The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The Gut Commensal Bacteroides thetaiotaomicron Exacerbates Enteric Infection through Modification of the Metabolic Landscape
Open accessAbstract
SUMMARY The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) causes severe diarrhea but the influence of the gut microbiota on EHEC infection is largely unknown. A predominant member of the microbiota, Bacteroides thetaiotaomicron (Bt), is resident at EHEC attachment sites. We show that Bt enhances EHEC virulence gene expression through the transcription factor, Cra, which is functionally sensitive to sugar concentrations. This enhanced virulence accompanies increased formation of attaching and effacing (AE) lesions requisite for EHEC colonization. Infection with Citrobacter rodentium, a natural mouse pathogen homologous to EHEC, in Bt-reconstituted mice results in increased gut permeability along with exacerbated host pathology and mortality compared to mice deplete of microflora. Bt modifies the metabolite environment at infection sites, increasing metabolites involved in gluconeogenesis, with stark increases in succinate, which can be sensed by Cra. Our findings suggest that microbiota composition affects disease outcome and may explain links between microbiota composition and disease susceptibility.
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Cites
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
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Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults
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A Genomic View of the Human- Bacteroides thetaiotaomicron Symbiosis
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Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens
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Cited by
Interactions between the microbiota and pathogenic bacteria in the gut
Bäumler, A. J., & Sperandio, V. (2016) · Nature · doi:10.1038/nature18849 · Cited by 1,420
Self-citationInteractions of commensal and pathogenic microorganisms with the intestinal mucosal barrier
Martens, E. C., Neumann, M., & Desai, M. S. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0036-x · Cited by 711
An insider's perspective: Bacteroides as a window into the microbiome
Wexler, A. G., & Goodman, A. L. (2017) · Nature Microbiology · doi:10.1038/nmicrobiol.2017.26 · Cited by 641
Qin, Y., Havulinna, A. S., Liu, Y., Jousilahti, P., Ritchie, S. C., Tokolyi, A., Sanders, J. G., Valsta, L., Brożyńska, M., Zhu, Q., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00991-z · Cited by 586
Gut Microbiota and Colonization Resistance against Bacterial Enteric Infection
Ducarmon, Q. R., Zwittink, R. D., Hornung, B. V. H., van Schaik, W., Young, V. B., & Kuijper, E. J. (2019) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00007-19 · Cited by 566
Metadata
- Authors
- Curtis, M. M., Hu, Z., Klimko, C., Narayanan, S., Deberardinis, R., & Sperandio, V.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 16
- Issue
- 6
- Pages
- 759-769
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2123583755
- Cited by
- 307
- References
- 13
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Curtis, M. M., Hu, Z., Klimko, C., Narayanan, S., Deberardinis, R., & Sperandio, V. (2014). The Gut Commensal Bacteroides thetaiotaomicron Exacerbates Enteric Infection through Modification of the Metabolic Landscape. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2014.11.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
