The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Gender differences in the effects of childhood maltreatment on adult depression and anxiety: A systematic review and meta-analysis
Abstract
Child maltreatment has well-documented long-term, adverse effects on mental health, but it is not clear whether there are gender differences in these effects. We conducted a systematic review to investigate whether there are gender differences in the effects of maltreatment on adult depression and anxiety. Medline, PsycINFO, Web of Science, and Lilacs were searched for relevant studies published up to May 2016. Eligible studies included population-based studies (with a cohort, case-control or cross-sectional design) which assessed maltreatment during childhood or adolescence (≤18 years) and its association with major depression or generalized anxiety disorder (DSM/ICD diagnostic criteria) in adulthood (>18 years) separately for females and males. Meta-analysis was performed to estimate the association between each exposure and outcome using fixed and random effects models. Pooled odds ratios (OR) were estimated separately for women and men and compared. Five studies of physical and sexual abuse were included in the meta-analyses. These provided twenty-two effects sizes estimates (11 for men, 11 for women) for associations between physical/sexual abuse and depression/anxiety. Exposure to each kind of abuse increased the odds of depression/anxiety. Associations were larger for women than for men, however, these gender differences were not statistically significant. Physical and sexual abuse in childhood/adolescence are risk factors for depression/anxiety in adulthood and the effect could be larger for women; however, currently there is insufficient evidence to definitively identify gender differences in the effects of maltreatment.
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“Childhood maltreatment is known to substantially increase the risk of developing neuropsychiatric conditions in adulthood, including anxiety and mood disorders (1–3).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [3]
In the citing paper
“Women with a history of CSA have stronger anxiety and depression symptoms than men [ 29 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [29]
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Reprint—Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
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Gender Differences in Depression: Biological, Affective, Cognitive, and Sociocultural Factors
Hyde, J. S., & Mezulis, A. H. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000230 · Cited by 385
Sahle, B. W., Reavley, N. J., Li, W., Morgan, A. J., Yap, M. B. H., Reupert, A., & Jorm, A. F. (2022) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01745-2 · Cited by 375
Maternal history of childhood maltreatment and later parenting behavior: A meta-analysis
Savage, L.-É., Tarabulsy, G. M., Pearson, J., Collin-Vézina, D., & Gagné, L.-M. (2019) · Development and Psychopathology · doi:10.1017/s0954579418001542 · Cited by 209
Lacey, R. E., Howe, L. D., Kelly‐Irving, M., Bartley, M., & Kelly, Y. J. (2020) · Journal of Interpersonal Violence · doi:10.1177/0886260520935096 · Cited by 181
Opel, N., Redlich, R., Dohm, K., Zaremba, D., Goltermann, J., Repple, J., Flint, C., Grotegerd, D., Leehr, E. J., Böhnlein, J., et al. (2019) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30044-6 · Cited by 149
Metadata
- Authors
- Gallo, E. A. G., Munhoz, T. N., Loret de Mola, C., & Murray, J.
- Affiliations
- Universidade Federal de Pelotas (BR)
- Corresponding author
- Murray, Joseph
- Venue
- Child Abuse & Neglect
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 79
- Pages
- 107-114
- ISSN
- 0145-2134 (ISSN-L)
- OpenAlex
- W2790792517
- Cited by
- 279
- References
- 56
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 34 · 2023: 45 · 2022: 42 · 2021: 36 · 2020: 34 · 2019: 16 · 2018: 6
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child Abuse & Neglect (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- child abuse, gender differences, adult depression, generalized anxiety disorder, physical abuse, sexual abuse, childhood adversity, adolescent maltreatment, mental health outcomes
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Child, Child Abuse, Depressive Disorder, Major, Major Depressive Disorder, Epidemiologic Methods, Female, Humans, Male, Mental Health, Sex Factors, Adult Survivors of Child Abuse
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