The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System
Open accessAbstract
Pattern recognition receptors (PRRs) detect conserved microbial structures generally absent from eukaryotes. Bacterial pathogens commonly utilize pore-forming toxins or specialized secretion systems to deliver virulence factors that promote bacterial replication by modulating host cell physiology. Detection of these secretion systems or toxins by nucleotide-binding oligomerization domain leucine-rich-repeat proteins (NLRs) triggers the assembly of multiprotein complexes, termed inflammasomes, necessary for caspase-1 activation. Here we demonstrate that caspase-1 activation in response to the Yersinia type III secretion system (T3SS) requires the adapter ASC, and involves both NLRP3 and NLRC4 inflammasomes. We further identify a Yersinia type III secreted effector protein, YopK, which prevents inflammasome activation by preventing cellular recognition of the T3SS. Inflammasome-mediated sensing of the T3SS promotes bacterial clearance from infected tissues in vivo. These data demonstrate that a class of bacterial proteins interferes with cellular recognition of bacterial secretion systems, which contributes to bacterial survival within host tissues.
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Cites
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Self-citationMartinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066
Gout-associated uric acid crystals activate the NALP3 inflammasome
Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326
Toll-like receptors: critical proteins linking innate and acquired immunity
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Cryopyrin activates the inflammasome in response to toxins and ATP
Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
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The Inflammasomes: Guardians of the Body
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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
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Cited by
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618
Pyroptotic cell death defends against intracellular pathogens
Jorgensen, I., & Miao, E. A. (2015) · Immunological Reviews · doi:10.1111/imr.12287 · Cited by 1,021
Newly described pattern recognition receptors team up against intracellular pathogens
Broz, P., & Monack, D. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3479 · Cited by 462
Casson, C. N., Yu, J., Reyes, V. M., Taschuk, F. O., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421699112 · Cited by 276
Mycobacterium tuberculosis and the host cell inflammasome: a complex relationship
Briken, V., Ahlbrand, S. E., & Shah, S. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00062 · Cited by 92
Metadata
- Authors
- Brodsky, I. E., Palm, N. W., Sadanand, S., Ryndak, M. B., Sutterwala, F. S., Flavell, R. A., Bliska, J. B., & Medzhitov, R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 7
- Issue
- 5
- Pages
- 376-387
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2055408817
- Cited by
- 307
- References
- 12
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brodsky, I. E., Palm, N. W., Sadanand, S., Ryndak, M. B., Sutterwala, F. S., Flavell, R. A., Bliska, J. B., & Medzhitov, R. (2010). A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion System. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2010.04.009
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