The Long-Term Stability of the Human Gut Microbiota
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Inheritance Guts: We know little about the stability of the constituent microbiota in the human gut or the extent to which the gut microbiota are a potential target for long-term health interventions. Faith et al. (p. 10.1126/science.1237439 ) analyzed the fecal microbiota of 37 individuals and found that, on average, 60% of bacterial strains remained stable for up to 5 years and many were estimated to remain stable for decades.
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Firmicutes and Bacteroidetes are the major bacterial phyla in gut microbiota, and their proportions appear stable over time within individuals and family members.
“The major taxa present in gut microbiota consist primarily of 2 major bacterial phyla, Firmicutes and Bacteroidetes, whose proportions appear to remain remarkably stable over time within individuals and their family members (9, 10).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [10]
An individual's microbiota could be remarkably stable, with 60% of strains remaining over the course of five years.
“A study demonstrated that an individual’s microbiota could be remarkably stable, with 60% of strains remaining over the course of five years”
From Gut microbiome affects the response to anti-PD-1 immunotherapy in patients with hepatocellular carcinoma (2019) · cites this paper as [15]
The microbiota is generally highly stable over an extended period of time in the absence of significant perturbations.
“Although the microbiota is generally highly stable over an extended period of time in the absence of significant perturbations [45]”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [45]
The composition of the gut microbiota appears sensitive to caloric balance, as noted in subjects studied before, during, and after weight loss.
“the composition of the gut microbiota does appear to be sensitive to caloric balance as noted in subjects studied before, during, and after weight loss [38].”
From The athletic gut microbiota (2020) · cites this paper as [38]
Mock-community data supported diversity and precision-sensitivity analyses.
“Data from the mock communities were used for diversity and precisionsensitivity analyses employing methods described previously15,23.”
From Persistent gut microbiota immaturity in malnourished Bangladeshi children (2014) · cites this paper as [15]
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“Although the microbiota is generally highly stable over an extended period of time in the absence of significant perturbations [45], dietary interventions can induce quick changes in composition [13, 15].”
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- Authors
- Faith, J. J., Guruge, J. L., Charbonneau, M., Subramanian, S., Seedorf, H., Goodman, A. L., Clemente, J. C., Knight, R., Heath, A. C., Leibel, R. L., Rosenbaum, M., & Gordon, J. I.
- Affiliations
- Washington University in St. Louis (US)
- Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
- Howard Hughes Medical Institute (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Gordon, Jeffrey I.
- ORCID
- Venue
- Science
- Published
- 2013-07-05
- Volume
- 341
- Issue
- 6141
- Pages
- 1237439-1237439
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3791589
- OpenAlex
- W2137195441
- Cited by
- 2,058
- References
- 41
- Citations by year
- 2026: 98 · 2025: 117 · 2024: 134 · 2023: 178 · 2022: 197 · 2021: 222 · 2020: 197 · 2019: 191 · 2018: 154 · 2017: 157 · 2016: 138 · 2015: 147 · 2014: 102 · 2013: 25
- FWCI
- 61.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- Crohn's and Colitis Foundation
- National Institutes of Health (UL1TR000040)
- National Institute on Alcohol Abuse and Alcoholism (K05AA017688)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK030292, DK-30292, DK078669, P01DK078669, R01DK064773, DK 70977, DK64774, R01DK070977, P30DK026687, R01DK030292)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, microbiome stability, power-law distribution, fecal microbiota, liquid diet, body weight, 16S rRNA amplicon sequencing
- MeSH terms
- Adult, Bacteria, Body Composition, Family, Feces, Female, Humans, Male, Models, Biological, RNA, Ribosomal, 16S, Time Factors, Weight Loss, Genome, Bacterial, Sequence Analysis, DNA, Caloric Restriction, Gastrointestinal Tract, Genomic Instability, Metagenome, Young Adult
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