Mechanisms of genetic variation in polioviruses

Savolainen‐Kopra, Carita; Blomqvist, Soile

doi:10.1002/rmv.663

Cited by 67Evolution and Genetic DynamicsViral Infections and Immunology ResearchVirology and Viral Diseases

Mechanisms of genetic variation in polioviruses

Savolainen‐Kopra, Carita, Blomqvist, Soile·2010·Reviews in Medical Virology

DOI 10.1002/rmv.663

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Abstract

Polioviruses, as with all RNA viruses, are in a constant process of evolution driven by different mechanisms. With multiple mechanisms for genetic variability, they are successful conformists, adapting to changes in their habitat. The evolution of polioviruses may occur with generation of point mutations followed by genetic drift and selection. The mutation rate of polioviruses based on several studies is approximately 3 × 10−2 mutations/synonymous site/year in the gene encoding viral protein 1. Genetic variation in polioviruses may also be increased by sharing of genetic data of two different poliovirus lineages by means of homologous recombination. According to the current view, recombination is considered usually to occur by strand‐switching, but a non‐replicative model has also been described. In recombination, polioviruses may either gain a set of advantageous mutations selected and fixed in previous generations of the parental viruses or get rid of deleterious ones. The prerequisites and constraints of the evolution mechanisms will be discussed. Furthermore, consequences of poliovirus evolution will be reviewed in the light of observations made on currently circulating polioviruses. We will also describe how polioviruses strike back: as wild type polioviruses approach eradication, vaccine derived strains increase their occurrence and genetic variability. Copyright © 2010 John Wiley & Sons, Ltd.

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The capsid-encoding region of poliovirus, with a rate of fixation of total substitutions in the order of 10−2 substitutions/site/year, appears less genetically stable than the region encoding non-structural proteins.
“However, the capsid-encoding region, with a rate of fixation of total substitutions in the order of 10−2 substitutions/site/year, appears less genetically stable than the region encoding non-structural proteins [17,18].”
From Recombination between Poliovirus and Coxsackie A Viruses of Species C: A Model of Viral Genetic Plasticity and Emergence (2011) · cites this paper as [18]

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Why do RNA viruses recombine?
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Molecular Epidemiology and Evolution of Human Enterovirus Serotype 68 in Thailand, 2006–2011
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Sabin Vaccine Reversion in the Field: a Comprehensive Analysis of Sabin-Like Poliovirus Isolates in Nigeria
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Feasibility of Quantitative Environmental Surveillance in Poliovirus Eradication Strategies
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Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses
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A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase
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Cross-reactive Neutralizing Antibody Responses to Enterovirus 71 Infections in Young Children: Implications for Vaccine Development
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Epidemiology and Sequence-Based Evolutionary Analysis of Circulating Non-Polio Enteroviruses
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Genetic diversity and recombination of enterovirus G strains in Japanese pigs: High prevalence of strains carrying a papain-like cysteine protease sequence in the enterovirus G population
Tsuchiaka, S., Naoi, Y., Imai, R., Masuda, T., Ito, M., Akagami, M., Ouchi, Y., Ishii, K., Sakaguchi, S., Omatsu, T., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190819 · Cited by 43 · see citing works
Emergency Services of Viral RNAs: Repair and Remodeling
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An infectious recombinant foot-and-mouth disease virus expressing a fluorescent marker protein
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Extensive Gene Remodeling in the Viral World: New Evidence for Nongradual Evolution in the Mobilome Network
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Whole Genome Sequencing of Enterovirus species C Isolates by High-Throughput Sequencing: Development of Generic Primers
Bessaud, M., Sadeuh‐Mba, S. A., Joffret, M., Razafindratsimandresy, R., Polston, P. M., Volle, R., Andrianarivelo, M. R., Blondel, B., Njouom, R., & Delpeyroux, F. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01294 · Cited by 30 · see citing works
A Glimpse on the Evolution of RNA Viruses: Implications and Lessons from SARS-CoV-2
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Anderson's and Stebbins' Prophecy Comes True: Genetic Exchange in Fluctuating Environments
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Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications
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Detection of enterovirus genome sequence from diarrheal feces of goat
Omatsu, T., Tsuchiaka, S., Hirata, T., Shiroma, Y., Okazaki, S., Katayama, Y., Oba, M., Nishiura, N., Sassa, Y., Furuya, T., et al. (2014) · Virus Genes · doi:10.1007/s11262-014-1057-9 · Cited by 23 · see citing works
Impact of cell lines included in enterovirus isolation protocol on perception of nonpolio enterovirus species C diversity
Adeniji, J. A., & Faleye, T. O. C. (2014) · Journal of Virological Methods · doi:10.1016/j.jviromet.2014.07.016 · Cited by 20 · see citing works
Clinical and enterovirus findings associated with acute flaccid paralysis in the republic of Korea during the recent decade
Kim, H.-J., Kang, B., Hwang, S., Lee, S., Cheon, D., Kim, K., Jeong, Y., & Hyeon, J.-Y. (2013) · Journal of Medical Virology · doi:10.1002/jmv.23763 · Cited by 18 · see citing works
Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing
Sahoo, M. K., Holubar, M. K., Huang, C., Mohamed-Hadley, A. A., Liu, Y., Waggoner, J. J., Troy, S. B., García‐García, L., Ferreyra-Reyes, L. D., Maldonado, Y., et al. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00144-17 · Cited by 15 · see citing works
Vaccine preventable viral diseases and risks associated with waterborne transmission
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Correlated substitutions reveal SARS-like coronaviruses recombine frequently with a diverse set of structured gene pools
Steinberg, A. P., Silander, O., & Kussell, E. L. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2206945119 · Cited by 11 · see citing works
Reliability of non-culturable virus monitoring by PCR-based detection methods in environmental waters containing various concentrations of target RNA
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Genotyping of Infectious Pancreatic Necrosis Virus Isolates from Mexico State
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Molecular epidemiology and evolutionary dynamics of Echovirus 3 serotype
Kyriakopoulou, Z., Bletsa, M., Tsakogiannis, D., Dimitriou, T. G., Amoutzias, G. D., Gartzonika, C., Levidiotou-Stefanou, S., & Markoulatos, P. (2015) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2015.03.008 · Cited by 11 · see citing works
Genetic diversity of enterovirus G detected in faecal samples of wild boars in Japan: identification of novel genotypes carrying a papain-like cysteine protease sequence
Nagata, A., Sekiguchi, Y., Oi, T., Sunaga, F., Madarame, H., Imai, R., Sano, K., Katayama, Y., Omatsu, T., Oba, M., et al. (2020) · Journal of General Virology · doi:10.1099/jgv.0.001446 · Cited by 10 · see citing works
Genome analysis of two type 6 echovirus (E6) strains recovered from sewage specimens in Greece in 2006
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Reversion of neurovirulent mutations, recombination and high intra‐host diversity in vaccine‐derived poliovirus excreted by patients with primary immune deficiency
Salem, I. B., Khemiri, H., Drechsel, O., Arbi, M., Böttcher, S., Mekki, N., Fraj, I. B., Souiaï, O., Yahyaoui, M., Farhat, E. B., et al. (2024) · Journal of Medical Virology · doi:10.1002/jmv.29918 · Cited by 8 · see citing works
Viral metagenomics of pharyngeal secretions from children with acute respiratory diseases with unknown etiology revealed diverse viruses
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Novel recombinant porcine enterovirus G viruses lacking structural proteins are maintained in pig farms in Japan
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Multiple genotypes of enterovirus G carrying a papain-like cysteine protease (PL-CP) sequence circulating on two pig farms in Japan: first identification of enterovirus G10 carrying a PL-CP sequence
Sekiguchi, Y., Nagata, A., Sunaga, F., Oi, T., Imai, R., Madarame, H., Katayama, Y., Oba, M., Okabayashi, T., Misawa, N., et al. (2020) · Archives of Virology · doi:10.1007/s00705-020-04816-y · Cited by 7 · see citing works
A national cross-sectional study for poliovirus seroprevalence in the Republic of Korea in 2012: implication for deficiency in immunity to polio among middle-aged people
Kim, H.-J., Hwang, S., Lee, S., Kwon, Y., Park, K., Park, Y. J., Bae, G., Lee, S., Jeong, Y., & Hyeon, J.-Y. (2015) · BMC Infectious Diseases · doi:10.1186/s12879-015-0894-z · Cited by 7 · see citing works
Polio Eradication in India
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Polio is back? The risk of poliomyelitis recurrence globally, and the legacy of the severe acute respiratory syndrome coronavirus 2 pandemic
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Identification and Typing of Human Enterovirus: A Genomic Barcode Approach
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Rare natural type 3/type 2 intertypic capsid recombinant vaccine-related poliovirus isolated from a case of acute flaccid paralysis in Brazil, 2015
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Prevalence and genetic diversity in bovine parechovirus infecting Japanese cattle
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Evolution of Type 2 Vaccine Derived Poliovirus Lineages. Evidence for Codon-Specific Positive Selection at Three Distinct Locations on Capsid Wall
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Authors: Savolainen‐Kopra, C., & Blomqvist, S.
Affiliations: Finnish Institute for Health and Welfare (FI)
Corresponding author: Savolainen‐Kopra, Carita
ORCID: Blomqvist, Soile
Venue: Reviews in Medical Virology
Publisher: Wiley
Published: 2010-10-15
Volume: 20
Issue: 6
Pages: 358-371
ISSN: 1052-9276 (ISSN-L)
1099-1654
DOI: 10.1002/rmv.663
OpenAlex: W2041436148
Cited by: 67
References: 110
Citations by year: 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 9
FWCI: 0.81
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Reviews in Medical Virology (publishedVersion)
PubMed (publishedVersion)
STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
WOS
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: poliovirus, genetic variation, viral evolution, point mutations, genetic drift, natural selection, mutation rate, homologous recombination, vaccine-derived poliovirus, polio eradication, RNA viruses
MeSH terms: Adaptation, Biological, Biological Evolution, Humans, Mutation, Recombination, Genetic, Genetic Variation, Poliovirus, Evolution, Molecular

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