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Statin Use and Risk of Cirrhosis and Related Complications in Patients With Chronic Liver Diseases: A Systematic Review and Meta-analysis
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“A meta‐analysis and retrospective cohort study has also shown a survival benefit of statin therapy in patients with ACLD [94, 95].”
From Current treatment of non‐alcoholic fatty liver disease (2022) · cites this paper as [94]
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Statin use and non-alcoholic steatohepatitis in at risk individuals
Dongiovanni, P., Petta, S., Mannisto, V., Mancina, R. M., Pipitone, R., Karja, V., Maggioni, M., Kakela, P., Wiklund, O., Mozzi, E., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.05.006 · Cited by 390
Mabuchi, H., Haba, T., Tatami, R., Miyamoto, S., Sakai, Y., Wakasugi, T., Watanabe, A., Koizumi, J., & Takeda, R. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108273050902 · Cited by 262
Research works printed but not linked: 53
- Xu, 2016, Deaths: final data for 2013, National Vital Statistics Reports, 64, 1
- Grundy, 1988, HMG-CoA reductase inhibitors for treatment of hypercholesterolemia, N Engl J Med, 319, 24, 10.1056/NEJM198807073190105 · DOI
- Endo, 1976, Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity, FEBS Lett, 72, 323, 10.1016/0014-5793(76)80996-9 · DOI
- Tsujita, 1979, Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, Atherosclerosis, 32, 307, 10.1016/0021-9150(79)90174-6 · DOI
- Shigematsu, 1979, Treatment of hypercholesterolemia with a HMG CoA reductase inhibitor (CS-500). I. Phase I study in normal subjects, Geriatr Med, 17, 1564
- Yamamoto, 1980, Therapeutic effects of ML-236B in primary hypercholesterolemia, Atherosclerosis, 35, 259, 10.1016/0021-9150(80)90124-0 · DOI
- Tobert, 1982, Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, in healthy volunteers, J Clin Invest, 69, 913, 10.1172/JCI110530 · DOI
- 1986, Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia: a multicenter study, JAMA, 256, 2829, 10.1001/jama.1986.03380200067023 · DOI
- Havel, 1987, Lovastatin (mevinolin) in the treatment of heterozygous familial hypercholesterolemia: a multicenter study, Ann Intern Med, 107, 609, 10.7326/0003-4819-107-5-609 · DOI
- Musial, 2001, Anti-inflammatory effects of simvastatin in subjects with hypercholesterolemia, Int J Cardiol, 77, 247, 10.1016/S0167-5273(00)00439-3 · DOI
- Ridker, 2001, Rapid reduction in C-reactive protein with cerivastatin among 785 patients with primary hypercholesterolemia, Circulation, 103, 1191, 10.1161/01.CIR.103.9.1191 · DOI
- Albert, 2001, The pravastatin inflammation CRP evaluation (PRINCE): rationale and design, Am Heart J, 141, 893, 10.1067/mhj.2001.115297 · DOI
- Lefer, 2002, Statins as potent antiinflammatory drugs, Circulation, 106, 2041, 10.1161/01.CIR.0000033635.42612.88 · DOI
- McGirt, 2002, Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage, Stroke, 33, 2950, 10.1161/01.STR.0000038986.68044.39 · DOI
- Kalinowski, 2002, Increased nitric oxide bioavailability in endothelial cells contributes to the pleiotropic effect of cerivastatin, Circulation, 105, 933, 10.1161/hc0802.104283 · DOI
- Laufs, 1998, Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors, Circulation, 97, 1129, 10.1161/01.CIR.97.12.1129 · DOI
- Laufs, 1997, Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase, J Biol Chem, 272, 31725, 10.1074/jbc.272.50.31725 · DOI
- Hernandez-Perera, 1998, Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells, J Clin Invest, 101, 2711, 10.1172/JCI1500 · DOI
- Llevadot, 2001, HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells, J Clin Invest, 108, 399, 10.1172/JCI200113131 · DOI
- Anderson, 1995, The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion, N Engl J Med, 332, 488, 10.1056/NEJM199502233320802 · DOI
- Treasure, 1995, Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease, N Engl J Med, 332, 481, 10.1056/NEJM199502233320801 · DOI
- O'Driscoll, 1997, Simvastatin, an HMG-coenzyme A reductase inhibitor, improves endothelial function within 1 month, Circulation, 95, 1126, 10.1161/01.CIR.95.5.1126 · DOI
- Zafra, 2004, Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis, Gastroenterology, 126, 749, 10.1053/j.gastro.2003.12.007 · DOI
- Abraldes, 2007, Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl4 cirrhotic rats, J Hepatol, 46, 1040, 10.1016/j.jhep.2007.01.020 · DOI
- Moreno, 2009, Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver, Am J Physiol Gastrointest Liver Physiol, 296, G147, 10.1152/ajpgi.00462.2007 · DOI
- Trebicka, 2010, Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells, J Hepatol, 53, 702, 10.1016/j.jhep.2010.04.025 · DOI
- Mura, 2013, Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction, Hepatology, 57, 1172, 10.1002/hep.26127 · DOI
- Marrone, 2015, KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins, Gut, 64, 1434, 10.1136/gutjnl-2014-308338 · DOI · Paper page
- Singh, 2013, Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis, Gastroenterology, 144, 323, 10.1053/j.gastro.2012.10.005 · DOI
- Tsan, 2012, Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection, Value Health, 15, A602, 10.1016/j.jval.2012.08.008 · DOI
- El-Serag, 2009, Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes, Gastroenterology, 136, 1601, 10.1053/j.gastro.2009.01.053 · DOI · Paper page
- Abraldes, 2009, Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial, Gastroenterology, 136, 1651, 10.1053/j.gastro.2009.01.043 · DOI
- Abraldes, 2016, Addition of simvastatin to standard therapy for the prevention of variceal rebleeding does not reduce rebleeding but increases survival in patients with cirrhosis, Gastroenterology, 150, 1160, 10.1053/j.gastro.2016.01.004 · DOI · Paper page
- Huang, 2016, Statins reduce the risk of cirrhosis and its decompensation in chronic hepatitis B patients: a nationwide cohort study, Am J Gastroenterol, 111, 976, 10.1038/ajg.2016.179 · DOI
- Kumar, 2014, Statin use in patients with cirrhosis: a retrospective cohort study, Dig Dis Sci, 59, 1958, 10.1007/s10620-014-3179-2 · DOI
- Mohanty, 2016, Statins are associated with a decreased risk of decompensation and death in veterans with hepatitis C-related compensated cirrhosis, Gastroenterology, 150, 430, 10.1053/j.gastro.2015.10.007 · DOI
- Pollo-Flores, 2015, Three months of simvastatin therapy vs. placebo for severe portal hypertension in cirrhosis: a randomized controlled trial, Dig Liver Dis, 47, 957, 10.1016/j.dld.2015.07.156 · DOI
- Simon, 2016, Atorvastatin and fluvastatin are associated with dose-dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: results from ERCHIVES, Hepatology, 64, 47, 10.1002/hep.28506 · DOI
- Simon, 2015, Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C, J Hepatol, 62, 18, 10.1016/j.jhep.2014.08.013 · DOI
- Yang, 2015, Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection, J Hepatol, 63, 1111, 10.1016/j.jhep.2015.07.006 · DOI
- Hsiang, 2015, Statin and the risk of hepatocellular carcinoma and death in a hospital-based hepatitis B-infected population: a propensity score landmark analysis, J Hepatol, 63, 1190, 10.1016/j.jhep.2015.07.009 · DOI
- Oliver, 2016, Statin drugs decrease progression to cirrhosis in HIV/hepatitis C virus coinfected individuals, AIDS, 30, 2469, 10.1097/QAD.0000000000001219 · DOI
- Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, PLoS Med, 6, e1000100, 10.1371/journal.pmed.1000100 · DOI · Paper page
- DerSimonian, 1986, Meta-analysis in clinical trials, Control Clin Trials, 7, 177, 10.1016/0197-2456(86)90046-2 · DOI · Paper page
- Higgins, 2003, Measuring inconsistency in meta-analyses, BMJ, 327, 557, 10.1136/bmj.327.7414.557 · DOI · Paper page
- Guyatt, 2013, Making an overall rating of confidence in effect estimates for a single outcome and for all outcomes, J Clin Epidemiol, 66, 151, 10.1016/j.jclinepi.2012.01.006 · DOI · Paper page
- Chang, 2017, Statins decrease the risk of decompensation in HBV- and HCV-related cirrhosis: a population-based study, Hepatology
- Bang, 2016, The impact of statins on mortality in patients with compensated or decompensated alcoholic cirrhosis in a nationwide retrospective study, Hepatology, 54, 131A
- Butt, 2015, Effect of addition of statins to antiviral therapy in hepatitis C virus-infected persons: results from ERCHIVES, Hepatology, 62, 365, 10.1002/hep.27835 · DOI
- Gupta, 1998, Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats, Hepatology, 28, 926, 10.1002/hep.510280405 · DOI
- Rockey, 1998, Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: endothelial dysfunction in portal hypertension, Gastroenterology, 114, 344, 10.1016/S0016-5085(98)70487-1 · DOI
- Shah, 1999, Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat, Gastroenterology, 117, 1222, 10.1016/S0016-5085(99)70408-7 · DOI
- Targownik, 2015, Understanding and avoiding immortal-time bias in gastrointestinal observational research, Am J Gastroenterol, 110, 1647, 10.1038/ajg.2015.210 · DOI
Cited by
Sorted by citations
Kanwal, F., Shubrook, J. H., Adams, L. A., Pfotenhauer, K., Wai-Sun Wong, V., Wright, E., Abdelmalek, M. F., Harrison, S. A., Loomba, R., Mantzoros, C. S., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.07.049 · Cited by 618
Self-citationMach, F., Ray, K. K., Wiklund, O., Corsini, A., Catapano, A. L., Bruckert, E., De Backer, G., Hegele, R. A., Hovingh, G. K., Jacobson, T. A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy182 · Cited by 370
Current treatment of non‐alcoholic fatty liver disease
Paternostro, R., & Trauner, M. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13531 · Cited by 305
Statin use is associated with improved outcomes of patients with primary sclerosing cholangitis
Stokkeland, K., Höijer, J., Bottai, M., Söderberg-Löfdal, K., & Bergquist, A. (2019) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2018.11.002 · Cited by 63
Vascular targets for the treatment of portal hypertension
Brusilovskaya, K., Königshofer, P., Schwabl, P., & Reiberger, T. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1693115 · Cited by 28
Metadata
- Authors
- Kim, R. G., Loomba, R., Prokop, L. J., & Singh, S.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2017-10
- Volume
- 15
- Issue
- 10
- Pages
- 1521-1530.e8
- ISSN
- 1542-3565
- PMC
- PMC5605397
- Cited by
- 174
- References
- 2
- Language
- en
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