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Cited by 516

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System

Open access
Vance, Russell E., Isberg, Ralph R., Portnoy, Daniel A.·2009·Cell Host & Microbe

Abstract

The dominant conceptual framework for understanding innate immunity has been that host cells respond to evolutionarily conserved molecular features of pathogens called ‘pathogen-associated molecular patterns’ (PAMPs). PAMPs should be understood in the context of how they are naturally presented by pathogens. This can be experimentally challenging since pathogens, almost by definition, bypass host defense. Nevertheless, in this review, we explore the idea that the immune system responds to PAMPs in the context of additional signals that derive from common ‘patterns of pathogenesis’ employed by pathogens to infect, multiply within, and spread among their hosts.

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Crossref · 10.1016/j.chom.2009.06.007

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Metadata

Authors
Vance, R. E., Isberg, R. R., & Portnoy, D. A.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2009-07
Volume
6
Issue
1
Pages
10-21
ISSN
1931-3128 (ISSN-L)
OpenAlex
W2089228242
Cited by
516
References
20
FWCI
16.42
Type
journal article
Language
en
Open access
bronze

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Vance, R. E., Isberg, R. R., & Portnoy, D. A. (2009). Patterns of Pathogenesis: Discrimination of Pathogenic and Nonpathogenic Microbes by the Innate Immune System. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2009.06.007

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.