Ulcerative colitis in Olmsted County, Minnesota, 1940–1993: incidence, prevalence, and survival
Open accessAbstract
BACKGROUND: There is significant geographic variation in the reported incidence of ulcerative colitis. AIMS: To update the incidence and prevalence of ulcerative colitis in Olmsted County, Minnesota, examine temporal trends, and determine overall survival. PATIENTS: All Olmsted County residents diagnosed with ulcerative colitis between 1940 and 1993 (incidence cases), and all residents with ulcerative colitis alive on 1 January 1991 (prevalence cases). METHODS: Incidence and prevalence rates were adjusted using 1990 US census figures for whites. The effects of age, sex, and calendar year on incidence rates were evaluated using Poisson regression. Survival from diagnosis was compared with that expected for US north-central whites. RESULTS: Between 1940 and 1993, 278 incidence cases were identified, for an adjusted incidence rate of 7.6 cases per 100 000 person years (95% confidence interval (CI), 6.7 to 8.5). On 1 January 1991, there were 218 residents with definite or probable ulcerative colitis, for an adjusted prevalence rate of 229 cases per 100 000 (95% CI, 198 to 260). Increased incidence rates were associated with later calendar years (p<0.002), younger age (p<0.0001), urban residence (p<0.0001), and male sex (p<0.003). Overall survival was similar to that expected (p>0.2). CONCLUSIONS: The overall incidence rate of ulcerative colitis in Olmsted County increased until the 1970s, and remained stable thereafter. Incidence rates among men and urban residents were significantly higher. The prevalence rate in Rochester in 1991 was 19% higher than that in 1980. Overall survival was similar to that of the general population.
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In Olmsted County, MN, USA, ulcerative colitis incidence rose from 0.6 per 100,000 in 1940-43 to 12.2 per 100,000 in 2000-2010.
“Similarly, a longitudinal cohort study of ulcerative colitis in Olmsted County, MN, USA, showed a rise in incidence from 0.6 per 100,000 (1940–43), to 4.0 per 100,000 (1944–53), 6.4 per 100,000 (1954–63), 9.3 per 100,000 (1964–1973), 10.2 per 100,000 (1980–89 and 1990–99) and to 12.2 per 100,000 (2000–2010)28,32.”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [32]
In Olmsted County, the IBD Prevalence Doubling Period was about 25 years, rising from 145 per 100,000 in 1965 to 362 per 100,000 in 1991.
“for example, in Olmsted County, MN, USA, the Prevalence Doubling Period was approximately 25 years from 145 per 100,000 in 1965 to 362 per 100,000 in 1991 (refs32,67,68).”
From The four epidemiological stages in the global evolution of inflammatory bowel disease (2021) · cites this paper as [32]
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- Authors
- Loftus, E. V., Silverstein, M. D., Sandborn, W. J., Tremaine, W. J., Harmsen, W. S., & Zinsmeister, A. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Loftus, E V
- ORCID
- Loftus, E V
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2000-03-01
- Volume
- 46
- Issue
- 3
- Pages
- 336-343
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727835
- OpenAlex
- W2053395478
- Cited by
- 492
- References
- 42
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 22 · 2020: 17 · 2019: 17 · 2018: 20 · 2017: 19 · 2016: 21 · 2015: 18 · 2014: 21 · 2013: 31 · 2012: 27
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- American Gastroenterological Association
- National Institutes of Health
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR030582, AR30582)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- ulcerative colitis, incidence, prevalence, survival, temporal trends, regional variation, Olmsted County, Minnesota, Rochester, Minnesota, urban residence, sex differences, age differences, inflammatory bowel disease
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Colitis, Ulcerative, Female, Humans, Male, Middle Aged, Minnesota, Cohort Studies, Incidence, Prevalence, Survival Rate, Age Distribution, Sex Distribution
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