The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
Open accessAbstract
Summary The majority of bacterial species do not grow on synthetic media. Many non-growers require growth factors from other bacteria, but the nature of these compounds is largely unknown. We show here that previously uncultured isolates from marine sediment biofilm grow on a Petri dish in the presence of cultured organisms from the same environment. The growth factors produced by one cultured helper strain were identified as new acyl-desferrioxamine siderophores. A panel of previously uncultured isolates exhibited a range of siderophore promiscuity for growth promotion. This siderophore-based approach has enabled the culturing of organisms only distantly related to previously cultured microbes. The lack of growth in the lab for many strains from this habitat stems from an inability to autonomously produce siderophores, and the resulting chemical dependence on other microorganisms regulates community establishment in the environment.
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Cites
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Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Natural products as sources of new drugs over the last 25 years
Newman, D. J., & Cragg, G. M. (2007) · Journal of Natural Products · doi:10.1021/np068054v · Cited by 5,517
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052
Self-citationShah, I. M., Laaberki, M.-H., Popham, D. L., & Dworkin, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.039 · Cited by 489
Microbial siderophore-mediated transport.
Winkelmann, G. (2002) · Biochemical Society Transactions · doi:10.1042/bst0300691 · Cited by 301 · cited 1×
“Siderophore synthesis is typically upregulated when available iron is low (Winkelmann, 2002), but some uncultured bacteria do not seem to follow this strategy.”
Background
Cited by
Platforms for antibiotic discovery
Lewis, K. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3975 · Cited by 1,445
Self-citationGABA-modulating bacteria of the human gut microbiota
Strandwitz, P., Kim, K. H., Terekhova, D., Liu, J. K., Sharma, A., Levering, J., McDonald, D., Dietrich, D., Ramadhar, T. R., Lekbua, A., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0307-3 · Cited by 1,170
Self-citationThe Black Queen Hypothesis: Evolution of Dependencies through Adaptive Gene Loss
Morris, J. J., Lenski, R. E., & Zinser, E. R. (2012) · mBio · doi:10.1128/mbio.00036-12 · Cited by 1,208
Stewart, E. J. (2012) · Journal of Bacteriology · doi:10.1128/jb.00345-12 · Cited by 1,161
Self-citationBacterial siderophores in community and host interactions
Kramer, J., Özkaya, Ö., & Kümmerli, R. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0284-4 · Cited by 998
Metadata
- Authors
- D'Onofrio, A., Crawford, J. M., Stewart, E. J., Witt, K., Gavrish, E., Epstein, S., Clardy, J., & Lewis, K.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 17
- Issue
- 3
- Pages
- 254-264
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2163645872
- Cited by
- 453
- References
- 6
- FWCI
- 23.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- D'Onofrio, A., Crawford, J. M., Stewart, E. J., Witt, K., Gavrish, E., Epstein, S., Clardy, J., & Lewis, K. (2010). Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2010.02.010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
