The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology
Open accessAbstract
DNA-damaging agents have a long history of use in cancer chemotherapy. The full extent of their cellular mechanisms, which is essential to balance efficacy and toxicity, is often unclear. In addition, the use of many anticancer drugs is limited by dose-limiting toxicities as well as the development of drug resistance. Novel anticancer compounds are continually being developed in the hopes of addressing these limitations; however, it is essential to be able to evaluate these compounds for their mechanisms of action. This review covers the current DNA-damaging agents used in the clinic, discusses their limitations, and describes the use of chemical genomics to uncover new information about the DNA damage response network and to evaluate novel DNA-damaging compounds.
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Metadata
- Authors
- Cheung-Ong, K., Giaever, G., & Nislow, C.
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 20
- Issue
- 5
- Pages
- 648-659
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W1966834115
- Cited by
- 591
- References
- 95
- FWCI
- 11.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Cheung-Ong, K., Giaever, G., & Nislow, C. (2013). DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2013.04.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
