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Systematic Review and Meta-analysis of the Prevalence of Irritable Bowel Syndrome in Individuals With Dyspepsia
Open accessAbstract
Background & aims Dyspepsia and irritable bowel syndrome (IBS) are common conditions that can coexist in patients. We performed a systematic review and meta-analysis to estimate prevalence of IBS in dyspepsia.Methods Relevant articles published through August 2008 were identified from MEDLINE and EMBASE literature searches (23,457 citations). Eligible studies included adults recruited from the community, the workplace, blood donation or screening clinics, and family physician offices or internal medicine clinics. Selected studies reported prevalence of dyspepsia and IBS within the same population. The prevalence of IBS in subjects with and without dyspepsia was pooled for all studies and compared. Odds ratios (OR) and confidence intervals (CI) were calculated. The degree of overlap between dyspepsia and IBS was determined.Results Of 239 papers evaluated, 150 reported prevalence of dyspepsia and 19 (involving 18,173 subjects) reported the proportion of subjects with IBS within the same population. The prevalence of dyspepsia was 27% (95% CI, 23%-31%). The prevalence of IBS in subjects with dyspepsia was 37% (95% CI, 30%-45%) compared with 7% (95% CI, 5%-10%) in those without. The pooled OR for IBS in subjects with dyspepsia was 8 (95% CI, 5.74-11.16). The degree of overlap between the 2 conditions varied from 15% to 42%, depending on diagnostic criteria used for each.Conclusions Individuals with dyspepsia have an 8-fold increase in prevalence of IBS compared with the population. The strength of the association suggests common pathogenic mechanisms. Dyspeptic patients should be assessed routinely for IBS.
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“Probably the most common association is the one between IBS and functional dyspepsia (FD).”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“A high prevalence of overlap between these 2 conditions has been consistently reported in numerous studies.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“Moreover people with dyspepsia had an 8-fold increase in the prevalence of IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“In a recent meta-analysis, Ford et al.11 reported the degree of overlap to be between 15-42%.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“Although IBS patients have been reported to have lower, rather than higher thresholds for somatic stimulation,11,12”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“[23] identified 19 studies which met their eligibility criteria, comprising 18,173 subjects, and they showed that the prevalence of IBS in subjects with dyspepsia was 37% (95% confidence interval [CI], 30–45%).”
BackgroundTreatment of irritable bowel syndrome: beyond fiber and antispasmodic agents
Sainsbury, A., & Ford, A. (2011) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x10387203 · Cited by 36
“In general, prevalence is increased in younger individuals, females, and those with coexisting functional GI diseases [Drossman et al. 1993], particularly dyspepsia [Ford et al. 2010].”
BackgroundSelf-citationIs small intestinal bacterial overgrowth involved in the pathogenesis of functional dyspepsia?
Tziatzios, G., Giamarellos-Bourboulis, E. J., Papanikolaou, I. S., Pimentel, M., Dimitriadis, G. D., & Triantafyllou, K. (2017) · Medical Hypotheses · doi:10.1016/j.mehy.2017.07.005 · Cited by 30
El‐Salhy, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i32.9577 · Cited by 28
Decreased Basal and Postprandial Plasma Serotonin Levels in Patients With Functional Dyspepsia
Cheung, C., Lee, Y. Y., Chan, Y., Cheong, P. K., Law, W. T., Lee, S. F., Sung, J. J. �., Chan, F. K. L., & Wu, J. C. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.03.026 · Cited by 28
Coffin, B., Bortolloti, C., Bourgeois, O., & Denicourt, L. (2011) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2011.02.009 · Cited by 26
Romano, C., Valenti, S., Cardile, S., & Benninga, M. A. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001344 · Cited by 26
“A meta-analysis has shown that the prevalence of IBS in patients with dyspepsia is higher compared with patients without dyspepsia (35).”
Jaka, H., Mushi, M. F., Mirambo, M. M., Wilson, L., Seni, J., Majigo, M. V., & Mshana, S. E. (2016) · African Health Sciences · doi:10.4314/ahs.v16i3.7 · Cited by 24
Perveen, I. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/20900.8832 · Cited by 24
Stomach antral endocrine cells in patients with irritable bowel syndrome
El‐Salhy, M., Gilja, O. H., Hatlebakk, J. G., & Hausken, T. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1887 · Cited by 22
“The present findings of increased gastrin and decreased somatostatin in all IBS subtypes may cause a high level of gastric acid secretion, which may account for the high incidence of dyspepsia and gastro-oesophageal reflux observed in patients with IBS (53-61).”
Futagami, S., Yamawaki, H., Shimpuku, M., Izumi, N., Wakabayashi, T., Kodaka, Y., Nagoya, H., Shindo, T., Kawagoe, T., & Sakamoto, C. (2013) · Journal of Nippon Medical School · doi:10.1272/jnms.80.362 · Cited by 21
Ford, A. C., & Moayyedi, P. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328365d45d · Cited by 21
“This is surprising as there is a large overlap between IBS and functional dyspepsia [52], and the duodenum is the first point at which gluten sensitivity is manifested [53].”
Self-citationBarberio, B., Pinto-Sánchez, M. I., Berčík, P., Sood, R., Savarino, E. V., Moayyedi, P., Black, C. J., & Ford, A. C. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.16184 · Cited by 21
Self-citationSleep Quality and Insomnia Are Associated With Quality of Life in Functional Dyspepsia
Wuestenberghs, F., Melchior, C., Desprez, C., Leroi, A., Netchitaïlo, M., & Gourcerol, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.829916 · Cited by 24
“%) reported in a recent meta-analysis (Ford et al., 2010).”
Nakov, R., Dimitrova‐Yurukova, D., Snegarova, V., Uzunova, M., Lyutakov, I., Ivanova, M., Madzharova, K., Valkov, H. Y., Hristova, R., Ivanov, K., et al. (2020) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-2645 · Cited by 21
Lee, J. Y., Kim, N., Park, J. H., Yu, J. E., Song, Y. J., Yoon, J. W., & Lee, D. H. (2022) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm21047 · Cited by 20
“According to a systematic review and meta-analysis, the prevalence of IBS among FD patients was 37%, which was significantly higher than that among those without FD (7%).(5) In addition, the prevalence of FD in patients with IBS was 29-87%.”
BackgroundMadisch, A., Frieling, T., Zimmermann, A., Hollenz, M., Labenz, J., Stracke, B. A., & Miehlke, S. (2022) · Digestive Diseases · doi:10.1159/000528553 · Cited by 19
Moayyedi, P., & Ford, A. C. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.007 · Cited by 19
Self-citationKeszthelyi, D., Dackus, G. M. H. E., Masclee, G. M. C., Kruimel, J. W., & Masclee, A. (2012) · BMC Gastroenterology · doi:10.1186/1471-230x-12-121 · Cited by 19
“For instance, IBS patients often suffer from functional dyspepsia; the degree of overlap varies between 15 and 42% [15,16].”
BackgroundHussain, Z., Kim, H. W., Huh, C. W., Lee, Y. J., & Park, H. (2017) · Yonsei Medical Journal · doi:10.3349/ymj.2017.58.4.872 · Cited by 18
“org Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) diseases, comprising 10 to 25% of the general population.(1,2) However, there are several reports regarding frequent overlap between FD and IBS patients.”
BackgroundBayer, S. B., Frampton, C. M., Gearry, R. B., & Barbara, G. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac025 · Cited by 17
“The most well-described association is between functional dyspepsia and IBS (43, 45).”
BackgroundNon-Chinese herbal medicines for functional dyspepsia
Báez, G., Vargas, C., Marcelo Arancibia, M., Papuzinski, C., & Franco, J. V. A. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013323.pub2 · Cited by 19
The Effect of Trimebutine on the Overlap Syndrome Model of Guinea Pigs
Hussain, Z., Jung, D. H., Lee, Y. J., & Park, H. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm18049 · Cited by 17
“Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are common gastrointestinal (GI) diseases comprising 10% to 25% of the general population.(1,2) However, there are several reports regarding frequent overlap between FD and IBS patients.”
BackgroundEngsbro, A. L., Begtrup, L. M., Haastrup, P., Storsveen, M. M., Bytzer, P. M., Kjeldsen, J., de Muckadell, O. B. S., & Jarbøl, D. E. (2020) · Neurogastroenterology & Motility · doi:10.1111/nmo.14004 · Cited by 17
Corsetti, M., & Fox, M. R. (2017) · F1000Research · doi:10.12688/f1000research.12089.1 · Cited by 16
“Moreover, longitudinal studies demonstrate that the risk of a patient with FD developing IBS is increased by up to eightfold compared with the general population 23 .”
BackgroundRole of Low-FODMAP diet in functional dyspepsia: “Why”, “When”, and “to Whom”
Rettura, F., Lambiase, C., Grosso, A., Rossi, A., Tedeschi, R., Ceccarelli, L., & Bellini, M. (2023) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2023.101831 · Cited by 16
Functional Gastrointestinal Disorders in Young Military Men
Bang, C. S., Kim, Y. S., Han, J. H., Lee, Y. S., Baik, G. H., Kim, J. B., Suk, K. T., Yoon, J. H., & Kim, D. J. (2014) · Gut and Liver · doi:10.5009/gnl14109 · Cited by 16
“2).(5,31) However, our study showed that FD+FH+FCP (n=7, 3.”
BackgroundThe Association between Helicobacter pylori Infection and Irritable Bowel Syndrome: A Meta-Analysis
Kim, Y.-A., Cho, Y. J., & Kwak, S. G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072524 · Cited by 16
“Besides, the likelihood for coexistence of IBS in subjects with dyspepsia was eight times higher compared with subjects without dyspepsia [41].”
BackgroundMoayyedi, P. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e328358ad9b · Cited by 16
Self-citationThe relationship between gut microbiota and proteolytic activity in irritable bowel syndrome
Hou, J., Wang, X., Li, Y., Su, S., Wang, Y., & Wang, B. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.104995 · Cited by 18
Huang, Q., Yuan, H., Li, Q., Li, Y., Geng, S., Zhu, Y., Liao, M., & Jiang, H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1218001 · Cited by 14
Importancia de la dieta en el síndrome del intestino irritable
Mearin, F., Peña, E., & Balboa, A. (2014) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2013.12.010 · Cited by 15
Diagnosis of Irritable Bowel Syndrome: a Systematic Review
Park, J. H., Byeon, J., Shin, W.-G., Yoon, Y. H., Cheon, J. H., Lee, K. J., Park, H., & The Korean Society of Neurogastroenterology and Motility (2010) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2010.55.5.308 · Cited by 15
Smeets, F. G. M., Keszthelyi, D., Vork, L., Tack, J. F., Talley, N. J., Simrén, M., Aziz, Q., Ford, A. C., Conchillo, J. M., Kruimel, J. W., et al. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13496 · Cited by 14
Self-citationRuderstam, H., & Ohlsson, B. (2022) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2031281 · Cited by 14
“Patients with dyspepsia have an 8-fold risk of also having IBS, and 25% of IBS patients have gastroesophageal reflux [29,30].”
Background
Metadata
- Authors
- Ford, A. C., Marwaha, A., Lim, A., & Moayyedi, P.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Ford, Alexander C.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 8
- Issue
- 5
- Pages
- 401-409
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W1968773048
- Cited by
- 195
- References
- 62
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 9 · 2015: 14 · 2014: 15 · 2013: 9 · 2012: 16
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, dyspepsia, prevalence, comorbidities, diagnostic criteria, pathophysiological mechanisms, screening
- MeSH terms
- Dyspepsia, Humans, Comorbidity, Prevalence, Irritable Bowel Syndrome
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