The DOI matches its Crossref record; 60 of the 62 references it cites were found in a registry or an index.
Systematic Review and Meta-analysis of the Prevalence of Irritable Bowel Syndrome in Individuals With Dyspepsia
Open accessAbstract
Background & aims Dyspepsia and irritable bowel syndrome (IBS) are common conditions that can coexist in patients. We performed a systematic review and meta-analysis to estimate prevalence of IBS in dyspepsia.Methods Relevant articles published through August 2008 were identified from MEDLINE and EMBASE literature searches (23,457 citations). Eligible studies included adults recruited from the community, the workplace, blood donation or screening clinics, and family physician offices or internal medicine clinics. Selected studies reported prevalence of dyspepsia and IBS within the same population. The prevalence of IBS in subjects with and without dyspepsia was pooled for all studies and compared. Odds ratios (OR) and confidence intervals (CI) were calculated. The degree of overlap between dyspepsia and IBS was determined.Results Of 239 papers evaluated, 150 reported prevalence of dyspepsia and 19 (involving 18,173 subjects) reported the proportion of subjects with IBS within the same population. The prevalence of dyspepsia was 27% (95% CI, 23%-31%). The prevalence of IBS in subjects with dyspepsia was 37% (95% CI, 30%-45%) compared with 7% (95% CI, 5%-10%) in those without. The pooled OR for IBS in subjects with dyspepsia was 8 (95% CI, 5.74-11.16). The degree of overlap between the 2 conditions varied from 15% to 42%, depending on diagnostic criteria used for each.Conclusions Individuals with dyspepsia have an 8-fold increase in prevalence of IBS compared with the population. The strength of the association suggests common pathogenic mechanisms. Dyspeptic patients should be assessed routinely for IBS.
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“Probably the most common association is the one between IBS and functional dyspepsia (FD).”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“A high prevalence of overlap between these 2 conditions has been consistently reported in numerous studies.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“Moreover people with dyspepsia had an 8-fold increase in the prevalence of IBS.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“In a recent meta-analysis, Ford et al.11 reported the degree of overlap to be between 15-42%.”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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“Although IBS patients have been reported to have lower, rather than higher thresholds for somatic stimulation,11,12”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [11]
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Cites
2 retracted
Psychological interventions for non-ulcer dyspepsia
Soo, S., Moayyedi, P., Deeks, J. J., Delaney, B. C., Lewis, M., & Forman, D. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002301.pub5 · Cited by 74
Self-citationRetractedPsychological interventions for non-ulcer dyspepsia
Soo, S., Moayyedi, P., Deeks, J. J., Delaney, B. C., Lewis, M., & Forman, D. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002301.pub4 · Cited by 40
Self-citationRetractedMeasuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Functional Gastroduodenal Disorders
Tack, J., Talley, N. J., Camilleri, M., Holtmann, G., Hu, P., Malagelada, J.-R., & Stanghellini, V. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.059 · Cited by 2,418
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404
Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002
Research works printed but not linked: 1
- Drossman, 1990, Identification of sub-groups of functional gastrointestinal disorders, Gastroenterology Intl, 3, 159
Cited by
Sorted by citations
Irritable bowel syndrome: a clinical review.
Chey, W., Kurlander, J. E., & Eswaran, S. (2015) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2015.0954 · Cited by 748
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,102
ACG and CAG Clinical Guideline: Management of Dyspepsia
Moayyedi, P., Lacy, B. E., Andrews, C. N., Enns, R., Howden, C. W., & Vakil, N. B. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.154 · Cited by 704
Self-citationFunctional gastrointestinal disorders: advances in understanding and management
Black, C. J., Drossman, D. A., Talley, N. J., Ruddy, J., & Ford, A. C. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32115-2 · Cited by 605
Self-citationBritish Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Vasant, D. H., Paine, P. A., Black, C. J., Houghton, L. A., Everitt, H. A., Corsetti, M., Agrawal, A., Aziz, I., Farmer, A. D., Eugenicos, M. P., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324598 · Cited by 592
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Metadata
- Authors
- Ford, A. C., Marwaha, A., Lim, A., & Moayyedi, P.
- Affiliations
- McMaster University (CA)
- Corresponding author
- Ford, Alexander C.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 8
- Issue
- 5
- Pages
- 401-409
- ISSN
- 1542-3565 (ISSN-L)
- OpenAlex
- W1968773048
- Cited by
- 195
- References
- 62
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 18 · 2021: 12 · 2020: 18 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 9 · 2015: 14 · 2014: 15 · 2013: 9 · 2012: 16
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, dyspepsia, prevalence, comorbidities, diagnostic criteria, pathophysiological mechanisms, screening
- MeSH terms
- Dyspepsia, Humans, Comorbidity, Prevalence, Irritable Bowel Syndrome
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