Cited by 381Tuberculosis Research and EpidemiologyBacterial Genetics and BiotechnologyMycobacterium research and diagnosis

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Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

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Botella, Hélène, Peyron, Pascale, Levillain, Florence, Poincloux, Renaud, Poquet, Yannick, Brandli, Irène, Wang, Chuan, Tailleux, Ludovic, Tilleul, Sylvain, Charrière, Guillaume M., Waddell, Simon J., Foti, Maria, Lugo-Villarino, Geanncarlo, Gao, Qian, Maridonneau-Parini, Isabelle, Butcher, Philip D., Castagnoli, Paola Ricciardi, Gicquel, Brigitte, de Chastellier, Chantal, Neyrolles, Olivier·2011·Cell Host & Microbe

DOI 10.1016/j.chom.2011.08.006PMC PMC3221041

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Abstract

Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey of intracellular mycobacteria and their host macrophages revealed signatures of heavy metal poisoning. In particular, mycobacterial genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection. Consistent with this pattern of gene modulation, we observed a burst of free zinc inside macrophages, and intraphagosomal zinc accumulation within a few hours postinfection. Zinc exposure led to rapid CtpC induction, and ctpC deficiency caused zinc retention within the mycobacterial cytoplasm, leading to impaired intracellular growth of the bacilli. Thus, the use of P(1)-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages. We propose that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.

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Authors: Botella, H., Peyron, P., Levillain, F., Poincloux, R., Poquet, Y., Brandli, I., Wang, C., Tailleux, L., Tilleul, S., Charrière, G. M., Waddell, S. J., Foti, M., Lugo-Villarino, G., Gao, Q., Maridonneau-Parini, I., Butcher, P. D., Castagnoli, P. R., Gicquel, B., de Chastellier, C., & Neyrolles, O.
Affiliations: Centre National de la Recherche Scientifique (FR)
Institut Pasteur (FR)
Brighton and Sussex Medical School (GB)
University of Milano-Bicocca (IT)
Shanghai Medical College of Fudan University (CN)
St George's, University of London (GB)
Singapore Immunology Network (SG)
Corresponding author: Neyrolles, Olivier
ORCID: Poincloux, Renaud
Poquet, Yannick
Wang, Chuan
Tailleux, Ludovic
Charrière, Guillaume M.
Waddell, Simon J.
Foti, Maria
Gao, Qian
Butcher, Philip D.
Neyrolles, Olivier
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2011-09
Volume: 10
Issue: 3
Pages: 248-259
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2011.08.006
PMC: PMC3221041
OpenAlex: W2128702173
Cited by: 381
References: 48
Citations by year: 2026: 23 · 2025: 20 · 2024: 32 · 2023: 21 · 2022: 27 · 2021: 41 · 2020: 30 · 2019: 32 · 2018: 23 · 2017: 27 · 2016: 19 · 2015: 23 · 2014: 23 · 2013: 21 · 2012: 17
FWCI: 13.38
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/3.0/ (vor, 684 d)
Locations: Cell Host & Microbe (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Sussex Research Online (University of Sussex) (submittedVersion, cc-by)
HAL (submittedVersion)
HAL AMU (submittedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Wellcome Trust (086547)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, zinc efflux, zinc toxicity, metallothionein, ZnT1, phagosome maturation, intracellular bacterial growth, macrophages
MeSH terms: Animals, Cells, Cultured, Female, Humans, Macrophages, Mice, Inbred BALB C, Mycobacterium tuberculosis, Tuberculosis, Zinc, Bacterial Proton-Translocating ATPases, Mice

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Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages

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