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Gender differences in the effects of childhood maltreatment on adult depression and anxiety: A systematic review and meta-analysis
Abstract
Child maltreatment has well-documented long-term, adverse effects on mental health, but it is not clear whether there are gender differences in these effects. We conducted a systematic review to investigate whether there are gender differences in the effects of maltreatment on adult depression and anxiety. Medline, PsycINFO, Web of Science, and Lilacs were searched for relevant studies published up to May 2016. Eligible studies included population-based studies (with a cohort, case-control or cross-sectional design) which assessed maltreatment during childhood or adolescence (≤18 years) and its association with major depression or generalized anxiety disorder (DSM/ICD diagnostic criteria) in adulthood (>18 years) separately for females and males. Meta-analysis was performed to estimate the association between each exposure and outcome using fixed and random effects models. Pooled odds ratios (OR) were estimated separately for women and men and compared. Five studies of physical and sexual abuse were included in the meta-analyses. These provided twenty-two effects sizes estimates (11 for men, 11 for women) for associations between physical/sexual abuse and depression/anxiety. Exposure to each kind of abuse increased the odds of depression/anxiety. Associations were larger for women than for men, however, these gender differences were not statistically significant. Physical and sexual abuse in childhood/adolescence are risk factors for depression/anxiety in adulthood and the effect could be larger for women; however, currently there is insufficient evidence to definitively identify gender differences in the effects of maltreatment.
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“Childhood maltreatment is known to substantially increase the risk of developing neuropsychiatric conditions in adulthood, including anxiety and mood disorders (1–3).”
From Perineuronal nets, inhibitory interneurons and anxiety-related ventral hippocampal neuronal oscillations are altered by early life adversity (2019) · cites this paper as [3]
In the citing paper
“Women with a history of CSA have stronger anxiety and depression symptoms than men [ 29 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [29]
Citations
Cites
Kessler, R. C., Berglund, P., Demler, O., Jin, R., Merikangas, K. R., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.593 · Cited by 20,391
Downs, S. H., & Black, N. (1998) · Journal of Epidemiology and Community Health · doi:10.1136/jech.52.6.377 · Cited by 8,252
Transforming our world: the 2030 Agenda for Sustainable Development
(2022) · doi:10.5040/9781509934058.0025 · Cited by 6,750
Whiteford, H. A., Degenhardt, L., Rehm, J., Baxter, A. J., Ferrari, A. J., Erskine, H. E., Charlson, F. J., Norman, R. E., Flaxman, A. D., Johns, N., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)61611-6 · Cited by 6,006
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
Norman, R. E., Byambaa, M., De, R., Butchart, A., Scott, J., & Vos, T. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001349 · Cited by 3,387
Reprint—Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & and the PRISMA Group (2009) · Physical Therapy · doi:10.1093/ptj/89.9.873 · Cited by 2,486
Gender differences in depression: Critical review
Piccinelli, M., & Wilkinson, G. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.486 · Cited by 2,376
The prevalence of child maltreatment across the globe: review of a series of meta-analyses
Stoltenborgh, M., Bakermans‐Kranenburg, M. J., Alink, L. R. A., & van IJzendoorn, M. H. (2015) · Child Abuse Review · doi:10.1002/car.2353 · Cited by 1,542
Nanni, V., Uher, R., & Danese, A. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020335 · Cited by 1,480
Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey
Molnar, B. E., Buka, S. L., & Kessler, R. C. (2001) · American Journal of Public Health · doi:10.2105/ajph.91.5.753 · Cited by 1,193
Spatz Widom, C., DuMont, K., & Czaja, S. J. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.49 · Cited by 1,059
Sexual abuse and lifetime diagnosis of psychiatric disorders: Systematic review and meta-analysis
Chen, L. P., Murad, M. H., Paras, M. L., Colbenson, K. M., Sattler, A. L., Goranson, E. N., Elamin, M. B., Seime, R. J., Shinozaki, G., Prokop, L. J., et al. (2010) · Mayo Clinic Proceedings · doi:10.4065/mcp.2009.0583 · Cited by 1,056
Childhood abuse and lifetime psychopathology in a community sample
MacMillan, H. L., Fleming, J. E., Streiner, D. L., Lin, E., Boyle, M. H., Jamieson, E., Duku, E. K., Walsh, C. A., Wong, M. Y.-Y., & Beardslee, W. R. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1878 · Cited by 1,035
The impact of child sexual abuse on health: a systematic review of reviews
Maniglio, R. (2009) · Clinical Psychology Review · doi:10.1016/j.cpr.2009.08.003 · Cited by 887
Adolescents' Exposure to Violence and Associated Symptoms of Psychological Trauma
Singer, M. I. (1995) · JAMA · doi:10.1001/jama.1995.03520300051036 · Cited by 771
Li, M., D'Arcy, C., & Meng, X. (2016) · Psychological Medicine · doi:10.1017/s0033291715002743 · Cited by 751
Gillies, G. E., & McArthur, S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002071 · Cited by 733
The long-term sequelae of child and adolescent abuse: a longitudinal community study
Silverman, A. B., Reinherz, H. Z., & Giaconia, R. M. (1996) · Child Abuse & Neglect · doi:10.1016/0145-2134(96)00059-2 · Cited by 730
Experiences of domestic violence and mental disorders: a systematic review and meta-analysis
Trevillion, K., Oram, S., Feder, G., & Howard, L. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051740 · Cited by 729
Infurna, M. R., Reichl, C., Parzer, P., Schimmenti, A., Bifulco, A. T., & Kaess, M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.09.006 · Cited by 651
Lindert, J., Ehrenstein, O. S. V., Grashow, R. G., Gal, G., Brähler, E., & Weisskopf, M. G. (2013) · International Journal of Public Health · doi:10.1007/s00038-013-0519-5 · Cited by 637
Hormones and mood: from menarche to menopause and beyond
Steiner, M. S. (2003) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00432-9 · Cited by 573
Horswell, B. B., & Istfan, S. (2012) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2012.04.002 · Cited by 468
Estrogen control of central neurotransmission: Effect on mood, mental state, and memory
Fink, G., SUMNER, B. E. H., Rosie, R., Grace, O., & Quinn, J. P. (1996) · Cellular and Molecular Neurobiology · doi:10.1007/bf02088099 · Cited by 431
Shapero, B. G., Black, S. K., Liu, R. T., Klugman, J., Bender, R. E., Abramson, L. Y., & Alloy, L. B. (2013) · Journal of Clinical Psychology · doi:10.1002/jclp.22011 · Cited by 349
Hillberg, T., Hamilton-Giachritsis, C., & Dixon, L. (2011) · Trauma, Violence, & Abuse · doi:10.1177/1524838010386812 · Cited by 342
Early sexual abuse and lifetime psychopathology: a co-twin–control study
Dinwiddie, S. H., Heath, A. C., Dunne, M. P., Bucholz, K. K., Madden, P. A. F., Slutske, W. S., Bierut, L. J., Statham, D. J., & Martin, N. G. (2000) · Psychological Medicine · doi:10.1017/s0033291799001373 · Cited by 326
Childhood and Adolescent Predictors of Major Depression in the Transition to Adulthood
Reinherz, H. Z., Paradis, A. D., Giaconia, R. M., Stashwick, C. K., & Fitzmaurice, G. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.12.2141 · Cited by 309
Cougle, J. R., Timpano, K. R., Sachs-Ericsson, N., Keough, M. E., & Riccardi, C. J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.03.008 · Cited by 281
Power for tests of interaction: effect of raising the Type I error rate
Marshall, S. W. (2007) · Epidemiologic Perspectives & Innovations · doi:10.1186/1742-5573-4-4 · Cited by 276
Harkness, K. L., Bruce, A. E., & Lumley, M. N. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.4.730 · Cited by 272
The origins of sex differences in depressive disorder: bridging the gap
Bebbington, P. (1996) · International Review of Psychiatry · doi:10.3109/09540269609051547 · Cited by 240
Gender, victimization, and outcomes: Reconceptualizing risk.
Kubiak, S. P., & Cortina, L. M. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.3.528 · Cited by 221
Childhood abuse, chronic pain, and depression in the National Comorbidity Survey
Sachs‐Ericsson, N., Kendall-Tackett, K. A., & Hernandez, A. (2007) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2006.12.007 · Cited by 201
Accounting for sex differences in depression through female victimization: Childhood sexual abuse
Cutler, S. E., & Nolen–Hoeksema, S. (1991) · Sex Roles · doi:10.1007/bf00289332 · Cited by 187
Iverson, K. M., Dick, A. M., McLaughlin, K. A., Smith, B. N., Bell, M. E., Gerber, M. R., Cook, N., & Mitchell, K. S. (2012) · Psychology of Violence · doi:10.1037/a0030956 · Cited by 159
Levitan, R. D., Rector, N. A., Sheldon, C. T., & Goering, P. N. (2003) · Depression and Anxiety · doi:10.1002/da.10077 · Cited by 140
HISTORY OF CHILDHOOD ABUSE IN PANIC DISORDER, SOCIAL PHOBIA, AND GENERALIZED ANXIETY DISORDER
Safren, S. A., Gershuny, B. S., Marzol, P. C., Otto, M. W., & Pollack, M. H. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200207000-00005 · Cited by 139
Chaney, A., Carballedo, A., Amico, F., Fagan, A., Skokauskas, N., Meaney, J., & Frodl, T. (2014) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120208 · Cited by 138
Relations among gender, violence exposure, and mental health: The national survey of adolescents.
Hanson, R. F., Borntrager, C. F., Brown, S., Kilpatrick, D. G., Saunders, B. E., Resnick, H. S., & Amstadter, A. B. (2008) · American Journal of Orthopsychiatry · doi:10.1037/a0014056 · Cited by 137
Childhood abuse in late-life depression
Comijs, H. C., van Exel, E., van der Mast, R. C., Paauw, A., Oude Voshaar, R., & Stek, M. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.11.010 · Cited by 123
Childhood psychological maltreatment subtypes and adolescent depressive symptoms
Paul, E., & Eckenrode, J. J. (2015) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2015.05.018 · Cited by 120
Ribeiro, W. S., Andreoli, S. B., Ferri, C. P., Prince, M. J., & Mari, J. D. J. (2009) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462009000600003 · Cited by 120
Childhood adversity, gender and depression over the life-course
Wainwright, N. W. J., & Surtees, P. G. (2002) · Journal of Affective Disorders · doi:10.1016/s0165-0327(01)00420-7 · Cited by 109
Exposure to violence, depression, and hostility in a sample of inner city high school youth
Moses, A. (1999) · Journal of Adolescence · doi:10.1006/jado.1998.0198 · Cited by 96
Fonzo, G. A., Ramsawh, H. J., Flagan, T., Simmons, A. N., Sullivan, S. G., Allard, C. B., Paulus, M. P., & Stein, M. B. (2015) · Psychological Medicine · doi:10.1017/s0033291715002603 · Cited by 96
Gender, victimization, and psychiatric outcomes
Gershon, A., Minor, K., & Hayward, C. (2008) · Psychological Medicine · doi:10.1017/s0033291708003000 · Cited by 95
Dunn, E. C., Gilman, S. E., Willett, J. B., Slopen, N. B., & Molnar, B. E. (2012) · Depression and Anxiety · doi:10.1002/da.21916 · Cited by 88
Does Gender Moderate the Relationship Between Childhood Maltreatment and Adult Depression?
Arnow, B. A., Blasey, C. M., Hunkeler, E. M., Lee, J., & Hayward, C. (2011) · Child Maltreatment · doi:10.1177/1077559511412067 · Cited by 84
Childhood adversity, recent life events and depression in late life
Comijs, H. C., Beekman, A. T. F., Smit, F., Bremmer, M. A., van Tilburg, T. G., & Deeg, D. J. H. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.012 · Cited by 73
Goldstein, J. M., Holsen, L. M., Handa, R. J., & Tobet, S. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00247 · Cited by 64
Brensilver, M., Negriff, S. L., Mennen, F. E., & Trickett, P. K. (2011) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2011.581618 · Cited by 42
Chaffin, M. J., Silovsky, J. F., & Vaughn, C. (2005) · Journal of Clinical Child & Adolescent Psychology · doi:10.1207/s15374424jccp3402_1 · Cited by 26
Diaz-Granados, N., McDermott, S., Wang, F., Posada‐Villa, J., Saavedra, J. E., Rondón, M. B., DesMeules, M., Dorado, L., Torres, Y., & Stewart, D. E. (2011) · Psychiatric Services · doi:10.1176/ps.62.5.pss6205_0516 · Cited by 19
Childhood maltreatment is linked to recurrent depression
White, C. (2011) · BMJ · doi:10.1136/bmj.d5246 · Cited by 3
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Sahle, B. W., Reavley, N. J., Li, W., Morgan, A. J., Yap, M. B. H., Reupert, A., & Jorm, A. F. (2022) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01745-2 · Cited by 375
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Metadata
- Authors
- Gallo, E. A. G., Munhoz, T. N., Loret de Mola, C., & Murray, J.
- Affiliations
- Universidade Federal de Pelotas (BR)
- Corresponding author
- Murray, Joseph
- Venue
- Child Abuse & Neglect
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 79
- Pages
- 107-114
- ISSN
- 0145-2134 (ISSN-L)
- OpenAlex
- W2790792517
- Cited by
- 279
- References
- 56
- Citations by year
- 2026: 28 · 2025: 38 · 2024: 34 · 2023: 45 · 2022: 42 · 2021: 36 · 2020: 34 · 2019: 16 · 2018: 6
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child Abuse & Neglect (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Keywords
- child abuse, gender differences, adult depression, generalized anxiety disorder, physical abuse, sexual abuse, childhood adversity, adolescent maltreatment, mental health outcomes
- MeSH terms
- Adolescent, Adult, Anxiety Disorders, Child, Child Abuse, Depressive Disorder, Major, Major Depressive Disorder, Epidemiologic Methods, Female, Humans, Male, Mental Health, Sex Factors, Adult Survivors of Child Abuse
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