The DOI matches its Crossref record; 33 of the 35 references it cites were found in a registry or an index.
Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells.
Open accessAbstract
We screened small molecules to identify two compounds, which we named RSL3 and RSL5, that have increased lethality in the presence of oncogenic RAS. Counter screening with biologically active compounds defined aspects of the mechanism of action for RSL3 and RSL5, such as a nonapoptotic, MEK-dependent, and iron-dependent oxidative cell death. Erastin, a previously reported compound with RAS-selective lethality, showed similar properties. RNA interference experiments targeting voltage-dependent anion channel 3 (VDAC3), a target of erastin, demonstrated that RSL5 is a scaffold that acts through VDACs to activate the observed pathway. RSL3 activated a similar death mechanism but in a VDAC-independent manner. We found that cells transformed with oncogenic RAS have increased iron content relative to their normal cell counterparts through upregulation of transferrin receptor 1 and downregulation of ferritin heavy chain 1 and ferritin light chain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Under normal circumstances, glutathione peroxidase (GPX) neutralizes lipid peroxide to lipid alcohols, but the depletion of intracellular glutathione (GSH, GPX substrate) reduces GPX functionality (Yang and Stockwell, 2008; Friedmann Angeli et al., 2014).”
From Toxic Concentrations of Glutamate Induce Ferroptosis without Affecting Mitochondrial Respiration in Rodent Brain Slice Cultures (2026) · cites this paper as Yang and Stockwell, 2008
Experimental — accuracy not yet measuredIn the citing paper
“the ferroptosis-inhibiting effect of iron depletion by either chelators [539, 543, 548] or phosphorylase kinase catalytic subunit gamma 2 (PHKG2) knockdown [566]”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [543]
In the citing paper
“The mode of cell death induced by these compounds was surprisingly found to be non-apoptotic, as cells treated with erastin and RSL3 died in the absence of apoptotic hallmarks [11, 12, 13], and in cells where the core apoptosis machinery – caspases, BAX, and BAK was suppressed [14].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“The first ferroptosis-inducing compounds, erastin [11] and RSL3 [12], were discovered using high-throughout screening of small molecule libraries [11, 12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Cell death induced by RSL3 shares common features with erastin-mediated ferroptosis, such as iron, MEK, and ROS dependencies [12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Moreover, iron chelators were identified as inhibitors of cell death induction, after RSL3 treatment, revealing the requirement of cellular iron [12].”
From Ferroptosis: Death by Lipid Peroxidation (2016) · cites this paper as [12]
In the citing paper
“Cells are also desensitized to ferroptosis through genetic silencing of iron uptake (TfR1), metabolism (IRP2 and ISCU) and storage (ferritin) genes [62], [66], [82], or through depletion of transferrin in the extracellular environment [83].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“Cell death elicited by ferroptosis-inducing compounds (FINs) (e.g. erastin and RSL3) can also be mitigated through various iron chelators (Dfo, 2,2-bipyridile or compound 311) [62], [66], [81].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“Ferroptosis, a unique cell death pathway distinct from apoptosis [62], [66], [80], is reliant on the availability of iron [62], [66], [81] liberated through ferritinophagy [63].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
In the citing paper
“two structurally different inducers of ferroptosis that affect distinct pathways [66].”
From Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis (2018) · cites this paper as [66]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
The ferritins: molecular properties, iron storage function and cellular regulation
Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667
Creation of human tumour cells with defined genetic elements
Hahn, W. C., Counter, C. M., Lundberg, A. S., Beijersbergen, R. L., Brooks, M. W., & Weinberg, R. A. (1999) · Nature · doi:10.1038/22780 · Cited by 2,345
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
Tong, A. H. Y., Evangelista, M., Parsons, A. B., Xu, H., Bader, G. D., Pagé, N., Robinson, M., Raghibizadeh, S., Hogue, C. W. V., Bussey, H., et al. (2001) · Science · doi:10.1126/science.1065810 · Cited by 2,138
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
Moffat, J., Grueneberg, D. A., Yang, X., Kim, S. Y., Kloepfer, A. M., Hinkle, G., Piqani, B., Eisenhaure, T., Luo, B., Grenier, J. K., et al. (2006) · Cell · doi:10.1016/j.cell.2006.01.040 · Cited by 1,804
Self-citationDiscovery and development of sorafenib: a multikinase inhibitor for treating cancer
Wilhelm, S., Carter, C. A., Lynch, M., Lowinger, T., Dumas, J., Smith, R., Schwartz, B., Simantov, R., & Kelley, S. (2006) · Nature reviews. Drug discovery · doi:10.1038/nrd2130 · Cited by 1,651
RAS–RAF–MEK-dependent oxidative cell death involving voltage-dependent anion channels
Yagoda, N., von Rechenberg, M., Zaganjor, E., Bauer, A. J., Yang, W. S., Fridman, D. J., Wolpaw, A. J., Smukste, I., Peltier, J. M., Boniface, J. J., et al. (2007) · Nature · doi:10.1038/nature05859 · Cited by 1,631
Self-citationDolma, S., Lessnick, S. L., Hahn, W. C., & Stockwell, B. R. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00050-3 · Cited by 1,446
Self-citationEnhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
Neshat, M. S., Mellinghoff, I. K., Tran, C., Stiles, B. L., THOMAS, G. V., Petersen, R., Frost, P., Gibbons, J. J., Wu, H., & Sawyers, C. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171076798 · Cited by 971
Paull, K. D., Shoemaker, R. H., Hodes, L., Monks, A. P., Scudiero, D. A., Rubinstein, L., Plowman, J., & Boyd, M. R. (1989) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/81.14.1088 · Cited by 970
Flagged first, then by citations
2 of the 35 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 1,002
Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells
Yang, R., Li, Y., Wang, X., Yan, J., Pan, D., Xu, Y., Wang, L., & Yang, M. (2019) · RSC Advances · doi:10.1039/c9ra04478g · Cited by 57
Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway
Oh, B. M., Lee, S., Park, G. L., Hwang, Y. S., Lim, J., Park, E. S., Lee, K. H., Kim, B. Y., Kwon, Y. T., Cho, H. J., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8122210 · Cited by 54
Liu, Y., Duan, C., Dai, R., & Zeng, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.739392 · Cited by 58
Li, J., Li, J., Pu, Y., Li, S., Gao, W., & He, B. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.0c01679 · Cited by 54
Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease
Ko, C., Gao, S.-L., Lin, T., Chu, P., & Lin, H. (2021) · Biomedicines · doi:10.3390/biomedicines9111679 · Cited by 54
Ferroptosis: A potential target for the intervention of intervertebral disc degeneration
Zhou, L.-P., Zhang, R., Jia, C.-Y., Kang, L., Zhang, Z., Zhang, H., Wang, J., Zhang, B., & Shen, C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1042060 · Cited by 55
Ferroptosis mechanism and Alzheimer's disease
Feng, L., Sun, J. J., Xia, L., Shi, Q., Hou, Y., Zhang, L., Li, M., Fan, C., & Sun, B. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.389362 · Cited by 56
Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets
Tian, X., Li, X., Pan, M., Yang, L. Z., Li, Y., & Fang, W. (2024) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01457-6 · Cited by 59
Targeting ferroptosis: a new therapeutic opportunity for kidney diseases
Long, Z., Luo, Y., Yu, M., Wang, X., Zeng, L., & Yang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435139 · Cited by 59
Wei, C. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.111065 · Cited by 58
VDAC3 and Mps1 negatively regulate ciliogenesis
Majumder, S., & Fisk, H. A. (2013) · Cell Cycle · doi:10.4161/cc.23824 · Cited by 54
Nuclear factor erythroid 2-related factor 2 as a treatment target of kidney diseases
Ito, M., Tanaka, T., & Nangaku, M. (2019) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000556 · Cited by 53
Regulation of ferroptosis by non‑coding RNAs in the development and treatment of cancer (Review)
Luo, Y., Huang, Q., He, B., Liu, Y., Huang, S., & Xiao, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7836 · Cited by 52
The interplay of autophagy and non-apoptotic cell death pathways
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.004 · Cited by 50
Ferroptosis-mediated immune responses in cancer
Qi, D., & Peng, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1188365 · Cited by 53
Targeting Ferroptosis to Treat Cardiovascular Diseases: A New Continent to Be Explored
Huang, F., Yang, R., Xiao, Z., Xie, Y., Lin, X., Zhu, P., Zhou, P., Lu, J., & Zheng, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.737971 · Cited by 54
Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis
Karaj, E., Sindi, S. H., Kuganesan, N., Perera, L., Taylor, W. R., & Tillekeratne, L. M. V. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00909 · Cited by 52
Wogonin induces ferroptosis in pancreatic cancer cells by inhibiting the Nrf2/GPX4 axis
Liu, X., Peng, X., Cen, S., Yang, C., Ma, Z., & Shi, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1129662 · Cited by 52
Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review
Liu, C., Li, Z., Li, B., Liu, W., Zhang, S., Qiu, K., & Zhu, W. (2023) · PeerJ · doi:10.7717/peerj.14952 · Cited by 53
Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells
Vermonden, P., Vancoppenolle, M., Dierge, E., Mignolet, É., Cuvelier, G., Knoops, B., Page, M. M., Debier, C., Féron, O., & Larondelle, Y. (2021) · Nutrients · doi:10.3390/nu13082751 · Cited by 56
Azuma, K., Koumura, T., Iwamoto, R., Matsuoka, M., Terauchi, R., Yasuda, S., Shiraya, T., Watanabe, S., Aihara, M., Imai, H., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101824 · Cited by 54
Iron, Oxidative Damage and Ferroptosis in Rhabdomyosarcoma
Fanzani, A., & Poli, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081718 · Cited by 50
Ou, Z., Wen, Q., Deng, Y., Yu, Y., Chen, Z., & Sun, L. (2020) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00615-x · Cited by 54
Molecular mechanisms of ferroptosis and their role in inflammation
Wang, F., He, J., Xing, R., Sha, T., & Sun, B. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.2016739 · Cited by 50
SUFU Suppresses Ferroptosis Sensitivity in Breast Cancer Cells via Hippo/YAP Pathway
Fang, K., Du, S., Shen, D., Xiong, Z., Jiang, K., Liang, D., Wang, J., Xu, H., Hu, L., Zhai, X., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104618 · Cited by 51
Kang, X., Huo, Y., Jia, S., He, F., Li, H., Zhou, Q., Chang, N., Liu, D., Li, R., Hu, Y., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.939605 · Cited by 49
Ferroptosis of Endothelial Cells in Vascular Diseases
Zhang, H., Zhou, S., Sun, M., Hua, M., Liu, Z., Mu, G., Wang, Z., Xiang, Q., & Cui, Y. (2022) · Nutrients · doi:10.3390/nu14214506 · Cited by 50
Ferroptosis: Mechanism and connections with cutaneous diseases
Liu, L., Lian, N., Shi, L., Hao, Z., & Chen, K. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1079548 · Cited by 52
Review and Chemoinformatic Analysis of Ferroptosis Modulators with a Focus on Natural Plant Products
Stepanić, V., & Kučerová-Chlupáčová, M. (2023) · Molecules · doi:10.3390/molecules28020475 · Cited by 54
LncFASA promotes cancer ferroptosis via modulating PRDX1 phase separation
Xiao, F., Liu, F., Wang, X., Wang, Y., Chen, Y., Shi, C., Su, X., Tan, M., Yan, Q., Peng, J., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2425-2 · Cited by 58
Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches
Luo, Y., Bai, X. Y., Zhang, L., Hu, Q., Zhang, N., Cheng, J., Hou, M. Z., & Liu, X. L. (2024) · Drug Design Development and Therapy · doi:10.2147/dddt.s472178 · Cited by 51
Regulated Cell Death Seen through the Lens of Islet Transplantation
Bruni, A. D. C., Bornstein, S. R., Linkermann, A., & Shapiro, A. M. J. (2018) · Cell Transplantation · doi:10.1177/0963689718766323 · Cited by 48
A Shortage of FTH Induces ROS and Sensitizes RAS-Proficient Neuroblastoma N2A Cells to Ferroptosis
Lu, R., Jiang, Y.-N., Lai, X., Liu, S., Sun, L., & Zhou, Z. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168898 · Cited by 50
Metabolic Reprogramming and Immune Evasion in Nasopharyngeal Carcinoma
Huang, H., Li, S., Tang, Q., & Zhu, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.680955 · Cited by 49
Mechanism of Ferroptosis and Its Role in Spinal Cord Injury
Li, F., Wang, H., Chen, H., Guo, J., Dang, X., Ru, Y., & Wang, H. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.926780 · Cited by 50
Gao, F., Li, J., Chen, Y., Talifu, Z., Liu, B., Guo, S., Yang, D., Yu, Y., Yang, M., & Du, L. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339491 · Cited by 49
Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity
Liu, Z., Lv, X., Yang, B. V., Qin, Q., Song, E., & Song, Y. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128413 · Cited by 45
Wei, S., Yu, Z., Shi, R., An, L., Zhang, Q., Zhang, Q., Zhang, T., Zhang, J., & Wang, H. (2022) · BMC Cancer · doi:10.1186/s12885-022-09986-3 · Cited by 48
Wu, L., Xian, X., Tan, Z., Dong, F., Xu, G., Zhang, M., & Zhang, F. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03245-7 · Cited by 51
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis
Jiang, D., Guo, Y., Wang, T., Wang, L., Yan, Y., Xia, L., Bam, R., Yang, Z., Lee, H., Iwawaki, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48330-0 · Cited by 52
Cao, J., Zhou, T., Wu, T., Lin, R., Huang, J. W., Shi, D., Yu, J., Ren, Y., Qian, C., He, L., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07354-0 · Cited by 53
Ferrous Iron-Dependent Pharmacology
Gonciarz, R. L., Collisson, E. A., & Renslo, A. R. (2020) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2020.11.003 · Cited by 47
Liu, L., Wang, M., Gong, N., Tian, P., & Deng, H. (2021) · Animal Cells and Systems · doi:10.1080/19768354.2021.1988704 · Cited by 46
Targeting ferroptosis in osteosarcoma
Zhao, J., Zhao, Y., Ma, X., Zhang, B., & Feng, H. (2021) · Journal of bone oncology · doi:10.1016/j.jbo.2021.100380 · Cited by 48
Galangin inhibited ferroptosis through activation of the PI3K / AKT pathway in vitro and in vivo
Chen, K., Xue, R., Geng, Y., & Zhang, S. (2022) · The FASEB Journal · doi:10.1096/fj.202200935r · Cited by 46
Ferroptosis in gastrointestinal cancer: from mechanisms to implications
Zhang, R., Kang, R., & Tang, D. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216147 · Cited by 46
Exploiting metabolic cell death for cancer therapy
Mao, C., Jiang, D., Koong, A. C., & Gan, B. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00879-8 · Cited by 70
Ferroptosis in Friedreich’s Ataxia: A Metal-Induced Neurodegenerative Disease
Rosa, P. L., Petrillo, S., Fiorenza, M. T., Bertini, E., & Piemonte, F. (2020) · Biomolecules · doi:10.3390/biom10111551 · Cited by 49
Application of natural products for inducing ferroptosis in tumor cells
Wu, Z., Zhong, M., Liu, Y., Xiong, Y., Gao, Z., Ma, J., Zhuang, G., & Hong, X. (2021) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.2096 · Cited by 46
Combination RSL3 Treatment Sensitizes Ferroptosis- and EGFR-Inhibition-Resistant HNSCCs to Cetuximab
Liu, S., Yan, S., Zhu, J., Lu, R., Kang, C., Tang, K. L., Zeng, J., Ding, M., Guo, Z., Lai, X., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169014 · Cited by 46
Ferroptosis: mechanisms and advances in ocular diseases
Liu, K., Li, H., Wang, F., & Su, Y. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04644-5 · Cited by 47
ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer
Ji, J., Ma, S., Zhu, Y., Zhao, J., Tong, Y., You, Q., & Jiang, Z. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01909 · Cited by 45
Yang, K., Zeng, L., Zeng, J., Deng, Y., Wang, S., Xu, H., He, Q., Yuan, M., Luo, Y., Ge, A., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102063 · Cited by 46
Padhi, D., Baruah, P., Ramesh, M., Moorthy, H., & Govindaraju, T. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103119 · Cited by 45
Zheng, Z., Zhang, S., Liu, X., Wang, X., Cheng, X., Wu, X., Zhang, X., Xu, X., Liu, Z., Yao, L., et al. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31250 · Cited by 48
Stearic acid metabolism in human health and disease
Shen, X., Miao, S., Zhang, Y., Guo, X., Li, W., Mao, X., & Zhang, Q. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.012 · Cited by 54
The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction
Komai, K., Kawasaki, N. K., Higa, J. K., & Matsui, T. (2022) · Cells · doi:10.3390/cells11091399 · Cited by 48
Ferroptosis and Its Emerging Role in Pre-Eclampsia
Chen, Z., Gan, J., Zhang, M., Du, Y., & Zhao, H. (2022) · Antioxidants · doi:10.3390/antiox11071282 · Cited by 46
Molecular Mechanism of Ferroptosis in Orthopedic Diseases
Gao, L., Hua, W., Tian, L., Zhou, X., Wang, D., Yang, Y., & Ni, G. (2022) · Cells · doi:10.3390/cells11192979 · Cited by 44
Role of ferroptosis in pregnancy related diseases and its therapeutic potential
Xu, J., Zhou, F., Wang, X., & Mo, C. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1083838 · Cited by 45
Ferroptosis in non-alcoholic liver disease: Molecular mechanisms and therapeutic implications
Cheng, Z., Chu, H., Zhu, Q., & Yang, L. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1090338 · Cited by 45
Huang, M., Wang, Z., Yao, L., Zhang, L., Gou, X., Mo, H., Li, H., Hu, L., & Zhou, X. (2023) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2023.106794 · Cited by 44
Jin, Y., Qiu, J., Lu, X., Ma, Y., & Li, G. (2023) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.32604/or.2023.027815 · Cited by 46
Impact of ferroptosis on preeclampsia: A review
Shan, Y., Guan, C., Wang, J., Qi, W., Chen, A., & Liu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115466 · Cited by 47
Targeting ferroptosis in melanoma: cancer therapeutics
Khorsandi, K., Esfahani, H., Keyvani‐Ghamsari, S., & lakhshehei, P. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01296-w · Cited by 48
Broadening horizons: ferroptosis as a new target for traumatic brain injury
Wei, Z., Yu, H., Zhao, H., Wei, M., Xing, H., Pei, J., Yang, Y., & Ren, K. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad051 · Cited by 53
Understanding the unique mechanism of ferroptosis: a promising therapeutic target
Kong, Y., Li, J., Lin, R., Lu, S., Rong, L., Yao, X. X., & Fang, Y. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1329147 · Cited by 49
Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis
Hussain, M. S., Gupta, G., Shahwan, M. J., Bansal, P., Kaur, H., Deorari, M., Pant, K., Ali, H., Singh, S. K., Allam, V. S. R. R., et al. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.05.007 · Cited by 44
Ferroptosis in cancer therapeutics: a materials chemistry perspective
Guan, Q., Zhou, L., & Dong, Y. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01654g · Cited by 44
Aerobic pyruvate metabolism sensitizes cells to ferroptosis primed by GSH depletion
Vučković, A., Venerando, R., Tibaldi, E. V., Bosello-Travain, V., Roveri, A., Bordin, L., Miotto, G., Cozza, G., Toppo, S., Maiorino, M., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.045 · Cited by 44
Wang, F., Li, W., Shen, L., Jiang, T., Xia, J., You, D., Hu, S., Wang, L., & Wu, X. R. (2022) · Neurotoxicity Research · doi:10.1007/s12640-022-00500-y · Cited by 43
Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE
Li, W., Luo, L., Zhou, Q., Gong, H., Fu, Y., Yan, C., Li, E., Sun, J. Y., Luo, Z., Ding, Z., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102421 · Cited by 44
Non-lethal outcomes of engaging regulated cell death pathways in cancer
Kalkavan, H., Rühl, S., Shaw, J. J. P., & Green, D. R. (2023) · Nature Cancer · doi:10.1038/s43018-023-00571-6 · Cited by 48
Shen, Y., Zhang, G., Wei, C., Zhao, P., Wang, Y., Li, M., & Sun, L. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01343 · Cited by 44
Schoeneberger, H., Belz, K., Schenk, B., & Fulda, S. (2014) · Oncogene · doi:10.1038/onc.2014.338 · Cited by 42
Iron-Bound Lipocalin-2 Protects Renal Cell Carcinoma from Ferroptosis
Meier, J. K., Schnetz, M., Beck, S., Schmid, T., Dominguez, M., Kalinovic, S., Daiber, A., Brüne, B., & Jung, M. (2021) · Metabolites · doi:10.3390/metabo11050329 · Cited by 45
Ferroptosis, novel therapeutics in asthma
Lv, X., Dong, M., Tang, W., Qin, J., Wang, W., Li, M., Teng, F., Yi, L., Dong, J., & Wei, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113516 · Cited by 43
Nrf2 Is a Potential Modulator for Orchestrating Iron Homeostasis and Redox Balance in Cancer Cells
Zhang, L., Zhang, J., Jin, Y., Yao, G., Zhao, H., Qiao, P., & Wu, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728172 · Cited by 45
Wang, X., Chen, Y., Xiang, Y., Cheng, L., He, Z., Xin, Y., Huang, S., Meng, F., Zhang, P., & Luo, L. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05462-9 · Cited by 46
Emerging role of miRNAs in the regulation of ferroptosis
Lamouki, R. M., Kadkhoda, S., Hussen, B. M., & Ghafouri‐Fard, S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1115996 · Cited by 44
Ferroptosis: a potential therapeutic target for stroke
Liu, C., Wang, G., Han, W., Tian, Q., & Li, M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385284 · Cited by 44
Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways
Alrouji, M., Anwar, S., Venkatesan, K., Shahwan, M. J., Hassan, M. I., Islam, A., & Shamsi, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102575 · Cited by 45
Translating ferroptosis into oncology: challenges, opportunities and future directions
Kang, R., Liu, J., Wang, J., Kroemer, G., & Tang, D. (2026) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-026-01128-z · Cited by 55
Tonnus, W., Gembardt, F., Latk, M., Parmentier, S. P., Hugo, C., Bornstein, S. R., & Linkermann, A. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0193-5 · Cited by 44
Ferroptosis in Low-Grade Glioma: A New Marker for Diagnosis and Prognosis
Liu, Y., Xu, Z., Jin, T., Xu, K., Liu, M., & Xu, H. (2020) · Medical Science Monitor · doi:10.12659/msm.921947 · Cited by 42
Ferroptosis: a new unexpected chance to treat metastatic melanoma?
Gagliardi, M., Saverio, V., Monzani, R., Ferrari, E., Piacentini, M., & Corazzari, M. (2020) · Cell Cycle · doi:10.1080/15384101.2020.1806426 · Cited by 44
Clemente, L. P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J., Culmsee, C., & von Karstedt, S. (2020) · Cells · doi:10.3390/cells9102259 · Cited by 41
An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
Turchi, R., Faraonio, R., Lettieri‐Barbato, D., & Aquilano, K. (2020) · Biomolecules · doi:10.3390/biom10111489 · Cited by 42
The Regulatory Effects and the Signaling Pathways of Natural Bioactive Compounds on Ferroptosis
Zhang, S., Hu, R., Geng, Y., Chen, K., Wang, L., & Imam, M. U. (2021) · Foods · doi:10.3390/foods10122952 · Cited by 42
Radiotherapy-induced ferroptosis for cancer treatment
Beretta, G. L., & Zaffaroni, N. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1216733 · Cited by 43
Can Polyphenols Inhibit Ferroptosis?
Lesjak, M. M., Simin, N. Đ., & Srai, S. K. (2022) · Antioxidants · doi:10.3390/antiox11010150 · Cited by 44
Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis
Chen, H., Tang, H.-H., Hsu, W., Wu, S., Cheng, W., Wang, B.-Y., & Su, C. (2022) · Antioxidants · doi:10.3390/antiox11020298 · Cited by 41
Ferroptosis in Neurological Disease
David, S., Ryan, F., Jhelum, P., & Kroner, A. (2022) · The Neuroscientist · doi:10.1177/10738584221100183 · Cited by 43
The emerging roles of ferroptosis in organ fibrosis and its potential therapeutic effect
Huang, X., Song, Y., Wei, L., Guo, J., Xu, W., & Li, M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109812 · Cited by 42
Cheff, D. M., Cheng, Q., Guo, H., Travers, J., Klumpp-Thomas, C. A., Shen, M., Arnér, E. S. J., & Hall, M. D. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102719 · Cited by 40
How do different lipid peroxidation mechanisms contribute to ferroptosis?
Do, Q., & Xu, L. (2023) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2023.101683 · Cited by 45
Programmed cell death in tumor immunity: mechanistic insights and clinical implications
Wang, M., Yu, F., Zhang, Y., & Li, P. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1309635 · Cited by 43
A review on ferroptosis and photodynamic therapy synergism: Enhancing anticancer treatment
Chang, Q., Wang, P., Zeng, Q., & Wang, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28942 · Cited by 41
Li, J., Fu, C., Feng, B., Liu, Q., Gu, J. J., Khan, M. N., Sun, L., Wu, H., & Wu, H. (2024) · Advanced Science · doi:10.1002/advs.202400527 · Cited by 41
SLC7A11: the Achilles heel of tumor?
Jiang, Y., & Sun, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1438807 · Cited by 41
Metadata
- Authors
- Yang, W. S., & Stockwell, B. R.
- Affiliations
- Columbia University (US)
- Corresponding author
- Stockwell, Brent R.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 15
- Issue
- 3
- Pages
- 234-245
- ISSN
- 1074-5521 (ISSN-L)
- PMC
- PMC2683762
- OpenAlex
- W2114138419
- Cited by
- 1,876
- References
- 35
- Citations by year
- 2026: 138 · 2025: 231 · 2024: 319 · 2023: 312 · 2022: 271 · 2021: 202 · 2020: 135 · 2019: 66 · 2018: 58 · 2017: 38 · 2016: 35 · 2015: 19 · 2014: 11 · 2013: 7 · 2012: 10
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA097061)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- synthetic lethality, oncogenic Ras, RSL3, erastin, non-apoptotic cell death, iron-dependent cell death, oxidative cell death, VDAC3, voltage-dependent anion channel, transferrin receptor 1, ferritin, iron metabolism, small molecule screening, cancer cell death
- MeSH terms
- Drug Evaluation, Preclinical, Humans, Iron, Mutation, Neoplasms, Piperazines, Substrate Specificity, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins p21(ras), Cell Death, Apoptosis, Cell Line, Tumor, Voltage-Dependent Anion Channels, Small Molecule Libraries
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
