The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Bacterial Secretion Systems: An Overview
Open accessAbstract
Bacterial pathogens utilize a multitude of methods to invade mammalian hosts, damage tissue sites, and thwart the immune system from responding. One essential component of these strategies for many bacterial pathogens is the secretion of proteins across phospholipid membranes. Secreted proteins can play many roles in promoting bacterial virulence, from enhancing attachment to eukaryotic cells, to scavenging resources in an environmental niche, to directly intoxicating target cells and disrupting their functions. Many pathogens use dedicated protein secretion systems to secrete virulence factors from the cytosol of the bacteria into host cells or the host environment. In general, bacterial protein secretion apparatuses can be divided into classes, based on their structures, functions, and specificity. Some systems are conserved in all classes of bacteria and secrete a broad array of substrates, while others are only found in a small number of bacterial species and/or are specific to only one or a few proteins. In this chapter, we review the canonical features of several common bacterial protein secretion systems, as well as their roles in promoting the virulence of bacterial pathogens. Additionally, we address recent findings that indicate that the innate immune system of the host can detect and respond to the presence of protein secretion systems during mammalian infection.
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Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Pym, A. S., Brodin, P., Brosch, R., Huerre, M., & Cole, S. T. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03237.x · Cited by 729
Hoffmann, C., Leis, A., Niederweis, M., Plitzko, J. M., & Engelhardt, H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709530105 · Cited by 596
Direct Visualization of the Outer Membrane of Mycobacteria and Corynebacteria in Their Native State
Zuber, B., Chami, M., Houssin, C., Dubochet, J., Griffiths, G., & Daffé, M. (2008) · Journal of Bacteriology · doi:10.1128/jb.01919-07 · Cited by 458
The ESAT-6 gene cluster of Mycobacterium tuberculosis and other high G+C Gram-positive bacteria
Gey van Pittius, N. C., Gamieldien, J., Hide, W., Brown, G. D., Siezen, R. J., & Beyers, A. D. (2001) · Genome Biology · doi:10.1186/gb-2001-2-10-research0044 · Cited by 375
Braunstein, M., Espinosa, B. J., Chan, J., Belisle, J. T., & R. Jacobs, W. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03438.x · Cited by 272
Take five — Type VII secretion systems of Mycobacteria
Houben, E. N. G., Korotkov, K. V., & Bitter, W. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.003 · Cited by 223
Selective transport by SecA2: An expanding family of customized motor proteins
Bensing, B. A., Seepersaud, R., Yen, Y. T., & Sullam, P. M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.10.019 · Cited by 68
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A comprehensive review of signal peptides: Structure, roles, and applications
Owji, H., Nezafat, N., Negahdaripour, M., Hajiebrahimi, A., & Ghasemi, Y. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.06.003 · Cited by 523
Large-Scale Analyses of Human Microbiomes Reveal Thousands of Small, Novel Genes
Sberro, H., Fremin, B. J., Zlitni, S., Edfors, F., Greenfield, N., Snyder, M. P., Pavlopoulos, G. A., Kyrpides, N. C., & Bhatt, A. S. (2019) · Cell · doi:10.1016/j.cell.2019.07.016 · Cited by 237
Colorectal cancer: the facts in the case of the microbiota
Clay, S. L., Fonseca-Pereira, D., & Garrett, W. S. (2022) · Journal of Clinical Investigation · doi:10.1172/jci155101 · Cited by 166
Kostovcikova, K., Coufal, S., Galanova, N., Fajstova, A., Hudcovic, T., Kostovcik, M., Prochazkova, P., Jiraskova Zakostelska, Z., Cermakova, M., Sediva, B., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00919 · Cited by 126
Geldart, K. G., Kommineni, S., Forbes, M., Hayward, M., Dunny, G. M., Salzman, N. H., & Kaznessis, Y. N. (2018) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10107 · Cited by 93
Metadata
- Authors
- Green, E. R., & Mecsas, J.
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2016-01-29
- Volume
- 4
- Issue
- 1
- ISSN
- 2165-0497 (ISSN-L)
- OpenAlex
- W2308145610
- Cited by
- 1,079
- References
- 8
- FWCI
- 59.20
- Type
- journal article
- Language
- en
- Open access
- green
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