Magnitude and Impact of Multimorbidity on Clinical Outcomes in Older Adults with Cardiovascular Disease
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The authors aim to synthesize the current literature on the magnitude and impact of multimorbidity on clinical outcomes in older adults with cardiovascular disease (CVD). Most studies reported a significant association between the number of morbidities and the risk of dying. Multimorbidity was assessed either by counting the number of conditions or by use of the Charlson or Elixhauser indices. There are limited data available on the magnitude and impact of multimorbidity on clinical outcomes in patients with CVD and essentially no data on universal health outcomes (eg, health-related quality of life, symptom burden, and function).
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The presence of comorbid diseases affects treatment response and prognosis for hard clinical outcomes such as cardiovascular and all-cause mortality, hospitalization, and health-care utilization.
“The presence of comorbid diseases is well established to affect both the response to treatment and the prognosis for hard clinical outcomes, such as cardiovascular and all-cause mortality, as well as hospitalization and health-care utilization”
From Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty (2018) · cites this paper as [197]
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- Authors
- Tisminetzky, M., Goldberg, R., & Gurwitz, J. H.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Corresponding author
- Gurwitz, Jerry H.
- Venue
- Clinics in Geriatric Medicine
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 32
- Issue
- 2
- Pages
- 227-246
- ISSN
- 0749-0690 (ISSN-L)
- PMC
- PMC4848462
- OpenAlex
- W2337199893
- Cited by
- 30
- References
- 25
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 1 · 2018: 4 · 2017: 3 · 2016: 1
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinics in Geriatric Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship@UMassChan (submittedVersion)
- Funders
- National Institute on Aging (R21AG045320, R24AG045050)
- National Heart, Lung, and Blood Institute (U01HL105268, R01HL035434)
- Topics
- Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- multimorbidity, cardiovascular disease, older adults, mortality risk, Charlson Comorbidity Index, Elixhauser comorbidity index, health-related quality of life, symptom burden, functional status, clinical outcomes
- MeSH terms
- Aged, Cardiovascular Diseases, Humans, Patient Care Management, Comorbidity, Patient Outcome Assessment
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