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A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism
Open accessAbstract
Summary Bacteroidetes are a phylum of Gram-negative bacteria abundant in mammalian-associated polymicrobial communities, where they impact digestion, immunity and resistance to infection. Despite extensive competition at high cell density that occurs in these settings, cell contact-dependent mechanisms of interbacterial antagonism, such as the type VI secretion system (T6SS), have not been defined in this group of organisms. Herein we report the bioinformatic and functional characterization of a T6SS-like pathway in diverse Bacteroidetes. Using prominent human gut commensal and soil-associated species, we demonstrate that these systems localize dynamically within the cell, export antibacterial proteins, and target competitor bacteria. The Bacteroidetes system is a distinct pathway with marked differences in gene content and high evolutionary divergence from the canonical T6S pathway. Our findings offer a potential molecular explanation for the abundance of Bacteroidetes in polymicrobial environments, the observed stability of Bacteroidetes in healthy humans, and the barrier presented by the microbiota against pathogens.
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Self-citationDiversity, stability and resilience of the human gut microbiota
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Wexler, A. G., & Goodman, A. L. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.26 · Cited by 641
Self-citationMicrobiota-mediated colonization resistance: mechanisms and regulation
Caballero-Flores, G., Pickard, J. M., & Núñez, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00833-7 · Cited by 474
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The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function
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Metadata
- Authors
- Russell, A. B., Wexler, A. G., Harding, B. N., Whitney, J. C., Bohn, A. J., Goo, Y. A., Tran, B. Q., Barry, N. A., Zheng, H., Peterson, S. B., Chou, S., Gonen, T., Goodlett, D. R., Goodman, A. L., & Mougous, J. D.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 16
- Issue
- 2
- Pages
- 227-236
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2108687405
- Cited by
- 372
- References
- 7
- FWCI
- 15.85
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Russell, A. B., Wexler, A. G., Harding, B. N., Whitney, J. C., Bohn, A. J., Goo, Y. A., Tran, B. Q., Barry, N. A., Zheng, H., Peterson, S. B., Chou, S., Gonen, T., Goodlett, D. R., Goodman, A. L., & Mougous, J. D. (2014). A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2014.07.007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
