The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
The Emerging Role of RNA as a Therapeutic Target for Small Molecules
Open accessAbstract
Recent advances in understanding different RNAs and unique features of their biology have revealed a wealth of information. However, approaches to identify small molecules that target these newly discovered biological regulatory elements have been lacking. The application of new biochemical screening and design-based technologies, coupled with a resurgence of interest in phenotypic screening, has resulted in several compelling successes in targeting RNA. A number of recent advances suggest that achieving the longstanding goal of developing druglike, biologically active small molecules that target RNA is in fact possible. This review highlights advances and successes in approaches to targeting RNA with diverse small molecules, and the potential for these technologies to pave the way to new types of RNA-targeted therapeutics.
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BackgroundInfluentialNon-coding RNAs in human disease
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Cited by
Long Noncoding RNA in Cancer: Wiring Signaling Circuitry
Lin, C., & Yang, L. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.11.008 · Cited by 488
Phenotypic drug discovery: recent successes, lessons learned and new directions
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The emerging role of mass spectrometry-based proteomics in drug discovery
Meissner, F., Geddes-McAlister, J., Mann, M., & Bantscheff, M. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00409-3 · Cited by 341
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look
Rangan, R., Zheludev, I. N., Hagey, R. J., Pham, E. A., Wayment-Steele, H. K., Glenn, J. S., & Das, R. (2020) · RNA · doi:10.1261/rna.076141.120 · Cited by 281
RNA-Targeted Therapies and High-Throughput Screening Methods
Zhu, S., Rooney, S., & Michlewski, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082996 · Cited by 41
Metadata
- Authors
- Connelly, C. M., Moon, M. H., & Schneekloth, J. S.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 23
- Issue
- 9
- Pages
- 1077-1090
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W2508330908
- Cited by
- 316
- References
- 86
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
