Targeting Metabolism for Cancer Therapy

Luengo, Alba, Gui, Dan Y., Vander Heiden, Matthew G.·2017·Cell Chemical Biology

Cited by (929)

Items 101–200 of 929

  1. The Warburg effect as a therapeutic target for bladder cancers and intratumoral heterogeneity in associated molecular targets
    Julie E. Burns, Carolyn D. Hurst, Margaret A. Knowles, Roger M. Phillips, Simon J. Allison · 2021 · Cancer Science
  2. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
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  3. Adoptive T reg therapy with metabolic intervention via perforated microneedles ameliorates psoriasis syndrome
    Wentao Zhang, Yingxin Chen, Zhengjie Zhao, Hanqi Zheng, Shenqiang Wang, Ziyan Liao, Tao Sheng, Sheng Zhao, Wenhui Hou, Xinmin Yu et al. · 2023 · Science Advances
  4. The emerging role of targeting cancer metabolism for cancer therapy
    Pegah Farhadi, Reza Yarani, Sadat Dokaneheifard, Kamran Mansouri · 2020 · Tumor Biology
  5. Targeting Pyruvate Carboxylase by a Small Molecule Suppresses Breast Cancer Progression
    Qingxiang Lin, Yuan He, Xue Wang, Yong Zhang, Meichun Hu, Weikai Guo, Yundong He, Tao Zhang, Li Lai, Zhenliang Sun et al. · 2020 · Advanced Science
  6. PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer
    Huan Deng, Yamei Chen, Peijing Li, Qingqing Hang, Peng Zhang, Ying Jin, Ming Chen · 2022 · Cancer Pathogenesis and Therapy
  7. Metabolic flux analysis of 3D spheroids reveals significant differences in glucose metabolism from matched 2D cultures of colorectal cancer and pancreatic ductal adenocarcinoma cell lines
    Tia Tidwell, Gro Vatne Røsland, Karl Johan Tronstad, Kjetil Søreide, Hanne Røland Hagland · 2022 · Cancer & Metabolism
  8. Metabolic determinants of tumour initiation
    Julia S. Brunner, Lydia W.S. Finley · 2022 · Nature Reviews Endocrinology
  9. Targeting Metabolic Reprogramming in Acute Myeloid Leukemia
    Isabel Castro, Belém Sampaio‐Marques, Paula Ludovico · 2019 · Cells
  10. HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity
    Dimitris Karagiannis, Theodoros N Rampias · 2021 · Cancers
  11. Mass spectrometry imaging-based metabolomics to visualize the spatially resolved reprogramming of carnitine metabolism in breast cancer
    Chenglong Sun, Fukai Wang, Yang Zhang, Jinqian Yu, Xiao Wang · 2020 · Theranostics
  12. Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD–Driven Acute Myeloid Leukemia
    Stefan Bjelosevic, Emily Gruber, Andrea Newbold, Carolyn Shembrey, Jennifer R. Devlin, Simon J. Hogg, Lev M. Kats, Izabela Todorovski, Zheng Fan, Thomas C. Abrehart et al. · 2021 · Cancer Discovery
  13. A second Warburg‐like effect in cancer metabolism: The metabolic shift of glutamine‐derived nitrogen
    Manabu Kodama, Keiichi I. Nakayama · 2020 · BioEssays
  14. Inhibition of Cancer Cell Migration and Glycolysis by Terahertz Wave Modulation via Altered Chromatin Accessibility
    Lan Sun, Yangmei Li, Yun Yu, Peiliang Wang, Shengquan Zhu, Kaijie Wu, Yan Liu, Ruixing Wang, Li Min, Chao Chang · 2022 · Research
  15. Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer
    Mans Broekgaarden, Sriram R. Anbil, Anne‐Laure Bulin, Girgis Obaid, Zhiming Mai, Yan Baglo, Imran Rizvi, Tayyaba G. Hasan · 2019 · Biomaterials
  16. Breast cancer–associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells
    Valentí Gómez, Thomas R. Eykyn, Rami Mustapha, Fabian Flores‐Borja, Victoria H. Male, Paul R. Barber, Antonia Patsialou, Ryan J. Green, Fani Panagaki, Chun W. Li et al. · 2020 · Science Signaling
  17. Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer
    Alba Luengo, Keene L. Abbott, Shawn M. Davidson, Aaron M. Hosios, Brandon Faubert, Sze Ham Chan, Elizaveta Freinkman, Lauren G. Zacharias, Thomas P. Mathews, Clary B. Clish et al. · 2019 · Nature Communications
  18. Metabolic reprogramming and disease progression in cancer patients
    Laura Torresano, Cristina Nuevo‐Tapioles, Fulvio Santacatterina, Jose Manuel Cuezva · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  19. Androgen Receptor Signaling and Metabolic and Cellular Plasticity During Progression to Castration Resistant Prostate Cancer
    Takuma Uo, Cynthia C.T. Sprenger, Stephen R. Plymate · 2020 · Frontiers in Oncology
  20. Deregulated transcription factors in cancer cell metabolisms and reprogramming
    Rajni Kant, Rajesh Manne, Mohammad Anas, Vasudevarao Penugurti, Tingjin Chen, Bo‐Syong Pan, Che-Chia Hsu, Hui‐Kuan Lin · 2022 · Seminars in Cancer Biology
  21. Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma
    Maria Victoria Recouvreux, Shea F. Grenier, Yijuan Zhang, Edgar Esparza, Guillem Lambies, Cheska Marie Galapate, Swetha Maganti, Karen Duong‐Polk, Deepika Bhullar, Razia F. Naeem et al. · 2023 · Nature Cancer
  22. Uncovering Spatiotemporal Heterogeneity of High-Grade Gliomas: From Disease Biology to Therapeutic Implications
    Andrea Comba, Syed Mohd Faisal, Maria Luisa Varela, Todd Charles Hollon, Wajd N. Al‐Holou, Yoshie Umemura, Felipe Javier Núñez, Sébastien Motsch, Maria Graciela Castro, Pedro Ricardo Lowenstein · 2021 · Frontiers in Oncology
  23. Fatty Acid Synthesis in Prostate Cancer: Vulnerability or Epiphenomenon?
    Laura A. Sena, Samuel Ray Denmeade · 2021 · Cancer Research
  24. Emerging roles of nucleotide metabolism in cancer development: progress and prospect
    Jingsong Ma, Mengya Zhong, Yubo Xiong, Zhi Gao, Zhengxin Wu, Yu Liu, Xuehui Hong · 2021 · Aging
  25. Inhibition of Δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolution
    Andreas Körner, Enchen Zhou, Christoph Müller, Yassene Mohammed, Sandra Herceg, Franz Bracher, Patrick C.N. Rensen, Yanan Wang, Valbona Mirakaj, Martin A. Giera · 2019 · Proceedings of the National Academy of Sciences
  26. Trained immunity as a novel therapeutic strategy
    Vera P. Mourits, Jac CHM Wijkmans, Leo A. B. Joosten, Mihai Gheorghe Netea · 2018 · Current Opinion in Pharmacology
  27. The Role of the Microbiome in the Etiopathogenesis of Colon Cancer
    Geniver El Tekle, Natalia Andreeva, Wendy S. Garrett · 2024 · Annual Review of Physiology
  28. Targeting Altered Energy Metabolism in Colorectal Cancer: Oncogenic Reprogramming, the Central Role of the TCA Cycle and Therapeutic Opportunities
    Carina Neitzel, Philipp Demuth, Simon Wittmann, Jörg Fahrer · 2020 · Cancers
  29. The interactive role of inflammatory mediators and metabolic reprogramming in pancreatic cancer
    Yuuki Ohara, Paloma Valenzuela, S. Perwez Hussain · 2022 · Trends in cancer
  30. RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells
    Cristina Santoriello, Audrey Sporrij, Song P. Yang et al. · 2020 · Nature Cell Biology
  31. An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma
    Chenlei Wen, Ke Huang, Lu-Lu Jiang, Xiongxiong Lu, Yuting Dai, Min-Min Shi, Xiao-Mei Tang, Qingbing Wang, Xiaodan Zhang, Peng‐Hui Wang et al. · 2019 · Proceedings of the National Academy of Sciences
  32. Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth
    Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi et al. · 2022 · Journal of Experimental & Clinical Cancer Research
  33. Recent advances in cancer metabolism: a technological perspective
    Yun Pyo Kang, Nathan P. Ward, Gina M. DeNicola · 2018 · Experimental & Molecular Medicine
  34. Deregulation of SPOP in Cancer
    Hui Zhang, Xiaofeng Jin, Haojie Huang · 2022 · Cancer Research
  35. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells
    Chiara Ghezzi, Alicia Wong, Bao Ying Chen, Bernard Ribalet, Robert D. Damoiseaux, Peter M. Clark · 2019 · Nature Communications
  36. Control of cell metabolism by the epidermal growth factor receptor
    Laura A. Orofiamma, Dafne Vural, Costin N. Antonescu · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  37. Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression
    Lei Zhou, Ken HO Yu, Tin Lok Wong, Zhao Zhang, Chun Ho Chan, Jane Ho Chun Loong, Noélia Che, Hua Yu, Kel Vin Tan, Man Tong et al. · 2021 · Gut
  38. Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation
    Tashbib Khan, Mitchell A. Sullivan, Jennifer H. Gunter, Thomas Kryza, Nicholas Lyons, Yaowu He, John David Hooper · 2020 · Frontiers in Oncology
  39. The roles of metabolic profiles and intracellular signaling pathways of tumor microenvironment cells in angiogenesis of solid tumors
    Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi‐Afjadi, Razieh Forghaniesfidvajani, Nima Rezaei · 2022 · Cell Communication and Signaling
  40. Novel Strategies for Disrupting Cancer-Cell Functions with Mitochondria-Targeted Antitumor Drug–Loaded Nanoformulations
    Khaled S. Allemailem, Ahmad Almatroudi, Mohammed A. Alsahli, Aseel Aljaghwani, Asmaa M. El-Kady, Arshad Husain Rahmani, Amjad Ali Khan · 2021 · International Journal of Nanomedicine
  41. Targeting the pentose phosphate pathway increases reactive oxygen species and induces apoptosis in thyroid cancer cells
    Chien‐Liang Liu, Yi‐Chiung Hsu, Jie-Jen Lee, Ming‐Jen Chen, Chi‐Hsin Lin, Shih‐Yuan Huang, Shih‐Ping Cheng · 2019 · Molecular and Cellular Endocrinology
  42. The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth
    Xi Liu, Yun Lu, Zibo Chen, Xiuxia Liu, Weiguo Hu, Lin Zheng, Yulong Chen, Jonathan M. Kurie, Mi Shi, Lisa Maria Mustachio et al. · 2020 · Molecular Cancer Research
  43. APC loss induces Warburg effect via increased PKM2 transcription in colorectal cancer
    Pu-Hyeon Cha, Jeongha Hwang, Dong-Kyu Kwak, Eunjin Koh, Kyung‐Sup Kim, Kang‐Yell Choi · 2020 · British Journal of Cancer
  44. Cancer metabolism and intervention therapy
    Huakan Zhao, Yongsheng Li · 2021 · Molecular Biomedicine
  45. NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond
    Daria Capece, Daniela Verzella, Barbara Di Francesco, Edoardo Alesse, Guido Franzoso, Francesca Zazzeroni · 2019 · Seminars in Cell and Developmental Biology
  46. Metabolic Reprogramming as a Driver of Fibroblast Activation in PulmonaryFibrosis
    Rachel Para, Freddy Romero, Gautam George, Ross S. Summer · 2019 · The American Journal of the Medical Sciences
  47. Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
    Ramya S. Kuna, Avi Kumar, Héctor Gálvez, Karl A. Wessendorf-Rodriguez, Courtney R. Green, Grace H. McGregor, Thekla Cordes, Reuben J. Shaw, Robert U Svensson, Christian M. Metallo · 2023 · Science Advances
  48. NK Cell Metabolism and TGFβ – Implications for Immunotherapy
    Karen Slattery, Clair M. Gardiner · 2019 · Frontiers in Immunology
  49. Linking Metabolic Reprogramming, Plasticity and Tumor Progression
    Shuvalov, Oleg, Daks, Alexandra, Fedorova, Olga, Petukhov, Alexey, Barlev, Nickolai · 2021 · Cancers
  50. Exploiting metabolic vulnerabilities for personalized therapy in acute myeloid leukemia
    Lucille Stuani, Marie Sabatier, Jean‐Emmanuel Sarry · 2019 · BMC Biology
  51. Metabolism and immunity in breast cancer
    Deyu Zhang, Xiaojie Xu, Qinong Ye · 2020 · Frontiers of Medicine
  52. Endogenous toxic metabolites and implications in cancer therapy
    Namgyu Lee, Meghan E. Spears, Anne E. Carlisle, Dohoon Kim · 2020 · Oncogene
  53. LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer
    Ramona Rudalska, Jule Harbig, Marteinn Thor Snaebjornsson, Sabrina Klotz, Stefan Zwirner, Liudmyla Taranets, Florian Heinzmann, Thales Kronenberger, Michael Förster, Wei Cui et al. · 2021 · Nature Cancer
  54. A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines
    Sheree D. Martin, Sean L. McGee · 2019 · Cancer & Metabolism
  55. The bidirectional relationship between metabolism and cell cycle control
    Frances F. Diehl, Kiera M. Sapp, Matthew G. Vander Heiden · 2023 · Trends in Cell Biology
  56. A Phase I clinical trial of dose-escalated metabolic therapy combined with concomitant radiation therapy in high-grade glioma
    Keren Porper, Yael Shpatz, Л. Л. Плоткин, Ronit Goldman Pechthold, Alisa Talianski, Colin Eamon Champ, Orit Furman, Ariel Shimoni-Sebag, Zvi Symon, Uri Amit et al. · 2021 · Journal of Neuro-Oncology
  57. Pegargiminase Plus First-Line Chemotherapy in Patients With Nonepithelioid Pleural Mesothelioma
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  58. Recent advances in metabolism and toxicity of tyrosine kinase inhibitors
    Zhao, Qi, Wu, Zhanxuan E., Li, Bin, Li, Fei · 2022 · Pharmacology & Therapeutics
  59. MTAP Deficiency–Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting De Novo Purine Synthesis and Glycolysis in Pancreatic Cancer
    Qiangsheng Hu, Yi Qin, Shunrong Ji, Xiuhui Shi, Weixing Dai, Guixiong Fan, Shuo Li, Wenyan Xu, Wensheng Liu, Mengqi Liu et al. · 2021 · Cancer Research
  60. Metabolomic profiling for the identification of novel diagnostic markers and therapeutic targets in prostate cancer: an update
    Giuseppe Tiziano Lucarelli, Davide Loizzo, Matteo Ferro, Monica Rutigliano, Mihai Dorin Vartolomei, Francesco Cantiello, Carlo Buonerba, Giuseppe Di Lorenzo, Daniela Terracciano, Ottavio DE COBELLI et al. · 2019 · Expert Review of Molecular Diagnostics
  61. Pharmacological properties and mechanism insights of Moroccan anticancer medicinal plants: What are the next steps?
    Abdelhakim Bouyahya, Omar Belmehdi, Abdelaziz Benjouad, Rabii Ameziane El Hassani, Saaïd Amzazi, Nadia Dakka, Youssef Bakri · 2020 · Industrial Crops and Products
  62. Targets (Metabolic Mediators) of Therapeutic Importance in Pancreatic Ductal Adenocarcinoma
    Vikrant Rai, Swati Agrawal · 2020 · International Journal of Molecular Sciences
  63. Identification of purine biosynthesis as an NADH-sensing pathway to mediate energy stress
    Ronghui Yang, Chuanzhen Yang, Lingdi Ma, Yiliang Zhao, Zihao Guo, Jing Niu, Qiaoyun Chu, Yingmin Ma, Binghui Li · 2022 · Nature Communications
  64. Antimetabolic Effects of Polyphenols in Breast Cancer Cells: Focus on Glucose Uptake and Metabolism
    Elisa Keating, Fátima Martel · 2018 · Frontiers in Nutrition
  65. The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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  66. Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16
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  67. Phenotypic plasticity during metastatic colonization
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  68. Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
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  69. Pan-cancer analysis of the metabolic reaction network
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  74. Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
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  75. Targeted therapy of esophageal squamous cell carcinoma: the NRF2 signaling pathway as target
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  77. Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma
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  78. Metabolic Reprogramming in Cancer: Implications for Immunosuppressive Microenvironment
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  79. Targeting Cell Metabolism as Cancer Therapy
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  84. Targeted Inhibition of Purine Metabolism Is Effective in Suppressing Hepatocellular Carcinoma Progression
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  92. Genetically Encoded ATP Biosensors for Direct Monitoring of Cellular ATP Dynamics
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  93. Carrier Free O2‐Economizer for Photodynamic Therapy Against Hypoxic Tumor by Inhibiting Cell Respiration
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  95. Natural quinazolinones: From a treasure house to promising anticancer leads
    Hanbing Li, Gaohang Fu, Weihui Zhong · 2022 · European Journal of Medicinal Chemistry
  96. Targeting cancer-specific metabolic pathways for developing novel cancer therapeutics
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  97. Pharmacologically inhibiting phosphoglycerate kinase 1 for glioma with NG52
    Wenliang Wang, Zongru Jiang, Chen Hu, Cheng Chen, Zhenquan Hu, Aoli Wang, Li Wang, Jing L. Liu, Wenchao Wang, Qingsong Liu · 2020 · Acta Pharmacologica Sinica
  98. Reprogramming of mitochondrial proline metabolism promotes liver tumorigenesis
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  99. Circumventing the Crabtree effect: forcing oxidative phosphorylation (OXPHOS) via galactose medium increases sensitivity of HepG2 cells to the purine derivative kinetin riboside
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  100. Metabolic reprogramming in type 2 diabetes and the development of breast cancer
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