Cited by 729Per- and polyfluoroalkyl substances researchFluorine in Organic ChemistryToxic Organic Pollutants Impact

Fluorinated organics in the biosphere

Key, Blake D., Howell, Robert D., Criddle, Craig S.·1997·Environmental Science & Technology

Abstract

The use of organofluorine compounds has increased throughout this century, and they are now ubiquitous environmental contaminants. Although generally viewed as recalcitrant because of their lack of chemical reactivity, many fluorinated organics are biologically active. Several questions surround their distribution, fate, and effects. Of particular interest is the fate of perfluoroalkyl substituents, such as the trifluoromethyl group. Most evidence to date suggest that such groups resist defluorination, yet they can confer significant biological activity. Certain volatile fluorinated compounds can be oxidized in the troposphere yielding nonvolatile compounds, such as trifluoroacetic acid. In addition, certain nonvolatile fluorinated compounds can be transformed in the biosphere to volatile compounds. Research is needed to assess the fate and effects of nonvolatile fluorinated organics, the fluorinated impurities present in commercial formulations, and the transformation products generated by biochemical processes and/or oxidation in the troposphere.

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Crossref · 10.1021/es961007c

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Authors
Key, B. D., Howell, R. D., & Criddle, C. S.
Affiliations
Michigan State University (US)
Venue
Environmental Science & Technology
Published
1997-08-28
Volume
31
Issue
9
Pages
2445-2454
ISSN
  • 0013-936X (ISSN-L)
  • 1520-5851
OpenAlex
W2004024071
Cited by
729
References
2
Citations by year
2026: 17 · 2025: 19 · 2024: 26 · 2023: 20 · 2022: 29 · 2021: 32 · 2020: 39 · 2019: 29 · 2018: 24 · 2017: 28 · 2016: 33 · 2015: 30 · 2014: 44 · 2013: 38 · 2012: 38
FWCI
4.92
Type
journal article
Language
en
Open access
closed
Locations
Environmental Science & Technology (publishedVersion)
Funders
National Science Foundation
Topics
  • Physical Sciences › Environmental Science › Environmental Chemistry › Per- and polyfluoroalkyl substances research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Fluorine in Organic Chemistry
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
organofluorine compounds, environmental pollutants, perfluorinated compounds, trifluoromethyl group, biological activity, tropospheric oxidation, trifluoroacetic acid, degradation intermediates, commercial formulations, bioaccumulation

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