The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Investigating the biodegradability of perfluorooctanoic acid
Abstract
Perfluorooctanoic acid (PFOA) is an industrial chemical that has become disseminated globally in aquatic and terrestrial habitats, humans, and wildlife. Understanding PFOA's biodegradability (susceptibility to microbial metabolic attack) is a crucial element in developing an informed strategy for predicting and managing this compound's environmental fate. Reasoning that PFOA might be susceptible to reductive defluorination by anaerobic microbial communities, we embarked on a 2-phase experimental approach examining the potential of five different microbial communities (from a municipal waste-water treatment plant, industrial site sediment, an agricultural soil, and soils from two fire training areas) to alter PFOA's molecular structure. A series of primarily anaerobic incubations (up to 259d in duration) were established with acetate, lactate, ethanol, and/or hydrogen gas as electron donors and PFOA (at concentrations of 100 ppm and 100 ppb) as the electron acceptor. Cometabolism of PFOA during reductive dechlorination of trichloroethene (TCE) and during reduction of nitrate, iron, sulfate, and methanogenesis were also examined. Endpoints of potential PFOA transformation included release of fluoride and detection of potential transformation products by LC/Orbitrap MS and LC/accurate radioisotope counting in a (14)C radiotracer study. The strongest indication of PFOA transformation occurred during its potential cometabolism at the 100 ppb concentration during reductive dechlori…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“PFAS are seriously persistent to environmental degradation processes (i.e., not readily biodegradable) [3,11,12]”
From A Mini-Review of Full-Scale Drinking Water Treatment Plants for Per- and Polyfluoroalkyl Substances (PFAS) Removal: Possible Solutions and Future Directions (2025) · cites this paper as [11]
Citations
Cites
Perfluoroalkyl Acids: A Review of Monitoring and Toxicological Findings
Lau, C., Anitole, K., Hodes, C., Lai, D., Pfahles-Hutchens, A., & Seed, J. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm128 · Cited by 2,620
Sources, fate and transport of perfluorocarboxylates
Prevedouros, K., Cousins, I. T., Buck, R. C., & Korzeniowski, S. H. (2006) · Environmental Science & Technology · doi:10.1021/es0512475 · Cited by 2,594
Biodegradation and bioremediation
(1994) · Choice Reviews Online · doi:10.5860/choice.32-1511 · Cited by 1,665
Manual of environmental microbiology.
Hurst, C. J., Crawford, R. L., Garland, J. L., Lipson, D. A., Mills, A., & Stetzenbach, L. D. (2007) · Cited by 1,413
Manual of Environmental Microbiology
(2007) · Wiley eBooks · doi:10.1128/9781555815882 · Cited by 1,379
Biological Monitoring of Polyfluoroalkyl Substances: A Review
Houde, M., Martin, J. W., Letcher, R. J., Solomon, K. R., & Muir, D. C. G. (2006) · Environmental Science & Technology · doi:10.1021/es052580b · Cited by 1,280
The toxicology of perfluorooctanoate
Kennedy, G. L., Butenhoff, J. L., Olsen, G. W., O'Connor, J. C., Seacat, A. M., Perkins, R. G., Biegel, L. B., Murphy, S. R., & Farrar, D. G. (2004) · Critical Reviews in Toxicology · doi:10.1080/10408440490464705 · Cited by 742
Fluorinated organics in the biosphere
Key, B. D., Howell, R. D., & Criddle, C. S. (1997) · Environmental Science & Technology · doi:10.1021/es961007c · Cited by 729
Are There Other Persistent Organic Pollutants? A Challenge for Environmental Chemists
Muir, D. C. G., & Howard, P. H. (2006) · Environmental Science & Technology · doi:10.1021/es061677a · Cited by 614
Fluorotelomer alcohol biodegradation yields poly-and perfluorinated acids
Dinglasan, M. J. A., Ye, Y., Edwards, E. A., & Mabury, S. A. (2004) · Environmental Science & Technology · doi:10.1021/es0350177 · Cited by 554
Research works printed but not linked: 1
- Kissa, E., (Ed.), 2001. Fluorinated Surfactant and Repellents, second ed. Marcel Dekker, Inc., New York, NY, 615 p.
Cited by
Sorted by citations
Li, F., Duan, J., Tian, S., Ji, H., Zhu, Y., Wei, Z., & Zhao, D. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122506 · Cited by 707
The overlooked short- and ultrashort-chain poly- and perfluorinated substances: A review
Ateia, M., Maroli, A., Tharayil, N., & Karanfil, T. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2018.12.186 · Cited by 639
Zareitalabad, P., Siemens, J., Hamer, M., & Amelung, W. (2013) · Chemosphere · doi:10.1016/j.chemosphere.2013.02.024 · Cited by 642
Trojanowicz, M., Bojanowska-Czajka, A., Bartosiewicz, I., & Kulisa, K. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.10.153 · Cited by 550
Microbial degradation of polyfluoroalkyl chemicals in the environment: A review
Liu, J., & Mejia Avendaño, S. (2013) · Environment International · doi:10.1016/j.envint.2013.08.022 · Cited by 525
Metadata
- Authors
- Liou, J. S.-C., Szostek, B., DeRito, C. M., & Madsen, E. L.
- Affiliations
- Cornell University (US)
- DuPont (United States) (US)
- Corresponding author
- Madsen, E.L.
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 80
- Issue
- 2
- Pages
- 176-183
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W2035382121
- Cited by
- 191
- References
- 42
- Citations by year
- 2026: 13 · 2025: 22 · 2024: 27 · 2023: 22 · 2022: 15 · 2021: 12 · 2020: 8 · 2019: 19 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 8 · 2014: 6 · 2013: 10 · 2012: 3
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
- Physical Sciences › Environmental Science › Environmental Chemistry › Environmental Chemistry and Analysis
- Physical Sciences › Environmental Science › Pollution › Microbial bioremediation and biosurfactants
- Keywords
- perfluorooctanoic acid, biodegradability, reductive defluorination, anaerobic microbial communities, cometabolism, reductive dechlorination, trichloroethylene, degradation intermediates, fluoride release, environmental persistence, wastewater treatment plants, soil, electron donors
- MeSH terms
- Bacteria, Biodegradation, Environmental, Caprylates, Environmental Pollutants, Fluorocarbons, Fungi, Microbiological Phenomena
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
