The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Open accessAbstract
We screened small molecules to identify two compounds, which we named RSL3 and RSL5, that have increased lethality in the presence of oncogenic RAS. Counter screening with biologically active compounds defined aspects of the mechanism of action for RSL3 and RSL5, such as a nonapoptotic, MEK-dependent, and iron-dependent oxidative cell death. Erastin, a previously reported compound with RAS-selective lethality, showed similar properties. RNA interference experiments targeting voltage-dependent anion channel 3 (VDAC3), a target of erastin, demonstrated that RSL5 is a scaffold that acts through VDACs to activate the observed pathway. RSL3 activated a similar death mechanism but in a VDAC-independent manner. We found that cells transformed with oncogenic RAS have increased iron content relative to their normal cell counterparts through upregulation of transferrin receptor 1 and downregulation of ferritin heavy chain 1 and ferritin light chain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Under normal circumstances, glutathione peroxidase (GPX) neutralizes lipid peroxide to lipid alcohols, but the depletion of intracellular glutathione (GSH, GPX substrate) reduces GPX functionality (Yang and Stockwell, 2008; Friedmann Angeli et al., 2014).”
From Toxic Concentrations of Glutamate Induce Ferroptosis without Affecting Mitochondrial Respiration in Rodent Brain Slice Cultures (2026) · cites this paper as Yang and Stockwell, 2008
Experimental — accuracy not yet measuredIn the citing paper
“the ferroptosis-inhibiting effect of iron depletion by either chelators [539, 543, 548] or phosphorylase kinase catalytic subunit gamma 2 (PHKG2) knockdown [566]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [543]
In the citing paper
“The mode of cell death induced by these compounds was surprisingly found to be non-apoptotic, as cells treated with erastin and RSL3 died in the absence of apoptotic hallmarks [11, 12, 13], and in cells where the core apoptosis machinery – caspases, BAX, and BAK was suppressed [14].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“The first ferroptosis-inducing compounds, erastin [11] and RSL3 [12], were discovered using high-throughout screening of small molecule libraries [11, 12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Cell death induced by RSL3 shares common features with erastin-mediated ferroptosis, such as iron, MEK, and ROS dependencies [12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Moreover, iron chelators were identified as inhibitors of cell death induction, after RSL3 treatment, revealing the requirement of cellular iron [12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Cells are also desensitized to ferroptosis through genetic silencing of iron uptake (TfR1), metabolism (IRP2 and ISCU) and storage (ferritin) genes [62], [66], [82], or through depletion of transferrin in the extracellular environment [83].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“Cell death elicited by ferroptosis-inducing compounds (FINs) (e.g. erastin and RSL3) can also be mitigated through various iron chelators (Dfo, 2,2-bipyridile or compound 311) [62], [66], [81].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“Ferroptosis, a unique cell death pathway distinct from apoptosis [62], [66], [80], is reliant on the availability of iron [62], [66], [81] liberated through ferritinophagy [63].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“two structurally different inducers of ferroptosis that affect distinct pathways [66].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T., Luo, B., Grenier, J. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.040 · Cited by 1,804
Self-citationDiscovery and development of sorafenib: a multikinase inhibitor for treating cancer
Wilhelm, S., Carter, C. A., Lynch, M., Lowinger, T., Dumas, J., Smith, R., Schwartz, B., Simantov, R., & Kelley, S. (2006) · Nature reviews. Drug discovery · doi:10.1038/nrd2130 · Cited by 1,651
RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631
Self-citationDolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446
Self-citationEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B. L., THOMAS, G. V., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., & Sawyers, C. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171076798 · Cited by 971
Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A. P., Scudiero, D. A., Rubinstein, L., Plowman, J., & Boyd, M. R. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.14.1088 · Cited by 970
Flagged first, then by citations
2 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 901–1,000 of 1,002
Turning the Spotlight on Lipids in Non-Apoptotic Cell Death
Parisi, L. R., Morrow, L. M., Visser, M. B., & Atilla‐Gokcumen, G. E. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.7b01082 · Cited by 25
Sorafenib sensitizes melanoma cells to vemurafenib through ferroptosis
Tang, F., Li, S., Liu, D., Chen, J., & Han, C. (2020) · Translational Cancer Research · doi:10.21037/tcr.2020.01.62 · Cited by 25
Opportunities for Ferroptosis in Cancer Therapy
Fujihara, K. M., Zhang, B. Z., & Clemons, N. J. (2021) · Antioxidants · doi:10.3390/antiox10060986 · Cited by 27
A narrative review of mechanisms of ferroptosis in cancer: new challenges and opportunities
Jiang, M., Hu, R., Yu, R., Tang, Y., & Li, J. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-4863 · Cited by 26
Insight into the Double-Edged Role of Ferroptosis in Disease
Zhang, L., Jia, R., Li, H., Yu, H., Ren, K., Jia, S., Li, Y., & Wang, Q. (2021) · Biomolecules · doi:10.3390/biom11121790 · Cited by 26
The key roles of organelles and ferroptosis in Alzheimerʼs disease
Long, H., Cheng, Y., Zhou, Z., Luo, H., Wen, D., & Gao, L. (2022) · Journal of Neuroscience Research · doi:10.1002/jnr.25033 · Cited by 28
Acid-Responsive Micelles Releasing Cinnamaldehyde Enhance RSL3-Induced Ferroptosis in Tumor Cells
Yan, Z., Wu, S., Zhou, Y., & Li, F. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00236 · Cited by 26
The Role of Ferroptosis in Nervous System Disorders
Du, L., Wu, Y., Fan, Z., Li, Y., Guo, X., Fang, Z., & Zhang, X. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2201019 · Cited by 26
Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells
He, J., Abikoye, A. M., McLaughlin, B. P., Middleton, R. S., Sheldon, R. D., Jones, R. G., & Schafer, Z. T. (2023) · iScience · doi:10.1016/j.isci.2023.106827 · Cited by 25
Chen, G., Luo, S., Guo, H., Lin, J., & Xu, S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02863-1 · Cited by 26
Molecular Mechanisms of Ferroptosis and Its Role in Viral Pathogenesis
Huang, R.-W., Wu, J., Ma, Y., & Kang, K. (2023) · Viruses · doi:10.3390/v15122373 · Cited by 26
Son, Y., Lee, H. J., Ryu, D., Kim, J.-R., & Kim, H. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03732-3 · Cited by 25
Mechanism of metal ion-induced cell death in gastrointestinal cancer
Luan, M., Feng, Z., Zhu, W., Xing, Y., Ma, X., Zhu, J., Wang, Y., & Jia, Y. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116574 · Cited by 24
Arnér, E. S. J., & Schmidt, E. E. (2024) · Advances in cancer research · doi:10.1016/bs.acr.2024.04.001 · Cited by 25
Neuronal autosis is Na+/K+-ATPase alpha 3-dependent and involved in hypoxic-ischemic neuronal death
Depierre, P., Ginet, V., Truttmann, A. C., & Puyal, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06750-2 · Cited by 27
Broadening horizons: the multifaceted role of ferroptosis in breast cancer
Ge, A., Wang, X., Li, Y., Da, Z., Chen, J., Daga, P., Dai, C. C., Yang, K., Yan, Y., Hao, M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1455741 · Cited by 30
Iron and ferroptosis in kidney disease: molecular and metabolic mechanisms
Wang, W., Chen, J., Zhan, L., Zou, H., Wang, L., Guo, M., Gao, H., Xu, J., & Wu, W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1531577 · Cited by 28
Ferroptosis: a potential therapeutic target in cardio-cerebrovascular diseases
Jiang, C., Yang, Y., Long, T., Xu, J., Chang, C., Kang, M., Wang, X., Chen, Y., & Qiu, J. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05262-7 · Cited by 26
SMARCA4: Promises and challenges in the treatment of cancers
Ye, W., An, D., & Ou, W. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217811 · Cited by 25
Huang, Q., Zhang, H., Chen, S., Wang, Y., & Zhou, J. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1593963 · Cited by 28
Xu, L., Zhang, W., Sánchez-Tejeda, J. F., Holovan, D., McCain, J., Lovell, T. C., & Cosa, G. (2025) · Nature Chemistry · doi:10.1038/s41557-025-01966-x · Cited by 25
Geng, D., & Wu, H. (2022) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo-22-341 · Cited by 24
Zhan, S., Yung, M. M. H., Siu, M. K. Y., Jiao, P., Ngan, H., Chan, D. W., & Chan, K. K. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315263 · Cited by 28
Park, J. S., Kim, D.-H., Choi, H., Kim, C. S., Bae, E. H., Kwon, S., & Kim, S. W. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05601-w · Cited by 25
Lai, J., Miao, S., & Ran, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-29305-5 · Cited by 25
What is the impact of ferroptosis on diabetic cardiomyopathy: a systematic review
Lou, X., Zhang, Y., Guo, J., Gao, L., Ding, Y., Zhuo, X., Lei, Q., Bian, J., Lei, R., Gong, W., et al. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10336-z · Cited by 25
Adverse effects of ferroptotic therapy: mechanisms and management
Liu, J., Kang, R., & Tang, D. (2024) · Trends in cancer · doi:10.1016/j.trecan.2024.01.002 · Cited by 25
Important molecular mechanisms in ferroptosis
Lai, L., Tan, M., Hu, M., Yue, X., Tao, L., Zhai, Y., & Li, Y. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05009-w · Cited by 24
Saha, S., Skeie, J. M., Schmidt, G. A., Eggleston, T., Shevalye, H., Sáles, C. S., Phruttiwanichakun, P., Dusane, A., Field, M. G., Rinkoski, T. A., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103348 · Cited by 24
Miller, M. R., Landis, H. E., Miller, R. E., & Tizabi, Y. (2024) · Cells · doi:10.3390/cells13181554 · Cited by 26
León-Oliva, D. D., Boaru, D. L., Minaya‐Bravo, A., Castro-Martinez, P. D., Fraile‐Μartinez, O., Montero, C. G., Cobo-Prieto, D., Barrena-Blázquez, S., López-González, L., Albillos, A., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39684 · Cited by 24
Duan, C., Li, B., Liu, H., Zhang, Y., Yao, X., Liu, K., Wu, X., Mao, X., Wu, H., Xu, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202408945 · Cited by 26
The interplay between cell death and senescence in cancer
Shimizu, K., Inuzuka, H., & Tokunaga, F. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.11.001 · Cited by 28
Endocytosis is essential for cysteine-deprivation-induced ferroptosis
Liu, X., Zhao, Z., Bian, Z., Benthani, F. A., Hu, Y., Liang, D., & Jiang, X. (2025) · Molecular Cell · doi:10.1016/j.molcel.2025.08.006 · Cited by 24
No Time to Die: How Kidney Cancer Evades Cell Death
Ganini, C., Montanaro, M., Scimeca, M., Palmieri, G., Anemona, L., Concetti, L., Melino, G., Bove, P., Amelio, I., Candi, E., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116198 · Cited by 24
Backer, J. D., Maric, D., Zuhra, K., Bogaerts, A., Szabó, C., Berghe, W. V., & Hoogewijs, D. (2022) · Antioxidants · doi:10.3390/antiox11081548 · Cited by 24
Realgar‑induced KRAS mutation lung cancer cell death via KRAS/Raf/MAPK mediates ferroptosis
Liu, X., Hai, Y., Dong, J., Xu, L., Hou, W., Su, J., Ren, W., & Liu, D. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5447 · Cited by 26
Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target
Groenewoud, A., Yin, J., Gelmi, M. C., Alsafadi, S., Némati, F., Decaudin, D., Roman‐Roman, S., Kalirai, H., Coupland, S. E., Jochemsen, A. G., et al. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01446-6 · Cited by 27
The multidrug resistance transporter P-glycoprotein confers resistance to ferroptosis inducers
Frye, W. J. E., Huff, L. M., Dalmasy, J. M. G., Salazar, P. B., Carter, R. M., Gensler, R. T., Esposito, D., Robey, R. W., Ambudkar, S. V., & Gottesman, M. M. (2023) · Cancer Drug Resistance · doi:10.20517/cdr.2023.29 · Cited by 23
Role of carbonic anhydrases in ferroptosis-resistance
Li, Z., Jiang, L., & Toyokuni, S. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108440 · Cited by 24
Rodríguez, L. R., Lapeña-Luzón, T., Calap-Quintana, P., Moltó, M. D., González‐Cabo, P., & Navarro, J. A. (2020) · Antioxidants · doi:10.3390/antiox9080664 · Cited by 24
Mechanisms and therapeutic targets of ferroptosis: Implications for nanomedicine design
Zhang, M., Guo, M., Gao, Y., Wu, C., Pan, X., & Huang, Z. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.03.001 · Cited by 26
Guo, C., Peng, J., Cheng, P., Yang, C., Gong, S., Zhang, L., Zhang, T., & Peng, J. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1290234 · Cited by 25
Ferroptosis: a potential target for acute lung injury
Wen, Y., Liu, Y., Liu, W., Liu, W., Dong, J., Liu, Q., Yu, Z., Ren, H., & Hao, H. (2024) · Inflammation Research · doi:10.1007/s00011-024-01919-z · Cited by 26
He, Z., Zheng, D., Li, F., Chen, L., Wu, C., Zeng, Z., & Yu, C. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101171 · Cited by 23
Small molecule probes for cellular death machines
Li, Y., Qian, L., & Yuan, J. (2017) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2017.05.007 · Cited by 23
Ferroptosis Holds Novel Promise in Treatment of Cancer Mediated by Non-coding RNAs
Zhi, Y., Gao, L., Wang, B., Ren, W., Liang, K. X., & Zhi, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.686906 · Cited by 26
Li, H., Deng, N.-H., Xiao, J., & Xiu-sheng, H. (2021) · Oncology Letters · doi:10.3892/ol.2021.13031 · Cited by 25
Ferroptosis: A Specific Vulnerability of RAS-Driven Cancers?
Andreani, C., Bartolacci, C., & Scaglioni, P. P. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.923915 · Cited by 26
Autophagy-dependent ferroptosis in kidney disease
Yang, Y., Cheng, J., Lin, Q., & Ni, Z. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1071864 · Cited by 24
Ferroptosis Detection: From Approaches to Applications
Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie · doi:10.1002/ange.202300379 · Cited by 25
The mechanisms crosstalk and therapeutic opportunities between ferroptosis and ovary diseases
Yao, Y., Wang, B., Jiang, Y., Guo, H. W., & Li, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1194089 · Cited by 25
Xu, Z., Wang, Y., Yang, W., Han, W., Ma, B., Zhao, Y., Bao, T., Zhang, Q., & Lin, X. T. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118582 · Cited by 25
Self-citationHaß, C., Belz, K., Schoeneberger, H., & Fulda, S. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.01.004 · Cited by 23
Panzilius, E., Holstein, F., Dehairs, J., Planque, M., von Toerne, C., Koenig, A.-C., Doll, S. G., Bannier-Hélaouët, M., Ganz, H. M., Hauck, S. M., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/417949 · Cited by 24
The important role of ferroptosis in inflammatory bowel disease
Xie, H., Cao, C., Shu, D., Liu, T., & Zhang, T. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1449037 · Cited by 23
Ferroptosis and bone health: bridging the gap between mechanisms and therapy
Xiao, R., Han, Z., Peng, J., Li, P., Gong, M., Cai, Y., Pang, L., Ye, X., & Jin, S. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1634516 · Cited by 24
Navigating Transition Metal‐Dependent Cell Death: Mechanisms, Crosstalk, and Future Directions
Song, Q., Yang, Y., & Yang, L. (2025) · Advanced Science · doi:10.1002/advs.202501974 · Cited by 24
Li, X., Fang, M., Liu, X., Jiang, J., Wang, S., Mao, X., Zou, Z., & Jin, W. L. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02780-7 · Cited by 23
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches
Wang, J., Guo, D., Jiang, S., Wu, W., & Gao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00416-5 · Cited by 27
Aguirre, C., Morale, M. C., Peng, Q., Sánchez-Alavez, M., Cintrón-Colón, R., Feng, K., Fazelpour, S., Maher, P. A., & Conti, B. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.04.007 · Cited by 21
Ferroptosis Biology and Implication in Cancers
Qu, C., Peng, Y., & Liu, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.892957 · Cited by 22
Crosstalk between ferroptosis and stress—Implications in cancer therapeutic responses
Zhang, C., Yu, J., Yang, C., Shang, S., Lv, X., Cui, B., & Hua, F. (2022) · Cancer Innovation · doi:10.1002/cai2.7 · Cited by 25
Li, D., Wang, T., Lai, J., Zeng, D., Chen, W., Zhang, X., Zhu, X., Zhang, G., & Hu, Z. (2022) · Cytotechnology · doi:10.1007/s10616-022-00545-z · Cited by 22
Molecular mechanism of ferroptosis and its role in the occurrence and treatment of diabetes
Du, G.-H., Zhang, Q., Huang, X., & Wang, Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1018829 · Cited by 22
Ferroptosis Inducers in Thyroid Cancer
Sekhar, K. R., Cyr, S., & Baregamian, N. (2022) · World Journal of Surgery · doi:10.1007/s00268-022-06738-z · Cited by 22
Die hard: cell death mechanisms and their implications in nanotoxicology
Lomphithak, T., & Fadeel, B. (2023) · Toxicological Sciences · doi:10.1093/toxsci/kfad008 · Cited by 24
Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?
Hajj, S. E., Canabady‐Rochelle, L., & Gaucher, C. (2023) · Molecules · doi:10.3390/molecules28062636 · Cited by 24
Ferroptosis in Haematological Malignancies and Associated Therapeutic Nanotechnologies
Mynott, R. L., Habib, A., Best, G., & Wallington-Beddoe, C. T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087661 · Cited by 23
Lomphithak, T., Helvacioglu, S., Armenia, I., Keshavan, S., Ovejero, J. G., Baldi, G., Ravagli, C., Grazú, V., & Fadeel, B. (2023) · Nanomaterials · doi:10.3390/nano13111719 · Cited by 23
Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy
Wang, W., Ma, F., Cheung, Y. T., Zeng, G., Zhou, Y., Chen, Z., Liang, L., Luo, T., & Tong, R. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00659 · Cited by 23
Zhu, F., Ding, S., Liu, Y., Wang, X., & Wu, Z. (2024) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2023.102387 · Cited by 22
Deciphering the link: ferroptosis and its role in glioma
Wang, H., Liu, Y., Che, S., Li, X., Tang, D., Lv, S., & Hai, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1346585 · Cited by 24
Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential
Lin, C., & Chi, J. (2020) · Oncotarget · doi:10.18632/oncotarget.27749 · Cited by 24
IP3R-Mediated Calcium Release Promotes Ferroptotic Death in SH-SY5Y Neuroblastoma Cells
Campos, J., Gleitze, S., Hidalgo, C., & Núñez, M. T. (2024) · Antioxidants · doi:10.3390/antiox13020196 · Cited by 19
Ioning out glioblastoma: ferroptosis mechanisms and therapeutic frontiers
Sun, H., Zhang, J., Qi, H., Jiang, D., Hu, C., Mao, C., Liu, W., Qi, H., & Zong, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02711-6 · Cited by 23
Wang, W., Ma, P., Gao, W., Lu, P., Ding, X., Chen, J., Yuan, H., & Lu, L. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2210733 · Cited by 22
Hepcidin regulates neuronal ferroptosis: A mechanism for postoperative cognitive dysfunction
Shen, H., Zhai, L., & Wang, G. (2022) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23190 · Cited by 21
Lai, H.-T., Naumova, N., Marchais, A., Gaspar, N., Geoerger, B., & Brenner, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.948097 · Cited by 23
More than a duologue: In-depth insights into epitranscriptomics and ferroptosis
Cheung, J. C. T., Deng, G., Wong, N., Dong, Y., & Ng, S. S. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.982606 · Cited by 23
Zhang, W., Li, X., Xu, J., Wang, Y., Xing, Z., Hu, S., Fan, Q., Lu, S., Cheng, J., Gu, J., et al. (2022) · Cancers · doi:10.3390/cancers14215233 · Cited by 21
New perspectives on ferroptosis and its role in hepatocellular carcinoma
Cong, T., Luo, Y., Fu, Y. H. H., Liu, Y., Li, Y., & Li, X. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002327 · Cited by 21
Wang, G., Wang, J., Zhu, Z., Xu, X.-N., Shi, F., & Fu, X.-L. (2023) · Science Progress · doi:10.1177/00368504221147173 · Cited by 22
Hu, Y., Wang, Y., Liu, S., & Wang, H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12062125 · Cited by 21
Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells
Hou, M., Wang, P., & Zhu, B. T. (2023) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2023058 · Cited by 20
Zhou, X., Kang, J., Zhang, L., & Yue, C. (2023) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-023-04549-0 · Cited by 22
Ferroptosis, a subtle talk between immune system and cancer cells: To be or not to be?
Zhou, Q., Tao, C., Yuan, J., Pan, F., & Wang, R. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115251 · Cited by 21
Molecular Mechanisms of Ferroptosis and Their Involvement in Acute Kidney Injury
Liu, J., Han, X., Zhou, J., & Leng, Y. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s427505 · Cited by 20
Ruan, D., Wen, J., Fang, F., Lei, Y., Zhao, Z., & Miao, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01721-6 · Cited by 21
Zhang, L., Xu, J., Yin, S., Wang, Q., Jia, Z., & Wen, T. (2024) · Inflammation · doi:10.1007/s10753-024-01978-8 · Cited by 21
Faraji, P., Kühn, H., & Ahmadian, S. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02224-4 · Cited by 25
Wang, H., Stephens, B. J., Hoff, D. D. V., & Han, H. (2009) · Pancreas · doi:10.1097/mpa.0b013e31819d7415 · Cited by 21
Emanuele, S., Oddo, E., D’Anneo, A., Notaro, A., Calvaruso, G., Lauricella, M., & Giuliano, M. (2018) · RENDICONTI LINCEI · doi:10.1007/s12210-018-0704-9 · Cited by 21
NSC ‐34 motor neuron‐like cells are sensitized to ferroptosis upon differentiation
Martinez, A. M., Mirkovic, J., Stanisz, Z., Patwari, F. S., & Yang, W. S. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12577 · Cited by 22
Self-citationThe Effect of Chinese Traditional Medicine Huaiqihuang (HQH) on the Protection of Nephropathy
Zhang, X., Cheng, Y., Zhou, Q., Huang, H., Dong, Y., Yang, Y., Zhao, M., & He, Q. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2153912 · Cited by 21
Georgieva, A. P., Ilieva, Y. E., Kokanova-Nedialkova, Z. K., Zaharieva, M. M., Nedialkov, P. T., Dobreva, A. M., Kroumov, A. D., Najdenski, H. M., & Mileva, M. M. (2021) · Antioxidants · doi:10.3390/antiox10101615 · Cited by 22
Tian, P., Xu, Z., Guo, J., Zhao, J., Wang, R., Chen, W., Yang, Y., Huang, W., Mi, C., & Zhang, H. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.113028 · Cited by 21
Nie, J., Zhang, H., Li, X., Qin, J., Zhou, J., Lu, Y., Yang, N., Li, Y., Li, H., & Li, C. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38800 · Cited by 20
Yuan, J., Liu, C., Jiang, C., Liu, N., Yang, Z., & Hua, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-85774-w · Cited by 21
Current understanding of ferroptosis in the progression and treatment of pancreatic cancer
Dong, S., Li, X., Jiang, W., Chen, Z., & Zhou, W. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02166-6 · Cited by 21
Metadata
- Authors
- Yang, W. S., & Stockwell, B. R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Stockwell, Brent R.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 15
- Issue
- 3
- Pages
- 234-245
- ISSN
- 1074-5521 (ISSN-L)
- PMC
- PMC2683762
- OpenAlex
- W2114138419
- Cited by
- 1,876
- References
- 35
- Citations by year
- 2026: 138 · 2025: 231 · 2024: 319 · 2023: 312 · 2022: 271 · 2021: 202 · 2020: 135 · 2019: 66 · 2018: 58 · 2017: 38 · 2016: 35 · 2015: 19 · 2014: 11 · 2013: 7 · 2012: 10
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA097061)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- synthetic lethality, oncogenic Ras, RSL3, erastin, non-apoptotic cell death, iron-dependent cell death, oxidative cell death, VDAC3, voltage-dependent anion channel, transferrin receptor 1, ferritin, iron metabolism, small molecule screening, cancer cell death
- MeSH terms
- Drug Evaluation, Preclinical, Humans, Iron, Mutation, Neoplasms, Piperazines, Substrate Specificity, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Cell Death, Apoptosis, Cell Line, Tumor, Voltage-Dependent Anion Channels, Small Molecule Libraries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
