The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens
Open accessAbstract
Significance: The innate immune system provides a first line of defense against invading pathogens. The inflammasome is an innate immune complex that activates inflammatory caspases upon infection, causing cell death and IL-1 cytokine release, which initiate defense against gram-negative bacterial pathogens but also mediate septic shock. Many inflammasome studies have been performed using cells from mice, but mice and humans differ in their complement of inflammatory caspases. Instead of caspase-11, humans encode the putative orthologs caspase-4 and caspase-5. Here, we show that caspase-4 plays a conserved role in inflammasome activation in response to virulent gram-negative pathogens in primary human macrophages. Our findings provide important insight into how inflammasomes are regulated in human cells.
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Cites
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Non-canonical inflammasome activation targets caspase-11
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Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
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Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4
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Cited by
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
NLRP3 inflammasome activation and cell death
Huang, Y., Xu, W., & Zhou, R. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00740-6 · Cited by 1,527
NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis
Grebe, A., Hoss, F., & Latz, E. (2018) · Circulation Research · doi:10.1161/circresaha.118.311362 · Cited by 926
Caspases Connect Cell-Death Signaling to Organismal Homeostasis
Galluzzi, L., López-Soto, A., Kumar, S., & Kroemer, G. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.020 · Cited by 350
Metadata
- Authors
- Casson, C. N., Yu, J., Reyes, V. M., Taschuk, F. O., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2015-05-11
- Volume
- 112
- Issue
- 21
- Pages
- 6688-6693
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1801353699
- Cited by
- 276
- References
- 47
- FWCI
- 11.45
- Type
- journal article
- Language
- en
- Open access
- green
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- Casson, C. N., Yu, J., Reyes, V. M., Taschuk, F. O., Yadav, A., Copenhaver, A. M., Nguyen, H. T., Collman, R. G., & Shin, S. (2015). Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1421699112
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