see citing works
Hypertension, cerebrovascular impairment, and cognitive decline in aged AβPP/PS1 mice
Wiesmann, M., Zerbi, V., Jansen, D., Lütjohann, D., Veltien, A. A., Heerschap, A., & Kiliaan, A. J. (2017) · Theranostics · doi:10.7150/thno.18509 · Cited by 52 · see citing works
Cytochrome P450 in the central nervous system as a therapeutic target in neurodegenerative diseases
Navarro‐Mabarak, C., Camacho‐Carranza, R., & Espinosa-Aguirre, J. J. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1439502 · Cited by 53 · see citing works
Spagnuolo, M. S., Donizetti, A., Iannotta, L., Aliperti, V., Cupidi, C., Bruni, A. C., & Cigliano, L. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26480 · Cited by 52 · see citing works
Relationship between high dietary fat intake and Parkinson’s disease risk: a meta-analysis
Sun, Q., Qu, Y., Chen, X., & Xu, M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.262599 · Cited by 51 · see citing works
Dhanwani, R., Lima-Júnior, J. R., Sethi, A., Pham, J. W., Williams, G. P., Frazier, A., Xu, Y., Amara, A. W., Standaert, D. G., Goldman, J. G., et al. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00282-2 · Cited by 51 · see citing works
Pharmacogenetic Considerations in the Treatment of Alzheimer’s Disease
Cacabelos, R., Torrellas, C., Teijido, Ó., & Carril, J. C. (2016) · Pharmacogenomics · doi:10.2217/pgs-2016-0031 · Cited by 50 · see citing works
Jie, F., Yang, X., Wu, L., Wang, M., & Lu, B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867819 · Cited by 50 · see citing works
microRNAs: A connection between cholesterol metabolism and neurodegeneration
Goedeke, L., & Fernandez-Hernando, C. F. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.05.034 · Cited by 49 · see citing works
Universal phase behaviors of intracellular lipid droplets
Shimobayashi, S. F., & Ohsaki, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916248116 · Cited by 49 · see citing works
Kober, A. C., Manavalan, A. P. C., Tam‐Amersdorfer, C., Holmér, A., Saeed, A., Fanaee‐Danesh, E., Zandl‐Lang, M., Albrecher, N. M., Björkhem, I., Kostner, G. M., et al. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.03.003 · Cited by 47 · see citing works
Glaaser, I. W., & Slesinger, P. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-04681-x · Cited by 45 · see citing works
Neuroprotective effects of statins against amyloid β-induced neurotoxicity
Huang, C., Li, H., & Lin, C. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.226379 · Cited by 47 · see citing works
Damiano, F., Giannotti, L., Gnoni, G. V., Siculella, L., & Gnoni, A. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105618 · Cited by 44 · see citing works
Simvastatin treatment exerts antidepressant-like effect in rats exposed to chronic mild stress
Lin, P.-Y., Chang, A. Y. W., & Lin, T.-K. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.06.006 · Cited by 43 · see citing works
Astrocytic Factors Controlling Synaptogenesis: A Team Play
Fossati, G., Matteoli, M., & Menna, E. (2020) · Cells · doi:10.3390/cells9102173 · Cited by 44 · see citing works
Tiscione, S. A., Vivas, O., Ginsburg, K. S., Bers, D. M., Ory, D. S., Santana, L. F., Dixon, R. E., & Dickson, E. J. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201903018 · Cited by 43 · see citing works
Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese Health Study
Tan, L., Methawasin, K., Tan, E., Tan, J. H., Au, W., Yuan, J., & Koh, W. (2015) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2014-310065 · Cited by 42 · see citing works
Sathya, M., Ponnusamy, M., Palanisamy, P., Kandasamy, M., Jayachandran, K. S., & Anusuyadevi, M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161034 · Cited by 41 · see citing works
Lorizate, M., Terrones, O., Nieto‐Garai, J. A., Rojo‐Bartolomé, I., Ciceri, D., Morana, O., Olazar‐Intxausti, J., Arboleya, A., Martin, A., Szynkiewicz, M., et al. (2021) · Small Methods · doi:10.1002/smtd.202100430 · Cited by 40 · see citing works
Becktel, D. A., Zbesko, J. C., Frye, J. B., Chung, A. G., Hayes, M., Calderon, K., Grover, J. W., Li, A., Garcia, F. G., Tavera-Garcia, M. A., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0933-21.2021 · Cited by 40 · see citing works
Visualization of accessible cholesterol using a GRAM domain-based biosensor
Koh, D. H. Z., Naito, T., Na, M., Yeap, Y. J., Rozario, P., Zhong, F. L., Lim, K., & Saheki, Y. (2023) · Nature Communications · doi:10.1038/s41467-023-42498-7 · Cited by 40 · see citing works
Granic, A., & Potter, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060718 · Cited by 40 · see citing works
Singh, V. M., & Panwar, R. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1899-9 · Cited by 40 · see citing works
Gordts, S. C., Muthuramu, I., Amin, R., Jacobs, F., & Geest, B. D. (2014) · Pharmaceuticals · doi:10.3390/ph7040419 · Cited by 39 · see citing works
Azizidoost, S., Babaahmadi‐Rezaei, H., Nazeri, Z., Cheraghzadeh, M., & Kheirollah, A. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159069 · Cited by 39 · see citing works
Aging Induces Tissue‐Specific Changes in Cholesterol Metabolism in Rat Brain and Liver
Smiljanić, K., Vanmierlo, T., Mladenović, A., Perović, M., Lončarević‐Vasiljković, N., Tešić, V., Rakić, L., Ruždijić, S., Lütjohann, D., & Kanazir, S. (2013) · Lipids · doi:10.1007/s11745-013-3836-9 · Cited by 39 · see citing works
Brain cholesterol homeostasis and its association with neurodegenerative diseases
Gao, Y., Ye, S., Tang, Y., Tong, W., & Sun, S. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105635 · Cited by 38 · see citing works
Ali, T., Hannaoui, S., Nemani, S. K., Tahir, W., Zemlyankina, I., Cherry, P., Shim, S. Y., Sim, V. L., Schaetzl, H. M., & Gilch, S. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01162-1 · Cited by 38 · see citing works
Liu, Y., Yu, X., Han, P., Chen, X., Wang, F., Lian, X., Li, J., Li, R., Wang, B., Xu, C., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.900523 · Cited by 38 · see citing works
McMillin, M., Grant, S. M., Frampton, G. A., Petrescu, A. D., Kain, J., Williams, E., Haines, R., Canady, L., & DeMorrow, S. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.02.008 · Cited by 38 · see citing works
Lipid efflux mechanisms, relation to disease and potential therapeutic aspects
Castaño, D., Rattanasopa, C., Monteiro-Cardoso, V. F., Corlianò, M., Liu, Y., Zhong, A., Rusu, M., Liehn, E. A., & Singaraja, R. R. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.04.013 · Cited by 37 · see citing works
Novel therapeutic strategies for Alzheimer’s disease targeting brain cholesterol homeostasis
Samant, N. P., & Gupta, G. L. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14949 · Cited by 36 · see citing works
Simvastatin impairs hippocampal synaptic plasticity and cognitive function in mice
Guo, Y., Zou, G., Qi, K., Jin, J., Yao, L., Pan, Y., & Xiong, W. (2021) · Molecular Brain · doi:10.1186/s13041-021-00758-x · Cited by 37 · see citing works
- Authors
- Vance, J. E.
- Affiliations
- University of Alberta (CA)
- Corresponding author
- Vance, Jean E.
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2012-01-01
- Volume
- 5
- Issue
- 6
- Pages
- 746-55
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- PMC
- PMC3484857
- OpenAlex
- W2166069871
- Cited by
- 342
- References
- 123
- Citations by year
- 2026: 2 · 2025: 13 · 2024: 26 · 2023: 33 · 2022: 27 · 2021: 37 · 2020: 34 · 2019: 29 · 2018: 24 · 2017: 24 · 2016: 18 · 2015: 28 · 2014: 31 · 2013: 15 · 2012: 1
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Disease Models & Mechanisms (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- cholesterol homeostasis, brain cholesterol metabolism, neurodegenerative diseases, Alzheimer's disease, Huntington's disease, Parkinson's disease, Niemann-Pick disease type C, Smith-Lemli-Opitz syndrome, apolipoprotein E, APOE ε4, statins, blood-brain barrier, cholesterol biosynthesis, cholesterol transport
- MeSH terms
- Animals, Brain, Cholesterol, Humans, Models, Biological, Neurodegenerative Diseases
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