Multiple Chronic Conditions: Prevalence, Health Consequences, and Implications for Quality, Care Management, and Costs

Prevalence of the Metabolic Syndrome Among US Adults: Findings From the Third National Health and Nutrition Examination Survey

Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works

Definition of Metabolic Syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition

Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works

The quality of health care delivered to adults in the United States

McGlynn, E. A., Asch, S. M., Adams, J., Keesey, J., Hicks, J., DeCristofaro, A., & Kerr, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmsa022615 · Cited by 5,079 · see citing works

The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men

Lakka, H.-M. (2002) · JAMA · doi:10.1001/jama.288.21.2709 · Cited by 5,033 · see citing works

Crossing the Quality Chasm: A New Health System for the 21st Century

Bloom, B. S. (2002) · JAMA · doi:10.1001/jama.287.5.646-a · Cited by 3,732 · see citing works

Organizing Care for Patients with Chronic Illness

Wagner, E. H., Austin, B. T., & Korff, M. V. (1996) · The Milbank Quarterly · doi:10.2307/3350391 · Cited by 2,877 · see citing works

Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance

Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581 · see citing works

Prevalence, Expenditures, and Complications of Multiple Chronic Conditions in the Elderly

Wolff, J. L., Starfield, B. H., & Anderson, G. F. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.20.2269 · Cited by 2,237 · see citing works

The Metabolic Syndrome: Prevalence and Associated Risk Factor Findings in the US Population From the Third National Health and Nutrition Examination Survey, 1988-1994

Park, Y.-W., Zhu, S., Palaniappan, L., Heshka, S., Carnethon, M. R., & Heymsfield, S. B. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.427 · Cited by 2,074 · see citing works

Incidence and Preventability of Adverse Drug Events Among Older Persons in the Ambulatory Setting

Gurwitz, J. H., Field, T. S., Harrold, L. R., Rothschild, J. M., DeBellis, K. R., Seger, A. C., Cadoret, C. A., Fish, L. S., Garber, L., Kelleher, M., et al. (2003) · JAMA · doi:10.1001/jama.289.9.1107 · Cited by 1,666 · see citing works

Adverse Drug Events in Ambulatory Care

Gandhi, T. K., Weingart, S. N., Borus, J. S., Seger, A. C., Peterson, J. F., Burdick, E., Seger, D. L., Shu, K. M., Federico, F. A., Leape, L. L., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmsa020703 · Cited by 1,371 · see citing works

Collaborative Management of Chronic Illness

Von Korff, M., Gruman, J., Schaefer, J., Curry, S. J., & Wagner, E. H. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-127-12-199712150-00008 · Cited by 1,269 · cited 1× · see citing works

Prevalence of the Metabolic Syndrome and Its Relation to All-Cause and Cardiovascular Mortality in Nondiabetic European Men and Women

Hu, G. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.10.1066 · Cited by 1,135 · see citing works

Potential pitfalls of disease-specific guidelines for patients with multiple conditions.

Tinetti, M., Bogardus, S., & Agostini, J. V. (2004) · New England Journal of Medicine · doi:10.1056/nejmsb042458 · Cited by 969 · see citing works

Causes and consequences of comorbidity

Gijsen, R., Hoeymans, N., Schellevis, F. G., Ruwaard, D., Satariano, W. A., & van den Bos, G. A. M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(00)00363-2 · Cited by 962 · see citing works

Readmission After Hospitalization for Congestive Heart Failure Among Medicare Beneficiaries

Krumholz, H. M. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440220103013 · Cited by 821 · see citing works

Noncardiac comorbidity increases preventable hospitalizations and mortality among medicare beneficiaries with chronic heart failure

Braunstein, J. B., Anderson, G. F., Gerstenblith, G., Weller, W. E., Niefeld, M. R., Herbert, R. J., & Wu, A. W. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00947-1 · Cited by 778 · see citing works

The Treatment of Unrelated Disorders in Patients with Chronic Medical Diseases

Redelmeier, D. A., Tan, S. H., & Booth, G. L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199805213382106 · Cited by 635 · see citing works

Association of Comorbidity with Disability in Older Women

Fried, L. P., Bandeen‐Roche, K., Kasper, J. D., & Guralnik, J. M. (1999) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(98)00124-3 · Cited by 456 · see citing works

Comorbidity of Medical Illnesses Among Adults With Serious Mental Illness Who Are Receiving Community Psychiatric Services

Sokal, J., Messias, E., Dickerson, F. B., Kreyenbuhl, J., Brown, C. H., Goldberg, R. W., & Dixon, L. B. (2004) · Journal of Nervous & Mental Disease · doi:10.1097/01.nmd.0000130135.78017.96 · Cited by 320 · see citing works

Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Jemtel, T. H. L., Padeletti, M., & Jelić, S. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.08.046 · Cited by 320 · see citing works

Chronic Medical Illness, Depression, and Use of Acute Medical Services Among Medicare Beneficiaries

Himelhoch, S. S., Weller, W. E., Wu, A. W., Anderson, G. F., & Cooper, L. A. (2004) · Medical Care · doi:10.1097/01.mlr.0000127998.89246.ef · Cited by 266 · see citing works

Somatic Comorbidity of Epilepsy in the General Population in Canada

Téllez‐Zenteno, J. F., Matijevic, S., & Wiebe, S. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.00344.x · Cited by 254 · see citing works

Improving depression outcomes in older adults with comorbid medical illness

Harpole, L. H., Williams, J. W., Olsen, M. K., Stechuchak, K. M., Oddone, E. Ž., Callahan, C. M., Katon, W. J., Lin, E. H. B., Grypma, L., & Unützer, J. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2004.09.004 · Cited by 185 · see citing works

Competing Demands From Physical Problems: Effect on Initiating and Completing Depression Care Over 6 Months

Nutting, P. A. (2000) · Archives of Family Medicine · doi:10.1001/archfami.9.10.1059 · Cited by 182 · see citing works

Managing multiple morbidity in mid-life: A qualitative study of attitudes to drug use

Townsend, A., Hunt, K., & Wyke, S. (2003) · BMJ · doi:10.1136/bmj.327.7419.837 · Cited by 181 · see citing works

Return on investment in disease management: a review.

Goetzel, R. Z., Ozminkowski, R. J., Villagra, V. G., & Duffy, J. (2005) · PubMed Central · Cited by 172 · see citing works

The Effect of Age and Chronic Illness on Life Expectancy after a Diagnosis of Colorectal Cancer: Implications for Screening

Gross, C. P., McAvay, G., Krumholz, H. M., Paltiel, A. D., Bhasin, D., & Tinetti, M. E. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-9-200611070-00006 · Cited by 171 · see citing works

Arthritis and Heart Disease as Risk Factors for Major Depression

Dunlop, D. D., Lyons, J. S., Manheim, L. M., Song, J., & Chang, R. W. (2004) · Medical Care · doi:10.1097/01.mlr.0000127997.51128.81 · Cited by 132 · see citing works

Preventable Hospitalization Among Elderly Medicare Beneficiaries With Type 2 Diabetes

Niefeld, M. R., Braunstein, J. B., Wu, A. W., Saudek, C. D., Weller, W. E., & Anderson, G. F. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1344 · Cited by 121 · see citing works

Patterns and Impact of Comorbidity and Multimorbidity Among Community-Resident American Indian Elders

John, R. M. S., Kerby, D. S., & Hennessy, C. H. (2003) · The Gerontologist · doi:10.1093/geront/43.5.649 · Cited by 121 · see citing works

Health Spending Growth Slows In 2003

Smith, C. E., Cowan, C. A., Sensenig, A., Catlin, A., & the Health Accounts Team (2005) · Health Affairs · doi:10.1377/hlthaff.24.1.185 · Cited by 114 · see citing works

Polymorphisms in the Fatty Acid-Binding Protein 2 and Apolipoprotein C-III Genes Are Associated with the Metabolic Syndrome and Dyslipidemia in a South Indian Population

Guettier, J.-M., Georgopoulos, A., Tsai, M. Y., Radha, V., Shanthirani, S., Deepa, R., Gross, M., Rao, G., & Mohan, V. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1338 · Cited by 108 · see citing works

Disease management in the American market

Bodenheimer, T. (2000) · BMJ · doi:10.1136/bmj.320.7234.563 · Cited by 90 · see citing works

The Influence of Comorbid Chronic Medical Conditions on the Adequacy of Depression Care for Older Americans

Harman, J. S., Edlund, M. J., Fortney, J. C., & Kallas, H. E. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.00511.x · Cited by 80 · see citing works

Additive and Interactive Effects of Comorbid Physical and Mental Conditions on Functional Health

Fultz, N. H., Ofstedal, M. B., Herzog, A. R., et al. (2003) · Journal of Aging and Health · doi:10.1177/0898264303253502 · Cited by 68 · see citing works

Relation between atherogenic dyslipidemia and the Adult Treatment Program-III definition of metabolic syndrome (Genetic Epidemiology of Metabolic Syndrome Project)

Wyszynski, D. F., Waterworth, D. M., Barter, P. J., Cohen, J. C., Kesäniemi, Y. A., Mahley, R. W., McPherson, R., Waeber, G., Bersot, T. P., Sharma, S., et al. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.08.091 · Cited by 67 · see citing works

Predictors of Overall Quality of Care Provided to Vulnerable Older People

Min, L. C., Reuben, D. B., MacLean, C. H., Shekelle, P., Solomon, D. H., Higashi, T., Chang, J. T., Roth, C. P., KAMBERG, C. J., Adams, J., et al. (2005) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53520.x · Cited by 60 · see citing works

Physician, Public, and Policymaker Perspectives on Chronic Conditions

Anderson, G. F. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.4.437 · Cited by 59 · see citing works

Managed Care Rebound? Recent Changes In Health Plans' Cost Containment Strategies

Mays, G. P., Claxton, G., & White, J. S. (2004) · Health Affairs · doi:10.1377/hlthaff.w4.427 · Cited by 57 · see citing works

Characteristics of comorbidity in adult asthma.

Ben-Noun, L. L. (2001) · PubMed · Cited by 38 · see citing works

Disease management: a leap of faith to lower-cost, higher-quality health care.

Short, A. C., Mays, G. P., & Mittler, J. (2003) · PubMed · Cited by 28 · see citing works

Osteoarthritis: A Comorbid Marker for Longer Life?

Lee, T. A., Pickard, A. S., Bartle, B., & Weiss, K. B. (2007) · Annals of Epidemiology · doi:10.1016/j.annepidem.2007.01.033 · Cited by 25 · see citing works

Disease management to population-based health: steps in the right direction?

Sprague, L. (2003) · PubMed · Cited by 21 · see citing works

Medicare: Preparing for the Challenges of the 21st Century

Reischauer, R. D., Butler, S. M., & Lave, J. R. (2001) · Medical Entomology and Zoology · Cited by 11 · see citing works

Challenges In Improving Care For High-Risk Seniors In Medicare

Gold, M., Lake, T. K., Black, W., & Smith, M. D. (2005) · Health Affairs · doi:10.1377/hlthaff.w5.199 · Cited by 11 · see citing works

Heart Failure and Diabetes: Collateral Benefit of Chronic Disease Management

Ware, M. G., Flavell, C. M., Lewis, E. F., Nohria, A., Warner‐Stevenson, L., & Givertz, M. M. (2006) · Congestive Heart Failure · doi:10.1111/j.1527-5299.2005.05354.x · Cited by 10 · see citing works

Dissecting racial bias in an algorithm used to manage the health of populations

Obermeyer, Z., Powers, B., Vogeli, C., & Mullainathan, S. (2019) · Science · doi:10.1126/science.aax2342 · Cited by 7,137 · see citing works

Prevalence, determinants and patterns of multimorbidity in primary care: a systematic review of observational studies

Violan, C., Foguet-Boreu, Q., Flores-Mateo, G., Salisbury, C., Blom, J., Freitag, M., Glynn, L., Muth, C., & Valderas, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102149 · Cited by 1,125 · see citing works

Confronting The Growing Burden Of Chronic Disease: Can The U.S. Health Care Workforce Do The Job?

Bodenheimer, T., Chen, E., & Bennett, H. D. (2009) · Health Affairs · doi:10.1377/hlthaff.28.1.64 · Cited by 544 · see citing works

Prevalence and patterns of multimorbidity in Australia

Britt, H. C., Harrison, C. M., Miller, G. C., & Knox, S. A. (2008) · Medical Journal of Australia · doi:10.5694/j.1326-5377.2008.tb01919.x · Cited by 402 · see citing works

Living with a rare disorder: a systematic review of the qualitative literature

von der Lippe, C., Diesen, P. S., & Feragen, K. B. (2017) · Molecular Genetics & Genomic Medicine · doi:10.1002/mgg3.315 · Cited by 378 · see citing works

Risk of developing multimorbidity across all ages in an historical cohort study: differences by sex and ethnicity

St Sauver, J. L., Boyd, C. M., Grossardt, B. R., Bobo, W. V., Finney Rutten, L. J., Roger, V. L., Ebbert, J. O., Therneau, T. M., Yawn, B. P., & Rocca, W. A. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006413 · Cited by 257 · see citing works

Aging and mental health in the decade ahead: What psychologists need to know

Karel, M. J., Gatz, M., & Smyer, M. A. (2012) · American Psychologist · doi:10.1037/a0025393 · Cited by 228 · see citing works

What are the effective elements in patient-centered and multimorbidity care? A scoping review

Poitras, M.-E., Maltais, M.-E., Bestard-Denommé, L., Stewart, M., & Fortin, M. (2018) · BMC Health Services Research · doi:10.1186/s12913-018-3213-8 · Cited by 219 · see citing works

Treatment adjustment and medication adherence for complex patients with diabetes, heart disease, and depression: a randomized controlled trial

Lin, E. H. B., Von Korff, M., Ciechanowski, P., Peterson, D., Ludman, E. J., Rutter, C. M., Oliver, M., Young, B. A., Gensichen, J., McGregor, M., et al. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1343 · Cited by 150 · see citing works

Association Between Accelerated Multimorbidity and Age‐Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia

Fabbri, E., An, Y., Zoli, M., Tanaka, T., Simonsick, E. M., Kitner‐Triolo, M. H., Studenski, S. A., Resnick, S. M., & Ferrucci, L. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14092 · Cited by 123 · see citing works

Expanding the role of community pharmacists: policymaking in the absence of policy-relevant evidence?

Mossialos, E., Naci, H., & Courtin, E. (2013) · Health Policy · doi:10.1016/j.healthpol.2013.04.003 · Cited by 104 · see citing works

The Effectiveness of Self-Management Interventions for Individuals with Low Health Literacy and/or Low Income: A Descriptive Systematic Review

Schaffler, J., Leung, K., Tremblay, S., Merdsoy, L., Belzile, E., Lambrou, A., & Lambert, S. D. (2018) · Journal of General Internal Medicine · doi:10.1007/s11606-017-4265-x · Cited by 97 · see citing works

Cross-national differences in the prevalence and correlates of burden among older family caregivers in the World Health Organization World Mental Health (WMH) Surveys

Shahly, V., Chatterji, S., Gruber, M. J., Al-Hamzawi, A., Alonso, J., Andrade, L. H., Angermeyer, M. C., Bruffaerts, R., Bunting, B., Caldas-de-Almeida, J. M., et al. (2013) · Psychological Medicine · doi:10.1017/s0033291712001468 · Cited by 90 · see citing works

Future directions in the study of early-life stress and physical and emotional health: implications of the neuroimmune network hypothesis.

Hostinar, C. E., Nusslock, R., & Miller, G. E. (2018) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1266647 · Cited by 90 · see citing works

The complex web of health: Relationships among chronic conditions, disability, and health services

Gulley, S. P., Rasch, E. K., & Chan, L. (2011) · Public Health Reports® · doi:10.1177/003335491112600406 · Cited by 79 · see citing works

Optimal Screening for Prediction of Referral and Outcome (OSPRO) for Musculoskeletal Pain Conditions: Results From the Validation Cohort

George, S. Z., Beneciuk, J. M., Lentz, T. A., Wu, S. S., Dai, Y., Bialosky, J. E., & Zeppieri, G. (2018) · Journal of Orthopaedic & Sports Physical Therapy · doi:10.2519/jospt.2018.7811 · Cited by 79 · see citing works

Multidimensional analysis of treatment adherence in patients with multiple chronic conditions. A cross-sectional study in a tertiary hospital

Jansà, M., Hernández, C., Vidal, M., Nuñez, M., Bertran, M. J., Sanz, S., Castell, C., & Sanz, G. (2010) · Patient Education and Counseling · doi:10.1016/j.pec.2009.12.012 · Cited by 61 · see citing works

Mindfulness Meditation Targets Transdiagnostic Symptoms Implicated in Stress-Related Disorders: Understanding Relationships between Changes in Mindfulness, Sleep Quality, and Physical Symptoms

Greeson, J. M., Zarrin, H., Smoski, M. J., Brantley, J. G., Lynch, T. R., Webber, D. M., Hall, M. H., Suarez, E. C., & Wolever, R. Q. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/4505191 · Cited by 55 · see citing works

The Core of Care Management: The Role of Authentic Relationships in Caring for Patients with Frequent Hospitalizations

Grinberg, C., Hawthorne, M., LaNoue, M., Brenner, J., & Mautner, D. (2016) · Population Health Management · doi:10.1089/pop.2015.0097 · Cited by 33 · see citing works

Magnitude and Impact of Multimorbidity on Clinical Outcomes in Older Adults with Cardiovascular Disease

Tisminetzky, M., Goldberg, R., & Gurwitz, J. H. (2016) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2016.01.014 · Cited by 30 · see citing works

Parent Experiences Raising Young People with Type 1 Diabetes and Celiac Disease

Erickson, K., Freeborn, D., Roper, S. O., Mandleco, B., Anderson, A., & Dyches, T. (2015) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2014.09.011 · Cited by 28 · see citing works

Impact of a primary-based telemonitoring programme in HRQOL, satisfaction and usefulness in a sample of older adults with chronic diseases in Valencia (Spain)

Doñate-Martínez, A., Ródenas, F., & Garcés, J. (2016) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2015.09.008 · Cited by 17 · see citing works

Comparison of Health Information Technology Use Between American Adults With and Without Chronic Health Conditions: Findings From The National Health Interview Survey 2012

Zhang, Y., Lauche, R., Sibbritt, D. W., Olaniran, B. A., Cook, R. L., & Adams, J. (2017) · Journal of Medical Internet Research · doi:10.2196/jmir.6989 · Cited by 40 · see citing works

HEALTH CARE OUTCOMES FOR PEOPLE WITH MULTIPLE CHRONIC CONDITIONS IN ONTARIO, CANADA

Wodchis, W. P., Gruneir, A., Thavorn, K., et al. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.3814

Considerations in the design of service specific chronic disease management registers

Guda, R., Dugdale, P., Evans, S., et al. (2008) · Australasian epidemiologist · Cited by 4 · see citing works

Obstructive sleep apnoea in adults: A common chronic condition in need of a comprehensive chronic condition management approach

Ryswyk, E. V., Harris, M., Battersby, M., McEvoy, R. D., Chai‐Coetzer, C. L., & Antic, N. A. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.09.004 · Cited by 58 · see citing works

What are chronic conditions that contribute to multimorbidity?

Gordon, J., Miller, G. C., & Britt, H. C. (2018) · Australian Journal of General Practice · doi:10.31128/afp-08-17-4312 · Cited by 11 · see citing works