The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis
Open accessAbstract
Summary Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions leading to neuronal death, including programs of regulated death, are commonly viewed as an inevitable pathogenic penalty for acute neuro-injury and neurodegenerative diseases. Ferroptosis is one of these programs triggered by dyshomeostasis of three metabolic pillars—iron, thiols and polyunsaturated phospholipids. This review is focused on: i) lipid peroxidation (LPO) as the major instrument of cell demise, ii) iron as its catalytic mechanism, and iii) thiols as regulators of pro-ferroptotic signals, hydroperoxy-lipids. Given the central role of LPO, we discuss the engagement of selective and specific enzymatic pathways vs. random free radical chemical reactions in the context of the phospholipid substrates, their biosynthesis, intracellular location and related oxygenating machinery as participants in ferroptotic cascades. These concepts are discussed in lieu of emerging neuro-therapeutic approaches controlling intracellular production of pro-ferroptotic phospholipid signals and their non-cell-autonomous spreading leading to ferroptosis-associated necroinflammation.
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Cites
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
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Self-citationACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Self-citationInactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
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Self-citationThe CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
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Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
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Cited by
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Liu, J., Kang, R., & Tang, D. (2022) · The FEBS Journal · doi:10.1111/febs.16059 · Cited by 787
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio-Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 422
Ferroptosis in health and disease
Berndt, C., Alborzinia, H., Amen, V. S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C. M., Birsoy, K., Böttcher, J. P., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103211 · Cited by 334
Self-citationBayır, H., Dixon, S. J., Tyurina, Y. Y., Kellum, J. A., & Kagan, V. E. (2023) · Nature Reviews Nephrology · doi:10.1038/s41581-023-00689-x · Cited by 331
Self-citationInhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model
Pei, Z., Qin, Y., Fu, X., Yang, F., Huo, F., Liang, X., Wang, S., Cui, H., Lin, P., Zhou, G., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102509 · Cited by 269
Metadata
- Authors
- Bayır, H., Anthonymuthu, T. S., Tyurina, Y. Y., Patel, S. J., Amoscato, A. A., Lamade, A. M., Yang, Q., Vladimirov, G. K., Philpott, C. C., & Kagan, V. E.
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 27
- Issue
- 4
- Pages
- 387-408
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W3015312656
- Cited by
- 317
- References
- 40
- FWCI
- 17.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bayır, H., Anthonymuthu, T. S., Tyurina, Y. Y., Patel, S. J., Amoscato, A. A., Lamade, A. M., Yang, Q., Vladimirov, G. K., Philpott, C. C., & Kagan, V. E. (2020). Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2020.03.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
