Cited by 157Evolution and Genetic DynamicsViral Infections and Immunology ResearchRNA and protein synthesis mechanisms

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RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence

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Xiao, Yinghong, Rouzine, Igor M., Bianco, Simone, Acevedo, Ashley, Goldstein, Elizabeth Faul, Farkov, Mikhail, Brodsky, Leonid, Andino, Raul·2016·Cell Host & Microbe

DOI 10.1016/j.chom.2016.03.009PMC PMC4840895

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Abstract

Mutation and recombination are central processes driving microbial evolution. A high mutation rate fuels adaptation but also generates deleterious mutations. Recombination between two different genomes may resolve this paradox, alleviating effects of clonal interference and purging deleterious mutations. Here we demonstrate that recombination significantly accelerates adaptation and evolution during acute virus infection. We identified a poliovirus recombination determinant within the virus polymerase, mutation of which reduces recombination rates without altering replication fidelity. By generating a panel of variants with distinct mutation rates and recombination ability, we demonstrate that recombination is essential to enrich the population in beneficial mutations and purge it from deleterious mutations. The concerted activities of mutation and recombination are key to virus spread and virulence in infected animals. These findings inform a mathematical model to demonstrate that poliovirus adapts most rapidly at an optimal mutation rate determined by the trade-off between selection and accumulation of detrimental mutations.

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Authors: Xiao, Y., Rouzine, I. M., Bianco, S., Acevedo, A., Goldstein, E. F., Farkov, M., Brodsky, L., & Andino, R.
Affiliations: University of California, San Francisco (US)
IBM Research - Almaden (US)
University of Haifa (IL)
Corresponding author: Andino, Raul
ORCID: Xiao, Yinghong
Rouzine, Igor M.
Bianco, Simone
Acevedo, Ashley
Brodsky, Leonid
Andino, Raul
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2016-04
Volume: 19
Issue: 4
Pages: 493-503
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2016.03.009
PMC: PMC4840895
OpenAlex: W2335860311
Cited by: 157
References: 57
Citations by year: 2026: 10 · 2025: 10 · 2024: 14 · 2023: 19 · 2022: 13 · 2021: 17 · 2020: 20 · 2019: 16 · 2018: 21 · 2017: 11 · 2016: 6
FWCI: 14.53
Type: journal article
Language: en
Update notices: erratum (2017-09-13)
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 377 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (R01, AI36178, AI40085, P01 AI091575)
University of California
DoD-DARPA
Irvin “Tack” Kuntz
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: RNA recombination, poliovirus, viral adaptation, mutation rate, deleterious mutations, clonal interference, purging of deleterious mutations, viral virulence, viral spread, acute viral infection
MeSH terms: Adaptation, Physiological, Animals, Humans, Poliomyelitis, Recombination, Genetic, DNA-Directed RNA Polymerases, RNA, Viral, Selection, Genetic, Viral Proteins, Virulence, Virus Replication, Poliovirus, Evolution, Molecular

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RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence

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