Removal of drug losartan in environmental aquatic matrices by heat-activated persulfate: Kinetics, transformation products and synergistic effects
Abstract
In this study, the oxidative degradation of losartan (LOS), a widely administered medicine for high blood pressure by heat-activated persulfate was investigated. Increased temperature and persulfate concentration, as well as acidic conditions enhance the degradation efficiency of LOS, whose rate follows pseudo-first order kinetics. From the respective apparent rate constants in the range 40-60 °C, an apparent activation energy of 112.70 kJ/mol was computed. Radical scavenging tests demonstrated that both HO• and [Formula: see text] contribute towards LOS degradation. LOS degradation was suppressed in real water matrices including bottled water (BW) and secondary wastewater effluent (WW), while other experiments indicated that the presence of bicarbonates and humic acid negatively affected its oxidation. Instead, the addition of chloride ions at 250 mg/L resulted in a positive effect on LOS removal. The combination of heat-activated PS with low-frequency ultrasound exhibited a synergistic effect, with the ratio S being 2.29 in BW and 1.52 in WW. Five transformation products of LOS were identified through HRMS suspect and non-target screening approaches, among which two are reported for the first time. Using the in-house risk assessment program, ToxTrAMs was revealed that most of the identified TPs present higher toxicity than LOS against Daphnia magna.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A similar negative effect is reported for other pharmaceuticals, such as simazine, losartan, carbamazepine, thiamethoxam, etc.
“A similar effect is reported for other pharmaceuticals, such as simazine, losartan, carbamazepine, thiamethoxam, etc., [116-120].”
From Advanced Oxidation Processes for Degradation of Water Pollutants—Ambivalent Impact of Carbonate Species: A Review (2023) · cites this paper as [117]
Cites
Identifying Small Molecules via High Resolution Mass Spectrometry: Communicating Confidence
Schymanski, E. L., Jeon, J., Gulde, R., Fenner, K., Ruff, M., Singer, H. P., & Hollender, J. (2014) · Environmental Science & Technology · doi:10.1021/es5002105 · Cited by 4,519 · see citing works
Wang, J., & Wang, S. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.11.059 · Cited by 4,087 · see citing works
Radical Generation by the Interaction of Transition Metals with Common Oxidants
Anipsitakis, G. P., & Dionysiou, D. D. (2004) · Environmental Science & Technology · doi:10.1021/es035121o · Cited by 3,088 · see citing works
Ghanbari, F., & Moradi, M. (2016) · Chemical Engineering Journal · doi:10.1016/j.cej.2016.10.064 · Cited by 2,670 · see citing works
Zhou, B., Bentham, J., Di Cesare, M., Bixby, H., Danaei, G., Cowan, M. J., Paciorek, C. J., Singh, G., Hajifathalian, K., Bennett, J. E., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31919-5 · Cited by 2,579 · see citing works
Hu, P., & Long, M. (2015) · Applied Catalysis B: Environmental · doi:10.1016/j.apcatb.2015.07.024 · Cited by 2,189 · see citing works
Activated persulfate for organic chemical degradation: A review
Matzek, L. W., & Carter, K. E. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.02.055 · Cited by 1,492 · see citing works
Wastewater treatment by means of advanced oxidation processes based on cavitation—A review
Gągol, M., Przyjazny, A., & Boczkaj, G. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.01.049 · Cited by 1,222 · see citing works
Bolton, J. R., Bircher, K. G., Tumas, W., & Tolman, C. A. (2001) · Pure and Applied Chemistry · doi:10.1351/pac200173040627 · Cited by 1,164 · see citing works
Rate constants and mechanism of reaction of sulfate radical anion with aromatic compounds
Neta, P., Madhavan, V., Zemel, H., & Fessenden, R. W. (1977) · Journal of the American Chemical Society · doi:10.1021/ja00443a030 · Cited by 899 · see citing works
New perspectives for Advanced Oxidation Processes
Dewil, R., Mantzavinos, D., Poulios, I., & Rodrigo, M. A. (2017) · Journal of Environmental Management · doi:10.1016/j.jenvman.2017.04.010 · Cited by 687 · see citing works
Self-citationFedorov, K., Plata-Gryl, M., Khan, J. A., & Boczkaj, G. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122804 · Cited by 678 · see citing works
Gągol, M., Çako, E., Fedorov, K., Soltani, R. D. C., Przyjazny, A., & Boczkaj, G. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.113002 · Cited by 621 · see citing works
Combination of hydrodynamic cavitation and SR-AOPs for simultaneous degradation of BTEX in water
Fedorov, K., Sun, X., & Boczkaj, G. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.128081 · Cited by 616 · see citing works
Fan, Y., Ji, Y., Kong, D., Lu, J., & Zhou, Q. (2015) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2015.06.058 · Cited by 452 · see citing works
Oxidation of bisoprolol in heated persulfate/H2O systems: Kinetics and products
Ghauch, A., & Tuqan, A. M. (2011) · Chemical Engineering Journal · doi:10.1016/j.cej.2011.12.048 · Cited by 415 · see citing works
Standardization of ultrasonic power for sonochemical reaction
Kimura, T., Sakamoto, T., Lévêque, J., Sohmiya, H., Fujita, M., Ikeda, S., & Ando, T. (1996) · Ultrasonics Sonochemistry · doi:10.1016/s1350-4177(96)00021-1 · Cited by 387 · see citing works
Ghauch, A., Baalbaki, A., Amasha, M., Asmar, R. E., & Tantawi, O. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.02.133 · Cited by 341 · see citing works
Clinical pharmacokinetics of angiotensin II (AT1) receptor blockers in hypertension
Israili, Z. (2000) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000991 · Cited by 318 · see citing works
Ma, J., Yang, Y., Jiang, X., Xie, Z., Li, X., Chen, C., & Chen, H. (2017) · Chemosphere · doi:10.1016/j.chemosphere.2017.09.148 · Cited by 309 · see citing works
‘An investigation into the occurrence and removal of pharmaceuticals in Colombian wastewater’
Botero-Coy, A. M., Martínez‐Pachón, D., Boix, C., Rincón-Ortiz, R. J., Castillo, N. R., Marín, L. A., Losada, L. M., Torres-Palma, R. A., Moncayo‐Lasso, A., & Hernández, F. J. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.06.088 · Cited by 309 · see citing works
Darsinou, B., Frontistis, Z., Αντωνοπούλου, Μ., Konstantinou, I., & Mantzavinos, D. (2015) · Chemical Engineering Journal · doi:10.1016/j.cej.2015.06.061 · Cited by 234 · see citing works
Self-citationGurke, R., Rößler, M., Marx, C., Diamond, S. R., Schubert, S., Oertel, R., & Fauler, J. (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.06.067 · Cited by 223 · see citing works
Osorio, V., Larrañaga, A., Aceña, J., Pérez, S., & Barceló, . (2015) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2015.06.143 · Cited by 220 · see citing works
Wang, Q., Lu, X., Cao, Y., Ma, J., Jiang, J., Bai, X., & Hu, T. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.07.041 · Cited by 217 · see citing works
Sulfate radicals induced degradation of Triclosan in thermally activated persulfate system
Gao, H., Chen, J., Zhang, Y., & Zhou, X. (2016) · Chemical Engineering Journal · doi:10.1016/j.cej.2016.07.080 · Cited by 200 · see citing works
Fernandes, A., Makoś‐Chełstowska, P., & Boczkaj, G. (2018) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.05.207 · Cited by 193 · see citing works
Liu, L., Lin, S., Zhang, W., Farooq, U., Shen, G., & Hu, S. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.04.068 · Cited by 186 · see citing works
Fernandes, A., Makoś, P., Khan, J. A., & Boczkaj, G. (2019) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2018.10.081 · Cited by 185 · see citing works
Ashfaq, M., Li, Y., Wang, Y., Chen, W., Wang, H., Chen, X., Wu, W., Huang, Z., Yu, C.-P., & Sun, Q. (2017) · Water Research · doi:10.1016/j.watres.2017.07.014 · Cited by 183 · see citing works
Degradation of antipyrine by heat activated persulfate
Tan, C., Gao, N., Deng, Y., Rong, W., Zhou, S., & Lu, N. (2013) · Separation and Purification Technology · doi:10.1016/j.seppur.2013.03.003 · Cited by 176 · see citing works
Heat-activated persulfate oxidation of methyl- and ethyl-parabens: Effect, kinetics, and mechanism
Chen, Y., Deng, P., Xie, P., Shang, R., Wang, Z., & Wang, S. (2016) · Chemosphere · doi:10.1016/j.chemosphere.2016.11.143 · Cited by 168 · see citing works
Mandarić, L., Diamantini, E., Stella, E., Cano-Paoli, K., Valle-Sistac, J., Molins-Delgado, D., Bellin, A., Chiogna, G., Majone, B., Díaz‐Cruz, M. S., et al. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.02.185 · Cited by 157 · see citing works
Nödler, K., Hillebrand, O., Idzik, K. R., Strathmann, M., Schiperski, F., Zirlewagen, J., & Licha, T. (2013) · Water Research · doi:10.1016/j.watres.2013.08.034 · Cited by 150 · see citing works
Hai, H., Xing, X., Li, S., Xia, S., & Xia, J. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.139909 · Cited by 148 · see citing works
Wang, Y., Li, Y., Hu, A., Rashid, A., Ashfaq, M. A., Wang, Y., Wang, H., Luo, H.-Q., Yu, C., & Sun, Q. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.04.064 · Cited by 143 · see citing works
Salazar, C., Contreras, N., Mansilla, H. D., Yáñez, J., & Salazar, R. A. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.04.009 · Cited by 132 · see citing works
Bayer, A., Asner, R., Schüssler, W., Kopf, W., Weiß, K., Sengl, M., & Letzel, M. (2014) · Environmental Science and Pollution Research · doi:10.1007/s11356-014-3060-z · Cited by 127 · see citing works
Outsiou, A., Frontistis, Z., Ribeiro, R. S., Αντωνοπούλου, Μ., Konstantinou, I., Silva, A. M. T., Faria, J. L., Gomes, H. T., & Mantzavinos, D. (2017) · Water Research · doi:10.1016/j.watres.2017.07.046 · Cited by 127 · see citing works
Self-citationGenetic basis of blood pressure and hypertension
Padmanabhan, S., Newton‐Cheh, C., & Dominiczak, A. F. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.04.001 · Cited by 126 · see citing works
Oxidative degradation of diclofenac by thermally activated persulfate: implication for ISCO
Chen, J., Qian, Y., Liu, H., & Huang, T. (2015) · Environmental Science and Pollution Research · doi:10.1007/s11356-015-5630-0 · Cited by 106 · see citing works
de Andrade, J. R., Vieira, M. G. A., da Silva, M. G. C., & Wang, S. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122971 · Cited by 103 · see citing works
Patidar, R., & Srivastava, V. C. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.125736 · Cited by 96 · see citing works
Qian, Y., Xue, G., Chen, J., Luo, J., Zhou, X., Gao, P., & Wang, Q. (2018) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2018.05.004 · Cited by 92 · see citing works
Casado, J., Rodríguez, I., Ramil, M., & Cela, R. (2014) · Journal of Chromatography A · doi:10.1016/j.chroma.2014.02.087 · Cited by 91 · see citing works
Aalizadeh, R., von der Ohe, P. C., & Τhomaidis, Ν. S. (2017) · Environmental Science Processes & Impacts · doi:10.1039/c6em00679e · Cited by 87 · see citing works
Self-citationTriñanes, S., Casais, M. C., Mejuto, M. C., & Cela, R. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.10.004 · Cited by 81 · see citing works
Hakim, S. A., Baalbaki, A., Tantawi, O., & Ghauch, A. (2019) · RSC Advances · doi:10.1039/c9ra05362j · Cited by 81 · see citing works
Nuel, M., Laurent, J., Bois, P., Heintz, D., & Wanko, A. (2017) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2017.10.061 · Cited by 77 · see citing works
Cortez, F. S., Souza, L. D. S., Guimarães, L. L., Almeida, J. E. D., Pusceddu, F. H., Maranho, L. A., Mota, L. G., Nobre, C. R., Moreno, B. B., Abessa, D. M. D. S., et al. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.05.069 · Cited by 77 · see citing works
Photodegradation of ethyl paraben using simulated solar radiation and Ag3PO4 photocatalyst
Frontistis, Z., Αντωνοπούλου, Μ., Πεταλά, Α., Venieri, D., Konstantinou, I., Kondarides, D. Ι., & Mantzavinos, D. (2016) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2016.04.017 · Cited by 76 · see citing works
Self-citationRoveri, V., Guimarães, L. L., Toma, W., & Correia, A. T. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-10316-y · Cited by 75 · see citing works
Lebik-Elhadi, H., Frontistis, Z., Ait-Amar, H., Madjene, F., & Mantzavinos, D. (2020) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2019.11.041 · Cited by 71 · see citing works
Self-citationSerna-Galvis, E. A., Isaza-Pineda, L., Moncayo‐Lasso, A., Hernández, F. J., Ibáñez, M., & Torres-Palma, R. A. (2019) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2019.104635 · Cited by 48 · see citing works
Arvaniti, O. S., Bairamis, F., Konstantinou, I., Mantzavinos, D., & Frontistis, Z. (2020) · Chemical Engineering Journal Advances · doi:10.1016/j.ceja.2020.100062 · Cited by 45 · see citing works
Self-citationMartínez‐Pachón, D., Espinosa-Barrera, P. A., Rincón-Ortiz, R. J., & Moncayo‐Lasso, A. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-018-2645-3 · Cited by 42 · see citing works
World population ageing, 2019 :
Division, U. P. (2019) · Cited by 36 · see citing works
Persulfate oxidation for the aniline degradation in aqueous systems.
Anotai, J., Masomboon, N., Chuang, C.-L., & Lu, M. (2011) · PubMed · doi:10.2166/wst.2011.190 · Cited by 35 · see citing works
Carbocatalytic activation of persulfate for the removal of drug diclofenac from aqueous matrices
Dimitriadou, S., Frontistis, Z., Πεταλά, Α., Bampos, G., & Mantzavinos, D. (2019) · Catalysis Today · doi:10.1016/j.cattod.2019.02.025 · Cited by 35 · see citing works
Self-citationCoupling Persulfate-Based AOPs: A Novel Approach for Piroxicam Degradation in Aqueous Matrices
Stathoulopoulos, A., Mantzavinos, D., & Frontistis, Z. (2020) · Water · doi:10.3390/w12061530 · Cited by 29 · see citing works
Self-citationEcotoxicity and genotoxicity assessment of losartan after UV/H2O2 and UVC/photolysis treatments
Adams, E., Neves, B. B., Prola, L. D. T., de Liz, M. V., Martins, L. R. R., Ramsdorf, W. A., & de Freitas, A. M. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-11420-9 · Cited by 29 · see citing works
Guateque-Londoño, J. F., Serna-Galvis, E. A., Ávila-Torres, Y., & Torres-Palma, R. A. (2020) · Water · doi:10.3390/w12123398 · Cited by 28 · see citing works
Gao, Y.-Q., Fang, J.-N., Gao, N., Yi, X., Mao, W., & Zhang, J. (2018) · RSC Advances · doi:10.1039/c8ra08488b · Cited by 27 · see citing works
UV-assisted chemical oxidation of antihypertensive losartan in water
Kaur, B., & Dulova, N. (2020) · Journal of Environmental Management · doi:10.1016/j.jenvman.2020.110170 · Cited by 26 · see citing works
Carpinteiro, I., Castro, G., Rodríguez, I., & Cela, R. (2019) · Science of the Total Environment · doi:10.1016/j.scitotenv.2018.08.082 · Cited by 25 · see citing works
Zhou, R. M., Li, T., Yu, S. Y., Li, C., Jin, X., & Ren, H. (2019) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.6128 · Cited by 25 · see citing works
Martínez‐Pachón, D., Serna-Galvis, E. A., Ibáñez, M., Hernández, F. J., Ávila-Torres, Y., Torres-Palma, R. A., & Moncayo‐Lasso, A. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.129491 · Cited by 19 · see citing works
Persulfate oxidation for the aniline degradation in aqueous systems
Anotai, J., Masomboon, N., Chuang, C.-L., & Lu, M. (2011) · Water Science & Technology · doi:10.2166/wst.2011.325 · Cited by 17 · see citing works
Πεταλά, Α., Arvaniti, O. S., Christofili, M., Safakas, A., Frontistis, Z., & Mantzavinos, D. (2020) · Catalysts · doi:10.3390/catal10121373 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Rayaroth, M. P., Boczkaj, G., Aubry, O., Aravind, U. K., & Aravindakumar, C. T. (2023) · Water · doi:10.3390/w15081615 · Cited by 171 · see citing works
Li, X., Jie, B., Lin, H., Deng, Z., Qian, J., Yang, Y., & Zhang, X. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.114664 · Cited by 162 · see citing works
Li, N., Wu, S., Dai, H., Cheng, Z., Peng, W., Yan, B., Chen, G., Wang, S., & Duan, X. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137976 · Cited by 139 · see citing works
Arvaniti, O. S., Ioannidi, A. Α., Mantzavinos, D., & Frontistis, Z. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.115568 · Cited by 97 · see citing works
Self-citationSonawane, S., Rayaroth, M. P., Landge, V. K., Fedorov, K., & Boczkaj, G. (2022) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2022.100839 · Cited by 91 · see citing works
Cai, H., Zou, J., Lin, J., Li, Q., Li, J., Huang, Y., Yang, H., Yuan, B., & Ma, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.137765 · Cited by 73 · see citing works
Chen, H., Lin, T., Wang, P., Zhang, X., Jiang, F., & Wang, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138634 · Cited by 71 · see citing works
How to enhance persulfate processes by external-field effects: From fundamentals to applications
Chen, H., Yin, R., & Zhu, M. (2024) · Water Research · doi:10.1016/j.watres.2024.123026 · Cited by 62 · see citing works
Behnami, A., Aghayani, E., Benis, K. Z., Sattari, M., & Pourakbar, M. (2022) · RSC Advances · doi:10.1039/d2ra01618d · Cited by 61 · see citing works
Jiménez-Bambague, E. M., Madera-Parra, C. A., Rangel-Delgado, M. F., Quintero-Martinez, I., Miranda-Mosquera, D., Aristizabal-Apolinar, J. S., & Machuca‐Martínez, F. (2023) · Electrochimica Acta · doi:10.1016/j.electacta.2023.141905 · Cited by 52 · see citing works
Tisler, S., Engler, N., Jørgensen, M. B., Kilpinen, K., Tomasi, G., & Christensen, J. H. (2022) · Water Research · doi:10.1016/j.watres.2022.118599 · Cited by 46 · see citing works
Spaolonzi, M. P., Duarte, E. D. V., Oliveira, M. G., Costa, H. P. S., Ribeiro, M. C. B., da Silva, T. L., da Silva, M. G. C., & Vieira, M. G. A. (2022) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2022.133961 · Cited by 46 · see citing works
Chen, X., Wang, Y., Fan, X., Zhu, G., Liu, Y., & Quan, X. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173042 · Cited by 36 · see citing works
Lalas, K., Arvaniti, O. S., Zkeri, E., Nika, M., Τhomaidis, Ν. S., Mantzavinos, D., Stasinakis, A. S., & Frontistis, Z. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.157378 · Cited by 36 · see citing works
Self-citationGupta, S. P., & Samanta, S. K. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.107646 · Cited by 34 · see citing works
Advances in the Degradation of Emerging Contaminants by Persulfate Oxidation Technology
Su, R., Li, Z., Cheng, F., Dai, X., Wang, H., Luo, Y., & Huang, L. (2023) · Water Air & Soil Pollution · doi:10.1007/s11270-023-06770-2 · Cited by 33 · see citing works
Biswas, P., Vellanki, B. P., & Kazmi, A. A. (2022) · Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153757 · Cited by 33 · see citing works
Arvaniti, O. S., Ioannidi, A. Α., Politi, A., Miserli, K., Konstantinou, I., Mantzavinos, D., & Frontistis, Z. (2022) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2022.103134 · Cited by 31 · see citing works
Self-citationGiannakopoulos, S., Vakros, J., Frontistis, Z., Manariotis, I. D., Venieri, D., Poulopoulos, S. G., & Mantzavinos, D. (2023) · Catalysts · doi:10.3390/catal13020233 · Cited by 30 · see citing works
Self-citationSorption of two common antihypertensive drugs onto polystyrene microplastics in water matrices
Arvaniti, O. S., Antonopoulou, G., Gatidou, G., Frontistis, Z., Mantzavinos, D., & Stasinakis, A. S. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155786 · Cited by 29 · see citing works
Self-citationMechanism of the improved Fe(III)/persulfate reaction by gallic acid for ibuprofen degradation
Li, L., Zheng, D., Gu, X., Sun, C., Liu, Y., Dong, W., & Wu, Y. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.120318 · Cited by 26 · see citing works
Dhawle, R., Kajtazi, A., Sakellariou, M., Frontistis, Z., Lynen, F., & Mantzavinos, D. (2024) · Water Resources and Industry · doi:10.1016/j.wri.2024.100240 · Cited by 25 · see citing works
Self-citationda Conceição, K. C., Villamar-Ayala, C. A., Plaza-Garrido, A., & Toledo‐Neira, C. (2023) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2023.110984 · Cited by 25 · see citing works
Giannakopoulos, S., Frontistis, Z., Vakros, J., Poulopoulos, S. G., Manariotis, I. D., & Mantzavinos, D. (2022) · Journal of the Taiwan Institute of Chemical Engineers · doi:10.1016/j.jtice.2022.104440 · Cited by 23 · see citing works
Self-citationIoannidi, A. Α., Frigana, A., Vakros, J., Frontistis, Z., & Mantzavinos, D. (2024) · Catalysts · doi:10.3390/catal14020127 · Cited by 21 · see citing works
Self-citationPhoto-Fenton-Like Treatment of Municipal Wastewater
Kanafin, Y. N., Makhatova, A., Zarikas, V., Arkhangelsky, E., & Poulopoulos, S. G. (2021) · Catalysts · doi:10.3390/catal11101206 · Cited by 21 · see citing works
Chunsheng, D., Cai, Z., Hu, C., Lei, J., Wang, L., Li, Q., Li, X., & Deng, J. (2023) · Chemosphere · doi:10.1016/j.chemosphere.2023.138247 · Cited by 21 · see citing works
Combined ultrasound cavitation and persulfate for the treatment of pharmaceutical wastewater
Pandya, K., S., A. S. T., Kodgire, P. V., & Simon, S. (2022) · Water Science & Technology · doi:10.2166/wst.2022.304 · Cited by 20 · see citing works
UVA and goethite activated persulfate oxidation of landfill leachate
Kanafin, Y. N., Abdirova, P., Arkhangelsky, E., Dionysiou, D. D., & Poulopoulos, S. G. (2023) · Chemical Engineering Journal Advances · doi:10.1016/j.ceja.2023.100452 · Cited by 20 · see citing works
Sepman, H., Malm, L., Peets, P., & Kruve, A. (2023) · Trends in Environmental Analytical Chemistry · doi:10.1016/j.teac.2023.e00217 · Cited by 20 · see citing works
Using Sawdust Derived Biochar as a Novel 3D Particle Electrode for Micropollutants Degradation
Πεταλά, Α., Bampos, G., & Frontistis, Z. (2022) · Water · doi:10.3390/w14030357 · Cited by 20 · see citing works
Self-citationLi, S., Liu, X., Zheng, Y., Ma, J., You, S., & Zheng, H. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108971 · Cited by 17 · see citing works
Kalogerakis, G. C., Boparai, H. K., & Sleep, B. E. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129739 · Cited by 16 · see citing works
Ioannidi, A. Α., Vakros, J., Frontistis, Z., & Mantzavinos, D. (2022) · Catalysts · doi:10.3390/catal12101245 · Cited by 16 · see citing works
Self-citationLalas, K., Arvaniti, O. S., Panagopoulou, E. I., Τhomaidis, Ν. S., Mantzavinos, D., & Frontistis, Z. (2024) · Chemosphere · doi:10.1016/j.chemosphere.2024.141260 · Cited by 15 · see citing works
Self-citationde Souza, A. B., Gadi, N., van de Goor, T., Boelee, N. C., Dewil, R., & Cabooter, D. (2024) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2024.105899 · Cited by 14 · see citing works
Papalexopoulou, K., Triantaphyllidou, I. E., Skandalis, S. S., Rassias, G. A., & Aggelopoulos, C. A. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.163732 · Cited by 14 · see citing works
Peroxymonosulfate enhanced photoelectrocatalytic degradation of 17α-ethinyl estradiol
Dhawle, R., Giannakopoulos, S., Frontistis, Z., & Mantzavinos, D. (2023) · Catalysis Today · doi:10.1016/j.cattod.2023.02.003 · Cited by 14 · see citing works
Self-citationPhotocatalytic Degradation of Losartan with Bismuth Oxychloride: Batch and Pilot Scale Demonstration
Kouvelis, K., Ioannidi, A. Α., Πεταλά, Α., Souliotis, M., & Frontistis, Z. (2023) · Catalysts · doi:10.3390/catal13081175 · Cited by 13 · see citing works
Self-citationLED visible light assisted photochemical oxidation of HCHs in aqueous phases polluted with DNAPL
Conte, L., Cotillas, S., Sánchez-Yepes, A., Lorenzo, D., & Santos, A. (2022) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2022.10.015 · Cited by 12 · see citing works
Guo, F., Sun, S., Son, Y., Kim, J., Han, S., Zhang, Z. B., Cui, M., & Khim, J. (2025) · ACS ES&T Engineering · doi:10.1021/acsestengg.5c00360 · Cited by 11 · see citing works
Ali, I., de Souza, A. B., Liu, Z., Cabooter, D., Katsaounis, A. D., Laet, S. D., Eyck, K. V., & Dewil, R. (2023) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2023.104133 · Cited by 10 · see citing works
Dong, Z., Zhao, Z., Zhang, H., Wang, F., Wang, F., Xia, M., & Jia, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155479 · Cited by 10 · see citing works
Hamiche, A., Yahiaoui, I., Khenniche, L., Amrane, A., & Benissad, F. (2023) · Reaction Kinetics Mechanisms and Catalysis · doi:10.1007/s11144-023-02530-9 · Cited by 9 · see citing works
Estrada-Flórez, S. E., Serna-Galvis, E. A., Lee, J., & Torres-Palma, R. A. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-29189-y · Cited by 9 · see citing works
Estrada-Flórez, S. E., Serna-Galvis, E. A., Lee, J., & Torres-Palma, R. A. (2023) · Journal of Environmental Management · doi:10.1016/j.jenvman.2023.119548 · Cited by 9 · see citing works
Zheng, D., Duan, J., Wu, Y., & Dong, W. (2024) · Process Safety and Environmental Protection · doi:10.1016/j.psep.2024.05.022 · Cited by 8 · see citing works
Arvaniti, O. S., Cheiletzari, G., Panagopoulou, E. I., Τhomaidis, Ν. S., Mantzavinos, D., & Frontistis, Z. (2023) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2023.103890 · Cited by 8 · see citing works
Self-citationKravos, A., Gotvajn, A. Ž., & Prosen, H. (2024) · Processes · doi:10.3390/pr12102177 · Cited by 7 · see citing works
Романовна, С. М., Alekseev, K. D., Batoeva, A. A., & Aseev, D. G. (2025) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2025.118663 · Cited by 8 · see citing works
Fabrication of a novel MoB/BiOCl photocatalyst for losartan and Escherichia coli removal
Ioannidi, A. Α., Giannakopoulos, S., Πεταλά, Α., Frontistis, Z., & Mantzavinos, D. (2024) · Catalysis Today · doi:10.1016/j.cattod.2024.114510 · Cited by 6 · see citing works
Self-citationGhanbari, S., Nasiri, A., & Attar, H. M. (2025) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2025.108987 · Cited by 5 · see citing works
da Conceição, K. C., Freitas, L. D. S., & Villamar-Ayala, C. A. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.178891 · Cited by 5 · see citing works
Catalytic Processes for Water and Wastewater Treatment
Vakros, J. (2023) · MDPI eBooks · doi:10.3390/books978-3-0365-7298-7 · Cited by 4 · see citing works
Madi, K., Yahiaoui, I., Arfi, R., Benkerrou, L., Khenniche, L., Lebik, H., Assadi, A. A., Khezami, L., Kriaa, K., & Benissad, F. (2025) · Water · doi:10.3390/w17111679 · Cited by 4 · see citing works
Ioannidi, A. Α., Vlachodimitropoulou, M., Frontistis, Z., Πεταλά, Α., Koutra, E., Kornaros, M. E., & Mantzavinos, D. (2023) · Catalysts · doi:10.3390/catal13091285 · Cited by 4 · see citing works
Self-citationZheng, D., Duan, J., Wu, Y., & Dong, W. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135143 · Cited by 3 · see citing works
Zhang, Y., Yang, X., Wang, D. N., & Zhang, J. (2026) · Water Environment Research · doi:10.1002/wer.70405 · Cited by 2 · see citing works
Jiang, L., Wang, R., Shi, S., Yan, J., Feng, M., & Chi, L. (2024) · Journal of Water Process Engineering · doi:10.1016/j.jwpe.2024.106367 · Cited by 2 · see citing works
Jiang, L., Li, Y., Shi, S., Yan, J., Chi, L., Liu, H., & Feng, M. (2025) · Frontiers of Environmental Science & Engineering · doi:10.1007/s11783-025-1968-9 · Cited by 1 · see citing works
Vaz, T., Maia, I., Gomes, J., Quina, M. J., & Martins, R. C. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.122064 · Cited by 1 · see citing works
Georgin, J., Dehmani, Y., Messaoudi, N. E., & Franco, D. S. P. (2026) · Molecules · doi:10.3390/molecules31101746 · Cited by 1 · see citing works
Destruction of Pharmaceuticals
Lunn, G., & Sansone, E. B. (2023) · Wiley eBooks · doi:10.1002/9781119848851.ch3
Lai, W. W.-P., & Chang, C. (2024) · Environmental Science Water Research & Technology · doi:10.1039/d4ew00357h
Photocatalytic Destruction of Ceftriaxone in Aqueous Solutions
Романовна, С. М., Batoeva, A. A., & Alekseev, K. D. (2024) · Russian Journal of Physical Chemistry A · doi:10.1134/s0036024424701395
Huang, J., Huang, C., Zhang, X., Tan, W., Niu, J., Yang, Y., Yu, H., & Han, D. (2025) · Materials Research Bulletin · doi:10.1016/j.materresbull.2025.113327
Photoactivation of oxidative degradation and mineralization of ceftriaxone with excilamp radiation
Романовна, С. М., Batoeva, A. A., & Aseev, D. G. (2025) · Proceedings of universities Applied chemistry and biotechnology · doi:10.21285/achb.961
Characterization of ZnCl2 modified algae residue biochar for sewage treatment
Xu, L., Zhang, W., & Wang, J. (2025) · Journal of Applied Water Engineering and Research · doi:10.1080/23249676.2025.2508414
da Conceição, K. C., Villamar-Ayala, C. A., Ortíz-Calderón, C., & Rodríguez, S. C. (2026) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2026.181745
Yu, H., Yuan, A., Liu, S., & Yang, L. (2026) · Food Control · doi:10.1016/j.foodcont.2026.112256
García-Gómez, L. A., Sáez-Navarrete, C. A., Giordano, A., Arroyo-Avirama, A. F., & Baraza, X. (2026) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2026.123123
Ledjeri, A., Madi, K., Yahiaoui, I., Assadi, A. A., Rahman, M. H., Amrane, A., & Benissad, F. (2026) · Catalysts · doi:10.3390/catal16060553
Zhen, X., Zhang, Y., Yi, H., 刘琼峰, Wu, L., Ma, G., Ding, C., bai, L., Chen, Y., & liu, X. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7068804
Zhen, X., Zhang, Y., Yi, H., 刘琼峰, Wu, L., Ma, G., Ding, C., Bai, L., Chen, Y., & liu, X. (2026) · Environmental Research · doi:10.1016/j.envres.2026.125727
Patra, A., & Ghosh, P. (2026) · Chemical Engineering Science · doi:10.1016/j.ces.2026.125348
- Authors
- Ioannidi, A., Arvaniti, O. S., Nika, M.-C., Aalizadeh, R., Thomaidis, N. S., Mantzavinos, D., & Frontistis, Z.
- Affiliations
- University of Patras (GR)
- National and Kapodistrian University of Athens (GR)
- University of Western Macedonia (GR)
- Corresponding author
- Frontistis, Zacharias
- ORCID
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 287
- Issue
- Pt 1
- Pages
- 131952
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W3194312168
- Cited by
- 75
- References
- 69
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 14 · 2023: 19 · 2022: 19 · 2021: 2
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hellenic Foundation for Research and Innovation (1281)
- Topics
- Physical Sciences › Environmental Science › Water Science and Technology › Advanced oxidation water treatment
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Keywords
- losartan, heat-activated persulfate, advanced oxidation processes, pharmaceutical removal, degradation intermediates, pseudo-first-order kinetics, activation energy, hydroxyl radicals, sulfate radicals, chloride effect, humic acid, bicarbonate, low-frequency ultrasound, synergistic effect, wastewater effluent, bottled water, Daphnia magna toxicity
- MeSH terms
- Pharmaceutical Preparations, Hot Temperature, Kinetics, Oxidation-Reduction, Sulfates, Water Pollutants, Chemical, Losartan, Drinking Water
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
