The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont
Open accessAbstract
Summary The distal human gut is a microbial bioreactor that digests complex carbohydrates. The strategies evolved by gut microbes to sense and process diverse glycans have important implications for the assembly and operations of this ecosystem. The human gut bacterium Bacteroides thetaiotaomicron forages on host and dietary glycans. Its ability to target these substrates resides in 88 polysaccharide utilization loci (PULs), encompassing 18% of its genome. In this report, whole-genome transcriptional profiling and genetic tests are used to define the mechanisms underlying host glycan foraging in vivo and in vitro. PULs that target all major classes of host glycans were identified. Mucin O-glycans are the principal substrate foraged in vivo. Simultaneous deletion of five ECF-σ transcription factors that activate mucin O-glycan utilization produces defects in bacterial persistence in the gut and in mother-to-offspring transmission. Thus, PUL-mediated glycan catabolism is an important factor in gut colonization and likely impacts gut ecology.
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Self-citationObesity alters gut microbial ecology
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Self-citationEvolution of mammals and their gut microbes
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Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
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Metadata
- Authors
- Martens, E. C., Chiang, H. C., & Gordon, J. I.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 4
- Issue
- 5
- Pages
- 447-457
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2084512022
- Cited by
- 937
- References
- 7
- FWCI
- 7.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont. https://app.cochat.ai/papers/10.1016/j.chom.2008.09.007
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- Martens, E. C., Chiang, H. C., & Gordon, J. I. (2008). Mucosal Glycan Foraging Enhances Fitness and Transmission of a Saccharolytic Human Gut Bacterial Symbiont. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2008.09.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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