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Cited by 323

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections

Open access
de la Fuente-Núñez, César, Reffuveille, Fany, Mansour, Sarah C., Reckseidler-Zenteno, Shauna L., Hernández, Diego, Brackman, Gilles, Coenye, Tom, Hancock, Robert E.W.·2015·Chemistry & Biology
DOI 10.1016/j.chembiol.2015.01.002
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Abstract

SUMMARY In many infections, bacteria form surface-associated communities known as biofilms that are substantially more resistant to antibiotics than their planktonic counterparts. Based on the design features of active anti-biofilm peptides, we made a series of related 12-amino acid L-, D- and retro-inverso derivatives. Specific D-enantiomeric peptides were the most potent at inhibiting biofilm development and eradicating pre-formed biofilms of seven species of wild-type and multiply antibiotic resistant Gram-negative pathogens. Moreover, these peptides showed strong synergy with conventional antibiotics, reducing the antibiotic concentrations required for complete biofilm inhibition by up to 64-fold. As shown previously for 1018, these D-amino acid peptides targeted the intracellular stringent response signal (p)ppGpp. The most potent peptides DJK-5 and DJK-6 protected invertebrates from lethal P. aeruginosa infections, and were considerably more active than a previously described L-amino acid peptide 1018. Thus, the protease resistant peptides produced here were more effective both in vitro and in vivo.

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Metadata

Authors
de la Fuente-Núñez, C., Reffuveille, F., Mansour, S. C., Reckseidler-Zenteno, S. L., Hernández, D., Brackman, G., Coenye, T., & Hancock, R. E. W.
Venue
Chemistry & Biology
Publisher
Elsevier BV
Published
2015-02
Volume
22
Issue
2
Pages
196-205
ISSN
1074-5521 (ISSN-L)
DOI
10.1016/j.chembiol.2015.01.002
OpenAlex
W2158594038
Cited by
323
References
43
FWCI
12.35
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections. https://app.cochat.ai/papers/10.1016/j.chembiol.2015.01.002
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de la Fuente-Núñez, C., Reffuveille, F., Mansour, S. C., Reckseidler-Zenteno, S. L., Hernández, D., Brackman, G., Coenye, T., & Hancock, R. E. W. (2015). D-Enantiomeric Peptides that Eradicate Wild-Type and Multidrug-Resistant Biofilms and Protect against Lethal Pseudomonas aeruginosa Infections. Chemistry & Biology. https://doi.org/10.1016/j.chembiol.2015.01.002

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.