Measurement of bisphenol A concentrations in human colostrum
Abstract
Bisphenol A (BPA), an estrogenic endocrine disrupting chemical, has been reported to affect embryos and alter their postnatal development. In the present study, we measured the concentrations of BPA in human colostrum by a competitive enzyme-linked immunosorbent assay (ELISA) with the aim of understanding the present status of BPA burden in human breast milk in Shizuoka, Japan. Human colostral samples were collected from 101 healthy mothers within three days after delivery. The BPA concentrations of colostral samples were estimated by ELISA after the acetonitrile extraction and solid phase extraction column purification. BPA in 101 samples was detected in the concentration range of 1-7 ng ml(-1). The mean concentration of BPA was 3.41+/-0.13 (mean+/-SD) ng ml(-1). This is the first demonstration as to what BPA concentrations are in human colostrum. The BPA concentrations in colostrum were higher than those in blood sera samples obtained from healthy women in a previous study. In our study, there was no significant correlation between the concentrations of BPA in colostrum and the age and parity of mothers.
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Detectable levels of BPA have been found in human and animal fluids such as urine, blood, and breast milk.
“detectable levels of BPA have been found in fluids of human and animals, such as urine24, blood25 and breast milk26.”
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Cao, X.-L., Zhang, J., Goodyer, C. G., Hayward, S., Cooke, G. M., & Curran, I. H. A. (2012) · Chemosphere · doi:10.1016/j.chemosphere.2012.05.003 · Cited by 93 · see citing works
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- Authors
- Kuruto-Niwa, R., Tateoka, Y., Usuki, Y., & Nozawa, R.
- Affiliations
- Shizuoka University (JP)
- Otsuka (Japan) (JP)
- Corresponding author
- Kuruto-Niwa, Ryoko
- ORCID
- Tateoka, Yumiko
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 66
- Issue
- 6
- Pages
- 1160-1164
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W2067314116
- Cited by
- 213
- References
- 0
- Citations by year
- 2025: 8 · 2024: 2 · 2023: 6 · 2022: 10 · 2021: 17 · 2020: 7 · 2019: 11 · 2018: 11 · 2017: 16 · 2016: 13 · 2015: 22 · 2014: 16 · 2013: 15 · 2012: 9
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Otsuka Pharmaceutical
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- bisphenol A, human colostrum, breast milk, endocrine disruptors, estrogenic compounds, maternal exposure, maternal age and parity
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Colostrum, Environmental Monitoring, Environmental Pollutants, Enzyme-Linked Immunosorbent Assay, Female, Humans, Maternal Age, Parity, Phenols, Pregnancy
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