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Cited by 113Pharmaceutical and Antibiotic Environmental ImpactsWastewater Treatment and ReuseAntibiotic Use and Resistance

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Antibiotic resistance development and human health risks during wastewater reuse and biosolids application in agriculture

Sorinolu, Adeola Julian, Tyagi, Neha, Kumar, Arun, Munir, Mariya·2021·Chemosphere
DOI 10.1016/j.chemosphere.2020.129032
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Abstract

The reuse of treated wastewater (TWW) and sewage sludge are considered as solutions to the limited water resource and sludge disposal issues, respectively. The associated environmental and human health risks need to be analyzed to assess whether they are safe solutions or not. This paper discusses issues that relate to the accumulation of antibiotics and antibiotic resistance (AR) determinants in agricultural lands and crops, following TWW irrigation and biosolid amendment. Exposure assessment and dose-response assessment are the two important aspects of risk assessment discussed in this paper. Finally, research gaps in current knowledge that are relevant to a comprehensive and quantitative AR risk assessment were identified which includes: 1.) Studies on soil conditions that increase the frequency of horizontal gene transfer (HGT) between native soil resistome and pathogenic microbes in biosolids and TWW 2.) Holistic studies that examine the accumulation or dissipation of antibiotics, antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) from the irrigation/biosolids application stage to crop consumption stage 3.) The influences of soil environmental conditions (e.g. salinity, nutrients) on the fate of ARB and ARGs in soil and translocation in edible plants 4.) The development of dose-response models that explicitly incorporate the potential for ARGs transfer between microbes when quantifying the risks of infection due to ARB.

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Metadata

Authors
Sorinolu, A. J., Tyagi, N., Kumar, A., & Munir, M.
Affiliations
  • University of North Carolina at Charlotte (US)
  • Indian Institute of Technology Delhi (IN)
Corresponding author
Munir, Mariya
ORCID
Venue
Chemosphere
Publisher
Elsevier BV
Published
2021-02
Volume
265
Pages
129032
ISSN
0045-6535 (ISSN-L)
DOI
10.1016/j.chemosphere.2020.129032
OpenAlex
W3106839103
Cited by
113
References
2
Citations by year
2026: 9 · 2025: 16 · 2024: 26 · 2023: 24 · 2022: 22 · 2021: 16
FWCI
0.68
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Chemosphere (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Indian Institute of Technology Delhi
  • University of North Carolina at Charlotte
Topics
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
  • Physical Sciences › Environmental Science › Waste Management and Disposal › Wastewater Treatment and Reuse
  • Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Keywords
antibiotic resistance, antibiotic resistance genes, antibiotic resistance determinants, treated wastewater reuse, biosolids, sewage sludge, agricultural irrigation, human health risk assessment, exposure assessment, dose-response assessment, horizontal gene transfer, soil resistome, antibiotic-resistant bacteria, soil salinity, soil nutrients, dose-response modeling
MeSH terms
Biosolids, Agriculture, Angiotensin-Converting Enzyme Inhibitors, Anti-Bacterial Agents, Drug Resistance, Microbial, Humans, Angiotensin Receptor Antagonists, Wastewater

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