Incidence and Prevalence of Crohn’s Disease and Ulcerative Colitis in Olmsted County, Minnesota From 1970 Through 2010
Open accessAbstract
Background & aims The incidence and prevalence of inflammatory bowel diseases (IBD) continue to increase worldwide. We sought to update incidence rates of Crohn's disease (CD) and ulcerative colitis (UC) in a well-defined United States population, calculating values for Olmsted County, Minnesota through 2010. We also calculated prevalence values.Methods The resources of the Rochester Epidemiology Project were used to identify county residents who were diagnosed with IBD (CD or UC), based on previously set criteria. Those with new diagnoses of CD or UC between 1970 and 2010 were identified as incidence cases, and those meeting diagnostic criteria on January 1, 2011, were identified as prevalence cases. Incidence rates were estimated (adjusted for age and sex to the US white population in 2010). Trends in incidence based on age at diagnosis, sex, and year of diagnosis were evaluated by Poisson regression.Results The incidence cohort included 410 patients with CD (51% female) and 483 individuals with UC (56% male). Median age of diagnosis was 29.5 years for persons with CD (range, 4-93 years) and 34.9 years for UC (range, 1-91 years). From 2000 through 2010, the adjusted annual incidence rate for CD was 10.7 cases per 100,000 person-years (95% confidence interval [CI], 9.1-12.3 person-years) and for UC was 12.2 per 100,000 (95% CI, 10.5-14.0 person-years). On January 1, 2011, there were 380 residents with CD, with an adjusted prevalence of 246.7 cases per 100,000 persons (95% CI, 221.7-271.8 cases per 100,000 persons), and 435 residents with UC, with an adjusted prevalence of 286.3 (95% CI, 259.1-313.5 cases per 100,000 persons). Male sex was significantly associated with a higher incidence rate of UC, and younger age was significantly associated with a higher incidence rate of CD.Conclusions Estimated incidence rates for UC and CD in Olmsted County are among the highest in the United States. Extrapolating the adjusted prevalence to the most recent US Census, there could be approximately 1.6 million persons in the United States with IBD.
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In Olmsted County, MN, USA, ulcerative colitis incidence rose from 0.6 per 100,000 in 1940-43 to 12.2 per 100,000 in 2000-2010.
“Similarly, a longitudinal cohort study of ulcerative colitis in Olmsted County, MN, USA, showed a rise in incidence from 0.6 per 100,000 (1940–43), to 4.0 per 100,000 (1944–53), 6.4 per 100,000 (1954–63), 9.3 per 100,000 (1964–1973), 10.2 per 100,000 (1980–89 and 1990–99) and to 12.2 per 100,000 (2000–2010)28,32.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [28]
In 2008, IBD prevalence was 0.51% in Canada and 0.57% in Scotland, close to the 0.53% reported for Olmsted County in 2011.
“In 2008, the calculated prevalence of IBD in Canada and Scotland was 0.51%70 and 0.57%69, respectively, which was similar to the 0.53% reported in Olmsted County in 2011 (ref.28).”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [28]
Olmsted County IBD prevalence was 533 per 100,000 in 2011, nearly doubling again over the 20 years after 1991.
“In 2011, the prevalence of IBD was 533 per 100,000 in Olmsted County, and therefore almost doubled again in the 20 years from 1991 (ref.28).”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [28]
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- Authors
- Shivashankar, R., Tremaine, W. J., Harmsen, W. S., & Loftus, E. V.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Loftus, Edward V.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 15
- Issue
- 6
- Pages
- 857-863
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC5429988
- OpenAlex
- W2556960393
- Cited by
- 455
- References
- 28
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 50 · 2023: 57 · 2022: 69 · 2021: 60 · 2020: 64 · 2019: 54 · 2018: 27 · 2017: 22 · 2016: 4
- FWCI
- 28.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Gastroenterology and Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000135)
- National Institute on Aging (R01AG034676)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Keywords
- Crohn's disease, ulcerative colitis, inflammatory bowel disease, incidence, prevalence, Olmsted County, Minnesota, Rochester Epidemiology Project, age at diagnosis, sex differences, temporal trends
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Colitis, Ulcerative, Crohn Disease, Female, Humans, Infant, Male, Middle Aged, Minnesota, Cohort Studies, Incidence, Prevalence, Young Adult
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