The DOI matches its Crossref record; 215 of the 215 references it cites were found in a registry or an index.
Phenotypic drug discovery: recent successes, lessons learned and new directions
Open accessAbstract
Many drugs, or their antecedents, were discovered through observation of their effects on normal or disease physiology. For the past generation, this phenotypic drug discovery approach has been largely supplanted by the powerful but reductionist approach of modulating specific molecular targets of interest. Nevertheless, modern phenotypic drug discovery, which combines the original concept with modern tools and strategies, has re-emerged over the past decade to systematically pursue drug discovery based on therapeutic effects in realistic disease models. Here, we discuss recent successes with this approach, as well as consider ongoing challenges and approaches to address them. We also explore how innovation in this area may fuel the next generation of successful projects. Phenotypic drug discovery has re-emerged over the past decade as an approach to systematically pursue drug discovery based on therapeutic effects in realistic disease models. This article discusses recent successes with this approach, and considers ongoing challenges and strategies to address them.
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Repurposing drugs to treat cardiovascular disease in the era of precision medicine
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Self-citation
Metadata
- Authors
- Vincent, F., Nueda, A., Lee, J., Schenone, M., Prunotto, M., & Mercola, M.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2022-05-30
- Volume
- 21
- Issue
- 12
- Pages
- 899-914
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W4282036924
- Cited by
- 348
- References
- 215
- FWCI
- 9.60
- Type
- journal article
- Language
- en
- Open access
- green
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