Bacterial siderophores in community and host interactions

Kramer, Jos; Özkaya, Özhan; Kümmerli, Rolf

doi:10.1038/s41579-019-0284-4

Cited by 1,000Bacterial Genetics and BiotechnologyBacterial biofilms and quorum sensingMicrobial Community Ecology and Physiology

Bacterial siderophores in community and host interactions

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Kramer, Jos, Özkaya, Özhan, Kümmerli, Rolf·2020·Nature Reviews Microbiology

DOI 10.1038/s41579-019-0284-4PMC PMC7116523

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Abstract

Iron is an essential trace element for most organisms. A common way for bacteria to acquire this nutrient is through the secretion of siderophores, which are secondary metabolites that scavenge iron from environmental stocks and deliver it to cells via specific receptors. While there has been tremendous interest in understanding the molecular basis of siderophore synthesis, uptake and regulation, questions about the ecological and evolutionary consequences of siderophore secretion have only recently received increasing attention. In this Review, we outline how eco-evolutionary questions can complement the mechanistic perspective and help to obtain a more integrated view of siderophores. In particular, we explain how secreted diffusible siderophores can affect other community members, leading to cooperative, exploitative and competitive interactions between individuals. These social interactions in turn can spur co-evolutionary arms races between strains and species, lead to ecological dependencies between them and potentially contribute to the formation of stable communities. In brief, this Review shows that siderophores are much more than just iron carriers: they are important mediators of interactions between members of microbial assemblies and the eukaryotic hosts they inhabit.

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Some bacteria produce siderophores, small molecules with extremely high affinity for Fe3+, to hijack iron from host glycoproteins and scavenge residual free iron.
“As an alternative to directly taking up Tf or Lf, some bacteria produce siderophores; these are small molecules with extremely high affinity for Fe3+, frequently employed as a tool to hijack iron from host glycoproteins (such as Lf, Tf and Ft), and to scavenge residual free iron from the external milieu.”
From The battle for iron in enteric infections (2020) · cites this paper as [124]
Salmonella has the capacity to pirate exogenous siderophores produced by other bacteria and fungi, such as the fungal siderophore ferrichrome.
“In addition to producing enterobactin and salmochelin, Salmonella also has the capacity to pirate exogenous siderophores produced by other bacteria and fungi, such as the fungal siderophore ferrichrome – a hydroxamate siderophore. 124”
From The battle for iron in enteric infections (2020) · cites this paper as [124]

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Ross‐Gillespie, A., Gardner, A., Buckling, A. G. J., West, S. A., & Griffin, A. S. (2009) · Evolution · doi:10.1111/j.1558-5646.2009.00723.x · Cited by 128 · see citing works
Physical limits on iron uptake mediated by siderophores or surface reductases
Völker, C., & Wolf-Gladrow, D. A. (1999) · Marine Chemistry · doi:10.1016/s0304-4203(99)00004-3 · Cited by 126 · see citing works
Metallophores and Trace Metal Biogeochemistry
Kraemer, S. M., Duckworth, O. W., Harrington, J. M., & Schenkeveld, W. D. C. (2014) · Aquatic Geochemistry · doi:10.1007/s10498-014-9246-7 · Cited by 126 · see citing works
Cell–cell contacts confine public goods diffusion inside Pseudomonas aeruginosa clonal microcolonies
Julou, T., Mora, T., Guillon, L., Croquette, V., Schalk, I. J., Bensimon, D., & Desprat, N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301428110 · Cited by 126 · see citing works
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling
Jones, C. M., Wells, R. M., Madduri, A. V. R., Renfrow, M. B., Ratledge, C., Moody, D. B., & Niederweis, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1311402111 · Cited by 125 · see citing works
Siderotyping of fluorescent Pseudomonas: molecular mass determination by mass spectrometry as a powerful pyoverdine siderotyping method
Meyer, J., Gruffaz, C., Raharinosy, V., Петровна, Б. И., Schäfer, M., & Budzikiewicz, H. (2007) · BioMetals · doi:10.1007/s10534-007-9115-6 · Cited by 121 · see citing works
The tragedy of the commons in microbial populations: insights from theoretical, comparative and experimental studies
MacLean, R. C. (2007) · Heredity · doi:10.1038/sj.hdy.6801073 · Cited by 121 · see citing works
Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy
Barber, M. F., & Elde, N. C. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.09.001 · Cited by 118 · see citing works
Molecular and regulatory properties of a public good shape the evolution of cooperation
Kümmerli, R., & Brown, S. P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011154107 · Cited by 114 · see citing works
Self-citation
Engineering Acetyl Coenzyme A Supply: Functional Expression of a Bacterial Pyruvate Dehydrogenase Complex in the Cytosol of Saccharomyces cerevisiae
Kozak, B. U., van Rossum, H. M., Luttik, M. A. H., Akeroyd, M., Benjamin, K. R., Wu, L., de Vries, S., Daran, J.-M. G., Pronk, J. T., & van Maris, A. J. A. (2014) · mBio · doi:10.1128/mbio.01696-14 · Cited by 108 · see citing works
Fitness correlates with the extent of cheating in a bacterium
Jiricny, N., Diggle, S. P., West, S. A., Evans, B. A., Ballantyne, G. A., Ross‐Gillespie, A., & Griffin, A. S. (2010) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2010.01939.x · Cited by 108 · see citing works
Nutrient limitation determines the fitness of cheaters in bacterial siderophore cooperation
Sexton, D. J., & Schuster, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00222-2 · Cited by 108 · see citing works
Microbe-mediated host defence drives the evolution of reduced pathogen virulence
Ford, S. A., Kao, D., Williams, D., & King, K. (2016) · Nature Communications · doi:10.1038/ncomms13430 · Cited by 105 · see citing works
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy
Lamb, A. L. (2015) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2015.05.001 · Cited by 103 · see citing works
Effect of Exogenous Siderophores on Iron Uptake Activity of Marine Bacteria under Iron-Limited Conditions
Guan, L. L., Kanoh, K., & Kamino, K. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.4.1710-1717.2001 · Cited by 102 · see citing works
The Alternative Role of Enterobactin as an Oxidative Stress Protector Allows Escherichia coli Colony Development
Adler, C., Corbalán, N. S., Peralta, D. R., Pomares, M. F., de Cristóbal, R. E., & Vincent, P. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084734 · Cited by 97 · see citing works
Why microbes secrete molecules to modify their environment: the case of iron-chelating siderophores
Leventhal, G. E., Ackermann, M., & Schiessl, K. T. (2019) · Journal of The Royal Society Interface · doi:10.1098/rsif.2018.0674 · Cited by 97 · see citing works
Differential Siderophore Utilization and Iron Uptake by Soil and Rhizosphere Bacteria
Jurkevitch, É., Hadar, Y., & Chen, Y. (1992) · Applied and Environmental Microbiology · doi:10.1128/aem.58.1.119-124.1992 · Cited by 90 · see citing works
Private benefits and metabolic conflicts shape the emergence of microbial interdependencies
Estrela, S., Morris, J., & Kerr, B. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13028 · Cited by 89 · see citing works
THEORY FOR THE EVOLUTION OF DIFFUSIBLE EXTERNAL GOODS
Driscoll, W. W., & Pepper, J. W. (2010) · Evolution · doi:10.1111/j.1558-5646.2010.01002.x · Cited by 88 · see citing works
Cost of cooperation rules selection for cheats in bacterial metapopulations
Dumas, Z., & Kümmerli, R. (2011) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2011.02437.x · Cited by 87 · see citing works
Self-citation
Maintenance of Microbial Cooperation Mediated by Public Goods in Single- and Multiple-Trait Scenarios
Özkaya, Ö., Xavier, K. B., Dionísio, F., & Balbontín, R. (2017) · Journal of Bacteriology · doi:10.1128/jb.00297-17 · Cited by 86 · see citing works
Self-citation
Cheating fosters species co-existence in well-mixed bacterial communities
Leinweber, A., Inglis, R. F., & Kümmerli, R. (2017) · The ISME Journal · doi:10.1038/ismej.2016.195 · Cited by 85 · see citing works
Self-citation
Iron Release from the Siderophore Pyoverdine in Pseudomonas aeruginosa Involves Three New Actors: FpvC, FpvG, and FpvH
Ganne, G., Brillet, K., Basta, B., Roche, B., Hoegy, F., Gasser, V., & Schalk, I. J. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01077 · Cited by 84 · see citing works
EXPLORING THE SOCIOBIOLOGY OF PYOVERDIN-PRODUCINGPSEUDOMONAS
Zhang, X., & Rainey, P. B. (2013) · Evolution · doi:10.1111/evo.12183 · Cited by 78 · see citing works
Membrane Affinity of the Amphiphilic Marinobactin Siderophores
Xu, G., Martinez, J. S., Groves, J. T., & Butler, A. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026768w · Cited by 77 · see citing works
Microbial Copper-binding Siderophores at the Host-Pathogen Interface
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Loss of Social Behaviours in Populations of Pseudomonas aeruginosa Infecting Lungs of Patients with Cystic Fibrosis
Jiricny, N., Molin, S., Foster, K. R., Diggle, S. P., Scanlan, P. D., Ghoul, M., Johansen, H. K., Santorelli, L. A., Popat, R., West, S. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0083124 · Cited by 72 · see citing works
An evolutionary mechanism for diversity in siderophore‐producing bacteria
Lee, W., van Baalen, M., & Jansen, V. A. A. (2011) · Ecology Letters · doi:10.1111/j.1461-0248.2011.01717.x · Cited by 72 · see citing works
Co‐evolutionary dynamics between public good producers and cheats in the bacterium Pseudomonas aeruginosa
Kümmerli, R., Santorelli, L. A., Granato, E. T., Dumas, Z., Dobay, A., Griffin, A. S., & West, S. A. (2015) · Journal of Evolutionary Biology · doi:10.1111/jeb.12751 · Cited by 69 · see citing works
Self-citation
Social evolution of toxic metal bioremediation in Pseudomonas aeruginosa
O’Brien, S., Hodgson, D. J., & Buckling, A. G. J. (2014) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2014.0858 · Cited by 68 · see citing works
Integrated Metabolomics Approach Facilitates Discovery of an Unpredicted Natural Product Suite from Streptomyces coelicolor M145
Sidebottom, A. M., Johnson, A. R., Karty, J. A., Trader, D. J., & Carlson, E. E. (2013) · ACS Chemical Biology · doi:10.1021/cb4002798 · Cited by 64 · see citing works
Conditional privatization of a public siderophore enables Pseudomonas aeruginosa to resist cheater invasion
Jin, Z., Li, J., Ni, L., Zhang, R., Xia, A., & Jin, F. (2018) · Nature Communications · doi:10.1038/s41467-018-03791-y · Cited by 64 · see citing works
Sociality in Escherichia coli: Enterochelin Is a Private Good at Low Cell Density and Can Be Shared at High Cell Density
Scholz, R. L., & Greenberg, E. P. (2015) · Journal of Bacteriology · doi:10.1128/jb.02596-14 · Cited by 63 · see citing works
Pirated Siderophores Promote Sporulation in Bacillus subtilis
Grandchamp, G. M., Caro, L., & Shank, E. A. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.03293-16 · Cited by 62 · see citing works
Cheating on Cheaters Stabilizes Cooperation in Pseudomonas aeruginosa
Özkaya, Ö., Balbontín, R., Gordo, I., & Xavier, K. B. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.093 · Cited by 61 · see citing works
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The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis
Perry, R. D., Bobrov, A. G., & Fetherston, J. D. (2015) · Metallomics · doi:10.1039/c4mt00332b · Cited by 60 · see citing works
Evolutionary dynamics of interlinked public goods traits: an experimental study of siderophore production in Pseudomonas aeruginosa
Ross‐Gillespie, A., Dumas, Z., & Kümmerli, R. (2014) · Journal of Evolutionary Biology · doi:10.1111/jeb.12559 · Cited by 60 · see citing works
Self-citation
Siderophore cooperation of the bacterium Pseudomonas fluorescens in soil
Luján, A. M., Gómez, P., & Buckling, A. G. J. (2015) · Biology Letters · doi:10.1098/rsbl.2014.0934 · Cited by 60 · see citing works
Uropathogenic enterobacteria use the yersiniabactin metallophore system to acquire nickel
Robinson, A. E., Lowe, J. E., Koh, E., & Henderson, J. P. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004483 · Cited by 59 · see citing works
Acquisition of iron by the non-siderophore-producing Pseudomonas fragi
Champomier‐Vergès, M., Stintzi, A. P., & Meyer, J. (1996) · Microbiology · doi:10.1099/13500872-142-5-1191 · Cited by 57 · see citing works
The microbial ferrous wheel: iron cycling in terrestrial, freshwater, and marine environments
Emerson, D., Roden, E., & Twining, B. S. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00383 · Cited by 57 · see citing works
An antioxidant role for catecholate siderophores in Salmonella
Achard, M. E. S., Chen, K. W., Sweet, M. J., Watts, R. E., Schroder, K., Schembri, M. A., & McEwan, A. G. (2013) · Biochemical Journal · doi:10.1042/bj20121771 · Cited by 57 · see citing works
Environmental determinants of pyoverdine production, exploitation and competition in natural Pseudomonas communities
Butaitė, E., Kramer, J., Wyder, S., & Kümmerli, R. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14355 · Cited by 55 · see citing works
Self-citation
Magnitude and Mechanism of Siderophore-Mediated Competition at Low Iron Solubility in the Pseudomonas aeruginosa Pyochelin System
Schiessl, K. T., Janssen, E. M. ‐., Kraemer, S. M., McNeill, K., & Ackermann, M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01964 · Cited by 53 · see citing works
Bacterial host interactions in cystic fibrosis
Callaghan, M., & McClean, S. (2011) · Current Opinion in Microbiology · doi:10.1016/j.mib.2011.11.001 · Cited by 52 · see citing works
Spontaneous Gac Mutants of Pseudomonas Biological Control Strains: Cheaters or Mutualists?
Driscoll, W. W., Pepper, J. W., Pierson, L. S., & Pierson, E. A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.00679-11 · Cited by 52 · see citing works
The physical boundaries of public goods cooperation between surface-attached bacterial cells
Weigert, M., & Kümmerli, R. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.0631 · Cited by 52 · see citing works
Self-citation
A novel siderophore‐independent strategy of iron uptake in the genus B urkholderia
Mathew, A., Eberl, L., & Carlier, A. L. (2013) · Molecular Microbiology · doi:10.1111/mmi.12499 · Cited by 51 · see citing works
The bacteriumPseudomonas aeruginosasenses and gradually responds to interspecific competition for iron
Leinweber, A., Weigert, M., & Kümmerli, R. (2018) · Evolution · doi:10.1111/evo.13491 · Cited by 49 · see citing works
Self-citation
Interaction effects of cell diffusion, cell density and public goods properties on the evolution of cooperation in digital microbes
Dobay, A., Bagheri, H. C., Messina, A., Kümmerli, R., & Rankin, D. J. (2014) · Journal of Evolutionary Biology · doi:10.1111/jeb.12437 · Cited by 48 · see citing works
Self-citation
Presence of a loner strain maintains cooperation and diversity in well-mixed bacterial communities
Inglis, R. F., Biernaskie, J. M., Gardner, A., & Kümmerli, R. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.2682 · Cited by 45 · see citing works
Self-citation
Privatisation rescues function following loss of cooperation
Andersen, S. B., Ghoul, M., Marvig, R. L., Lee, Z.-B., Molin, S., Johansen, H. K., & Griffin, A. S. (2018) · eLife · doi:10.7554/elife.38594 · Cited by 45 · see citing works
Low spatial structure and selection against secreted virulence factors attenuates pathogenicity in Pseudomonas aeruginosa
Granato, E. T., Ziegenhain, C., Marvig, R. L., & Kümmerli, R. (2018) · The ISME Journal · doi:10.1038/s41396-018-0231-9 · Cited by 45 · see citing works
Self-citation
Joint evolution of multiple social traits: a kin selection analysis
Brown, S. P., & Taylor, P. (2009) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2009.1480 · Cited by 43 · see citing works
Do Bacterial “Virulence Factors” Always Increase Virulence? A Meta-Analysis of Pyoverdine Production in Pseudomonas aeruginosa As a Test Case
Granato, E. T., Harrison, F., Kümmerli, R., & Ross‐Gillespie, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01952 · Cited by 43 · see citing works
Self-citation
Adaptation to public goods cheats in Pseudomonas aeruginosa
O’Brien, S., Luján, A. M., Paterson, S., Cant, M. A., & Buckling, A. G. J. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.1089 · Cited by 41 · see citing works
Phage selection for bacterial cheats leads to population decline
Vasse, M., Barceló, C. T., & Hochberg, M. (2015) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.2207 · Cited by 36 · see citing works
Cheating and resistance to cheating in natural populations of the bacteriumPseudomonas fluorescens
Bruce, J. B., Cooper, G. A., Chabas, H., West, S. A., & Griffin, A. S. (2017) · Evolution · doi:10.1111/evo.13328 · Cited by 33 · see citing works
The effect of cheats on siderophore diversity in Pseudomonas aeruginosa
Stilwell, P., Lowe, C., & Buckling, A. G. J. (2018) · Journal of Evolutionary Biology · doi:10.1111/jeb.13307 · Cited by 33 · see citing works
Anguibactin‐ versus vanchrobactin‐mediated iron uptake in Vibrio anguillarum : evolution and ecology of a fish pathogen
Lemos, M. L., Balado, M., & Osorio, C. R. (2009) · Environmental Microbiology Reports · doi:10.1111/j.1758-2229.2009.00103.x · Cited by 30 · see citing works
Interactions mediated by a public good transiently increase cooperativity in growing Pseudomonas putida metapopulations
Becker, F., Wienand, K., Lechner, M., Frey, E., & Jung, H. (2018) · Scientific Reports · doi:10.1038/s41598-018-22306-9 · Cited by 30 · see citing works
Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia
Tyrrell, J., Whelan, N., Wright, C., Sá‐Correia, I., McClean, S., Thomas, M. S., & Callaghan, M. (2015) · BioMetals · doi:10.1007/s10534-015-9840-1 · Cited by 29 · see citing works
Dynamic social behaviour in a bacterium:Pseudomonas aeruginosapartially compensates for siderophore loss to cheats
Harrison, F. (2013) · Journal of Evolutionary Biology · doi:10.1111/jeb.12126 · Cited by 29 · see citing works
Pseudomonas protegens Pf‐5 favours self‐produced siderophore over free‐loading in interspecies competition for iron
Sexton, D. J., Glover, R. C., Loper, J. E., & Schuster, M. (2017) · Environmental Microbiology · doi:10.1111/1462-2920.13836 · Cited by 28 · see citing works
Individual‐ versus group‐optimality in the production of secreted bacterial compounds
Schiessl, K. T., Ross‐Gillespie, A., Cornforth, D. M., Weigert, M., Bigosch, C., Brown, S. P., Ackermann, M., & Kümmerli, R. (2019) · Evolution · doi:10.1111/evo.13701 · Cited by 27 · see citing works
Self-citation
Antibiotic stress selects against cooperation in the pathogenic bacterium Pseudomonas aeruginosa
Vasse, M., Noble, R., Akhmetzhanov, A. R., Barceló, C. T., Gurney, J., Benateau, S., Gougat‐Barbera, C., Kaltz, O., & Hochberg, M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612522114 · Cited by 23 · see citing works
Genetic architecture constrains exploitation of siderophore cooperation in Burkholderia cenocepacia
Sathe, S., Mathew, A., Agnoli, K., Eberl, L., & Kümmerli, R. (2019) · doi:10.1101/583898 · Cited by 23 · see citing works
Self-citation
Genetic architecture constrains exploitation of siderophore cooperation in the bacterium Burkholderia cenocepacia
Sathe, S., Mathew, A., Agnoli, K., Eberl, L., & Kümmerli, R. (2019) · Evolution Letters · doi:10.1002/evl3.144 · Cited by 23 · see citing works
Self-citation
Pyoverdin cheats fail to invade bacterial populations in stationary phase
Ghoul, M., West, S. A., McCorkell, F., Lee, Z.-B., Bruce, J. B., & Griffin, A. S. (2016) · Journal of Evolutionary Biology · doi:10.1111/jeb.12904 · Cited by 18 · see citing works
Siderophore production and the evolution of investment in a public good: An adaptive dynamics approach to kin selection
Lee, W., van Baalen, M., & Jansen, V. A. A. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.09.038 · Cited by 16 · see citing works
Influence of pigment production on resistance to ultraviolet irradiation in Pseudomonas aeruginosa ATCC 10145.
Burke, R. M., Upton, M., & McLoughlin, A. J. (1990) · Cited by 12 · see citing works
Defector clustering is linked to cooperation in a pathogenic bacterium
Tekwa, E. W., Nguyen, D. M., Loreau, M., & Gonzalez, A. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.2001 · Cited by 11 · see citing works
Functional amyloids promote retention of public goods in bacteria
Bruce, J. B., West, S. A., & Griffin, A. S. (2019) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2019.0709 · Cited by 8 · see citing works

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Metals to combat antimicrobial resistance
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Rhizosphere Engineering With Plant Growth-Promoting Microorganisms for Agriculture and Ecological Sustainability
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Xiang, L., Harindintwali, J. D., Wang, F., Redmile-Gordon, M. A., Chang, S. X., Fu, Y., He, C., Muhoza, B., Brahushi, F., Bolan, N. S., et al. (2022) · Environmental Science & Technology · doi:10.1021/acs.est.2c02976 · Cited by 460 · see citing works
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Bacterial Plant Biostimulants: A Sustainable Way towards Improving Growth, Productivity, and Health of Crops
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Antibiotic Discovery and Resistance: The Chase and the Race
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Authors: Kramer, J., Özkaya, Ö., & Kümmerli, R.
Affiliations: University of Zurich (CH)
Corresponding author: Kümmerli, Rolf
ORCID: Kramer, Jos
Özkaya, Özhan
Kümmerli, Rolf
Venue: Nature Reviews Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2019-11-20
Volume: 18
Issue: 3
Pages: 152-163
ISSN: 1740-1526 (ISSN-L)
1740-1534
DOI: 10.1038/s41579-019-0284-4
PMC: PMC7116523
OpenAlex: W2990378266
Cited by: 998
References: 166
Citations by year: 2026: 168 · 2025: 199 · 2024: 170 · 2023: 169 · 2022: 115 · 2021: 132 · 2020: 45
FWCI: 10.03
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Microbiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Funders: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (182499)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Keywords: siderophores, iron acquisition, bacterial community interactions, host-bacteria interactions, eco-evolutionary dynamics, microbial cooperation, microbial competition, iron scavenging, bacterial social interactions
MeSH terms: Bacteria, Biological Evolution, Iron, Selection, Genetic, Siderophores, Microbial Interactions

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Bacterial siderophores in community and host interactions

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