Cited by 150Pluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationEpigenetics and DNA Methylation

The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Open access

Yang, Pengyi, Humphrey, Sean J., Cinghu, Senthilkumar, Pathania, Rajneesh, Oldfield, Andrew J., Kumar, Dhirendra, Perera, Dinuka, Yang, Jean Y.H., James, David E., Mann, Matthias, Jothi, Raja·2019·Cell Systems

DOI 10.1016/j.cels.2019.03.012PMC PMC6544180

Published version of a preprint

Open this paper in CoChat — free account Open PDF

Abstract

Pluripotency is highly dynamic and progresses through a continuum of pluripotent stem cell states. The two states that bookend the pluripotency continuum, naive and primed, are well characterized, but our understanding of the intermediate states and transitions between them remains incomplete. Here, we dissect the dynamics of pluripotent state transitions underlying pre- to post-implantation epiblast differentiation. Through comprehensive mapping of the proteome, phosphoproteome, transcriptome, and epigenome of embryonic stem cells transitioning from naive to primed pluripotency, we find that rapid, acute, and widespread changes to the phosphoproteome precede ordered changes to the epigenome, transcriptome, and proteome. Reconstruction of the kinase-substrate networks reveals signaling cascades, dynamics, and crosstalk. Distinct waves of global proteomic changes mark discrete phases of pluripotency, with cell-state-specific surface markers tracking pluripotent state transitions. Our data provide new insights into multi-layered control of the phased progression of pluripotency and a foundation for modeling mechanisms regulating pluripotent state transitions (www.stemcellatlas.org).

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cels.2019.03.012

Cites

110 of 110 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
Cox, J., & Mann, M. (2008) · Nature Biotechnology · doi:10.1038/nbt.1511 · Cited by 14,855
Self-citation
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Adjusting batch effects in microarray expression data using empirical Bayes methods
Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658

Flagged first, then by citations

Show all 109 references

Sorted by citations

Items 101–150 of 150

USP9X deubiquitinase couples the pluripotency network and cell metabolism to regulate ESC differentiation potentialPreprint
de Dieuleveult, M., Leduc, M., Salataj, E., Ransy, C., Dairou, J., Homma, K., Gall, M. L., Bossard, P., Lombès, A., Bouillaud, F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.13.904904 · Cited by 3
Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem CellsPreprint
Zhong, L., Gordillo, M., Wang, X., Qin, Y., Huang, Y., Soshnev, A. A., Kumar, R., Nanjangud, G. J., James, D., Allis, C. D., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.12.503780 · Cited by 3
Self-citation
Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during ESC differentiationPreprint
Boileau, R. M., Chen, K. X., & Blelloch, R. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.24.513607 · Cited by 3
Post-mitotic transcriptional activation and 3D regulatory interactions show locus- and differentiation-specific sensitivity to cohesin depletion
Lee, U., Laguillo-Diego, A., Wong, W., Ni, Z., Cheng, L., Li, J., Pelham-Webb, B., Pertsinidis, A., Leslie, C., & Apostolou, E. (2025) · doi:10.1101/2025.02.13.638153 · Cited by 3
RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene CoordinationPreprint
Ogami, K., Zheng, M., Yoshino, S., Sugimoto, Y., Seida, M., Mori, T., Yoshizawa, R., Onimaru, K., Kadota, M., Kuraku, S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.06.658161 · Cited by 3
Nanog in iPS cells and during reprogramming
Echegaray, C. V., & Guberman, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90059-1.00006-3 · Cited by 2
Global impact of phosphorylation on protein endurancePreprint
Wu, C.-D., Ba, Q., Li, W.-X., Šalovská, B., Hou, P., Mueller, T., Rosenberger, G. A., Gao, E., Di, Y., & Liu, Y.-S. (2020) · bioRxiv · doi:10.1101/2020.03.12.989467 · Cited by 3
Poised PABP-RNA hubs implement signal-dependent mRNA decay in developmentPreprint
Modic, M., Kuret, K., Steinhauser, S., Faraway, R., van Genderen, E., Lee, F. C. Y., Mozos, I. R. D. L., Vičič, Ž., Novljan, J., ten Berge, D., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3227673/v1 · Cited by 2
NIPBL-mediated 3D genome folding translates enhancer priming into gene activation and safeguards lineage fidelity during embryonic transitionsPreprint
Ni, Z., Ma, X., Do, S., Cheng, L., Glenn, R. A., Vierbuchen, T., & Pertsinidis, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.30.686824 · Cited by 2
OTX2 controls chromatin accessibility to direct somatic versus germline differentiation
Barbieri, E., & Chambers, I. (2025) · bioRxiv · doi:10.1038/s44319-025-00622-2 · Cited by 1
Bone marrow stromal cell antigen 2 is broadly expressed in the different pluripotent states of human pluripotent stem cells and regulates the expression of pluripotency genes and three germ layer markers
Choi, H. S., Lee, J. Y., Choi, M. J., Kim, M. S., & Ryu, C. J. (2024) · Human Cell · doi:10.1007/s13577-024-01160-0 · Cited by 1
KDM3A and KDM3B regulate alternative splicing in mouse pluripotent stem cells
Dillingham, C. M., Cormaty, H., Morgan, E. C., Tak, A. I., Esgdaille, D. E., Boutz, P. L., & Sridharan, R. (2025) · iScience · doi:10.1016/j.isci.2025.112612 · Cited by 1
The Sum of Two Halves May Be Different from the Whole—Effects of Splitting Sequencing Samples Across Lanes
Williams, E. C., Chazarra-Gil, R., Shahsavari, A., & Mohorianu, I. I. (2022) · Genes · doi:10.3390/genes13122265 · Cited by 1
The ETS Transcription Factor ERF controls the exit from the naïve pluripotent statePreprint
Vega-Sendino, M., Olbrich, T., Tillo, D., Tran, A. D., Domingo, C. N., Franco, M. M., FitzGerald, P. C., Kruhlak, M. J., & Ruiz, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.01.429223 · Cited by 1
Epiblast morphogenesis is controlled by selective mRNA decay triggered by LIN28A relocationPreprint
Modic, M., Mozos, I. R. D. L., Steinhauser, S., van Genderen, E., Schirge, S., Bergant, V., Ryan, J., Mulholland, C. B., Faraway, R., Lee, F. C. Y., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.15.433780 · Cited by 1
Ampk activation by glycogen expenditure primes the exit of naive pluripotencyPreprint
Kim, S.-M., Kwon, E., Oh, J., Kim, H. S., Park, S., Jang, G., Tae, J., Kim, K.-T., & Cha, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.541467 · Cited by 1
KDM3A and KDM3B Maintain Naïve Pluripotency Through the Regulation of Alternative SplicingPreprint
Dillingham, C. M., Cormaty, H., Morgan, E. C., Tak, A. I., Esgdaille, D. E., Boutz, P. L., & Sridharan, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.31.543088 · Cited by 1
Four-dimensional omics data reveals ribosome heterogeneity, regulation of translation efficacy, and nonsense-mediated decay in the differentiation of spermatocyte to round spermatidPreprint
Lee, S.-S., Kung, Y., & Jou, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548784 · Cited by 1
The transcription factor OCT6 promotes the dissolution of the naïve pluripotent state by repressing Nanog and activating a formative state gene regulatory networkPreprint
Waisman, A., Sevlever, F., Saulnier, D., Francia, M. G., Lombardi, A., Biani, C., Palma, M. B., Scarafía, A., Smucler, J., Amín, G., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548918 · Cited by 1
Integrative Analysis Reveals Histone Demethylase LSD1/KDM1A Associates with RNA Polymerase II PausingPreprint
Kim, H. J., Kim, T.-Y., Oldfield, A., & Yang, P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.13.338103
Self-citation
Generation of iPSCs from endangered Grevy’s zebra and comparative transcriptomic analysis of mammalian PSCsPreprint
Endo, Y., Kamei, K., Hasegawa, K., Okita, K., Ito, H., Terada, S., & Inoue‐Murayama, M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.08.10.455807
Investigation of Stem Cell Applications on In Vitro Fertilization in Rats
Gümürdü, A., OZTURK, S., Aydemir, I., & Tuğlu, M. (2021) · Journal of the Hellenic Veterinary Medical Society · doi:10.12681/jhvms.28489
Ribo-macs derived from nucleoli: big ribosome clusters in the cytoplasm of naïve stem cellsPreprint
Qin, K., Sun, L., Wu, X., Wen, J., & Xing, Z. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.04.11.487846
Measuring Endocytosis and Endosomal Uptake at Single Cell Resolution
Sangokoya, C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2281-0_6
Comprehensive chromatin proteomics resolves functional phases of pluripotencyPreprint
Ugur, E., de la Porte, A., Bultmann, S., Drukker, M., Mann, M., Wierer, M., & Leonhardt, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.08.503208
Self-citation
PAD2: interactive exploration of transcription factor genomic colocalization using ChIP-seq data
Kim, T.-Y., Kim, H. J., Oldfield, A., & Yang, P. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102203
Self-citation
Additional file 3 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682355
Additional file 2 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682352
Additional file 5 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682361
Additional file 4 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682358
Bone Marrow Stromal Cell Antigen 2 is Broadly Expressed in the Different Pluripotent States of Human Pluripotent Stem Cells and is Required for the Maintenance of Pluripotency GenesPreprint
Choi, H. S., Choi, M. J., Lee, J. Y., & Ryu, C. J. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4804355
Progress in Metabolomics of Acute Coronary Syndromes
段, 明. (2024) · Bioprocess · doi:10.12677/bp.2024.142014
Germ cell chromatin
Bakoulis, S., & Stewart-Morgan, K. R. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf165
Mechanisms of specific lncRNA function in early cardiac lineage development
Lin, Y. (2024) · doi:10.21248/gups.92107
N 6 -Methyladenosine Safeguards Mouse and Human Germline CompetencePreprint
Zuo, R.-J., Bai, B., Jin, K.-X., Søegaard, M. L. C., Ilaslan, E., Yao, Y., Li, J., Wyrożemski, Ł., Li, Y., Wu, X., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.18.688769
Additional file 1 of H3K18 lactylation marks tissue-specific active enhancers
Galle, E., Wong, C.-W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L. C., Castellano‐Castillo, D., Engl, M., de Sousa, J. A., Ruiz‐Ojeda, F. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21269501
Additional file 1 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682349
Additional file 4 of Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Boileau, R. M., Chen, K. X., & Blelloch, R. H. (2023) · Figshare · doi:10.6084/m9.figshare.22624372
Additional file 7 of H3K18 lactylation marks tissue-specific active enhancers
Galle, E., Wong, C.-W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L. C., Castellano‐Castillo, D., Engl, M., de Sousa, J. A., Ruiz‐Ojeda, F. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21269525
Additional file 6 of Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition
Zhang, H., Ji, S., Zhang, K., Chen, Y., Ming, J., Kong, F., Wang, L. N., Wang, S., Zou, Z., Xiong, Z., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23682364
Additional file 1 of Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Boileau, R. M., Chen, K. X., & Blelloch, R. H. (2023) · Figshare · doi:10.6084/m9.figshare.22624363
Additional file 5 of Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation
Boileau, R. M., Chen, K. X., & Blelloch, R. H. (2023) · Figshare · doi:10.6084/m9.figshare.22624375
Additional file 2 of H3K18 lactylation marks tissue-specific active enhancers
Galle, E., Wong, C.-W., Ghosh, A., Desgeorges, T., Melrose, K., Hinte, L. C., Castellano‐Castillo, D., Engl, M., de Sousa, J. A., Ruiz‐Ojeda, F. J., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21269504
Additional file 1 of AKT1 induces Nanog promoter in a SUMOylation-dependent manner in different pluripotent contexts
Francia, M. G., Verneri, P., Oses, C., Echegaray, C. V., García, M. R., Toro, A. R., Levi, V., & Guberman, A. (2024) · Figshare · doi:10.6084/m9.figshare.26635224
Rbm25 governs embryonic stem cell identity and fate through transcriptional regulation of pluripotency and epigenetic programs
Tang, W., Zhang, L., Cao, P., Bai, S., Sun, M., Li, J., Zhang, Y., Wang, Y., Tu, D., Wong, J., et al. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102748
Post-replicative chromatin accessibility predicts cell fate change
Knudsen, T. E., Reverón-Gómez, N., Biran, A., Alcaraz, N., Cheloufi, S., Hochedlinger, K., Brickman, J. M., Groth, A., & Stewart-Morgan, K. R. (2026) · Stem Cell Reports · doi:10.1016/j.stemcr.2026.102821
KMT2C and KMT2D amplify GRHL2-driven enhancer activationPreprint
Boileau, R. M., Chen, K. X., & Blelloch, R. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.10.710694
Wt1 splice isoforms bias lineage programmes during formative pluripotencyPreprint
Cerron-Alvan, L. M., Firfa, T., Pitasi, M., Löbker, A., Huth, M., Bindl, M., Drakos, L., Laos, T., & Laos, T. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.06.713568
Direct Mapping of CDK2 Substrates in Embryonic Stem Cells Uncovers an AP-Site Repair Mechanism via HMCES PhosphorylationPreprint
Topacio, B. R., Esvald, E., Tuvikene, J., Langroudi, L., Maity, T. K., Jenkins, L. M. M., Stracker, T. H., Kõivomägi, M., & Shariati, S. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.18.726044
ERK1/2 function as a central hub safeguarding primed human embryonic stem cell identity via multifaceted regulatory networks
Zhou, Y., Zhao, H., Shao, M., Lu, W., Jiao, H., Li, L., & Jin, Y. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117675

Authors: Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, M., & Jothi, R.
Affiliations: The University of Sydney (AU)
National Institutes of Health (US)
Max Planck Institute of Biochemistry (DE)
Corresponding author: Yang, Pengyi
Humphrey, Sean J.
Jothi, Raja
ORCID: Yang, Pengyi
Humphrey, Sean J.
Pathania, Rajneesh
Oldfield, Andrew J.
Kumar, Dhirendra
Yang, Jean Y.H.
James, David E.
Mann, Matthias
Venue: Cell Systems
Publisher: Elsevier BV
Published: 2019-05
Volume: 8
Issue: 5
Pages: 427-445.e10
ISSN: 2405-4712 (ISSN-L)
DOI: 10.1016/j.cels.2019.03.012
PMC: PMC6544180
OpenAlex: W2950402574
Cited by: 146
References: 109
Citations by year: 2026: 6 · 2025: 21 · 2024: 14 · 2023: 28 · 2022: 25 · 2021: 26 · 2020: 20 · 2019: 6
FWCI: 6.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Cell Systems (publishedVersion, cc-by-nc-nd)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion, cc-by-nc-nd)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg
Australian Research Council
National Institutes of Health
European Molecular Biology Organization
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: pluripotency, naive pluripotency, primed pluripotency, embryonic stem cells, phosphoproteome, proteome, transcriptome, epigenome, signaling pathways
MeSH terms: Epigenome, Animals, Cell Differentiation, Germ Layers, Humans, Signal Transduction, Gene Expression Regulation, Developmental, Cell Lineage, Proteome, Pluripotent Stem Cells, Embryonic Stem Cells, Transcriptome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks